Newmarket Scientific
Newmarket Scientific








Neuroscience Research - ALS and FTD Focus


Antibodies and reagents for Amyotrophic lateral sclerosis (ALS) and Frontotemporal dementia (FTD)


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Newmarket Scientific provides Antibodies, Proteins, ELISA kits and related reagents for neuroscience research with a focus on Amyotrophic lateral sclerosis (ALS) and Frontotemporal dementia (FTD).

 

Some products are highlighted below, but many more are available, so please use the search box above to find specific reagents or email us at tech@nktscientific.com

 

Also for more information on neuroscience research in general, including highlighted articles/papers and other resources follow our .

 



Antibodies for Amyotrophic Lateral Sclerosis Research

 

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterised by the progressive degeneration of motor neurons. There are a considerable number of genes associated with the pathogenesis of ALS, covering a wide range of cellular processes, which has made research into the causes of ALS particularly complex.

 

Newmarket Scientific provides antibodies to many proteins associated with ALS and we continually monitor the latest publications in this area with the aim of providing the antibodies required by those at the forefront of ALS research.

 

Some common targets for ALS-FTD to which we have antibodies are listed below with a link to a more comprehensive list detailing the individual antibodies.

 

CHMP2B   C9orf72   FUS/TLS   KIF5A   MATR3   SOD1   TDP-43   UBQLN2 

...read more

 



Tdp 43 3 cat aa17 100105

TDP43 Antibodies

 

TAR DNA-binding protein 43 (TDP43) binds DNA and RNA and has multiple functions in transcriptional repression, pre-mRNA splicing and translational regulation.

 

Characterisation of transcriptome-wide binding sites shows that thousands of RNAs are bound by TDP43 in neurons.

 

Hyperphosphorylated, fragmented and ubiquitinated forms of TDP-43 have been identified as core components of cytosolic inclusions in ALS (amyotrophic lateral sclerosis) and FTLD (frontotemporal lobar degeneration). As well as...  read more

 



RNA-binding Proteins and Stress granules in ALS-FTD

 

Cytoplasmic stress granules are membrane-less aggregates that form through liquid phase separation as a protective response to physiological or pathological conditions such as oxidative stress, hypoxia or virus infection. They are transient and usually disappear after the stress is removed.

 

Stress granules are mainly composed of messenger RNAs (mRNAs) stalled in translation initiation, translation initiation components such as eukaryotic initiation factor 4G (eIF4G), RNA-binding proteins (RBPs) and ribonucleoproteins. Formation of stress granules can be initiated by the Ras GTPase-activating protein-binding protein 1 (G3BP1), which is commonly used as a stress granule marker.

 

Mutations in genes that encode RNA binding proteins (RBPs) such as FUS/TLS, TDP-43, Ataxin 2, TAF15, EWSR1, hnRNPA1 and hnRNPA2, MATR3 and TIA-1 have recently been linked to ALS/FTD. Some of these RNA binding proteins... read more.

 



Nerve Growth Factor Receptor (p75NTR)

 

The nerve growth factor (NGF) receptor, also known as p75 neurotrophin receptor (p75NTR), is a low affinity NGF receptor. The other members of the neurotrophin family, including brain-derived neurotrophic factor (BDNF), neurotrophin (NT)-3 and NT-4/5 bind to p75NTR with equal affinity. This receptor also binds pro-neurotrophins. p75NTR mediates signalling of neurotrophins for neuronal survival, apoptosis, neurite outgrowth and synaptic plasticity. Altered neurotrophin levels and p75NTR expression are implicated in degeneration of spinal motor neurons in human and mouse models of amyotrophic lateral sclerosis (ALS).

 

Our p75NTR antibody (clone 8J2) to the extracellular domain of p75NTR is ideal for:

 

- In vivo targeting: retrograde tracing and receptor trafficking

- Flow cytometry, immunopanning, western blot, immunohistochemistry and more.

- Most mammalian species, including human, mouse and rat

- Replacing clone MLR2 (A comparative study can be viewed here).

 

p75NTR antibody (clone 8J2)

 

Related products:

NGFR/p75ECD Rapid ELISA Kits (Human or Mouse),

Antibodies to p75NTR

NT3 Kits and Antibodies

NT4/5 Kits and Antibodies