Muller, B et al; High circulating levels of the IL-1 type II decoy receptor in critically ill patients with sepsis: association of high decoy receptor levels with glucocorticoid administration. J Leukoc Biol 2002, 72: 643
Judkins AR. Immunohistochemistry of INI1 expression: a new tool for old challenges in CNS and soft tissue pathology. Adv Anat Pathol. 2007 Sep;14(5):335-9. Review
Judkins AR. Immunohistochemistry of INI1 expression: a new tool for old challenges in CNS and soft tissue pathology. Adv Anat Pathol. 2007 Sep;14(5):335-9. Review
Insulin is a pancreatic hormone that regulates glucose level in blood and it is involved in the synthesis of proteins and fat. Insulin increases cell permeability to monosaccharides, amino acids, and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. Insulin is a heterodimer of a B chain and A chain linked by two disulfide bonds. Defects in insulin are the cause of familial hyperproinsulinemia. Insulin is present on the insulin secreted beta cells in islets of Langerhans.
Insulin is a pancreatic hormone that regulates glucose level in blood and it is involved in the synthesis of proteins and fat. Insulin increases cell permeability to monosaccharides, amino acids, and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. Insulin is a heterodimer of a B chain and A chain linked by two disulfide bonds. Defects in insulin are the cause of familial hyperproinsulinemia. Insulin is present on the insulin secreted beta cells in islets of Langerhans.
Myrsén, U. et al. Dexamethasone-induced neuropeptide Y expression in rat islet endocrine cells.Rapid reversibility and partial prevention by insulin. Diabetes Vol. 45(1996):1306-1313
Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Integrin alpha 2b (CD41) and integrin beta3 (CD61) associate to form the heterodimer integrin a2bB3, a fibronectin receptor expressed in platelets. Activation of a2B3 leads to platelet to platelet interaction through the binding of soluble fibrinogen, which in turn leads to rapid platelet aggregation which can physically block holes in an endothelial cell surface.
M148 binds to some medulloblastoma and neuroblastoma cells and rhabdomyosarcoma and some other solid tumours. It does not bind to marrow constituents other than platelets and megakaryocytes. Abnormal integrin expression has been shown in many epithelial tumours and is important for the growth and metastatic capacity of melanoma cells. M148 prevents aggregation of platelets and therefore is expected to block the binding of Integrin alpha 2b (CD41) and integrin beta3 (CD61).
Product Type:
NS Reagents Antibody
Antibody Type:
Monoclonal
Format:
100 µg in 100 µl PBS containing 0.02% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Clone number:
Clone M148
Antibody Isotype:
IgG1
Antibody Number:
10019
Category:
Primary Antibodies
Other names:
CD41, Alpha 2 Subunit Of VLA-2 Receptor
Research Areas:
Neuroscience, Cancer
NS Reagents Product Area:
Neuroscience
Molecular Weight:
113kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Plasma membrane
Purification:
Protein A Affinity Purified
References:
Alonso-Orgaz et al. 2014. J Proteomics. 109:368-81. PMID: 25065646. ; Cloutier et al. 2013. EMBO Mol Med. 5(2):235-49. PMID: 23165896. ; Boilard et al. 2011. J Immunol. 186(7):4361-6. PMID: 21357261. ; Jones et al. 1984. Br J Haematol. 57(4):621-31. PMID: 6234927.
Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Integrin alpha 2b (CD41) and integrin beta3 (CD61) associate to form the heterodimer integrin a2bB3, a fibronectin receptor expressed in platelets. Activation of a2B3 leads to platelet to platelet interaction through the binding of soluble fibrinogen, which in turn leads to rapid platelet aggregation which can physically block holes in an endothelial cell surface.
M148 binds to some medulloblastoma and neuroblastoma cells and rhabdomyosarcoma and some other solid tumours. It does not bind to marrow constituents other than platelets and megakaryocytes. Abnormal integrin expression has been shown in many epithelial tumours and is important for the growth and metastatic capacity of melanoma cells. M148 prevents aggregation of platelets and therefore is expected to block the binding of Integrin alpha 2b (CD41) and integrin beta3 (CD61).
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Clone number:
Clone M148
Antibody Isotype:
IgG1
Antibody Number:
10019
Category:
Primary Antibodies
Other names:
CD41, Alpha 2 Subunit Of VLA-2 Receptor
Research Areas:
Neuroscience, Cancer
NS Reagents Product Area:
Neuroscience
Molecular Weight:
113kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Plasma membrane
Purification:
Protein A Affinity Purified
References:
Alonso-Orgaz et al. 2014. J Proteomics. 109:368-81. PMID: 25065646. ; Cloutier et al. 2013. EMBO Mol Med. 5(2):235-49. PMID: 23165896. ; Boilard et al. 2011. J Immunol. 186(7):4361-6. PMID: 21357261. ; Jones et al. 1984. Br J Haematol. 57(4):621-31. PMID: 6234927.
Muller, B et al; High circulating levels of the IL-1 type II decoy receptor in critically ill patients with sepsis: association of high decoy receptor levels with glucocorticoid administration. J Leukoc Biol 2002, 72: 643
Polyclonal Rabbit anti-Interstinal Fatty Acid Binding Protein
Product Type:
Antibody
Antibody Type:
Polyclonal
Format:
predilute
Storage Temp:
2-8°C
Host Animal:
Rabbit
Applications:
F, P, IP, WB, E
Antibody Isotype:
Rabbit IgG
Monosan Brand:
Monosan
Concentration:
100 ug/ml
Specificity:
Interstinal Fatty Acid Binding Protein
References:
Lieberman, J et al; Human intestinal fatty acid binding protein: Report of an assay with studies in normal volunteers and intestinal ischemia. Surgery 1997, 121: 335
Bazzoni, G et al; Interaction of junctional adhesion molecule with the tight junction components ZO-1, cingulin, and occludin. J Biol Chem 2000, 275: 20520
Babinska, A et al; Two regions of the human platelet F11-receptor (F11R) are critical for platelet aggregation, potentiation and adhesion. Thromb Haemost 2002, 87: 712
Ki67, also known as MKI67, is aprototypic cell cycle related nuclear protein, expressed by proliferating cells in all phases of the active cell cycle (G1, S, G2 and M phase). It is absent in resting (G0) cells. Ki67 antibodies are useful in establishing the cell growing fraction in neoplasms (immunohistochemically quantified by determining the number of Ki67 positive cells among the total number of resting cells = Ki67 index). In neoplastic tissues the prognostic value is comparable to the tritiated thymidine labelling index. The correlation between low Ki67 index and histologically low grade tumours is strong. Ki67 is routinely used as a neuronal marker of cell cycling and proliferation
Ki67, also known as MKI67, is aprototypic cell cycle related nuclear protein, expressed by proliferating cells in all phases of the active cell cycle (G1, S, G2 and M phase). It is absent in resting (G0) cells. Ki67 antibodies are useful in establishing the cell growing fraction in neoplasms (immunohistochemically quantified by determining the number of Ki67 positive cells among the total number of resting cells = Ki67 index). In neoplastic tissues the prognostic value is comparable to the tritiated thymidine labelling index. The correlation between low Ki67 index and histologically low grade tumours is strong. Ki67 is routinely used as a neuronal marker of cell cycling and proliferation
Kinase D Interacting Substrate 220kDa (Kidins220) is a transmembrane protein that is preferentially expressed in brain and neuroendocrine cells. It is phosphorylated by protein Kinase (PKD) and has also been shown to function downstream of the Trk and Eph receptor tyrosine kinases.
Kidins220 controls neuronal cell survival, differentiation into exons and dendrites, and synaptic plasticity. It interacts with membrane receptors, cytosolic signaling components, and cytoskeletal proteins, serving as a scaffold that mediates crosstalk between the neurotrophin pathway and several other intracellular signaling pathways. Additionally, it has been shown to have an important role in the immune system by interacting with the B-cell and T-cell receptor.
Abnormal expression of this protein is associated with the onset of neurodegenerative diseases, including Alzheimer's disease.
Product Type:
NS Reagents Antibody
Antibody Type:
Monoclonal
Format:
100 µg in 100 µl PBS containing 0.02% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant protein from the C-terminal region of human GST-Kidins220
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Kinase D Interacting Substrate 220kDa (Kidins220) is a transmembrane protein that is preferentially expressed in brain and neuroendocrine cells. It is phosphorylated by protein Kinase (PKD) and has also been shown to function downstream of the Trk and Eph receptor tyrosine kinases.
Kidins220 controls neuronal cell survival, differentiation into exons and dendrites, and synaptic plasticity. It interacts with membrane receptors, cytosolic signaling components, and cytoskeletal proteins, serving as a scaffold that mediates crosstalk between the neurotrophin pathway and several other intracellular signaling pathways. Additionally, it has been shown to have an important role in the immune system by interacting with the B-cell and T-cell receptor.
Abnormal expression of this protein is associated with the onset of neurodegenerative diseases, including Alzheimer's disease.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant protein from the C-terminal region of human GST-Kidins220
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Kinesin heavy chain isoform 5A (KIF5A) is an ATPase-active molecular motor protein expressed in neurons that is the heavy chain A of kinesin, A motor protein involved in motility functions within neuron. KIF5A is involved in microtubule-dependent axonal transport of neurofilament proteins (NFH, NFM and NFL). It also contributes to the transport of other proteins in neurons including proteins essential for axon elongation. KIF5A consists of an N-terminal motor domain, a stalk domain and a C-terminal binding domain. The KIF5A gene has been identified as a causative gene in hereditary spastic paraplegia (HSP), Charcot-Marie-Tooth (CMT) type 2 (CMT2) and amyotrophic lateral sclerosis (ALS).
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage Temp:
Store at -20°C. Avoid freeze / thaw cycles.
Host Animal:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Expected Species:
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human KIF5A from the C-terminal region
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:1000-3000. IHC 1:50-200.
Antibody Number:
10081
Category:
Primary Antibodies
Other names:
NKHC, ALS25, MY050, NEIMY, SPG10, D12S1889
Research Areas:
Neuroscience, Amyotrophic lateral sclerosis
NS Reagents Product Area:
Neuroscience
Molecular Weight:
117kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Kinesin heavy chain isoform 5A (KIF5A) is an ATPase-active molecular motor protein expressed in neurons that is the heavy chain A of kinesin, A motor protein involved in motility functions within neuron. KIF5A is involved in microtubule-dependent axonal transport of neurofilament proteins (NFH, NFM and NFL). It also contributes to the transport of other proteins in neurons including proteins essential for axon elongation. KIF5A consists of an N-terminal motor domain, a stalk domain and a C-terminal binding domain. The KIF5A gene has been identified as a causative gene in hereditary spastic paraplegia (HSP), Charcot-Marie-Tooth (CMT) type 2 (CMT2) and amyotrophic lateral sclerosis (ALS).
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage Temp:
Store at -20°C. Avoid freeze / thaw cycles.
Host Animal:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Expected Species:
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human KIF5A from the C-terminal region
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:1000-3000. IHC 1:50-200.
Antibody Number:
10081
Category:
Primary Antibodies
Other names:
NKHC, ALS25, MY050, NEIMY, SPG10, D12S1889
Research Areas:
Neuroscience, Amyotrophic lateral sclerosis
NS Reagents Product Area:
Neuroscience
Molecular Weight:
117kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Kinesin heavy chain isoform 5A (KIF5A) is an ATPase-active molecular motor protein expressed in neurons that is the heavy chain A of kinesin, A motor protein involved in motility functions within neuron. KIF5A is involved in microtubule-dependent axonal transport of neurofilament proteins (NFH, NFM and NFL). It also contributes to the transport of other proteins in neurons including proteins essential for axon elongation. KIF5A consists of an N-terminal motor domain, a stalk domain and a C-terminal binding domain. The KIF5A gene has been identified as a causative gene in hereditary spastic paraplegia (HSP), Charcot-Marie-Tooth (CMT) type 2 (CMT2) and amyotrophic lateral sclerosis (ALS).
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
Storage Temp:
Store at -20°C. Avoid freeze / thaw cycles.
Host Animal:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Expected Species:
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the C-terminal region of human KIF5A
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
IHC 1:50-100.
Antibody Number:
10082
Category:
Primary Antibodies
Other names:
NKHC, ALS25, MY050, NEIMY, SPG10, D12S1889
Research Areas:
Neuroscience, Amyotrophic lateral sclerosis
NS Reagents Product Area:
Neuroscience
Molecular Weight:
117kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Kinesin heavy chain isoform 5A (KIF5A) is an ATPase-active molecular motor protein expressed in neurons that is the heavy chain A of kinesin, A motor protein involved in motility functions within neuron. KIF5A is involved in microtubule-dependent axonal transport of neurofilament proteins (NFH, NFM and NFL). It also contributes to the transport of other proteins in neurons including proteins essential for axon elongation. KIF5A consists of an N-terminal motor domain, a stalk domain and a C-terminal binding domain. The KIF5A gene has been identified as a causative gene in hereditary spastic paraplegia (HSP), Charcot-Marie-Tooth (CMT) type 2 (CMT2) and amyotrophic lateral sclerosis (ALS).
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
Storage Temp:
Store at -20°C. Avoid freeze / thaw cycles.
Host Animal:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Expected Species:
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the C-terminal region of human KIF5A
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
IHC 1:50-100.
Antibody Number:
10082
Category:
Primary Antibodies
Other names:
NKHC, ALS25, MY050, NEIMY, SPG10, D12S1889
Research Areas:
Neuroscience, Amyotrophic lateral sclerosis
NS Reagents Product Area:
Neuroscience
Molecular Weight:
117kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Thedieck C, Kuczyk M, Klingel K, Steiert I, Müller CA, Klein G. Expression of Ksp-cadherin during kidney development and in renal cell carcinoma. Br J Cancer. 2005 Jun 6;92(11):2010-7
Thedieck C, Kuczyk M, Klingel K, Steiert I, Müller CA, Klein G. Expression of Ksp-cadherin during kidney development and in renal cell carcinoma. Br J Cancer. 2005 Jun 6;92(11):2010-7
Cell adhesion molecule with an important role in the development of the nervous system. The L1, neural cell adhesion molecule (L1CAM) plays an important role in axon growth, fasciculation, neural migration and in mediating neuronal differentiation. L1 protein is expressed to tissues arising from neuroectoderm. L1CAM plays also an important role in the malignancy of human tumors and according to several studies, L1CAM positive carcinomas have a bad prognosis. L1CAM is overexpressed in many human carcinomas but it is useful especially in endometrium carcinoma diagnostic.
Cell adhesion molecule with an important role in the development of the nervous system. The L1, neural cell adhesion molecule (L1CAM) plays an important role in axon growth, fasciculation, neural migration and in mediating neuronal differentiation. L1 protein is expressed to tissues arising from neuroectoderm. L1CAM plays also an important role in the malignancy of human tumors and according to several studies, L1CAM positive carcinomas have a bad prognosis. L1CAM is overexpressed in many human carcinomas but it is useful especially in endometrium carcinoma diagnostic.
Veen, van H et al; Analytical cation-exchange chromatography to assess the identity, purity, and N-terminal integrity of human lactoferrin. Anal Biochem 2002, 309: 60
Aten J, Veninga A, Coers W, Sonnenberg A, Timpl R, Claessen N, Van Eendenburg JD, de Heer E, Weening JJ (1995) Autoantibodies to the laminin P1 fragment in HgCl2-induced membranous glomerulopathy. Am J Pathol 146: 1467-1480
Kliche S, Merten C, Schraven B, Horejsi V. LIME: a new membrane Raft-associated adaptor protein involved in CD4 and CD8 coreceptor signaling J Exp Med. 2003 Nov 17; 198(10):1453-62
Lymphoid Enhancing Factor 1 (LEF1) is a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt-signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. LEF1 has a role in lymphopoietic and it is expressed normally in nucleus of T and pre-mature B-lymphocytes. LEF1 is a useful marker of subtyping of lymphomas especially for differentiation diagnostic of CLL and small lymphocytic lymphoma from other B-cell neoplasia.
Lymphoid Enhancing Factor 1 (LEF1) is a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt-signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. LEF1 has a role in lymphopoietic and it is expressed normally in nucleus of T and pre-mature B-lymphocytes. LEF1 is a useful marker of subtyping of lymphomas especially for differentiation diagnostic of CLL and small lymphocytic lymphoma from other B-cell neoplasia.
Mouse anti-Leukocyte Common Antigen, CD45 (Monoclonal)
Product Type:
Antibody
Antibody Type:
Monoclonal
Format:
concentrate
Storage Temp:
2-8°C
Host Animal:
Mouse
Immunogen:
Isolated from REH6 cell line
Applications:
F,P
Clone number:
BRA-55
Antibody Isotype:
Mouse IgG1
Monosan Brand:
Monosan
Specificity:
Leukocyte Common Antigen, CD45
References:
Chorvath B, et al. Immunocytometric characteristics of a monoclonal antibody (BRA55) recognizing the leukocyte common antigen (LCA) (1988). Neoplasma, Vol 35(5), 495-501
Marchevsky AM, Wick MR. Evidence-based guidelines for the utilization of immunostains in diagnostic pathology: pulmonary adenocarcinoma versus mesothelioma. Appl Immunohistochem Mol Morphol. 2007 Jun;15(2):140-4
LGR5 (leucine-rich repeat-containing G protein-coupled receptor 5) is a member of the G-protein-coupled receptor family of proteins and a target of Wnt signalling [1]. It plays a role in the formation and maintenance of adult intestinal stem cells during postembryonic development, but is expressed by a wide range of adult tissues and organs acting as a biomarker for adult stem cells in certain tissues. Functionally, LGR5 is a part of Wnt signalling complex on the cell membrane, where it seems to enhance the activity of the Wnt/ß-catenin signalling.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS containing 0.02% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the C-terminal region of human LGR5
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:1000-2000. IF 1:50-200.
Antibody Number:
10066
Category:
Primary Antibodies
Other names:
FEX, GPR49, GPR67, GRP49, HG38
Research Areas:
Cell Signalling, Cancer, Neuroscience
NS Reagents Product Area:
Cell Signalling
Molecular Weight:
100kDa (Intended as a general guide and does not allow for all isoforms and species variations)
1. de LW, Barker N, Low TY, Koo B, Li VSW, Teunissen H, et al. Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling. Nature. 2011;476:293297.
LGR5 (leucine-rich repeat-containing G protein-coupled receptor 5) is a member of the G-protein-coupled receptor family of proteins and a target of Wnt signalling [1]. It plays a role in the formation and maintenance of adult intestinal stem cells during postembryonic development, but is expressed by a wide range of adult tissues and organs acting as a biomarker for adult stem cells in certain tissues. Functionally, LGR5 is a part of Wnt signalling complex on the cell membrane, where it seems to enhance the activity of the Wnt/ß-catenin signalling.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the C-terminal region of human LGR5
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:1000-2000. IF 1:50-200.
Antibody Number:
10066
Category:
Primary Antibodies
Other names:
FEX, GPR49, GPR67, GRP49, HG38
Research Areas:
Cell Signalling, Cancer, Neuroscience
NS Reagents Product Area:
Cell Signalling
Molecular Weight:
100kDa (Intended as a general guide and does not allow for all isoforms and species variations)
1. de LW, Barker N, Low TY, Koo B, Li VSW, Teunissen H, et al. Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling. Nature. 2011;476:293297.
LI-Cadherin (Cadherin-17, CDH17), is liver-intestinal cadherin and it belongs to the cadherin superfamily. Structure and cellular locations of LI-Cadherin differs from other cadherins like E-CAD, N-CAD or P-CAD. LI-Cadherin is expressed in epithelium of appendix, colon, and intestine and it is not expressed in other normal tissues. LI-Cadherin is positive in carcinomas of colorectal carcinomas and some cases of gastric and pancreas adenocarcinoma.
LI-Cadherin (Cadherin-17, CDH17), is liver-intestinal cadherin and it belongs to the cadherin superfamily. Structure and cellular locations of LI-Cadherin differs from other cadherins like E-CAD, N-CAD or P-CAD. LI-Cadherin is expressed in epithelium of appendix, colon, and intestine and it is not expressed in other normal tissues. LI-Cadherin is positive in carcinomas of colorectal carcinomas and some cases of gastric and pancreas adenocarcinoma.
Lipocalin-2 (LCN2) is a secreted glycoprotein involved in innate immunity that has roles in iron homeostasis, infection, and inflammation. It was originally identified as a major constituent of the neutrophil secondary granules, so it is also known as neutrophil gelatinase-associated lipocalin (NGAL).
It is highly expressed in the central nervous system in response to injury and inflammation and has also been identified as a potential marker for Alzheimers disease. Increased levels of Lipocalin-2 have been seen in plasma from patients with mild cognitive impairment (MCI) and in CSF from patients with multiple sclerosis. Experimental models of Vascular dementia have shown that Lipocalin-2 mediates hippocampal damage and that decreased levels are associated with less white matter damage and cognitive decline.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal Antibody
Format:
100 µg in 100 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
23kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Secreted, Cytosol
Purification:
Affinity purification
References:
Franc Llorens, Peter Hermann, Anna Villar-Piqué et al - Cerebrospinal fluid lipocalin 2 as a novel biomarker for the differential diagnosis of vascular dementia. Nat Commun. 2020; 11: 619.
Lipocalin-2 (LCN2) is a secreted glycoprotein involved in innate immunity that has roles in iron homeostasis, infection, and inflammation. It was originally identified as a major constituent of the neutrophil secondary granules, so it is also known as neutrophil gelatinase-associated lipocalin (NGAL).
It is highly expressed in the central nervous system in response to injury and inflammation and has also been identified as a potential marker for Alzheimers disease. Increased levels of Lipocalin-2 have been seen in plasma from patients with mild cognitive impairment (MCI) and in CSF from patients with multiple sclerosis. Experimental models of Vascular dementia have shown that Lipocalin-2 mediates hippocampal damage and that decreased levels are associated with less white matter damage and cognitive decline.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal Antibody
Format:
50 µg in 50 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
23kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Secreted, Cytosol
Purification:
Affinity purification
References:
Franc Llorens, Peter Hermann, Anna Villar-Piqué et al - Cerebrospinal fluid lipocalin 2 as a novel biomarker for the differential diagnosis of vascular dementia. Nat Commun. 2020; 11: 619.
Lipocalin-2 (LCN2) is a secreted glycoprotein involved in innate immunity that has roles in iron homeostasis, infection, and inflammation. It was originally identified as a major constituent of the neutrophil secondary granules, so it is also known as neutrophil gelatinase-associated lipocalin (NGAL).
It is highly expressed in the central nervous system in response to injury and inflammation and has also been identified as a potential marker for Alzheimers disease. Increased levels of Lipocalin-2 have been seen in plasma from patients with mild cognitive impairment (MCI) and in CSF from patients with multiple sclerosis. Experimental models of Vascular dementia have shown that Lipocalin-2 mediates hippocampal damage and that decreased levels are associated with less white matter damage and cognitive decline.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal Antibody
Format:
100 µg in 100 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
23kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Secreted, Cytosol
Purification:
Affinity purification
References:
Franc Llorens, Peter Hermann, Anna Villar-Piqué et al - Cerebrospinal fluid lipocalin 2 as a novel biomarker for the differential diagnosis of vascular dementia. Nat Commun. 2020; 11: 619.
Lipocalin-2 (LCN2) is a secreted glycoprotein involved in innate immunity that has roles in iron homeostasis, infection, and inflammation. It was originally identified as a major constituent of the neutrophil secondary granules, so it is also known as neutrophil gelatinase-associated lipocalin (NGAL).
It is highly expressed in the central nervous system in response to injury and inflammation and has also been identified as a potential marker for Alzheimers disease. Increased levels of Lipocalin-2 have been seen in plasma from patients with mild cognitive impairment (MCI) and in CSF from patients with multiple sclerosis. Experimental models of Vascular dementia have shown that Lipocalin-2 mediates hippocampal damage and that decreased levels are associated with less white matter damage and cognitive decline.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal Antibody
Format:
50 µg in 50 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
23kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Secreted, Cytosol
Purification:
Affinity purification
References:
Franc Llorens, Peter Hermann, Anna Villar-Piqué et al - Cerebrospinal fluid lipocalin 2 as a novel biomarker for the differential diagnosis of vascular dementia. Nat Commun. 2020; 11: 619.
Lipocalin-2 (LCN2) is a secreted glycoprotein involved in innate immunity that has roles in iron homeostasis, infection, and inflammation. It was originally identified as a major constituent of the neutrophil secondary granules, so it is also known as neutrophil gelatinase-associated lipocalin (NGAL).
It is highly expressed in the central nervous system in response to injury and inflammation and has also been identified as a potential marker for Alzheimers disease. Increased levels of Lipocalin-2 have been seen in plasma from patients with mild cognitive impairment (MCI) and in CSF from patients with multiple sclerosis. Experimental models of Vascular dementia have shown that Lipocalin-2 mediates hippocampal damage and that decreased levels are associated with less white matter damage and cognitive decline.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal Antibody
Format:
100 µg in 100 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
23kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Secreted, Cytosol
Purification:
Affinity purification
References:
Franc Llorens, Peter Hermann, Anna Villar-Piqué et al - Cerebrospinal fluid lipocalin 2 as a novel biomarker for the differential diagnosis of vascular dementia. Nat Commun. 2020; 11: 619.
Lipocalin-2 (LCN2) is a secreted glycoprotein involved in innate immunity that has roles in iron homeostasis, infection, and inflammation. It was originally identified as a major constituent of the neutrophil secondary granules, so it is also known as neutrophil gelatinase-associated lipocalin (NGAL).
It is highly expressed in the central nervous system in response to injury and inflammation and has also been identified as a potential marker for Alzheimers disease. Increased levels of Lipocalin-2 have been seen in plasma from patients with mild cognitive impairment (MCI) and in CSF from patients with multiple sclerosis. Experimental models of Vascular dementia have shown that Lipocalin-2 mediates hippocampal damage and that decreased levels are associated with less white matter damage and cognitive decline.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal Antibody
Format:
50 µg in 50 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
23kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Secreted, Cytosol
Purification:
Affinity purification
References:
Franc Llorens, Peter Hermann, Anna Villar-Piqué et al - Cerebrospinal fluid lipocalin 2 as a novel biomarker for the differential diagnosis of vascular dementia. Nat Commun. 2020; 11: 619.
Bax, D et al; High-grade dysplasia in Barrett's esophagus is associated with increased expression of calgranulin A and B. Scand J Gastroenterology 2007, 42: 902
Bax, D et al; High-grade dysplasia in Barrett's esophagus is associated with increased expression of calgranulin A and B. Scand J Gastroenterology 2007, 42: 902
Lysine-specific histone demethylase 1A (LSD1/KDM1A) regulates histone methylation and influences the epigenetic state of cells during the generation of induced pluripotent stem cells. It is a nuclear protein containing a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. It is a demethylase that acts on both Lys 4 and 9 of histone H3 (H3K4 and H3K9) and it is component of several histone deacetylase complexes. LSD1 has near ubiquitous expression and it may have roles critical in embryogenesis and tissue-specific differentiation, as well as oocyte growth and the repression of neuronal genes.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human LSD1 from the N-terminal region of the protein
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Lysine-specific histone demethylase 1A (LSD1/KDM1A) regulates histone methylation and influences the epigenetic state of cells during the generation of induced pluripotent stem cells. It is a nuclear protein containing a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. It is a demethylase that acts on both Lys 4 and 9 of histone H3 (H3K4 and H3K9) and it is component of several histone deacetylase complexes. LSD1 has near ubiquitous expression and it may have roles critical in embryogenesis and tissue-specific differentiation, as well as oocyte growth and the repression of neuronal genes.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 100 µl PBS containing 0.05% BSA and 0.05% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human LSD1 from the N-terminal region of the protein
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Rosseau, S et al; Phenotypic characterization of alveolar monocyte recruitment in acute respiratory distress syndrome. Am J Physiol Lung Cell Mol Physiol 2000, 279: L25
deparaffinized cell extracts of peripheral blood mononuclear cells
Applications:
F, P
Clone number:
LN-5
Antibody Isotype:
Mouse IgM
Monosan Brand:
Monosan
Concentration:
100 ug/ml
Specificity:
Macrophages
References:
Bhoopat, L. et al. Immunhistochemical characterization of two new monoclonal antibodies (LN-4, LN-5) reactive with human macrophage subsets and derived malignancies in B5-fixed paraffin-embedded tissues. Blood 71: 1079-1085, (1988)
Maltose binding protein (MBP) is encoded by the malE gene of E.coli. MBP is often used in protein expression studies because it creates a stable fusion product that does not appear to interfere with the bioactivity of the protein of interest. It also allows for its easy purification from bacterial extracts under mild conditions.
Product Type:
Antibody
Antibody Type:
Polyclonal
Format:
Liquid. PBS, pH 7.4 with 0.05% sodium azide
Storage Temp:
Stable for 1 year at -20 °C from the date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to opening the cap. Aliquot to avoid repeated freezing and thawing.
Western Blotting (WB) and ELISA. Suggested starting dilutions for WB of 1:1,000. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.
Shelf Life:
12 months
Specificity:
This antibody recognizes the MBP epitope tag fused to the amino- or carboxy- termini of targeted proteins. |
Mammaglobin is a gene that is expressed almost exclusively in the normal breast epithelium and human breast cancer. It is a member of the secretoglobin gene family and forms a heterodimer with lipophilin B. It has been suggested that mammaglobin may be a useful marker for breast cancer clinical research. Studies investigating the detection of mRNA by RT PCR from circulating carcinoma cells in the peripheral blood of breast cancer patients have shown that mammaglobin is a highly specific marker and correlates with several prognostic factors. Mammaglobin is mammary gland specific and it over expressed in breast cancer.
Mammaglobin is a gene that is expressed almost exclusively in the normal breast epithelium and human breast cancer. It is a member of the secretoglobin gene family and forms a heterodimer with lipophilin B. It has been suggested that mammaglobin may be a useful marker for breast cancer clinical research. Studies investigating the detection of mRNA by RT PCR from circulating carcinoma cells in the peripheral blood of breast cancer patients have shown that mammaglobin is a highly specific marker and correlates with several prognostic factors. Mammaglobin is mammary gland specific and it over expressed in breast cancer.
Noorman, F et al; Cluster Mannosides can inhibit mannose receptor-mediated tissue-type plasminogen activator degradation by both rat and human cells. Hepatology 1997, 26: 1303
Buckley, M.G. et al. (1999) The detection of mast cell subpopulations in formalin-fixed human tissues using a new monoclonal antibody specific for chymase. J. Pathol. 189: 138-143
Matrin 3 (MATR3) is a DNA and RNA binding protein with a range of functions in nucleic acid metabolism including gene transcription, splicing, RNA degradation and the DNA damage response.
Mutations of the MATR3 gene are associated with distal myopathy, vocal cord and pharyngeal weakness, amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). However even without the presence of MATR3 mutations, patients with ALS due to C9orf72 hexanucleotide expansions and FUS mutations may also have cytoplasmic Matrin 3 accumulation as well as strong nuclear Matrin 3 immunostaining indicating that Matrin 3 may more generally be a common mediator in ALS.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
Storage Temp:
Store at -20°C. Avoid freeze / thaw cycles.
Host Animal:
Rabbit
Species Reactivity:
Human, Mouse
Expected Species:
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000.
Antibody Number:
10089
Category:
Primary Antibodies
Other names:
MPD2, ALS21, VCPDM, Matrin-3, Vocal Cord And Pharyngeal Weakness With Distal Myopathy, Myopathy Distal 2, KIAA0723
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
95kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Matrin 3 (MATR3) is a DNA and RNA binding protein with a range of functions in nucleic acid metabolism including gene transcription, splicing, RNA degradation and the DNA damage response.
Mutations of the MATR3 gene are associated with distal myopathy, vocal cord and pharyngeal weakness, amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). However even without the presence of MATR3 mutations, patients with ALS due to C9orf72 hexanucleotide expansions and FUS mutations may also have cytoplasmic Matrin 3 accumulation as well as strong nuclear Matrin 3 immunostaining indicating that Matrin 3 may more generally be a common mediator in ALS.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
Storage Temp:
Store at -20°C. Avoid freeze / thaw cycles.
Host Animal:
Rabbit
Species Reactivity:
Human, Mouse
Expected Species:
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000.
Antibody Number:
10089
Category:
Primary Antibodies
Other names:
MPD2, ALS21, VCPDM, Matrin-3, Vocal Cord And Pharyngeal Weakness With Distal Myopathy, Myopathy Distal 2, KIAA0723
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
95kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Methyl-CpG-Binding Domain Protein 1 (MBD1) is a member of the MBD transcriptional repressor family and is predominantly expressed in neurons. It binds to methylated sequences in DNA, influencing transcription. It has been shown to play a role in chromatin modification through interaction with the histone H3K9 methyltransferase SETDB1. H3K9me3 is a repressive modification.
MBD1 acts as an epigenetic regulator via different mechanisms, such as the formation of the MCAF1/MBD1/SETDB1 complex or the MBD1-HDAC3 complex.
Product Type:
NS Reagents Antibody
Antibody Type:
Monoclonal
Format:
100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human MBD1 from the C-terminal region of the protein
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Methyl-CpG-Binding Domain Protein 1 (MBD1) is a member of the MBD transcriptional repressor family and is predominantly expressed in neurons. It binds to methylated sequences in DNA, influencing transcription. It has been shown to play a role in chromatin modification through interaction with the histone H3K9 methyltransferase SETDB1. H3K9me3 is a repressive modification.
MBD1 acts as an epigenetic regulator via different mechanisms, such as the formation of the MCAF1/MBD1/SETDB1 complex or the MBD1-HDAC3 complex.
Product Type:
NS Reagents Antibody
Antibody Type:
Monoclonal
Format:
50 µg in 100 µl PBS containing 0.05% BSA and 0.05% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human MBD1 from the C-terminal region of the protein
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
MBD2 and MDB3 are non-enzymatic subunits of the NuRD (nucleosome remodelling and deacetylation) complex. MBD2 and MBD3 are close relatives and probably descend via gene duplication from an ancestral MBD2/MBD3, that is present in some metazoans as for instance Caenorhabditis elegans and Drosophila. Outside the MBD domain, MBD2 and MBD3 share almost 80% homology; they both have an MBD and a coiled-coil domain (CC). Apart from this common domain, MBD2 contains an additional N-terminal glycine-arginine (GR) rich domain and a transcriptional repressor domain (TRD), whereas MBD3 has a C-terminal poly-glutamate region. Three isoforms have been described for MBD2 protein: the full length MBD2a, MBD2b lacking the N-terminal GR repeat and MBD2c that is a testis specific isoform lacking the C-terminus. Also MBD3 presents three isoforms: Mbd3b the major isoform in embryonic stem cells, Mbd3a and a smaller isoform Mbd3c. The crucial difference between MBD2 and MBD3 is that MBD3 does not bind methylated DNA, because it lacks four conserved amino acids in the MBD domain.
Product Type:
NS Reagents Antibody
Antibody Type:
Monoclonal
Format:
100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
MBD2 and MDB3 are non-enzymatic subunits of the NuRD (nucleosome remodelling and deacetylation) complex. MBD2 and MBD3 are close relatives and probably descend via gene duplication from an ancestral MBD2/MBD3, that is present in some metazoans as for instance Caenorhabditis elegans and Drosophila. Outside the MBD domain, MBD2 and MBD3 share almost 80% homology; they both have an MBD and a coiled-coil domain (CC). Apart from this common domain, MBD2 contains an additional N-terminal glycine-arginine (GR) rich domain and a transcriptional repressor domain (TRD), whereas MBD3 has a C-terminal poly-glutamate region. Three isoforms have been described for MBD2 protein: the full length MBD2a, MBD2b lacking the N-terminal GR repeat and MBD2c that is a testis specific isoform lacking the C-terminus. Also MBD3 presents three isoforms: Mbd3b the major isoform in embryonic stem cells, Mbd3a and a smaller isoform Mbd3c. The crucial difference between MBD2 and MBD3 is that MBD3 does not bind methylated DNA, because it lacks four conserved amino acids in the MBD domain.
Product Type:
NS Reagents Antibody
Antibody Type:
Monoclonal
Format:
50 µg in 100 µl PBS containing 0.05% BSA and 0.05% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called "Golli-MBP") that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes.
The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called "Golli-MBP") that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes.
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein forms a complex with MCM4, 6, and 7, and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated, and thus regulated by, protein kinases CDC2 and CDC7.
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein forms a complex with MCM4, 6, and 7, and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated, and thus regulated by, protein kinases CDC2 and CDC7.
Williams, G.H. et al. (1998) Improved cervical smear assessment using antibodies against proteins that regulate DNA replication. Proc. Natl. Acad. Sci. USA. 14932-14937
Monti, P et al; The CC Chemokine MCP-1/CCL2 in pancreatic cancer progression: regulation expression and potential mechanisms of antimalignant activity. Cancer Res 2003, 63:7451
Kool et al., Analysis of expression of cMOAB (MRP2), MRP3, MRP4 and MRP5, homologs of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines, Cancer Res 57, 3537-3547, 1997
Luc G Morris, et al., PNL2 melanocytic marker in immunohistochemical evaluation of primary mucosal melanoma of the head and neck. Head Neck 30: 771-775, 2008
Melan-A (MART-1) is a transmembrane protein which is recognized by autologous cytotoxic T lymphocytes. Melan a is expressed in skin melanocytes and melanocyte lineages. This antibody is useful for the identification of melanomas and it should be included into standard melanoma panel for diagnostic. This antibody not cross react with cells of adrenal cortex.
Melan-A (MART-1) is a transmembrane protein which is recognized by autologous cytotoxic T lymphocytes. Melan a is expressed in skin melanocytes and melanocyte lineages. This antibody is useful for the identification of melanomas and it should be included into standard melanoma panel for diagnostic. This antibody not cross react with cells of adrenal cortex.
Luc G Morris, et al., PNL2 melanocytic marker in immunohistochemical evaluation of primary mucosal melanoma of the head and neck. Head Neck 30: 771-775, 2008
Coli A, Bigotti G, Parente P, Federico F, Castri F, Massi G. Atypical thyroid nodules express both HBME-1 and Galectin-3, two phenotypicmarkers of papillary thyroid carcinoma.J Exp Clin Cancer Res. 2007 Jun;26(2):221-7
Mitofusin-2 (MFN2) is a mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion and contributes to the maintenance and operation of the mitochondrial network. MFN2 is involved in the regulation of vascular smooth muscle cell proliferation, and it may play a role in the pathophysiology of obesity. Mutations in this gene cause Charcot-Marie-Tooth disease type 2A2, and hereditary motor and sensory neuropathy VI, which are both disorders of the peripheral nervous system. Defects in this gene have also been associated with early-onset stroke.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
Mouse, Rat, Rabbit, Chicken, Guinea Pig, Chinese Hamster, Cat, Rainbow Trout, Turbot, Naked Mole Rat, Cuckoo and many other species
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide of 13 aa taken from human MFN2 between aa 100 and 300
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Mitofusin-2 (MFN2) is a mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion and contributes to the maintenance and operation of the mitochondrial network. MFN2 is involved in the regulation of vascular smooth muscle cell proliferation, and it may play a role in the pathophysiology of obesity. Mutations in this gene cause Charcot-Marie-Tooth disease type 2A2, and hereditary motor and sensory neuropathy VI, which are both disorders of the peripheral nervous system. Defects in this gene have also been associated with early-onset stroke.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
Mouse, Rat, Rabbit, Chicken, Guinea Pig, Chinese Hamster, Cat, Rainbow Trout, Turbot, Naked Mole Rat, Cuckoo and many other species
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide of 13 aa taken from human MFN2 between aa 100 and 300
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
DNA-mismatch repair (MMR), a conserved process that involves correcting errors made during DNA synthesis, is crucial to the maintenance of genomic integrity. Lack of a functional DNA-mismatch repair pathway is a common characteristic of several different types of human cancers, either due to an MMR gene mutation or promoter-methylation gene silencing. MLH1 is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in hereditary nonpolyposis colon cancer (HNPCC). MLH1 is an integral part of the protein complex responsible for mismatch repair expressed in lymphocytes, heart, colon, breast, lung, spleen, testis, prostate, thyroid and gall bladder, and is methylated in several ovarian tumors. Loss of MLH1 protein expression is associated with a mutated phenotype, microsatellite instability and a predisposition to cancer. In hereditary nonpolyposis colorectal cancer (HNPCC), an autosomal dominant inherited cancer syndrome that signifies a high risk of colorectal and various other types of cancer, the MLH1 gene exhibits a pathogenic mutation. Inactivation of the MLH1 gene causes genome instability and predisposition to cancer. MLH1 also plays a role in meiotic recombination.
DNA-mismatch repair (MMR), a conserved process that involves correcting errors made during DNA synthesis, is crucial to the maintenance of genomic integrity. Lack of a functional DNA-mismatch repair pathway is a common characteristic of several different types of human cancers, either due to an MMR gene mutation or promoter-methylation gene silencing. MLH1 is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in hereditary nonpolyposis colon cancer (HNPCC). MLH1 is an integral part of the protein complex responsible for mismatch repair expressed in lymphocytes, heart, colon, breast, lung, spleen, testis, prostate, thyroid and gall bladder, and is methylated in several ovarian tumors. Loss of MLH1 protein expression is associated with a mutated phenotype, microsatellite instability and a predisposition to cancer. In hereditary nonpolyposis colorectal cancer (HNPCC), an autosomal dominant inherited cancer syndrome that signifies a high risk of colorectal and various other types of cancer, the MLH1 gene exhibits a pathogenic mutation. Inactivation of the MLH1 gene causes genome instability and predisposition to cancer. MLH1 also plays a role in meiotic recombination.
