NEWS: Antibodies to Breast Cancer Drug Resistance Proteins

Breast Cancer Drug Resistance Antibodies 

Tumour cell insensitivity to anti-cancer drugs frequently appears as multidrug resistance (MDR), associated with the overexpression of one or more of a set of at least 10 different molecules, causing reduced drug levels at the intracellular target sites.

These overexpressed molecules include transmembrane transporter proteins such as P glycoprotein, MRP1-9 and BCRP. In addition, the lung-resistance protein, recently identified as the major vault protein, has also been associated with MDR.

Our Monosan monoclonal antibodies specifically recognise these proteins and so can be used to help identify their roles in clinical drug resistance and explore their occurrence in normal human tissues and physiology. 

We highlight 4 of our Multi Drug Resistance Antibodies below, followed by a list all of the available antibodies in our Multi Drug Resistance range.

Anti Breast Cancer Resistance Protein (ABCG2) Clone BXP-21. This monoclonal antibody reacts with an internal epitope of BCRP, a 70 kD transmembrane half-transporter which is involved in Multidrug resistance. BXP-21 did not cross-react with the human MDR1, MRP1or MRP2 gene products during testing.

Anti MDR3 P-gp (ABCB4) Clone P₃II-26. This monoclonal antibody reacts with an internal epitope of MDR3 P-gp (a fragment of MDR3 P-gp comprising amino acid 629 - 692). P₃II-26 does not cross-react with human MDR1 P-gp.

Anti MRP2 (ABCC2) Clone M₂III-6. This monoclonal antibody reacts with an internal epitope of cMOAT/MRP2, a 170-180 kD transmembrane protein known as the canalicular multi-organic anion transporter, absent in patients with the Dubin-Johnson syndrome, an autosomal recessive liver disorder characterised by chronic conjugated hyperbilirubinemia. cMOAT/MRP2 is closely related to the multidrug resistance related protein MRP, and its overexpression has been observed in a subset of cisplatin resistant cell lines. Clone M₂III-6 did not cross react with the human MDR1, MRP1, MRP3 and MRP5 gene products.

Follow the links below for further details of the other Multi Drug Resistance Antibodies Available and datsheets.

Need more information email us (tech@nktscientific.com).