DNA and Protein Modification

The NS reagents range covers many areas including antibodies to proteins involved in the modification of nucleic acids and other proteins.

More specifically this includes the areas of Histones, DNA methyltransferases, Methyl-CpG-Binding Domain Proteins, Protein arginine methyltransferases and many more proteins modifying the structure and/or activity of other proteins.

Some products are highlighted below, but many more are available, so please use the search box above to find specific reagents or email us at tech@nktscientific.com.

DNA damage-binding protein 1 (DDB1) is the large subunit (p127) of the heterodimeric DNA damage-binding (DDB) complex. DDB1 also functions as a core component of the cullin 4 (CUL4) ubiquitin E3 ligase complex, facilitating the binding of substrates and the ubiquitination of proteins. These factors (ubiquitin ligase substrates) regulate numerous essential processes in the cell including DNA repair, DNA replication, chromatin remodelling.

Our anti-DNA damage-binding protein 1 antibody has been tested with human samples, but we also guarantee it for use in many other species. See datasheet for details.

Applications: WB      Host: Rabbit      Reactivity: Human (and other species)

Click the links above for more information or email us at tech@nktscientific.com.

Anti-RAMP Antibodies (1, 2 and 3)

Receptor Activity Modifying Proteins (RAMPs) transport calcitonin-receptor-like receptors (CRLR or CALCRL) to the cell surface. CRLR is a G protein-coupled receptor with seven transmembrane domains, which can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which member of the RAMP family transports it to the cell surface. Wth RAMP1 it produces a CGRP receptor with RAMP2 it produces an adrenomedullin (AM) receptor (AM1) with RAMP3 it produces a dual CGRP/AM receptor (AM2).

Read more about RAMPs and our RAMP 1, 2 and 3 antibodies.