Newmarket Scientific
Newmarket Scientific








NS Reagents Antibodies (Newmarket Scientific)


The Newmarket Scientific range of antibodies


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Neuroscience | DNA & Protein Modification | Cell signalling

 

The areas above are those we cover right now, but we will be adding new research areas over time. Need an antibody to a new protein... Why not get in early?

 

For each focus areas we continually review the latest publications with the aim of identifying new target proteins of interest to make antibodies to. We develop many new antibodies each year.

 

NS Reagents

 



NEW NS Reagents Neuroscience Antibodies

 


 

 

PLCG2 Antibody (Cat No: AB21-10139)

Phospholipase C-gamma2 (PLCG2) is an enzyme mainly expressed in immune cells (including microglia) which are involved in innate immunity. PLCG2 has higher expression levels in pathologically affected brain regions in Alzheimer’s disease indicating that the immune system may play a key role in Alzheimer’s disease.

 


 

 

CD38 Antibody (Cat No: AB21-10136)

CD38 is a widely expressed multifunctional ectoenzyme catalysing multiple reactions and also has a role in signal transduction and calcium signaling. CD38 expression in the brain increases under neuroinflammatory conditions indicating a possible role in the regulation of neuroinflammation. In Alzheimer's disease, CD38 immunoreactivity is seen in intracellular tangles and neuropil threads.

 


 

SOD1 Western Blot Image

 

SOD1 Antibody (Cat No: AB19-10106)

Superoxide dismutase 1 (SOD1) is one of three superoxide dismutases with SOD1 being the principal cytoplasmic superoxide dismutase in humans. It binds copper and zinc ions for its activity and stability and plays a major role in redox potential regulation. SOD1 variants are a common cause of familial amyotrophic lateral sclerosis (ALS).


 

TREM2 Staining

 

TREM2 Antibody (Cat No: AB21-10133)

TREM2 (Triggering receptor expressed on myeloid cells 2) is a cell surface transmembrane glycoprotein expressed in myeloid cells including microglia. It plays a complex role in neuroinflammation with expression of TREM2 being upregulated in pathological conditions such as Parkinson's disease, Amyotrophic lateral sclerosis (ALS), stroke, traumatic brain injury and Alzheimer's Disease.

 


 

HRH3 Image

 

HRH3 Antibody (Cat No: AB21-10137)

Histamine is an important messenger molecule and neuromodulator, regulating the release of several neurotransmitters, including histamine release from histaminergic neurons. Dysregulated central histaminergic signalling has been associated with a number of psychiatric disorders including sleep disorders, ADHD, Alzheimer's disease, Parkinson's disease and schizophrenia.

 


 

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GBA Antibody (Cat No: AB19-10120)

Lysosomal acid glucosylceramidase (GBA or Glucocerebrosidase) is the lysosomal hydrolase. Mutations in the GBA gene cause Gaucher disease, a lysosomal storage disease characterised by an accumulation of glucocerebrosides. Patients with Gaucher disease are at increased risk of developing Parkinson's disease and Dementia with Lewy Bodies.

 



Tdp 43 3 cat aa17 100105

TDP43 Antibodies

 

TAR DNA-binding protein 43 (TDP43) binds DNA and RNA and has multiple functions in transcriptional repression, pre-mRNA splicing and translational regulation.

 

Characterisation of transcriptome-wide binding sites shows that thousands of RNAs are bound by TDP43 in neurons.

 

Hyperphosphorylated, fragmented and ubiquitinated forms of TDP-43 have been identified as core components of cytosolic inclusions in ALS (amyotrophic lateral sclerosis) and FTLD (frontotemporal lobar degeneration). As well as...  read more

 



New antibody for Alzheimer’s research: Learn how the enzyme CYP46A1 controls brain cholesterol levels

 

Brain cholesterol is an important membrane building component of glial cells, neurons and myelin sheaths. Unable to cross the blood-brain-barrier, cholesterol is synthesised in situ, transported between the various cells and eliminated via oxidative pathways to maintain appropriate levels.

 

Key to regulating brain cholesterol homeostasis the CNS-specific cytochrome P450 enzyme, cholesterol 24-hydroxylase (CYP46A1) is mostly expressed in the brain, converting excess cholesterol to membrane-permeable 24HC (oxysterol, 24S-hydroxycholesterol). This oxidised product diffuses through the blood-brain-barrier entering the systemic circulation to reach the liver where it is degraded to bile acids. Accumulation of cholest... read more and find out about our CYP46A1 antibodies.

 



RNA-binding Proteins and Stress granules in ALS-FTD

 

Cytoplasmic stress granules are membrane-less aggregates that form through liquid phase separation as a protective response to physiological or pathological conditions such as oxidative stress, hypoxia or virus infection. They are transient and usually disappear after the stress is removed.

 

Stress granules are mainly composed of messenger RNAs (mRNAs) stalled in translation initiation, translation initiation components such as eukaryotic initiation factor 4G (eIF4G), RNA-binding proteins (RBPs) and ribonucleoproteins. Formation of stress granules can be initiated by the Ras GTPase-activating protein-binding protein 1 (G3BP1), which is commonly used as a stress granule marker.

 

Mutations in genes that encode RNA binding proteins (RBPs) such as FUS/TLS, TDP-43, Ataxin 2, TAF15, EWSR1, hnRNPA1 and hnRNPA2, MATR3 and TIA-1 have recently been linked to ALS/FTD. Some of these RNA binding proteins... read more.

 



The role of retromer component VPS-35 in neurodegenerative diseases

 

Endosomes are important protein sorting stations contributing to cell homeostasis. Cargoes, originating from the plasma membrane or the biosynthesis pathways and entering the endosomal system, are either retained in endosomes for subsequent lysosomal degradation or exported from the endosomes for reuse or recycling. Deficiencies in the endosomal sorting system have been linked to neurodegenerative diseases such as Alzheimer’s and Parkinson’s.

 

Retromer is an evolutionarily conserved protein essential for the transport of transmembrane proteins from the endosomes back to the trans-Golgi network or to the plasma membrane via the recycling pathway. Retromer is a pentameric complex composed of a cargo-selective trimeric complex, with the major subunit being VPS-35 (vacuolar protein sorting 35)... read more and find out about our anti VPS35 antibodies.

 



Anti-RAMP Antibodies (1, 2 and 3)

 

Receptor Activity Modifying Proteins (RAMPs) transport calcitonin-receptor-like receptors (CRLR or CALCRL) to the cell surface. CRLR is a G protein-coupled receptor with seven transmembrane domains, which can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which member of the RAMP family transports it to the cell surface. Wth RAMP1 it produces a CGRP receptor with RAMP2 it produces an adrenomedullin (AM) receptor (AM1) with RAMP3 it produces a dual CGRP/AM receptor (AM2).

 

Read more about RAMPs and our RAMP 1, 2 and 3 antibodies.