Newmarket Scientific
Newmarket Scientific








Neuroscience Research - Alzheimer's Focus


Antibodies and reagents focussing on Alzheimer's disease research


Affinity Biosciences logo   Agrisera logo     Biosensis logo   ImmunoStar logo  NS Reagents logo  

 


 

Newmarket Scientific provides Antibodies, Proteins, Kits and related reagents for neuroscience research with a focus on Alzheimer's disease.

 

Some products are highlighted below, but many more are available, so please use the search box above to find specific reagents or email us at tech@nktscientific.com

 

Also for more information on neuroscience research in general, including highlighted articles/papers and other resources follow our .

 



Antibodies for Alzheimer’s Disease Research

 

Alzheimer’s disease is a progressive neurodegenerative disease characterised by the aggregation of beta‐amyloid (amyloid β or Aβ) in extracellular plaques and hyperphosphorylated tau protein in intracellular neurofibrillary tangles (NFTs), however many other proteins have also been associated with Alzheimer’s disease pathology.

 

Newmarket Scientific provides antibodies to a large number of Alzheimer’s disease associated proteins and we continually monitor the latest publications in this area with the aim of identifying new and emerging potential targets to develop antibodies to, allowing us to better serve those at the forefront of Alzheimer’s disease research.

 

TDP43    Tyrosine-Hydroxylase Antibody 22941    TLS/FUS Antibody DF8391     Phospho Tau AF3141.jpg    Other Alzheimer's Research Antibodies    Other Alzheimer's Research Antibodies

 

Some common targets for Alzheimer’s disease to which we have antibodies are listed below with a link to a more comprehensive list and more detailed information.

 

Amyloid beta   APP  Lipocalin 2  Nicastrin  Tau  TDP43  Tyrosine hydroxylase

...read more

 



NEW NS Reagents Neuroscience Antibodies

 


 

 

PLCG2 Antibody (Cat No: AB21-10139)

Phospholipase C-gamma2 (PLCG2) is an enzyme mainly expressed in immune cells (including microglia) which are involved in innate immunity. PLCG2 has higher expression levels in pathologically affected brain regions in Alzheimer’s disease indicating that the immune system may play a key role in Alzheimer’s disease.

 


 

 

CD38 Antibody (Cat No: AB21-10136)

CD38 is a widely expressed multifunctional ectoenzyme catalysing multiple reactions and also has a role in signal transduction and calcium signaling. CD38 expression in the brain increases under neuroinflammatory conditions indicating a possible role in the regulation of neuroinflammation. In Alzheimer's disease, CD38 immunoreactivity is seen in intracellular tangles and neuropil threads.

 


 

SOD1 Western Blot Image

 

SOD1 Antibody (Cat No: AB19-10106)

Superoxide dismutase 1 (SOD1) is one of three superoxide dismutases with SOD1 being the principal cytoplasmic superoxide dismutase in humans. It binds copper and zinc ions for its activity and stability and plays a major role in redox potential regulation. SOD1 variants are a common cause of familial amyotrophic lateral sclerosis (ALS).


 

TREM2 Staining

 

TREM2 Antibody (Cat No: AB21-10133)

TREM2 (Triggering receptor expressed on myeloid cells 2) is a cell surface transmembrane glycoprotein expressed in myeloid cells including microglia. It plays a complex role in neuroinflammation with expression of TREM2 being upregulated in pathological conditions such as Parkinson's disease, Amyotrophic lateral sclerosis (ALS), stroke, traumatic brain injury and Alzheimer's Disease.

 


 

HRH3 Image

 

HRH3 Antibody (Cat No: AB21-10137)

Histamine is an important messenger molecule and neuromodulator, regulating the release of several neurotransmitters, including histamine release from histaminergic neurons. Dysregulated central histaminergic signalling has been associated with a number of psychiatric disorders including sleep disorders, ADHD, Alzheimer's disease, Parkinson's disease and schizophrenia.

 


 

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GBA Antibody (Cat No: AB19-10120)

Lysosomal acid glucosylceramidase (GBA or Glucocerebrosidase) is the lysosomal hydrolase. Mutations in the GBA gene cause Gaucher disease, a lysosomal storage disease characterised by an accumulation of glucocerebrosides. Patients with Gaucher disease are at increased risk of developing Parkinson's disease and Dementia with Lewy Bodies.

 



Shinning bright with Biosensis Amylo-Glo!
Amylo glo

 

Beautifully stain amyloid plaques in tissues in multi-labelling and low magnification studies

 

Histologic dyes commonly used for amyloid plaque detection such as Congo Red or Thioflavin S or T come with a number of limitations, including their broad excitation frequencies which cause "bleed through" when using filters for other stains and the need for harsh chemicals during staining making them less compatible with the subsequent use of antibodies.

 

Amylo-Glo RTD (Cat. No. TR-300-AG) is a histological marker that shows clear superiority for visualising amyloid plaques over conventional markers with its... read more

 



Confidently measure mature BDNF

 

Brain-derived neurotrophic factor (BDNF) plays essential roles in the central nervous system regulating and supporting the growth, survival and differentiation of neurons. Brain insults or stress can cause variations in BDNF levels, which may contribute to depressive or neurological disorders such as epilepsy and Alzheimer’s disease.

 

To help researchers quantify BDNF, Biosensis have developed a robust ELISA for mature BDNF with high specificity that can be performed in less than 3 hours with high accuracy, sensitivity and reproducibility... read more and watch the video here.

 

Click for the Biosensis BDNF ELISA Tutorial

 



Biosensis Amyloid beta (40/42) antibody - (clone MOAB-2 / 6C3) Improved formulation - Same clone, so why pay more?
Moab 2 from biosensis

 

The presence of aggregated amyloid-β peptides (Aβ) is a hallmark of Alzheimer's Disease. However, the forms of Aβ-peptides associated with this pathology remains unclear, in part because antibodies thought to be specific for Aβ were later shown to also detect intraneuronal amyloid precursor protein (APP) and not just Aβ.

 

Our Biosensis monoclonal antibody to Amyloid beta peptide (M-1586-100) is a new formulation of the MOAB-2 clone (also known as Clone 6C3) that does not cross react with APP. This new formulation provides clearer staining and greater sensitivity than formulations from other maufacturers and is also the only one endorsed by the original developers. Additionally, unlike... read more.

 



New antibody for Alzheimer’s research: Learn how the enzyme CYP46A1 controls brain cholesterol levels

 

Brain cholesterol is an important membrane building component of glial cells, neurons and myelin sheaths. Unable to cross the blood-brain-barrier, cholesterol is synthesised in situ, transported between the various cells and eliminated via oxidative pathways to maintain appropriate levels.

 

Key to regulating brain cholesterol homeostasis the CNS-specific cytochrome P450 enzyme, cholesterol 24-hydroxylase (CYP46A1) is mostly expressed in the brain, converting excess cholesterol to membrane-permeable 24HC (oxysterol, 24S-hydroxycholesterol). This oxidised product diffuses through the blood-brain-barrier entering the systemic circulation to reach the liver where it is degraded to bile acids. Accumulation of cholest... read more and find out about our CYP46A1 antibodies.