Newmarket Scientific
Newmarket Scientific








Neuroscience Research - ALS and FTD Focus


Antibodies and reagents for Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD)


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Newmarket Scientific provides Antibodies, Proteins, ELISA kits and related reagents for neuroscience research with a focus on Amyotrophic lateral sclerosis (ALS) and Frontotemporal dementia (FTD).

 

Some products are highlighted below, but many more are available, so please use the search box above to find specific reagents or email us at tech@nktscientific.com

 

Also for more information on neuroscience research in general, including highlighted articles/papers and other resources follow our .

 



Antibodies for Amyotrophic Lateral Sclerosis Research

 

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterised by the progressive degeneration of motor neurons. There are a considerable number of genes associated with the pathogenesis of ALS, covering a wide range of cellular processes, which has made research into the causes of ALS particularly complex.

 

Newmarket Scientific provides antibodies to many proteins associated with ALS and we continually monitor the latest publications in this area with the aim of providing the antibodies required by those at the forefront of ALS research.

 

Some common targets for ALS-FTD to which we have antibodies are listed below with a link to a more comprehensive list detailing the individual antibodies.

 

CHMP2B   C9orf72   FUS/TLS   KIF5A   MATR3   SOD1   TDP-43   UBQLN2 

...read more

 



NEW NS Reagents Neuroscience Antibodies

 


 

 

PLCG2 Antibody (Cat No: AB21-10139)

Phospholipase C-gamma2 (PLCG2) is an enzyme mainly expressed in immune cells (including microglia) which are involved in innate immunity. PLCG2 has higher expression levels in pathologically affected brain regions in Alzheimer’s disease indicating that the immune system may play a key role in Alzheimer’s disease.

 


 

 

CD38 Antibody (Cat No: AB21-10136)

CD38 is a widely expressed multifunctional ectoenzyme catalysing multiple reactions and also has a role in signal transduction and calcium signaling. CD38 expression in the brain increases under neuroinflammatory conditions indicating a possible role in the regulation of neuroinflammation. In Alzheimer's disease, CD38 immunoreactivity is seen in intracellular tangles and neuropil threads.

 


 

SOD1 Western Blot Image

 

SOD1 Antibody (Cat No: AB19-10106)

Superoxide dismutase 1 (SOD1) is one of three superoxide dismutases with SOD1 being the principal cytoplasmic superoxide dismutase in humans. It binds copper and zinc ions for its activity and stability and plays a major role in redox potential regulation. SOD1 variants are a common cause of familial amyotrophic lateral sclerosis (ALS).


 

TREM2 Staining

 

TREM2 Antibody (Cat No: AB21-10133)

TREM2 (Triggering receptor expressed on myeloid cells 2) is a cell surface transmembrane glycoprotein expressed in myeloid cells including microglia. It plays a complex role in neuroinflammation with expression of TREM2 being upregulated in pathological conditions such as Parkinson's disease, Amyotrophic lateral sclerosis (ALS), stroke, traumatic brain injury and Alzheimer's Disease.

 


 

HRH3 Image

 

HRH3 Antibody (Cat No: AB21-10137)

Histamine is an important messenger molecule and neuromodulator, regulating the release of several neurotransmitters, including histamine release from histaminergic neurons. Dysregulated central histaminergic signalling has been associated with a number of psychiatric disorders including sleep disorders, ADHD, Alzheimer's disease, Parkinson's disease and schizophrenia.

 


 

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GBA Antibody (Cat No: AB19-10120)

Lysosomal acid glucosylceramidase (GBA or Glucocerebrosidase) is the lysosomal hydrolase. Mutations in the GBA gene cause Gaucher disease, a lysosomal storage disease characterised by an accumulation of glucocerebrosides. Patients with Gaucher disease are at increased risk of developing Parkinson's disease and Dementia with Lewy Bodies.

 



Tdp 43 3 cat aa17 100105

TDP43 Antibodies

 

TAR DNA-binding protein 43 (TDP43) binds DNA and RNA and has multiple functions in transcriptional repression, pre-mRNA splicing and translational regulation.

 

Characterisation of transcriptome-wide binding sites shows that thousands of RNAs are bound by TDP43 in neurons.

 

Hyperphosphorylated, fragmented and ubiquitinated forms of TDP-43 have been identified as core components of cytosolic inclusions in ALS (amyotrophic lateral sclerosis) and FTLD (frontotemporal lobar degeneration). As well as...  read more

 



RNA-binding Proteins and Stress granules in ALS-FTD

 

Cytoplasmic stress granules are membrane-less aggregates that form through liquid phase separation as a protective response to physiological or pathological conditions such as oxidative stress, hypoxia or virus infection. They are transient and usually disappear after the stress is removed.

 

Stress granules are mainly composed of messenger RNAs (mRNAs) stalled in translation initiation, translation initiation components such as eukaryotic initiation factor 4G (eIF4G), RNA-binding proteins (RBPs) and ribonucleoproteins. Formation of stress granules can be initiated by the Ras GTPase-activating protein-binding protein 1 (G3BP1), which is commonly used as a stress granule marker.

 

Mutations in genes that encode RNA binding proteins (RBPs) such as FUS/TLS, TDP-43, Ataxin 2, TAF15, EWSR1, hnRNPA1 and hnRNPA2, MATR3 and TIA-1 have recently been linked to ALS/FTD. Some of these RNA binding proteins... read more.

 



Nerve Growth Factor Receptor (p75NTR)

 

The nerve growth factor (NGF) receptor, also known as p75 neurotrophin receptor (p75NTR), is a low affinity NGF receptor. The other members of the neurotrophin family, including brain-derived neurotrophic factor (BDNF), neurotrophin (NT)-3 and NT-4/5 bind to p75NTR with equal affinity. This receptor also binds pro-neurotrophins. p75NTR mediates signalling of neurotrophins for neuronal survival, apoptosis, neurite outgrowth and synaptic plasticity. Altered neurotrophin levels and p75NTR expression are implicated in degeneration of spinal motor neurons in human and mouse models of amyotrophic lateral sclerosis (ALS).

 

Our p75NTR antibody (clone 8J2) to the extracellular domain of p75NTR is ideal for:

 

- In vivo targeting: retrograde tracing and receptor trafficking

- Flow cytometry, immunopanning, western blot, immunohistochemistry and more.

- Most mammalian species, including human, mouse and rat

- Replacing clone MLR2 (A comparative study can be viewed here).

 

p75NTR antibody (clone 8J2)

 

Related products:

NGFR/p75ECD Rapid ELISA Kits (Human or Mouse),

Antibodies to p75NTR

NT3 Kits and Antibodies

NT4/5 Kits and Antibodies