NEWS: The role of retromer component VPS-35 in neurodegenerative diseases
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Endosomes are important protein sorting stations contributing to cell homeostasis. Cargoes, originating from the plasma membrane or the biosynthesis pathways and entering the endosomal system, are either retained in endosomes for subsequent lysosomal degradation or exported from the endosomes for reuse or recycling. Deficiencies in the endosomal sorting system have been linked to neurodegenerative diseases such as Alzheimer’s and Parkinson’s.
Retromer is an evolutionarily conserved protein essential for the transport of transmembrane proteins from the endosomes back to the trans-Golgi network or to the plasma membrane via the recycling pathway. Retromer is a pentameric complex composed of a cargo-selective trimeric complex, with the major subunit being VPS-35 (vacuolar protein sorting 35) which is combined with a sorting nexin dimer.
The endosomal retromer is known to bind and recruit the WASH complex (Wiskott–Aldrich syndrome and SCAR homolog) to the endosomal membranes helping the formation of actin patches that facilitate protein sorting. It is thought that mutations in the VPS-35 gene weaken the binding of VPS-35 with an element of the WASH complex, which results in abnormal protein sorting. The D620N mutation in VPS-35 has been associated with Parkinson’s disease. Below we detail the NS reagents VPS-35 antibodies developed to aid research.in this area.
NS Reagents Anti-VPS35 antibody AB19-10109 Applications: WB | IHC Reactivity: Hu | Ms
NS Reagents Anti-VPS35 antibody AB19-10110 (N Terminal) Applications: WB Reactivity: Hu | Ms | Rt
Complete the form below to request a free sample of either antobody.
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