DNA and Protein Modification


Antibodies to proteins involved in DNA and protein modification


The NS reagents range includes a specific focus on antibodies to proteins involved in the modification of proteins and nucleic acids.

 

This includes the areas of Histones, DNA methyltransferases, Methyl-CpG-Binding Domain Proteins, Protein arginine methyltransferases and many more areas in development.

 

 

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Featured DNA and protein modification antibodies

Anti-RAMP Antibodies (1, 2 and 3)

 

Receptor Activity Modifying Proteins (RAMPs) are required to transport calcitonin-receptor-like receptor (CRLR or CALCRL) to the plasma membrane. CRLR is a G protein-coupled receptor receptor with seven transmembrane domains, which can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. 

 

Wth RAMP1 it produces a CGRP receptor with RAMP2 it produces an adrenomedullin (AM) receptor (AM1) with RAMP3 it produces a dual CGRP/AM receptor (AM2)

 

In general four roles have been reported for RAMPs:

1. RAMPs enable the forward-trafficking of some GPCRs to the cell surface.

2. RAMPs can alter GPCR pharmacology, switching ligand selectivity for some GPCRs.

3. RAMPs can influence coupling to GPCR signaling pathways.

4. RAMPs may alter the trafficking pathway of some GPCRs from the cell surface, with different RAMPs controlling receptor fate through recycling or degradative pathways.

 

We have 3 antiboies available as follows:

 

Anti-RAMP1 Antibody         

Applications: WB, IHC         

Host: Rabbit      Reactivity: Human, Mouse, Rat

 

Anti-RAMP2 Antibody         

Applications: WB                 

Host: Rabbit      Reactivity: Human, Mouse, Rat

 

Anti-RAMP3 Antibody         

Applications: WB, IF            

Host: Rabbit      Reactivity: Human, Mouse, Rat

 

All are available as 50ug or 100ug size

 

More information is available on the links above or complete the form below to request copies of the datasheets.

 


 

Anti-DNA damage-binding protein 1

 

DNA damage-binding protein 1 (DDB1) is the large subunit (p127) of the heterodimeric DNA damage-binding (DDB) complex. DDB1 also functions as a core component of the cullin 4 (CUL4) ubiquitin E3 ligase complex, facilitating the binding of substrates to this complex and the ubiquitination of proteins. These factors (ubiquitin ligase substrates) regulate numerous essential processes in the cell including DNA repair (DDB2), DNA replication, chromatin remodelling (Cdt2) and more.

 

Applications: WB           Host: Rabbit      Reactivity: Human

 


Submit this form to request datasheets for these antibodies


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