NEWS: Anti-RAMP Antibodies 1,2 and 3

Receptor Activity Modifying Proteins (RAMPs) are required to transport calcitonin-receptor-like receptors (CRLR or CALCRL) to the plasma membrane. CRLR is a G protein-coupled receptor with seven transmembrane domains, which can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which member of the RAMP family transports it to the cell surface.

Wth RAMP1 it produces a CGRP receptor with RAMP2 it produces an adrenomedullin (AM) receptor (AM1) with RAMP3 it produces a dual CGRP/AM receptor (AM2)

In general four roles have been reported for RAMPs:

1. RAMPs enable the forward-trafficking of some GPCRs to the cell surface.

2. RAMPs can alter GPCR pharmacology, switching the ligand selectivity.

3. RAMPs can influence coupling to GPCR signaling pathways.

4. RAMPs may alter the trafficking pathway of some GPCRs from the cell surface, with different RAMPs controlling receptor fate through recycling or degradative pathways.

We have 3 RAMP antibodies available:

Anti-RAMP1 Antibody         

Applications: WB, IHC  

Host: Rabbit     Reactivity: Human, Mouse, Rat  

Anti-RAMP2 Antibody         

Applications: WB  

Host: Rabbit     Reactivity: Human, Mouse, Rat  

Anti-RAMP3 Antibody         

Applications: WB, IF  

Host: Rabbit     Reactivity: Human, Mouse, Rat  

All are available as 50ug or 100ug size