Newmarket Scientific
Newmarket Scientific








NEWS: Neurofilaments



Neurofilaments (NF) are the major constituent of the neuronal cytoskeleton. They are composed of a mixture of subunits which principally include the neurofilament triplet proteins NF-L (light), NF-M (medium) and NF-H (heavy). Neurofilaments may also include peripherin, alpha-internexin, nestin and in some cases vimentin.

 

A role of neurofilaments in a variety of neurodegenerative diseases has been increasingly appreciated in recent years. The aggregation and hyper-phosphorylation of NFs, for instance, has been associated with the progression of some forms of multiple sclerosis and amyotrophic lateral sclerosis. Neurofilaments are also incorporated in the structure of intracellular Lewy bodies which are a histopathological hallmark of Parkinson’s Disease.

 

The Biosensis range includes antibodies to Neurofilaments that can help with your research and like every antibody we provide they are covered by our 100% antibody guarantee. Complete the form below to request further details.

 

Details of our neurofilament antibodies

 

rat cerebral cortex stained with rabbit polyclonal antibody to Neurofilament Rat CNS cells stained with mouse monoclonal antibody to alpha-Internexin [1D2]

Right: Section of rat cerebral cortex stained with rabbit polyclonal antibody to Neurofilament Medium Cat No R-1395-50 (red).

 

Left: Mixed cultures of rat CNS cells stained with mouse monoclonal antibody to alpha-Internexin [1D2] Cat No M-1378-250 (red) and Chicken polyclonal antibody to MAP2 Cat No C-1382-50 (green).

 



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