Newmarket Scientific
Newmarket Scientific








Neuroscience


Proteins, antibodies, kits and other reagents for neuroscience


Affinity Biosciences logo   Agrisera logo     Biosensis logo   ImmunoStar logo  NS Reagents logo  StressMarq logo 

 


 

Newmarket Scientific provides products for neuroscience including:

 

Antibodies, Proteins, Immunohistochemistry kits and Related reagents.

 

Please visit our immunohistochemistry page for details of our IHC kits or if you are having difficulty locating an item, simply use our contact form and we'll look for you.

 

More information on neuroscience research including highlighted papers and other resources is available on our Exosome Twitter feed:

 



Biosensis MOAB-2 antibody to Amyloid beta peptide (40/42)

The presence of aggregated amyloid-β peptides (Aβ) is one of the hallmarks of Alzheimer's Disease (AD). However, the form(s) of Aβ-peptides that are associated with this pathology remains unclear. In particular, the neurotoxicity of intraneuronal Aβ accumulation is an area of considerable research and controversy principally because antibodies thought to be specific for Aβ have been shown to actually detect intraneuronal amyloid precursor protein (APP) and not Aβ exclusively.

 

Our Biosensis MOAB-2 antibody (M-1586-100) is a new pan-specific monoclonal antibody to Amyloid beta residues 1-4 and provides unparalleled staining clarity, stronger reactivity and greater sensitivity than any other Abeta monoclonal antibodies previously available for research. Also, unlike other monoclonals such as 6E10 and 4G8, MOAB-2 does not cross react with APP or APP C-terminal fragments.

 

The Biosensis formulation of MOAB-2 is also the only one endorsed by the original developers.

 

Biosensis MOAB-2 antibody to Amyloid beta peptide (A beta 40/42)

 

Related products:

Biosensis APP antibodies, Oligomeric Amyloid-beta ELISA Kits,

Amylo-Glo - Amyloid beta plaque staining solution

 



StressMarq New Active Preformed Fibrils and Filaments for Neurodegeneration research

StressMarq has recently released new proteins for the study of neurodegenerative diseases including alpha synuclein, beta synuclein, gamma synuclein, tau, SOD1 and TTR.

 

Protein conformation disorders such as alpha-synucleinopathies, tauopathies, ALS and amyloidosis are characterised by the assembly of normally soluble proteins into insoluble aggregates. The use of the “preformed fibril model” where monomers are converted into preformed fibrils is gaining popularity amongst researchers to study neurodegenerative disorders such as Parkinson’s and Alzheimer’s.

 

Preformed fibrils can be used in vitro, adding them to the culture media or in vivo injecting them into the brain. Although pathological preformed fibrils can be generated from monomers, not all preformed fibrils formed are able to seed inclusions in cells/neurons.

 

However StressMarq has produced a wide range of already validated active preformed fibrils and monomers that produce consistent pathology (validated protein concentration, sedimentation assay, thioflavin T assay, electron microscopic visualisation of the fibrils) . These active preformed fibrils induce protein aggregation/biological activities both in vitro and in vivo.

 

Protocols: Cell Culture Assay, ASYN Thioflavin T Assay.

 

 

Alpha Synuclein Preformed Fibrils    Beta Synuclein Preformed Fibrils    Gamma Synuclein Preformed Fibrils

TTR Preformed Fibrils    SOD1 Preformed Fibrils    Tau Preformed Fibrils

 



Neuroscience - ImmunoStar
Immunostar neuroscience

 

Newmarket Scientific is the UK and Ireland Distributor for the ImmunoStar range of antibodies for neuroscience research.

 

This range of primary antibodies was originally provided by DiaSorin (formerly INCSTAR), but in 2001 the range became Immunostar. As these antibodies have been available for many years there are multiple references citing their use.

 

Additionally ImmunoStar antibodies are put through extensive testing before release to ensure both high quality and high titer. This provides excellent reliability and lot-to-lot consistency. These antibodies have also been specifically tested for use in immunohistochemistry. 

 

Details of the full range of 60+ well referenced neuroscience antibodies are available on this link.