Newmarket Scientific
Newmarket Scientific








StressMarq New Active Preformed Fibrils and Filaments for Neurodegeneration research



StressMarq has recently released new proteins for the study of neurodegenerative diseases including alpha synuclein, beta synuclein, gamma synuclein, tau, SOD1 and TTR.

 

Protein conformation disorders such as alpha-synucleinopathies, tauopathies, ALS and amyloidosis are characterised by the assembly of normally soluble proteins into insoluble aggregates. The use of the “preformed fibril model” where monomers are converted into preformed fibrils is gaining popularity amongst researchers to study neurodegenerative disorders such as Parkinson’s and Alzheimer’s.

 

Preformed fibrils can be used in vitro, adding them to the culture media or in vivo injecting them into the brain. Although pathological preformed fibrils can be generated from monomers, not all preformed fibrils formed are able to seed inclusions in cells/neurons.

 

However StressMarq has produced a wide range of already validated active preformed fibrils and monomers that produce consistent pathology (validated protein concentration, sedimentation assay, thioflavin T assay, electron microscopic visualisation of the fibrils) . These active preformed fibrils induce protein aggregation/biological activities both in vitro and in vivo.

 

Protocols: Cell Culture Assay, ASYN Thioflavin T Assay.

 

 

Alpha Synuclein Preformed Fibrils    Beta Synuclein Preformed Fibrils    Gamma Synuclein Preformed Fibrils

TTR Preformed Fibrils    SOD1 Preformed Fibrils    Tau Preformed Fibrils