Newmarket Scientific
Newmarket Scientific








Neuroscience Research - Parkinson's Focus


Antibodies and reagents focussing on Parkinson's disease research


Affinity Biosciences logo   Agrisera logo     Biosensis logo   ImmunoStar logo  NS Reagents logo  

 


 

Newmarket Scientific provides Antibodies, Proteins, Kits and related reagents for neuroscience research with a focus on Parkinson's disease.

 

Some products are highlighted below, but many more are available, so please use the search box above to find specific reagents or email us at tech@nktscientific.com

 

Also for more information on neuroscience research in general, including highlighted articles/papers and other resources follow our .

 



Antibodies for Parkinson’s Disease Research

 

Parkinson’s disease (PD) is a neurological disorder characterised by the progressive degeneration of dopaminergic neurones in the substantia nigra and the accumulation of misfolded and aggregated α-synuclein (α-syn/SNCA) into intraneuronal inclusions called Lewy bodies, however many different proteins are involved.

 

Newmarket Scientific provides antibodies to Parkinson’s disease associated proteins and molecules and we continually monitor the latest publications in this area to identify new and emerging potential targets to develop antibodies to.

 

Phospho eIF4G1 (Ser1185) Antibody    Tyrosine-Hydroxylase Antibody 22941    Chicken anti human alpha synuclein     ATXN2 Antibody    Phospho-synuclein antibodies    Sheep antibody to alpha synuclein

 

Some common targets for Parkinson’s disease to which we have antibodies are listed below with a link to a more comprehensive list and more detailed information.

 

LRRK2, DJ1/PARK7, PINK1, PRKN, Alpha-synuclein, GBA, UCHL1

...read more

 



NEW NS Reagents Neuroscience Antibodies

 


 

 

PLCG2 Antibody (Cat No: AB21-10139)

Phospholipase C-gamma2 (PLCG2) is an enzyme mainly expressed in immune cells (including microglia) which are involved in innate immunity. PLCG2 has higher expression levels in pathologically affected brain regions in Alzheimer’s disease indicating that the immune system may play a key role in Alzheimer’s disease.

 


 

 

CD38 Antibody (Cat No: AB21-10136)

CD38 is a widely expressed multifunctional ectoenzyme catalysing multiple reactions and also has a role in signal transduction and calcium signaling. CD38 expression in the brain increases under neuroinflammatory conditions indicating a possible role in the regulation of neuroinflammation. In Alzheimer's disease, CD38 immunoreactivity is seen in intracellular tangles and neuropil threads.

 


 

SOD1 Western Blot Image

 

SOD1 Antibody (Cat No: AB19-10106)

Superoxide dismutase 1 (SOD1) is one of three superoxide dismutases with SOD1 being the principal cytoplasmic superoxide dismutase in humans. It binds copper and zinc ions for its activity and stability and plays a major role in redox potential regulation. SOD1 variants are a common cause of familial amyotrophic lateral sclerosis (ALS).


 

TREM2 Staining

 

TREM2 Antibody (Cat No: AB21-10133)

TREM2 (Triggering receptor expressed on myeloid cells 2) is a cell surface transmembrane glycoprotein expressed in myeloid cells including microglia. It plays a complex role in neuroinflammation with expression of TREM2 being upregulated in pathological conditions such as Parkinson's disease, Amyotrophic lateral sclerosis (ALS), stroke, traumatic brain injury and Alzheimer's Disease.

 


 

HRH3 Image

 

HRH3 Antibody (Cat No: AB21-10137)

Histamine is an important messenger molecule and neuromodulator, regulating the release of several neurotransmitters, including histamine release from histaminergic neurons. Dysregulated central histaminergic signalling has been associated with a number of psychiatric disorders including sleep disorders, ADHD, Alzheimer's disease, Parkinson's disease and schizophrenia.

 


 

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GBA Antibody (Cat No: AB19-10120)

Lysosomal acid glucosylceramidase (GBA or Glucocerebrosidase) is the lysosomal hydrolase. Mutations in the GBA gene cause Gaucher disease, a lysosomal storage disease characterised by an accumulation of glucocerebrosides. Patients with Gaucher disease are at increased risk of developing Parkinson's disease and Dementia with Lewy Bodies.

 



Phospho-synuclein antibodies from Affinity Biosciences
Alpha synuclein phospho ant

 

Alpha-synuclein is a 140 amino acid protein predominantly expressed in the brain which due to its structural flexibility, can adopt different conformations depending on the environment, existing as a dynamic balance between monomeric unfolded and an amphipathic alpha-helix states. In pathological conditions such as Parkinson’s disease, soluble alpha-synuclein monomers associate to form large and insoluble neurotoxic aggregates, that cause the degeneration of dopaminergic neurons seen in PD.

 

Post-translational modifications can lead to conformational changes in alpha-synuclein resulting in it being more susceptible to aggregation. It has been shown that phosphorylated Ser129 alpha-synuclein is the most abundant form of alpha-synuclein present in aggregates.

 

Read about phosphpo-specific alpha-synuclein antibodies (ser129, Tyr133 and Tyr136).

 



The role of retromer component VPS-35 in neurodegenerative diseases

 

Endosomes are important protein sorting stations contributing to cell homeostasis. Cargoes, originating from the plasma membrane or the biosynthesis pathways and entering the endosomal system, are either retained in endosomes for subsequent lysosomal degradation or exported from the endosomes for reuse or recycling. Deficiencies in the endosomal sorting system have been linked to neurodegenerative diseases such as Alzheimer’s and Parkinson’s.

 

Retromer is an evolutionarily conserved protein essential for the transport of transmembrane proteins from the endosomes back to the trans-Golgi network or to the plasma membrane via the recycling pathway. Retromer is a pentameric complex composed of a cargo-selective trimeric complex, with the major subunit being VPS-35 (vacuolar protein sorting 35)... read more and find out about our anti VPS35 antibodies.

 



Why choose Biosensis sheep α-synuclein antibody?

 

Our Biosensis sheep anti alpha-synuclein antibodies offer a number of significant advantages over anti-α-synuclein antibodies raised in mouse and rabbit:

 

• Validated for multiple applications

• Perfect choice for rodent studies: avoiding cross-reactivity issues with mouse abs

• Optimal partner for mouse and rabbit antibodies in multi-labelling experiments

• Large batch sizes so no need to regularly re-validate as with rabbits antibodies

• Anti-goat secondary abs already in your freezer can be used for sheep primaries

 

Read more about the range of alpha-synuclein antibodies we have available.

 



Neurofilaments

 

Neurofilaments are a major constituent of the neuronal cytoskeleton and are composed principally of the neurofilament triplet proteins NF-L (light), NF-M (medium) and NF-H (heavy), but may also include peripherin, alpha-internexin, nestin and vimentin

 

Neurofilaments have a role in a variety of neurodegenerative diseases including multiple sclerosis and amyotrophic lateral sclerosis. They are also incorporated in the structure of intracellular Lewy bodies, in Parkinson’s Disease.

 

rat cerebral cortex stained with rabbit polyclonal antibody to Neurofilament     Rat CNS cells stained with mouse monoclonal antibody to alpha-Internexin [1D2]     Read more about Neurofilaments

 



Neuroscience - ImmunoStar
Immunostar neuroscience

 

Newmarket Scientific is the UK and Ireland Distributor of the ImmunoStar antibodies for neuroscience research. This set of antibodies was originally provided by DiaSorin (INCSTAR), before becoming ImmunoStar in 2001.

 

Having been available for many years this set of highly cited antibodies really has been tried and tested! Additionally ImmunoStar antibodies are put through extensive testing before release to ensure excellent reliability and lot-to-lot consistency.

 

Get further details of the full range of ImmunoStar antibodies for neuroscience research.

 



Biosensis chicken α-synuclein antibody
Chicken alpha synuclein ab

 

Our chicken anti-alpha-synuclein antibody from Biosensis provides a very clear detection signal with minimal background in Western Blot,  Immunocytochemistry and Immunohistochemistry AND because it is raised in chicken it can be used alongside other antibodies raised in mouse or rabbit for multiple staining work.

 

• Raised against non-amyloid β component of α-synuclein

• Validated for WB, ICC and IHC

• Superb signal with clean background

• Perfect partner for double or triple labelling experiments

• Detects alpha-synuclein in multiple species

 

Read more about this amazing anti-α-synuclein antibody.

 



Biosensis α-synuclein Rapid ELISA Kit
Alpha synuclein elisa and a

 

Alpha synuclein is an abundant 140 amino acid neuronal protein associated with a number of neurodegenerative diseases. Aggregated proteinaceous inclusions called Lewy bodies which are found in Parkinson's disease and cortical Lewy body dementia (LBD) have been shown to be predominantly alpha-synuclein.

 

Alpha-synuclein has also been detected in an increasing number of other neurodegenerative diseases, collectively known as synucleopathies. Alpha-synuclein is therefore a key target in neurodegenerative disease research.

 

The Biosensis Alpha-Synuclein Rapid ELISA Kit (BEK-2216-1P/2P) lets you quantifiy human alpha-synuclein in plasma, serum and CSF, in under 4 hours with a high level of accuracy... read more about our Biosensis alpha-synuclein ELISA and antibodies.