14-3-3 protein theta (YWHAQ) mediates signal transduction by binding to phosphoserine-containing proteins. It is found in both plants and mammals and is highly conserved across different species. 14-3-3 protein theta contains in its 5' UTR a 6 bp tandem repeat sequence which is polymorphic.
Another 14-3-3 protein family member (zeta/delta - YWHAZ) has been shown to interact with TDP-43 and SOD1 in ALS to modulate neurofilament light chain mRNA stability and 14-3-3 protein was also found in lewy bodies in sALS and also interacts with FUS in ALS. YWHAQ was reported to have significantly elevated mRNA level in sALS patients, so it may have a role in ALS pathology, however its specific role remains unknown.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
Rabbit, Bovine, Chicken, Dog, Golden Hamster, Naked Mole Rat
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:1000-5000. IHC 1:25-100.
Category:
Primary Antibodies
Other names:
1C5, HS1, 14-3-3, 14-3-3 protein theta, YWHAQ, 14-3-3 protein T-cell, 14-3-3 protein tau, Protein HS1
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
28kDa (Intended as a general guide and does not allow for all isoforms and species variations)
14-3-3 protein theta (YWHAQ) mediates signal transduction by binding to phosphoserine-containing proteins. It is found in both plants and mammals and is highly conserved across different species. 14-3-3 protein theta contains in its 5' UTR a 6 bp tandem repeat sequence which is polymorphic.
Another 14-3-3 protein family member (zeta/delta - YWHAZ) has been shown to interact with TDP-43 and SOD1 in ALS to modulate neurofilament light chain mRNA stability and 14-3-3 protein was also found in lewy bodies in sALS and also interacts with FUS in ALS. YWHAQ was reported to have significantly elevated mRNA level in sALS patients, so it may have a role in ALS pathology, however its specific role remains unknown.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
Rabbit, Bovine, Chicken, Dog, Golden Hamster, Naked Mole Rat
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:1000-5000. IHC 1:25-100.
Category:
Primary Antibodies
Other names:
1C5, HS1, 14-3-3, 14-3-3 protein theta, YWHAQ, 14-3-3 protein T-cell, 14-3-3 protein tau, Protein HS1
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
28kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Angiotensin converting enzyme (ACE) is a central component of the reninangiotensin system (RAS), which converts the hormone angiotensin I to the angiotensin II and active vasoconstrictor thereby controling blood pressure. ACE inhibitors are widely used as pharmaceutical drugs for treatment of cardiovascular diseases.
ACE in brain tissues appears to have a role in converting amyloid beta 42 to amyloid beta 40 with data in some studies indicatiing that Alzheimers disease (AD) patients taking ACE inhibitors declined more rapidly, however other studies have shown a reduced risk of Alzheimer's disease under certain conditions with AD patients taking ACE inhibitors. Additionally studies have indicated that ACE inhibitors may reduce the risk for developing ALS.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A long synthetic peptide from the middle of human ACE
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000, IHC 1:50-100
Category:
Primary Antibodies
Other names:
ACE1, CD143, DCP, DCP1, Dipeptidyl carboxypeptidase I, Angiotensin converting enzyme
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
79/83/132/150kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Cell membrane Cytoplasm Secreted Single-pass type I membrane protein
Angiotensin converting enzyme (ACE) is a central component of the reninangiotensin system (RAS), which converts the hormone angiotensin I to the angiotensin II and active vasoconstrictor thereby controling blood pressure. ACE inhibitors are widely used as pharmaceutical drugs for treatment of cardiovascular diseases.
ACE in brain tissues appears to have a role in converting amyloid beta 42 to amyloid beta 40 with data in some studies indicatiing that Alzheimers disease (AD) patients taking ACE inhibitors declined more rapidly, however other studies have shown a reduced risk of Alzheimer's disease under certain conditions with AD patients taking ACE inhibitors. Additionally studies have indicated that ACE inhibitors may reduce the risk for developing ALS.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A long synthetic peptide from the middle of human ACE
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000, IHC 1:50-100
Category:
Primary Antibodies
Other names:
ACE1, CD143, DCP, DCP1, Dipeptidyl carboxypeptidase I, Angiotensin converting enzyme
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
79/83/132/150kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Cell membrane Cytoplasm Secreted Single-pass type I membrane protein
Adenosine receptor A2a (ADORA2A) is a member of the G protein-coupled receptor (GPCR) family. The crystallographic structure of the adenosine A2A receptor has shown the presence of a ligand binding pocket distinct from other GPCRs of known structure (beta-2 adrenergic receptor and rhodopsin).[1] Additionally ADORA2A has a secondary sodium-ion binding pocket [2].
A1 and A2A receptors are likely to regulate myocardial oxygen demand and increase coronary circulation by vasodilation. In addition, A2A receptor can suppress immune cells, protecting tissue from inflammation. The A2A receptor is also expressed in the brain, where it has important roles in the regulation of dopamine and glutamate release. This makes it a potential therapeutic target for depression, and Parkinson's disease.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the N-terminal region of human ADORA2A
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-1000.
Category:
Primary Antibodies
Other names:
A2aR, ADORA2, ADORA2A, RDC8
Research Areas:
Neuroscience, Cell Signalling
NS Reagents Product Area:
Neuroscience
Molecular Weight:
45kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Cell membrane, Multi-pass membrane protein
Purification:
Affinity purification
References:
1. Veli-Pekka Jaakola et al The 2.6 Angstrom Crystal Structure of a Human A2A Adenosine Receptor Bound to an Antagonist. Science 21 Nov 2008: Vol. 322, Issue 5905, pp. 1211-1217.
2. Liu W, Chun E, Thompson AA, Chubukov P, Xu F, Katritch V, et al. Structural basis for allosteric regulation of GPCRs by sodium ions. Science. 337 (6091): 2326 July 2012.
Adenosine receptor A2a (ADORA2A) is a member of the G protein-coupled receptor (GPCR) family. The crystallographic structure of the adenosine A2A receptor has shown the presence of a ligand binding pocket distinct from other GPCRs of known structure (beta-2 adrenergic receptor and rhodopsin).[1] Additionally ADORA2A has a secondary sodium-ion binding pocket [2].
A1 and A2A receptors are likely to regulate myocardial oxygen demand and increase coronary circulation by vasodilation. In addition, A2A receptor can suppress immune cells, protecting tissue from inflammation. The A2A receptor is also expressed in the brain, where it has important roles in the regulation of dopamine and glutamate release. This makes it a potential therapeutic target for depression, and Parkinson's disease.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS containing 0.02% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the N-terminal region of human ADORA2A
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-1000.
Category:
Primary Antibodies
Other names:
A2aR, ADORA2, ADORA2A, RDC8
Research Areas:
Neuroscience, Cell Signalling
NS Reagents Product Area:
Neuroscience
Molecular Weight:
45kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Cell membrane, Multi-pass membrane protein
Purification:
Affinity purification
References:
1. Veli-Pekka Jaakola et al The 2.6 Angstrom Crystal Structure of a Human A2A Adenosine Receptor Bound to an Antagonist. Science 21 Nov 2008: Vol. 322, Issue 5905, pp. 1211-1217.
2. Liu W, Chun E, Thompson AA, Chubukov P, Xu F, Katritch V, et al. Structural basis for allosteric regulation of GPCRs by sodium ions. Science. 337 (6091): 2326 July 2012.
Alsin (ALS2) is a 184-kDa protein of 1657 amino acids which activates the GTPases of the Ras superfamily of GTPases by acting as a guanine nucleotide exchange factor. Alsin has three guanine nucleotide exchange factor domains (RLD, DH/PH and VPS9) and eight consecutive membrane occupation and recognition nexus (MORN) motifs that are related to membrane binding in the region between the DH/PH and VPS9 domains.
Alsin functions as a modulator for endosomal dynamics by activating the small GTPase Rab5 via the C-terminal MORN/VPS9 domain, localising with RAB5 on early endosomal compartments.
Alsin is produced in a wide range of tissues, being particularly abundant in motor neurons. Many mutations in the ALS2 gene have been linked to a range of motor neurone diseases including amyotrophic lateral sclerosis (ALS).
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Rat, Rabbit, Dog, Cat, Golden Hamster, Pig, Sheep, Bovine, Goat, Naked mole rat
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human ALS2 from the N-terminal region
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Alsin (ALS2) is a 184-kDa protein of 1657 amino acids which activates the GTPases of the Ras superfamily of GTPases by acting as a guanine nucleotide exchange factor. Alsin has three guanine nucleotide exchange factor domains (RLD, DH/PH and VPS9) and eight consecutive membrane occupation and recognition nexus (MORN) motifs that are related to membrane binding in the region between the DH/PH and VPS9 domains.
Alsin functions as a modulator for endosomal dynamics by activating the small GTPase Rab5 via the C-terminal MORN/VPS9 domain, localising with RAB5 on early endosomal compartments.
Alsin is produced in a wide range of tissues, being particularly abundant in motor neurons. Many mutations in the ALS2 gene have been linked to a range of motor neurone diseases including amyotrophic lateral sclerosis (ALS).
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Rat, Rabbit, Dog, Cat, Golden Hamster, Pig, Sheep, Bovine, Goat, Naked mole rat
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human ALS2 from the N-terminal region
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Alsin (ALS2) is a 184-kDa protein of 1657 amino acids which activates the GTPases of the Ras superfamily of GTPases by acting as a guanine nucleotide exchange factor. Alsin has three guanine nucleotide exchange factor domains (RLD, DH/PH and VPS9) and eight consecutive membrane occupation and recognition nexus (MORN) motifs that are related to membrane binding in the region between the DH/PH and VPS9 domains.
Alsin functions as a modulator for endosomal dynamics by activating the small GTPase Rab5 via the C-terminal MORN/VPS9 domain, localising with RAB5 on early endosomal compartments.
Alsin is produced in a wide range of tissues, being particularly abundant in motor neurons. Many mutations in the ALS2 gene have been linked to a range of motor neurone diseases including amyotrophic lateral sclerosis (ALS).
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Alsin (ALS2) is a 184-kDa protein of 1657 amino acids which activates the GTPases of the Ras superfamily of GTPases by acting as a guanine nucleotide exchange factor. Alsin has three guanine nucleotide exchange factor domains (RLD, DH/PH and VPS9) and eight consecutive membrane occupation and recognition nexus (MORN) motifs that are related to membrane binding in the region between the DH/PH and VPS9 domains.
Alsin functions as a modulator for endosomal dynamics by activating the small GTPase Rab5 via the C-terminal MORN/VPS9 domain, localising with RAB5 on early endosomal compartments.
Alsin is produced in a wide range of tissues, being particularly abundant in motor neurons. Many mutations in the ALS2 gene have been linked to a range of motor neurone diseases including amyotrophic lateral sclerosis (ALS).
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Anoctamin-5 (ANO5) is believed to be an integral membrane glycoprotein with a role in myogenesis and osteogenesis. It is found predominantly in the plasma membrane and intracellular membrane vesicles. In human tissues, ANO5 mRNA is detected in the brain, heart, kidney, lung and skeletal muscle, and in mice shows abundant expression in bone tissues including the calvarium, femur and mandible.
Mutations in this protein are linked to limb-girdle muscular dystrophy type 2L (LGMD2L), Miyoshi muscular dystrophy 3 (MMD3) and Gnathodiaphyseal dysplasia (GDD) and other dysferlinopathies.
ANO5 has an expected molecular mass of around 107kDa. However in western blot using lysates prepared from C2C12 cells (wt), RD and fibroblasts, 3 bands are detected at 107kDa, 55 kDa and 37 KDa.
Product Type:
NS Reagents Antibody
Antibody Type:
Monoclonal
Format:
100 µg in 100 µl PBS containing 0.02% sodium azide.
Very likely to bind to Anoctamin from other species due to 100% homology in Sheep, Goat, Dog and Cat
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the C-terminal region of Human ANO5
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Clone number:
Clone 5F7
Antibody Isotype:
IgM
Category:
Primary Antibodies
Other names:
Anoctamin-5, ANO5
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
37kDa, 55kDa and 107kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Anoctamin-5 (ANO5) is believed to be an integral membrane glycoprotein with a role in myogenesis and osteogenesis. It is found predominantly in the plasma membrane and intracellular membrane vesicles. In human tissues, ANO5 mRNA is detected in the brain, heart, kidney, lung and skeletal muscle, and in mice shows abundant expression in bone tissues including the calvarium, femur and mandible.
Mutations in this protein are linked to limb-girdle muscular dystrophy type 2L (LGMD2L), Miyoshi muscular dystrophy 3 (MMD3) and Gnathodiaphyseal dysplasia (GDD) and other dysferlinopathies.
ANO5 has an expected molecular mass of around 107kDa. However in western blot using lysates prepared from C2C12 cells (wt), RD and fibroblasts, 3 bands are detected at 107kDa, 55 kDa and 37 KDa.
Very likely to bind to Anoctamin from other species due to 100% homology in Sheep, Goat, Dog and Cat
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the C-terminal region of Human ANO5
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Clone number:
Clone 5F7
Antibody Isotype:
IgM
Category:
Primary Antibodies
Other names:
Anoctamin-5, ANO5
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
37kDa, 55kDa and 107kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Amine oxidase copper-containing 1 (AOC1) is an enzyme that catalyses the degradation of compounds such as neurotransmitters, putrescine, histamine and related substances involved in a wide range of funtions including allergic and immune responses, cell proliferation, tissue differentiation, tumor formation and apoptosis.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS containing 0.02% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human AOC1 from the N-terminal region
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Amine oxidase copper-containing 1 (AOC1) is an enzyme that catalyses the degradation of compounds such as neurotransmitters, putrescine, histamine and related substances involved in a wide range of funtions including allergic and immune responses, cell proliferation, tissue differentiation, tumor formation and apoptosis.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human AOC1 from the N-terminal region
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Apolipoprotein E (APOE) is a 34-kDa glycoprotein that mediates lipid metabolism. There are 3 common variants (APOE2, APOE3 and APOE4) that differ in two amino acid positions, 112 and 158. The N-terminal of APOE forms an anti-parallel four-helix bundle with the non-polar sides facing internally and the C-terminal domain contains three helices which form a large exposed hydrophobic surface, interacting with those in the N-terminal helix bundle. The C-terminal region also contains a low density lipoprotein receptor (LDLR)-binding site. The N and C terminal regions of the protein are connected by a hinge region.
In the brain, APOE is produced predominantly by astrocytes, microglia, vascular mural cells, and the choroid plexus. APOE functions through binding to cell surface receptors, including low-density lipoprotein receptor (LDLR) and a number of others [1]. Additionally recent studies have shown that triggering receptor expressed on myeloid cells 2 (TREM2), expressed by microglia in the brain, is also a receptor for APOE [2,3] APOE is the strongest genetic risk modifier of late-onset Alzheimers disease with APOE4 increasing risk through earlier and more abundant amyloid pathology.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal Antibody
Format:
50 µg in 50 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage Temp:
Store at -20°C. Avoid freeze / thaw cycles.
Host Animal:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Expected Species:
Dog, Sheep, Pig
Immunogen:
Partial length recombinant human ApoE from the C-terminal region
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:1000-3000. IHC 1:50-200. IF 1:50-100.
Category:
Primary Antibodies
Other names:
Apolipoprotein E, Apo-E4, LDLCQ5
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
36kDa
Subcellular location:
Secreted/Extracellular region
Purification:
Affinity purification
References:
[1] Holtzman DM, Herz J, Bu G. Apolipoprotein E and apolipoprotein E receptors: normal biology and roles in Alzheimer disease. Cold Spring Harb Perspect Med. 2012;2(3):a006312. [2] Atagi Y, et al. Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2). J Biol Chem. 2015;290(43):2604350. [3] Yeh FL, et al. TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia. Neuron. 2016;91(2):32840.
Apolipoprotein E (APOE) is a 34-kDa glycoprotein that mediates lipid metabolism. There are 3 common variants (APOE2, APOE3 and APOE4) that differ in two amino acid positions, 112 and 158. The N-terminal of APOE forms an anti-parallel four-helix bundle with the non-polar sides facing internally and the C-terminal domain contains three helices which form a large exposed hydrophobic surface, interacting with those in the N-terminal helix bundle. The C-terminal region also contains a low density lipoprotein receptor (LDLR)-binding site. The N and C terminal regions of the protein are connected by a hinge region.
In the brain, APOE is produced predominantly by astrocytes, microglia, vascular mural cells, and the choroid plexus. APOE functions through binding to cell surface receptors, including low-density lipoprotein receptor (LDLR) and a number of others [1]. Additionally recent studies have shown that triggering receptor expressed on myeloid cells 2 (TREM2), expressed by microglia in the brain, is also a receptor for APOE [2,3] APOE is the strongest genetic risk modifier of late-onset Alzheimers disease with APOE4 increasing risk through earlier and more abundant amyloid pathology.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal Antibody
Format:
100 µg in 100 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage Temp:
Store at -20°C. Avoid freeze / thaw cycles.
Host Animal:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Expected Species:
Dog, Sheep, Pig
Immunogen:
Partial length recombinant human ApoE from the C-terminal region
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:1000-3000. IHC 1:50-200. IF 1:50-100.
Category:
Primary Antibodies
Other names:
Apolipoprotein E, Apo-E4, LDLCQ5
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
36kDa
Subcellular location:
Secreted/Extracellular region
Purification:
Affinity purification
References:
[1] Holtzman DM, Herz J, Bu G. Apolipoprotein E and apolipoprotein E receptors: normal biology and roles in Alzheimer disease. Cold Spring Harb Perspect Med. 2012;2(3):a006312. [2] Atagi Y, et al. Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2). J Biol Chem. 2015;290(43):2604350. [3] Yeh FL, et al. TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia. Neuron. 2016;91(2):32840.
Apoptosis inducing factor (AIFM1/AIF) is a mitochondrial flavoprotein that has a fundamental housekeeping role in mitochondrial bioenergetics. It is also involved in caspase-independent cell death, where following an apoptotic trigger, proteolysis of the membrane-tethered precursor AIF, causes AIF to translocate to the nucleus, where it participates in chromatin condensation and DNA degradation.
Mutations in the AIFM1 gene cause combined oxidative phosphorylation deficiency 6 (COXPD6), a severe mitochondrial encephalomyopathy and X-linked recessive Charcot-Marie-Tooth disease-4 (CMTX-4), a disorder resulting in neuropathy, and axonal and motor-sensory defects with deafness and mental retardation.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human AIFM1 from the C-terminal region
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000. IHC 1:50-200. IF 1:50-200.
Category:
Primary Antibodies
Other names:
AIF, CMT2D, CMTX4, COWCK, COXPD6, DFNX5, NADMR, NAMSD, PDCD8, Apoptosis Inducing Factor Mitochondria Associated 1, Apoptosis-Inducing Factor, Mitochondrion-Associated 1, Programmed Cell Death 8 (Apoptosis-Inducing Factor), Auditory Neuropathy, X-Linked Recessive 1, PDCD8, Neuropathy, Axonal, Motor-Sensory With Deafness And Mental Retardation (Cowchock Syndrome), Striatal Apoptosis-Inducing Factor, Testicular Secretory Protein Li
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
67kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Apoptosis inducing factor (AIFM1/AIF) is a mitochondrial flavoprotein that has a fundamental housekeeping role in mitochondrial bioenergetics. It is also involved in caspase-independent cell death, where following an apoptotic trigger, proteolysis of the membrane-tethered precursor AIF, causes AIF to translocate to the nucleus, where it participates in chromatin condensation and DNA degradation.
Mutations in the AIFM1 gene cause combined oxidative phosphorylation deficiency 6 (COXPD6), a severe mitochondrial encephalomyopathy and X-linked recessive Charcot-Marie-Tooth disease-4 (CMTX-4), a disorder resulting in neuropathy, and axonal and motor-sensory defects with deafness and mental retardation.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the N-terminal region of human AIFM1
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:3000.
Category:
Primary Antibodies
Other names:
AIF, CMT2D, CMTX4, COWCK, COXPD6, DFNX5, NADMR, NAMSD, PDCD8, Apoptosis Inducing Factor Mitochondria Associated 1, Apoptosis-Inducing Factor, Mitochondrion-Associated 1, Programmed Cell Death 8 (Apoptosis-Inducing Factor), Auditory Neuropathy, X-Linked Recessive 1, PDCD8, Neuropathy, Axonal, Motor-Sensory With Deafness And Mental Retardation (Cowchock Syndrome), Striatal Apoptosis-Inducing Factor, Testicular Secretory Protein Li
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
67kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Apoptosis inducing factor (AIFM1/AIF) is a mitochondrial flavoprotein that has a fundamental housekeeping role in mitochondrial bioenergetics. It is also involved in caspase-independent cell death, where following an apoptotic trigger, proteolysis of the membrane-tethered precursor AIF, causes AIF to translocate to the nucleus, where it participates in chromatin condensation and DNA degradation.
Mutations in the AIFM1 gene cause combined oxidative phosphorylation deficiency 6 (COXPD6), a severe mitochondrial encephalomyopathy and X-linked recessive Charcot-Marie-Tooth disease-4 (CMTX-4), a disorder resulting in neuropathy, and axonal and motor-sensory defects with deafness and mental retardation.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the N-terminal region of human AIFM1
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:3000.
Category:
Primary Antibodies
Other names:
AIF, CMT2D, CMTX4, COWCK, COXPD6, DFNX5, NADMR, NAMSD, PDCD8, Apoptosis Inducing Factor Mitochondria Associated 1, Apoptosis-Inducing Factor, Mitochondrion-Associated 1, Programmed Cell Death 8 (Apoptosis-Inducing Factor), Auditory Neuropathy, X-Linked Recessive 1, PDCD8, Neuropathy, Axonal, Motor-Sensory With Deafness And Mental Retardation (Cowchock Syndrome), Striatal Apoptosis-Inducing Factor, Testicular Secretory Protein Li
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
67kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Apoptosis inducing factor (AIFM1/AIF) is a mitochondrial flavoprotein that has a fundamental housekeeping role in mitochondrial bioenergetics. It is also involved in caspase-independent cell death, where following an apoptotic trigger, proteolysis of the membrane-tethered precursor AIF, causes AIF to translocate to the nucleus, where it participates in chromatin condensation and DNA degradation.
Mutations in the AIFM1 gene cause combined oxidative phosphorylation deficiency 6 (COXPD6), a severe mitochondrial encephalomyopathy and X-linked recessive Charcot-Marie-Tooth disease-4 (CMTX-4), a disorder resulting in neuropathy, and axonal and motor-sensory defects with deafness and mental retardation.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human AIFM1 from the C-terminal region
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000. IHC 1:50-200. IF 1:50-200.
Category:
Primary Antibodies
Other names:
AIF, CMT2D, CMTX4, COWCK, COXPD6, DFNX5, NADMR, NAMSD, PDCD8, Apoptosis Inducing Factor Mitochondria Associated 1, Apoptosis-Inducing Factor, Mitochondrion-Associated 1, Programmed Cell Death 8 (Apoptosis-Inducing Factor), Auditory Neuropathy, X-Linked Recessive 1, PDCD8, Neuropathy, Axonal, Motor-Sensory With Deafness And Mental Retardation (Cowchock Syndrome), Striatal Apoptosis-Inducing Factor, Testicular Secretory Protein Li
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
67kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Autophagy-related protein 9 (ATG9) is essential component of the autophagy machinery and is found on autophagosomes. It is the only transmembrane protein in the autophagy core machinery and has been proposed to play a key role in directing membrane from donor organelles for autophagosome formation. In autophagy, the initiation of autophagosome formation requires the recruitment of ATG9 vesicles to the preautophagosomal structure. ATG9 cycles between the preautophagosomal structure/phagophore (PAS) and the cytoplasmic vesicle pool and may also participate in supplying membrane for the growing autophagosome. ATG9 is also involved in the endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress. ATG9 recruits vesicle-tethering proteins TRS85 and YPT1 to the autophagosome formation site and also recruits ATG23 and ATG8 to the PAS.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the C-terminal region of Human ATG9
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Clone number:
Clone Atg9 14F2 8B1
Antibody Isotype:
IgG
Application Details:
ELISA 1:1000 IHC 1:50-1:100 IF 1:50-1:100 WB 1:500
Category:
Primary Antibodies
Other names:
Autophagy-related protein 9 (ATG9), Cytoplasm to vacuole targeting protein 7
Research Areas:
Neuroscience, Autophagy
NS Reagents Product Area:
Neuroscience
Molecular Weight:
95kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Endosome, Endoplasmic reticulum, Golgi apparatus
Purification:
Protein A Affinity Purified
References:
Chan EY, et al. Kinase-inactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg13-independent mechanism. Mol Cell Biol.2009.29(1):157-71. PMID:18936157
Autophagy-related protein 9 (ATG9) is essential component of the autophagy machinery and is found on autophagosomes. It is the only transmembrane protein in the autophagy core machinery and has been proposed to play a key role in directing membrane from donor organelles for autophagosome formation. In autophagy, the initiation of autophagosome formation requires the recruitment of ATG9 vesicles to the preautophagosomal structure. ATG9 cycles between the preautophagosomal structure/phagophore (PAS) and the cytoplasmic vesicle pool and may also participate in supplying membrane for the growing autophagosome. ATG9 is also involved in the endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress. ATG9 recruits vesicle-tethering proteins TRS85 and YPT1 to the autophagosome formation site and also recruits ATG23 and ATG8 to the PAS.
Product Type:
NS Reagents Antibody
Antibody Type:
Monoclonal
Format:
100 µg in 100 µl PBS containing 0.02% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the C-terminal region of Human ATG9
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Clone number:
Clone Atg9 14F2 8B1
Antibody Isotype:
IgG
Application Details:
ELISA 1:1000 IHC 1:50-1:100 IF 1:50-1:100 WB 1:500
Category:
Primary Antibodies
Other names:
Autophagy-related protein 9 (ATG9), Cytoplasm to vacuole targeting protein 7
Research Areas:
Neuroscience, Autophagy
NS Reagents Product Area:
Neuroscience
Molecular Weight:
95kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Endosome, Endoplasmic reticulum, Golgi apparatus
Purification:
Protein A Affinity Purified
References:
Chan EY, et al. Kinase-inactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg13-independent mechanism. Mol Cell Biol.2009.29(1):157-71. PMID:18936157
BAG family molecular chaperone regulator 3 (BAG3) is involved in chaperone-assisted selective autophagy. Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release and has anti-apoptotic activity.
In muscle cells, BAG3 cooperates with the molecular chaperones Hsc70 and HspB8 to induce the degradation of mechanically damaged cytoskeleton components in lysosomes. This process is called chaperone-assisted selective autophagy (CASA) and is essential for maintaining muscle activity.
Defects in BAG3 are the cause of myopathy myofibrillar BAG3-related (MFM-BAG3) a neuromuscular disorder that results in early-onset, severe, progressive, diffuse muscle weakness associated with cardiomyopathy, severe respiratory insufficiency during adolescence, and a rigid spine in some patients.
This antibody is specific to human BAG3 and does not bind Rat or Mouse BAG3
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the C-terminal region of Human BAG3
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Clone number:
Clone V65P1E8*D2
Antibody Isotype:
IgG1 kappa
Category:
Primary Antibodies
Other names:
BAG3, Bcl-2-associated athanogene 3, Bcl-2-binding protein Bis, Docking protein CAIR-1
Research Areas:
Neuroscience, Autophagy
NS Reagents Product Area:
Neuroscience
Molecular Weight:
75kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Cytoplasm, Nucleus
Purification:
Protein A Affinity Purified
References:
[1] Sturner E. and Behl C. (2017). The role of the multifunctional BAG3 protein in cellular protein quality control and in disease. Front. Mol. Neurosci. 10, 177 10.3389/fnmol.2017.00177
BAG family molecular chaperone regulator 3 (BAG3) is involved in chaperone-assisted selective autophagy. Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release and has anti-apoptotic activity.
In muscle cells, BAG3 cooperates with the molecular chaperones Hsc70 and HspB8 to induce the degradation of mechanically damaged cytoskeleton components in lysosomes. This process is called chaperone-assisted selective autophagy (CASA) and is essential for maintaining muscle activity.
Defects in BAG3 are the cause of myopathy myofibrillar BAG3-related (MFM-BAG3) a neuromuscular disorder that results in early-onset, severe, progressive, diffuse muscle weakness associated with cardiomyopathy, severe respiratory insufficiency during adolescence, and a rigid spine in some patients.
Product Type:
NS Reagents Antibody
Antibody Type:
Monoclonal
Format:
100 µg in 100 µl PBS containing 0.02% sodium azide.
This antibody is specific to human BAG3 and does not bind Rat or Mouse BAG3
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the C-terminal region of Human BAG3
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Clone number:
Clone V65P1E8*D2
Antibody Isotype:
IgG1 kappa
Category:
Primary Antibodies
Other names:
BAG3, Bcl-2-associated athanogene 3, Bcl-2-binding protein Bis, Docking protein CAIR-, BAG family molecular chaperone regulator 3
Research Areas:
Neuroscience, Autophagy
NS Reagents Product Area:
Neuroscience
Molecular Weight:
75kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Cytoplasm, Nucleus
Purification:
Protein A Affinity Purified
References:
[1] Sturner E. and Behl C. (2017). The role of the multifunctional BAG3 protein in cellular protein quality control and in disease. Front. Mol. Neurosci. 10, 177 10.3389/fnmol.2017.00177
Microtubules are major components of the cytoskeleton found in all eukaryotic cells. They are involved in mitosis, cell motility, intracellular transport, and maintenance of cell shape. Tubulin, the protein subunit of microtubules (MTs), is an alpha/beta heterodimer. Because beta-tubulin is ubiquitously expressed in all eukaryotic cells, it can be used as a loading control for Western blotting.
Alpha- and beta-tubulin subunits are encoded by 19 genes in humans (10 alpha and 9 beta) with each tubulin showing over 90% amino acid homology with other tubulins of the same type. Tubulin isotype expression and distribution varies across different cells and tissues, indicating that all tubulins, whilst important for the basic structural functions they perform, are most likely important for other functions in specific cell types.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human beta Tubulin from the C-terminal region of the protein
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB: 4-6 µg/ml
Category:
Primary Antibodies
Other names:
TUBB, ?-tubulin
Research Areas:
Transcription and Translation, DNA Damage and Methylation, Protein and Nucleic Acid Modification
NS Reagents Product Area:
DNA & Protein Modification
Molecular Weight:
50kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Microtubules are major components of the cytoskeleton found in all eukaryotic cells. They are involved in mitosis, cell motility, intracellular transport, and maintenance of cell shape. Tubulin, the protein subunit of microtubules (MTs), is an alpha/beta heterodimer. Because beta-tubulin is ubiquitously expressed in all eukaryotic cells, it can be used as a loading control for Western blotting.
Alpha- and beta-tubulin subunits are encoded by 19 genes in humans (10 alpha and 9 beta) with each tubulin showing over 90% amino acid homology with other tubulins of the same type. Tubulin isotype expression and distribution varies across different cells and tissues, indicating that all tubulins, whilst important for the basic structural functions they perform, are most likely important for other functions in specific cell types.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 100 µl PBS containing 0.05% BSA and 0.05% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human beta Tubulin from the C-terminal region of the protein
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB: 4-6 µg/ml
Category:
Primary Antibodies
Other names:
TUBB, ?-tubulin
Research Areas:
Transcription and Translation, DNA Damage and Methylation, Protein and Nucleic Acid Modification
NS Reagents Product Area:
DNA & Protein Modification
Molecular Weight:
50kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Bifunctional apoptosis regulator (BFAR/BAR) is a multidomain protein originally identified as an inhibitor of Bax-induced apoptosis. It is predominantly found in the endoplasmic reticulum (ER) and is thought to be a scaffold protein that may bridge components of both extrinsic and intrinsic apoptosis pathways.
BFAR contains a DED (death effector domain) like domain that suppresses death receptor apoptosis signalling pathways. It is highly expressed in the brain and is believed to be involved in regulating neuronal survival, helping neurons to survive for the entire lifetime of the organism by playing a central role in inhibiting ER initiated apoptosis.
This antibody is not expected to bind to Bifunctional apoptosis regulator from other species. The immunogens was epcifically selected for this purpose.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the N-terminal region of Human BFAR (BAR)
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Bridging INtegrator 1 (BIN1) is a member of the Bin/Amphiphysin/Rvs (BAR) family of adaptor proteins that regulates lipid membrane dynamics. It is ubiquitously expressed throughout the body with high expression in brain tissues. In the brain, BIN1 is expressed in multiple isoforms, the ubiquitously expressed isoforms 9 and 10, along with brain-specific isoforms 1 to 7. BIN1 is involved in a wide range of cellular functions associated with membrane curvature, including phagocytosis and clathrin-mediated endocytosis and is believed to interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms expressed in the central nervous system are involved in synaptic vesicle endocytosis. BIN1 has N-terminal Bin-Amphiphysin-Rvs and C-terminal Src homology 3 domains. BIN1 is believed to be involved in the pathogenesis of Alzheimers disease (AD) as a modulator of Tau pathology, rather than as a promoter of A? deposition. Depletion of BIN1 increases cellular BACE1 levels through impaired endosomal trafficking, resulting in increased amyloid-beta production. In neuronal circuits, endocytosis regulation may influence the internalisation of paired helical filaments (PHF) tau aggregates.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human BIN1 from the C-terminal region of the protein
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000. IHC 1:50-200. IF 1:20-50.
Category:
Primary Antibodies
Other names:
AMPH2, AMPHL, SH3P9, amphiphysin II, amphiphysin-like protein, AMPHL, BIN1_HUMAN, box-dependent myc-interacting protein 1, myc box-dependent-interacting protein 1
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
65kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Bridging INtegrator 1 (BIN1) is a member of the Bin/Amphiphysin/Rvs (BAR) family of adaptor proteins that regulates lipid membrane dynamics. It is ubiquitously expressed throughout the body with high expression in brain tissues. In the brain, BIN1 is expressed in multiple isoforms, the ubiquitously expressed isoforms 9 and 10, along with brain-specific isoforms 1 to 7. BIN1 is involved in a wide range of cellular functions associated with membrane curvature, including phagocytosis and clathrin-mediated endocytosis and is believed to interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms expressed in the central nervous system are involved in synaptic vesicle endocytosis. BIN1 has N-terminal Bin-Amphiphysin-Rvs and C-terminal Src homology 3 domains. BIN1 is believed to be involved in the pathogenesis of Alzheimers disease (AD) as a modulator of Tau pathology, rather than as a promoter of A? deposition. Depletion of BIN1 increases cellular BACE1 levels through impaired endosomal trafficking, resulting in increased amyloid-beta production. In neuronal circuits, endocytosis regulation may influence the internalisation of paired helical filaments (PHF) tau aggregates.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human BIN1 from the C-terminal region of the protein
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000. IHC 1:50-200. IF 1:20-50.
Category:
Primary Antibodies
Other names:
AMPH2, AMPHL, SH3P9, amphiphysin II, amphiphysin-like protein, AMPHL, BIN1_HUMAN, box-dependent myc-interacting protein 1, myc box-dependent-interacting protein 1
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
65kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Cytoplasmic activation/proliferation?associated protein-1 (Caprin?1) is a ubiquitously expressed and highly conserved cytoplasmic phosphoprotein. It is an RNA?binding protein involved in the regulation of cell cycle control?associated genes, having the characteristic arginine-glycine-glycine (RGG) motif and RG enrichment region associated with RNA binding proteins, as well as two highly conserved regions, homologous region-1 and homologous region-2.
Caprin-1 levels (other than in the brain), are tightly correlated with cellular proliferation. In neurons it may specifically regulate the transport and translation of mRNAs for proteins involved in synaptic plasticity. . Mutations in Caprin-1 have been linked to conditions such as amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD) and autism spectrum disorder (ASD).
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Cytoplasmic activation/proliferation?associated protein-1 (Caprin?1) is a ubiquitously expressed and highly conserved cytoplasmic phosphoprotein. It is an RNA?binding protein involved in the regulation of cell cycle control?associated genes, having the characteristic arginine-glycine-glycine (RGG) motif and RG enrichment region associated with RNA binding proteins, as well as two highly conserved regions, homologous region-1 and homologous region-2.
Caprin-1 levels (other than in the brain), are tightly correlated with cellular proliferation. In neurons it may specifically regulate the transport and translation of mRNAs for proteins involved in synaptic plasticity. . Mutations in Caprin-1 have been linked to conditions such as amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD) and autism spectrum disorder (ASD).
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Caspases are a member of the cysteine-aspartic acid protease family. Caspase-3 (31 kDa) is an executionary caspase which directly cleaves and activates poly(ADP-ribose) polymerase (PARP), sterol regulatory element binding proteins (SREBPs) or it can also interact with other caspases like caspase-6, -7 and -9.
Caspase-3 is the principal caspase in mediating the cleavage of amyloid-beta 4A precursor protein (APP), which is related with neuronal death in Alzheimer's disease. Like other caspases, caspase-3 is also synthesized as a zymogen procaspase which is activated by specific proteolytic cleavage. High levels of caspase-3 are observed in lung, spleen, heart, liver and kidney, moderate levels in brain and skeletal muscle, and low in testis. Increased levels of caspase-3 are involved in Huntington Disease-associated cell death.
Product Type:
NS Reagents Antibody
Antibody Type:
Monoclonal
Format:
50 µg in 100 µl PBS containing 0.05% BSA and 0.05% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Caspases are a member of the cysteine-aspartic acid protease family. Caspase-3 (31 kDa) is an executionary caspase which directly cleaves and activates poly(ADP-ribose) polymerase (PARP), sterol regulatory element binding proteins (SREBPs) or it can also interact with other caspases like caspase-6, -7 and -9.
Caspase-3 is the principal caspase in mediating the cleavage of amyloid-beta 4A precursor protein (APP), which is related with neuronal death in Alzheimer's disease. Like other caspases, caspase-3 is also synthesized as a zymogen procaspase which is activated by specific proteolytic cleavage. High levels of caspase-3 are observed in lung, spleen, heart, liver and kidney, moderate levels in brain and skeletal muscle, and low in testis. Increased levels of caspase-3 are involved in Huntington Disease-associated cell death.
Product Type:
NS Reagents Antibody
Antibody Type:
Monoclonal
Format:
100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Anti-Caspase-3 Antibody (Pro and Active) (Clone ABM1C12)
Background Info:
Caspases are a member of the cysteine-aspartic acid protease family. Caspase-3 (31 kDa) is an executionary caspase which directly cleaves and activates poly(ADP-ribose) polymerase (PARP), sterol regulatory element binding proteins (SREBPs) or it can also interact with other caspases like caspase-6, -7 and -9.
Caspase-3 is the principal caspase in mediating the cleavage of amyloid-beta 4A precursor protein (APP), which is related with neuronal death in Alzheimer's disease. Like other caspases, caspase-3 is also synthesized as a zymogen procaspase which is activated by specific proteolytic cleavage. High levels of caspase-3 are observed in lung, spleen, heart, liver and kidney, moderate levels in brain and skeletal muscle, and low in testis. Increased levels of caspase-3 are involved in Huntington Disease-associated cell death.
Product Type:
NS Reagents Antibody
Antibody Type:
Monoclonal
Format:
50 µg in 100 µl PBS containing 0.05% BSA and 0.05% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Anti-Caspase-3 Antibody (Pro and Active) (Clone ABM1C12)
Background Info:
Caspases are a member of the cysteine-aspartic acid protease family. Caspase-3 (31 kDa) is an executionary caspase which directly cleaves and activates poly(ADP-ribose) polymerase (PARP), sterol regulatory element binding proteins (SREBPs) or it can also interact with other caspases like caspase-6, -7 and -9.
Caspase-3 is the principal caspase in mediating the cleavage of amyloid-beta 4A precursor protein (APP), which is related with neuronal death in Alzheimer's disease. Like other caspases, caspase-3 is also synthesized as a zymogen procaspase which is activated by specific proteolytic cleavage. High levels of caspase-3 are observed in lung, spleen, heart, liver and kidney, moderate levels in brain and skeletal muscle, and low in testis. Increased levels of caspase-3 are involved in Huntington Disease-associated cell death.
Product Type:
NS Reagents Antibody
Antibody Type:
Monoclonal
Format:
100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
CD2-associated protein (CD2AP) is an adaptor protein, that regulates membrane trafficking. It has three N-terminal SH3 domains and a C-terminal proline-rich actin binding domain and coiled-coil. CD2AP is active in a range of tissues including the nervous system. Its role in the nervous system is however not fully understood, but it is known to play a role in amyloid precursor protein trafficking and processing [1] making it a relevant protein in Alzheimer's disease research. It is also involved in axonal growth [2] and maintenance of blood-brain barrier integrity [3]
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the central region of human CD2AP
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:5000-8000.
Category:
Primary Antibodies
Other names:
CD2AP, CD2-associated protein, Adapter protein CMS, CMS,
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
71kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Cytoplasm
Purification:
Affinity purification
References:
[1] F. Ubelmann, T. Burrinha, L. Salavessa, R. Gomes, C. Ferreira, N. Moreno, C. Guimas Almeida. Bin1 and CD2AP polarise the endocytic generation of beta-amyloid. EMBO Rep., 18 (2017), pp. 102-122
[2] B.J. Harrison, G. Venkat, J.L. Lamb, T.H. Hutson, C. Drury, K.K. Rau, M.B. Bunge, L.M. Mendell, F.H. Gage, R.D. Johnson, et al. The Adaptor Protein CD2AP Is a Coordinator of Neurotrophin Signaling-Mediated Axon Arbor Plasticity. J. Neurosci., 36 (2016), pp. 4259-4275.
[3] J.N. Cochran, T. Rush, S.C. Buckingham, E.D. Roberson. The Alzheimers disease risk factor CD2AP maintains blood-brain barrier integrity. Hum. Mol. Genet., 24 (2015), pp. 6667-6674.
CD2-associated protein (CD2AP) is an adaptor protein, that regulates membrane trafficking. It has three N-terminal SH3 domains and a C-terminal proline-rich actin binding domain and coiled-coil. CD2AP is active in a range of tissues including the nervous system. Its role in the nervous system is however not fully understood, but it is known to play a role in amyloid precursor protein trafficking and processing [1] making it a relevant protein in Alzheimer's disease research. It is also involved in axonal growth [2] and maintenance of blood-brain barrier integrity [3]
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the central region of human CD2AP
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:5000-8000.
Category:
Primary Antibodies
Other names:
CD2AP, CD2-associated protein, Adapter protein CMS, CMS,
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
71kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Cytoplasm
Purification:
Affinity purification
References:
[1] F. Ubelmann, T. Burrinha, L. Salavessa, R. Gomes, C. Ferreira, N. Moreno, C. Guimas Almeida. Bin1 and CD2AP polarise the endocytic generation of beta-amyloid. EMBO Rep., 18 (2017), pp. 102-122
[2] B.J. Harrison, G. Venkat, J.L. Lamb, T.H. Hutson, C. Drury, K.K. Rau, M.B. Bunge, L.M. Mendell, F.H. Gage, R.D. Johnson, et al. The Adaptor Protein CD2AP Is a Coordinator of Neurotrophin Signaling-Mediated Axon Arbor Plasticity. J. Neurosci., 36 (2016), pp. 4259-4275.
[3] J.N. Cochran, T. Rush, S.C. Buckingham, E.D. Roberson. The Alzheimers disease risk factor CD2AP maintains blood-brain barrier integrity. Hum. Mol. Genet., 24 (2015), pp. 6667-6674.
CD38 is a widely expressed 45 kDa transmembrane glycoprotein with a short cytoplasmic tail (aa 121), a transmembrane domain (aa 2242) and an extracellular domain (aa 43300) [1]. It is a multifunctional ectoenzyme catalysing multiple reactions and also has a role in signal transduction and calcium signaling.
In the brain CD38 is expressed in neurons, astrocytes and microglial cells and expression was found to increase under neuroinflammatory conditions indicating that it may have a role in the regulation of neuroinflammation. In Alzheimers disease, CD38 immunoreactivity is seen in intracellular tangles and neuropil threads [2].
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal Antibody
Format:
50 µg in 50 µl Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
Storage Temp:
Store at -20°C. Avoid freeze / thaw cycles.
Host Animal:
Rabbit
Species Reactivity:
Human, Rat
Immunogen:
A synthetic peptide from the C-terminal region of human CD38
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
[1] Malavasi, F.; Deaglio, S.; Funaro, A.; Ferrero, E.; Horenstein, A.L.; Ortolan, E.; Vaisitti, T.; Aydin, S. Evolution and Function of the ADP Ribosyl Cyclase/CD38 Gene Family in Physiology and Pathology. Physiol. Rev. 2008, 88, 841886. [2] Otsuka K., Mizuguchi M., Aizawa T., Haga S., Sato M., Inoya H., Namba Y., Machinami R. Immunoreactivity in Alzheimers neurofibrillary tangles (abstract) Brain Pathol. 1994;4:558.
CD38 is a widely expressed 45 kDa transmembrane glycoprotein with a short cytoplasmic tail (aa 121), a transmembrane domain (aa 2242) and an extracellular domain (aa 43300) [1]. It is a multifunctional ectoenzyme catalysing multiple reactions and also has a role in signal transduction and calcium signaling.
In the brain CD38 is expressed in neurons, astrocytes and microglial cells and expression was found to increase under neuroinflammatory conditions indicating that it may have a role in the regulation of neuroinflammation. In Alzheimers disease, CD38 immunoreactivity is seen in intracellular tangles and neuropil threads [2].
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal Antibody
Format:
100 µg in 100 µl Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
Storage Temp:
Store at -20°C. Avoid freeze / thaw cycles.
Host Animal:
Rabbit
Species Reactivity:
Human, Rat
Immunogen:
A synthetic peptide from the C-terminal region of human CD38
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
[1] Malavasi, F.; Deaglio, S.; Funaro, A.; Ferrero, E.; Horenstein, A.L.; Ortolan, E.; Vaisitti, T.; Aydin, S. Evolution and Function of the ADP Ribosyl Cyclase/CD38 Gene Family in Physiology and Pathology. Physiol. Rev. 2008, 88, 841886. [2] Otsuka K., Mizuguchi M., Aizawa T., Haga S., Sato M., Inoya H., Namba Y., Machinami R. Immunoreactivity in Alzheimers neurofibrillary tangles (abstract) Brain Pathol. 1994;4:558.
Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine-threonine kinase belonging to the Cdc2/Cdk1 family that regulates various neuronal processes such as neurogenesis, neuronal migration, and axon guidance. It is essential for the development of the central nervous system, being highly expressed in the brain. Cdk5 is controlled by the neural specific activators p35, p39. Outside of the nervous system CDK5 regulates vesicular transport, apoptosis, cell adhesion, and migration in many cell types.
Cdk5 has been implicated in the pathology of multiple types of cancers and is a potential target for Glioblastoma. Deregulation of Cdk5 is also linked to neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), and Hungtington's disease (HD) and additionally it has been proposed that Cdk5 modulates the brain reward system and therefore it has consequently also been linked to psychiatric diseases.
Product Type:
NS Reagents Antibody
Antibody Type:
Monoclonal
Format:
100 µg in 100 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human CDK5 from the N-terminal region (expressed in E.coli)
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Clone number:
NSR-256
Antibody Isotype:
IgG1
Application Details:
WB 1:500. IHC 1:150.
Category:
Primary Antibodies
Other names:
LIS7, PSSALRE, Cyclin-dependent-like kinase 5, Cell division protein kinase 5, Serine/threonine-protein kinase PSSALRE, Tau protein kinase II catalytic subunit, CDKN5, TPKII Catalytic Subunit, Epididymis Secretory Sperm Binding Protein
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
33kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine-threonine kinase belonging to the Cdc2/Cdk1 family that regulates various neuronal processes such as neurogenesis, neuronal migration, and axon guidance. It is essential for the development of the central nervous system, being highly expressed in the brain. Cdk5 is controlled by the neural specific activators p35, p39. Outside of the nervous system CDK5 regulates vesicular transport, apoptosis, cell adhesion, and migration in many cell types.
Cdk5 has been implicated in the pathology of multiple types of cancers and is a potential target for Glioblastoma. Deregulation of Cdk5 is also linked to neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), and Hungtington's disease (HD) and additionally it has been proposed that Cdk5 modulates the brain reward system and therefore it has consequently also been linked to psychiatric diseases.
Product Type:
NS Reagents Antibody
Antibody Type:
Monoclonal
Format:
50 µg in 50 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human CDK5 from the N-terminal region (expressed in E.coli)
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Clone number:
NSR-256
Antibody Isotype:
IgG1
Application Details:
WB 1:500. IHC 1:150.
Category:
Primary Antibodies
Other names:
LIS7, PSSALRE, Cyclin-dependent-like kinase 5, Cell division protein kinase 5, Serine/threonine-protein kinase PSSALRE, Tau protein kinase II catalytic subunit, CDKN5, TPKII Catalytic Subunit, Epididymis Secretory Sperm Binding Protein
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
33kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Charged Multivesicular Body Protein 2B (CHMP2B) forms part of one of the endosomal sorting complexes required for transport (ESCRT), specifically ESCRT-III. (ESCRT)-III proteins catalyse a number of membrane remodeling processes essential for many cellular functions with CHMP2B mediating the endosomal sorting of ubiquitinated transmembrane proteins into the multivesicular bodies (MVBs) for transport to lysosomes.
ESCRT-III comprises IST1, two isoforms of CHMP1, two isoforms of CHMP2, CHMP3, three isoforms of CHMP4, CHMP5, CHMP6 and CHMP7. The ESCRT-III proteins are expressed ubiquitously with CHMP2B having a specialised role in neurons during the formation and maintenance of synapses. Mutations in the CHMP2B gene results in two C-terminally truncated variants of the protein leading to an autosomal dominant form of frontotemporal dementia (FTD).
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000. IHC 1:50-200.
Category:
Primary Antibodies
Other names:
ALS17, CHMP2.5, DMT1, VPS2-2, VPS2B, VPS2 Homolog B, Vacuolar Protein Sorting-Associated Protein 2-2,Charged Multivesicular Body Protein 2b
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
24kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Cytoplasm Late endosome membrane Peripheral membrane protein cytosol
Charged Multivesicular Body Protein 2B (CHMP2B) forms part of one of the endosomal sorting complexes required for transport (ESCRT), specifically ESCRT-III. (ESCRT)-III proteins catalyse a number of membrane remodeling processes essential for many cellular functions with CHMP2B mediating the endosomal sorting of ubiquitinated transmembrane proteins into the multivesicular bodies (MVBs) for transport to lysosomes.
ESCRT-III comprises IST1, two isoforms of CHMP1, two isoforms of CHMP2, CHMP3, three isoforms of CHMP4, CHMP5, CHMP6 and CHMP7. The ESCRT-III proteins are expressed ubiquitously with CHMP2B having a specialised role in neurons during the formation and maintenance of synapses. Mutations in the CHMP2B gene results in two C-terminally truncated variants of the protein leading to an autosomal dominant form of frontotemporal dementia (FTD).
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000. IHC 1:50-200.
Category:
Primary Antibodies
Other names:
ALS17, CHMP2.5, DMT1, VPS2-2, VPS2B, VPS2 Homolog B, Vacuolar Protein Sorting-Associated Protein 2-2,Charged Multivesicular Body Protein 2b
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
24kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Cytoplasm Late endosome membrane Peripheral membrane protein cytosol
The c-Myc and N-Myc oncogenes are members of the Myc family of transcription factors that regulate cell proliferation and apoptosis. c-MYC has a pivotal function in growth control, differentiation and apoptosis, being expressed in proliferating tissues, and its abnormal expression is associated with many tumors. Overexpression of c-MYC sensitises cells to apoptosis by a variety of stimuli. How the apoptotic response is regulated by c-MYC depends on the specific cell type and the physiological status of the cell.
The peptide sequence selected is conserved across many species so this antibody should react with cMyc in many other species including Rat, Mouse Bovine, Dog, Cat, Sheep and Pig.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the N-terminal region of Human c-Myc Conjugated to purified protein derivative (PPD)
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Clone number:
Clone PM3E7
Antibody Isotype:
IgG2a
Category:
Primary Antibodies
Other names:
MYCC, MYC Proto-oncogene, Myc proto-oncogene protein
Research Areas:
DNA & Protein Modification, Cancer
NS Reagents Product Area:
DNA & Protein Modification
Molecular Weight:
64kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Nucleoplasm, Nucleolus
Purification:
Protein A Affinity Purified
References:
Evan et al. 1988. Curr Top Microbiol Immunol. 141:189-201. PMID: 3063442.
The c-Myc and N-Myc oncogenes are members of the Myc family of transcription factors that regulate cell proliferation and apoptosis. c-MYC has a pivotal function in growth control, differentiation and apoptosis, being expressed in proliferating tissues, and its abnormal expression is associated with many tumors. Overexpression of c-MYC sensitises cells to apoptosis by a variety of stimuli. How the apoptotic response is regulated by c-MYC depends on the specific cell type and the physiological status of the cell.
Product Type:
NS Reagents Antibody
Antibody Type:
Monoclonal
Format:
100 µg in 100 µl PBS containing 0.02% sodium azide.
The peptide sequence selected is conserved across many species so this antibody should react with cMyc in many other species including Rat, Mouse Bovine, Dog, Cat, Sheep and Pig.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the N-terminal region of Human c-Myc Conjugated to purified protein derivative (PPD)
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Clone number:
Clone PM3E7
Antibody Isotype:
IgG2a
Category:
Primary Antibodies
Other names:
MYCC, MYC Proto-oncogene, Myc proto-oncogene protein
Research Areas:
DNA & Protein Modification, Cancer
NS Reagents Product Area:
DNA & Protein Modification
Molecular Weight:
64kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Nucleoplasm, Nucleolus
Purification:
Protein A Affinity Purified
References:
Evan et al. 1988. Curr Top Microbiol Immunol. 141:189-201. PMID: 3063442.
The c-Myc and N-Myc oncogenes are members of the Myc family of transcription factors that regulate cell proliferation and apoptosis. c-MYC has a pivotal function in growth control, differentiation and apoptosis, being expressed in proliferating tissues, and its abnormal expression is associated with many tumors. Overexpression of c-MYC sensitises cells to apoptosis by a variety of stimuli. How the apoptotic response is regulated by c-MYC depends on the specific cell type and the physiological status of the cell.
c-myc is often used as a protein tag in order to simplify the labeling and detection of proteins. This antibody can be used for detection of such proteins in western blotting.
Product Type:
NS Reagents Antibody
Antibody Type:
Monoclonal
Format:
100 µg in 100 µl PBS containing 0.02% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the C-terminal region of Human Myc proto-oncogene protein (c-Myc)
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Clone number:
Clone 9E11
Antibody Isotype:
IgG2a kappa
Application Details:
WB: 1:1,000 ELISA 1:100-1:2000 Flow Cytometry 1:200-1:400 Immunohistochemistry 1:100 ChIP 2 ug / 500 ug extract Immunoprecipitation 2ug/mg lysate
Category:
Primary Antibodies
Other names:
MYCC, MYC Proto-oncogene
Research Areas:
DNA & Protein Modification, Cancer
NS Reagents Product Area:
DNA & Protein Modification
Molecular Weight:
48kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Nucleoplasm, Nucleolus
Purification:
Protein A Affinity Purified
References:
Mittal et al. 2013. PLoS One. 8(8):e70352. PMID: 23936412. ; Mirzaei et al. 2013. Proc Natl Acad Sci U S A. 110(9):3645-50. PMID: 23388641. ; Keyhanfar et al. 2007. Biochem J. 401(1):269-77. PMID: 16981855. ; Halme et al. 2004. Cell. 116(3):405-15. PMID: 15016375. ; Kari et al. 1986. J Virol. 60(2):345-52. PMID: 3021969.
The c-Myc and N-Myc oncogenes are members of the Myc family of transcription factors that regulate cell proliferation and apoptosis. c-MYC has a pivotal function in growth control, differentiation and apoptosis, being expressed in proliferating tissues, and its abnormal expression is associated with many tumors. Overexpression of c-MYC sensitises cells to apoptosis by a variety of stimuli. How the apoptotic response is regulated by c-MYC depends on the specific cell type and the physiological status of the cell.
c-myc is often used as a protein tag in order to simplify the labeling and detection of proteins. This antibody can be used for detection of such proteins in western blotting.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the C-terminal region of human Myc proto-oncogene protein
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Clone number:
Clone 9E11
Antibody Isotype:
IgG2a kappa
Application Details:
WB: 1:1,000 ELISA 1:100-1:2000 Flow Cytometry 1:200-1:400 Immunohistochemistry 1:100 ChIP 2 ug / 500 ug extract Immunoprecipitation 2ug/mg lysate
Category:
Primary Antibodies
Other names:
MYCC, MYC Proto-oncogene
Research Areas:
DNA & Protein Modification, Cancer
NS Reagents Product Area:
DNA & Protein Modification
Molecular Weight:
48kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Nucleoplasm, Nucleolus
Purification:
Protein A Affinity Purified
References:
Mittal et al. 2013. PLoS One. 8(8):e70352. PMID: 23936412. ; Mirzaei et al. 2013. Proc Natl Acad Sci U S A. 110(9):3645-50. PMID: 23388641. ; Keyhanfar et al. 2007. Biochem J. 401(1):269-77. PMID: 16981855. ; Halme et al. 2004. Cell. 116(3):405-15. PMID: 15016375. ; Kari et al. 1986. J Virol. 60(2):345-52. PMID: 3021969.
COP9 signalosome subunit 5 (Jab1 / C-Jun activation domain-binding protein-1) is a co-activator of c-Jun, a transcription factor involved in numerous cellular processes including cell proliferation. Jab1 is encoded by the COPS5 gene and enhances the transcriptional function of c-Jun by binding to it. Jab1 is one of the eight subunits of the COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. Jab1/COPS5 dysregulation contributes to oncogenesis by deactivating several tumor suppressors and activating oncogenes. Jab1 overexpression is found in many tumor types, and has an important role in cancer initiation, progression, and prognosis.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Full length recombinant human COP9 signalosome subunit 5
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
COP9 signalosome subunit 5 (Jab1 / C-Jun activation domain-binding protein-1) is a co-activator of c-Jun, a transcription factor involved in numerous cellular processes including cell proliferation. Jab1 is encoded by the COPS5 gene and enhances the transcriptional function of c-Jun by binding to it. Jab1 is one of the eight subunits of the COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. Jab1/COPS5 dysregulation contributes to oncogenesis by deactivating several tumor suppressors and activating oncogenes. Jab1 overexpression is found in many tumor types, and has an important role in cancer initiation, progression, and prognosis.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Full length recombinant human COP9 signalosome subunit 5
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Carnitine palmitoyltransferase I (CPT1) is a liver enzyme involved in fatty acid oxidation. Three isoforms of CPT1 are currently known: CPT1A, CPT1B, and CPT1C. This antibody recognises CPT1A.
The carnitine palmitoyltransferase (CPT) enzyme system, with acyl-CoA synthetase and carnitine/acylcarnitine translocas, provide the mechanism for long-chain fatty acids to be transferred from the cytosol to the mitochondrial matrix to undergo beta-oxidation for energy production.
The mitochondrial oxidation of long-chain fatty acids is initiated by the sequential action of carnitine palmitoyltransferase I (which is located in the outer membrane and is detergent-labile) and carnitine palmitoyltransferase II (which is located in the inner membrane and is detergent-stable), together with a carnitine-acylcarnitine translocase.
Carnitine palmitoyltransferase I is responsible for the formation of acyl carnitines, catalysing the transfer of the acyl group of a long-chain fatty acyl-CoA from coenzyme A to l-carnitine, allowing movement of the acyl carnitine from the cytosol into the intermembrane space of mitochondria. CPT I is key for carnitine-dependent transport across the mitochondrial inner membrane and its deficiency results in a decreased rate of fatty acid beta-oxidation.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS containing 0.02% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human CPT1A from the C-terminal region
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000. IF 1:50-200. IP 1:50-100.
Category:
Primary Antibodies
Other names:
CPT1, CPT1-L, L-CPT1, Carnitine palmitoyltransferase IA
Research Areas:
Cell Signalling and Transport, Transcription and Translation, Protein Modification, Transcription, Chromatin
NS Reagents Product Area:
Cell Signalling
Molecular Weight:
88kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Mitochondrion outer membrane, Multi-pass membrane protein
Carnitine palmitoyltransferase I (CPT1) is a liver enzyme involved in fatty acid oxidation. Three isoforms of CPT1 are currently known: CPT1A, CPT1B, and CPT1C. This antibody recognises CPT1A.
The carnitine palmitoyltransferase (CPT) enzyme system, with acyl-CoA synthetase and carnitine/acylcarnitine translocas, provide the mechanism for long-chain fatty acids to be transferred from the cytosol to the mitochondrial matrix to undergo beta-oxidation for energy production.
The mitochondrial oxidation of long-chain fatty acids is initiated by the sequential action of carnitine palmitoyltransferase I (which is located in the outer membrane and is detergent-labile) and carnitine palmitoyltransferase II (which is located in the inner membrane and is detergent-stable), together with a carnitine-acylcarnitine translocase.
Carnitine palmitoyltransferase I is responsible for the formation of acyl carnitines, catalysing the transfer of the acyl group of a long-chain fatty acyl-CoA from coenzyme A to l-carnitine, allowing movement of the acyl carnitine from the cytosol into the intermembrane space of mitochondria. CPT I is key for carnitine-dependent transport across the mitochondrial inner membrane and its deficiency results in a decreased rate of fatty acid beta-oxidation.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human CPT1A from the C-terminal region
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000. IF 1:50-200. IP 1:50-100.
Category:
Primary Antibodies
Other names:
CPT1, CPT1-L, L-CPT1, Carnitine palmitoyltransferase IA
Research Areas:
Cell Signalling and Transport, Transcription and Translation, Protein Modification, Transcription, Chromatin
NS Reagents Product Area:
Cell Signalling
Molecular Weight:
88kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Mitochondrion outer membrane, Multi-pass membrane protein
CYFIP1 (Cytoplasmic FMRP interacting protein 1) is a synaptic protein involved in multiple biological pathways. It binds FMRP (fragile-X mental retardation protein) and the resulting CYFIP1-FMRP complex represses translation at dendritic and synaptic sites [1]. CYFIP1 is also part of the Wave Regulatory Complex (WRC) formed by WAVE1/2/3, CYFIP1, ABI1/2, NCKAP1 and HPSC300 [2], involved in the formation of the actin cytoskeleton. CYFIP1 inhibits the WAVE complex in an inhibited state through interaction with the Arp2/3 complex. Both processes, actin dynamics and regulated protein synthesis, are crucial for synaptic development and brain functioning. Synaptic activation changes the protein conformation of CYFIP1, from globular to planar, pushing CYFIP1 more towards the WAVE complex, thereby inhibiting actin remodelling. A loss of CYFIP1 leads to defective axonal growth and motor function showing that CYFIP1 is essential for synaptic plasticity.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal Antibody
Format:
100 µg in 100 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage Temp:
Store at -20°C. Avoid freeze / thaw cycles.
Host Animal:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Expected Species:
Cat, Dog, Chimpanzee, Zebrafish
Immunogen:
Partial length recombinant human CYFIP1 from the N-terminal region
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:1000-2000. IHC 1:50-200.
Category:
Primary Antibodies
Other names:
Specifically Rac1-associated protein 1, Cytoplasmic FMR1-interacting protein 1, Sra-1, Specifically Rac1-associated (Sra-1) protein36, p140sra-1
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
145kDa (Intended as a general guide and does not allow for all isoforms and species variations)
[1] Napoli I, Mercaldo V, Boyl PP, Eleuteri B, Zalfa F, De Rubeis S, et al. The fragile X syndrome protein represses activity-dependent translation through CYFIP1, a new 4E-BP. Cell. 2008;134(6):104254. [2] Chen, Z. et al. Structure and control of the actin regulatory WAVE complex. Nature 468, 533538 (2010). [3] De Rubeis S, Pasciuto E, Li KW, Fernández E, Di Marino D, Buzzi A, et al. CYFIP1 coordinates mRNA translation and cytoskeleton remodeling to ensure proper dendritic Spine formation. Neuron. 2013;79(6):116982.
CYFIP1 (Cytoplasmic FMRP interacting protein 1) is a synaptic protein involved in multiple biological pathways. It binds FMRP (fragile-X mental retardation protein) and the resulting CYFIP1-FMRP complex represses translation at dendritic and synaptic sites [1]. CYFIP1 is also part of the Wave Regulatory Complex (WRC) formed by WAVE1/2/3, CYFIP1, ABI1/2, NCKAP1 and HPSC300 [2], involved in the formation of the actin cytoskeleton. CYFIP1 inhibits the WAVE complex in an inhibited state through interaction with the Arp2/3 complex. Both processes, actin dynamics and regulated protein synthesis, are crucial for synaptic development and brain functioning. Synaptic activation changes the protein conformation of CYFIP1, from globular to planar, pushing CYFIP1 more towards the WAVE complex, thereby inhibiting actin remodelling. A loss of CYFIP1 leads to defective axonal growth and motor function showing that CYFIP1 is essential for synaptic plasticity.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal Antibody
Format:
50 µg in 50 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage Temp:
Store at -20°C. Avoid freeze / thaw cycles.
Host Animal:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Expected Species:
Cat, Dog, Chimpanzee, Zebrafish
Immunogen:
Partial length recombinant human CYFIP1 from the N-terminal region
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:1000-2000. IHC 1:50-200.
Category:
Primary Antibodies
Other names:
Specifically Rac1-associated protein 1, Cytoplasmic FMR1-interacting protein 1, Sra-1, Specifically Rac1-associated (Sra-1) protein36, p140sra-1
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
145kDa (Intended as a general guide and does not allow for all isoforms and species variations)
[1] Napoli I, Mercaldo V, Boyl PP, Eleuteri B, Zalfa F, De Rubeis S, et al. The fragile X syndrome protein represses activity-dependent translation through CYFIP1, a new 4E-BP. Cell. 2008;134(6):104254. [2] Chen, Z. et al. Structure and control of the actin regulatory WAVE complex. Nature 468, 533538 (2010). [3] De Rubeis S, Pasciuto E, Li KW, Fernández E, Di Marino D, Buzzi A, et al. CYFIP1 coordinates mRNA translation and cytoskeleton remodeling to ensure proper dendritic Spine formation. Neuron. 2013;79(6):116982.
Cholesterol 24-hydroxylase (CYP46A1) is a cytochrome P450 enzyme and endoplasmic reticulum protein expressed in brain tissues, It is important in brain cholesterol homeostasis being responsible for cholesterol elimination by its hydroxylation into 24S-hydroxycholesterol. Cholesterol cannot cross the blood-brain barrier, but 24S-hydroxycholesterol can, allowing it to travel via the circulatory system to the liver for catabolism. Increasing evidence suggests that CYP46A1 has a role in the pathogenesis and progression of neurodegenerative disorders with there being significant CYP46A1 expression in astrocytes and around amyloid plaques in Alzheimers disease, and increases in the level of CYP46A1 in the brain having a possible neuroprotective role in Huntingtons disease.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human CYP46A1 from the N-terminal region
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Cholesterol 24-hydroxylase (CYP46A1) is a cytochrome P450 enzyme and endoplasmic reticulum protein expressed in brain tissues, It is important in brain cholesterol homeostasis being responsible for cholesterol elimination by its hydroxylation into 24S-hydroxycholesterol. Cholesterol cannot cross the blood-brain barrier, but 24S-hydroxycholesterol can, allowing it to travel via the circulatory system to the liver for catabolism. Increasing evidence suggests that CYP46A1 has a role in the pathogenesis and progression of neurodegenerative disorders with there being significant CYP46A1 expression in astrocytes and around amyloid plaques in Alzheimers disease, and increases in the level of CYP46A1 in the brain having a possible neuroprotective role in Huntingtons disease.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human CYP46A1 from the N-terminal region
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Cytochrome P450 7B1 (25-hydroxycholesterol 7alpha-hydroxylase) is a member of the cytochrome P450 superfamily of enzymes involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. In the liver CYP7B1 most likely only plays a minor role in total bile acid synthesis, providing an alternate acidic pathway for the formation of bile acids through cholesterol degradation.
In the brain CYP7B1 is important in the metabolism of brain cholesterol. As there is little or no transfer of cholesterol across the blood-brain barrier, cholesterol must be produced in the brain locally, and CYP7B1 is important in maintaining the precise balance between the biosynthesis, storage, and catabolism of cholesterol metabolites.
Product Type:
NS Reagents Antibody
Antibody Type:
Monoclonal
Format:
100 µg in 100 µl PBS containing 0.02% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Ovalbumin-conjugated synthetic peptide from the C-terminal region of Human
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Cytochrome P450 7B1 (25-hydroxycholesterol 7alpha-hydroxylase) is a member of the cytochrome P450 superfamily of enzymes involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. In the liver CYP7B1 most likely only plays a minor role in total bile acid synthesis, providing an alternate acidic pathway for the formation of bile acids through cholesterol degradation.
In the brain CYP7B1 is important in the metabolism of brain cholesterol. As there is little or no transfer of cholesterol across the blood-brain barrier, cholesterol must be produced in the brain locally, and CYP7B1 is important in maintaining the precise balance between the biosynthesis, storage, and catabolism of cholesterol metabolites.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Ovalbumin-conjugated synthetic peptide from the C-terminal region of Human
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Death-domain-associated protein (DAXX) is a transcription regulator, that interacts with proteins involved in transcriptional silencing, such as histone deacetylases (HDAC1 and HDAC2) and DNA methyltransferase DNMT1. It represses the activity of several transcriptional factors, including C/EBP beta, c-Met, Pax3, Ets1, p53, p73, p63, glucocorticoid receptor, androgen receptor, and SMAD4.
DAXX is a nuclear protein associated with the promyelocytic leukaemia nuclear body (PML-NB) and other subnuclear domains. It can be either a pro-apoptotic or an anti-apoptotic factor, depending on the cell type and context. Daxx is thought to play a role in the pathology of human diseases including cancer and neurodegenerative disorders.
Mouse (single amino acid difference with the immunogen/human peptide sequence).
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the central region of Human Daxx
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
DNA damage-binding protein 1 (DDB1) is the large subunit (p127) of the heterodimeric DNA damage-binding (DDB) complex. DDB1 also functions as a core component of the cullin 4 (CUL4) ubiquitin E3 ligase complex, facilitating the binding of substrates to this complex and the ubiquitination of proteins. These factors (ubiquitin ligase substrates) regulate numerous essential processes in the cell including DNA repair (DDB2), DNA replication, chromatin remodelling (Cdt2) and more.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide.
Mouse, Rat, Bovine, Chicken, Cat, Guinea pig, Goat
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human DDB1 from the central region of the protein
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB: 2-4 µg/ml
Category:
Primary Antibodies
Other names:
DNA damage-binding protein 1, DDBP1, DDB1
Research Areas:
Transcription and Translation, DNA Damage, Chromatin
NS Reagents Product Area:
DNA & Protein Modification
Molecular Weight:
127kDa (Intended as a general guide and does not allow for all isoforms and species variations)
DNA damage-binding protein 1 (DDB1) is the large subunit (p127) of the heterodimeric DNA damage-binding (DDB) complex. DDB1 also functions as a core component of the cullin 4 (CUL4) ubiquitin E3 ligase complex, facilitating the binding of substrates to this complex and the ubiquitination of proteins. These factors (ubiquitin ligase substrates) regulate numerous essential processes in the cell including DNA repair (DDB2), DNA replication, chromatin remodelling (Cdt2) and more.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 100 µl PBS containing 0.05% BSA and 0.05% sodium azide.
Mouse, Rat, Bovine, Chicken, Cat, Guinea pig, Goat
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human DDB1 from the central region of the protein
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB: 2-4 µg/ml
Category:
Primary Antibodies
Other names:
DNA damage-binding protein 1, DDBP1, DDB1
Research Areas:
Transcription and Translation, DNA Damage, Chromatin
NS Reagents Product Area:
DNA & Protein Modification
Molecular Weight:
127kDa (Intended as a general guide and does not allow for all isoforms and species variations)
DNA fragmentation factor subunit alpha (DFFA, ICAD, DFF45) is an inhibitor of the caspase-activated DNase (DFFB, CAD, DFF40). DNA fragmentation factor (DFF) consists of two subunits, a 40 kDa caspase-activated nuclease (DFFB, CAD, DFF40) and a 45 kDa inhibitor (DFFA, ICAD, DFF45). In proliferating cells DFFB forms a complex with DFFA. When cells undergo apoptosis, caspase 3 cleaves DFFA at two sites to dissociate the DFFA:DFFB complex (ICAD:CAD), allowing DFFB (CAD) to cleave chromosomal DNA. DFFA is expressed in brain, blood, skin, spleen, adipose tissue. It has 2 isoforms produced by alternative splicing. In addition to blocking the DNase activity of DFFB, the C-terminal region of DFFA is also important for the DFFB-specific folding chaperone activity, as demonstrated by the ability of DFFA to refold DFFB.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 100 µl PBS containing 0.05% BSA and 0.05% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human DFFA from the C-terminal region of the protein
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB: 1-2 µg/ml
Category:
Primary Antibodies
Other names:
DNA fragmentation factor subunit alpha, DFFA, inhibitor of caspase-activated Dnase, ICAD, DFF1, DFF-45
Research Areas:
Transcription and Translation, Nucleic Acid Modification, DNA Damage
NS Reagents Product Area:
DNA & Protein Modification
Molecular Weight:
37kDa (Intended as a general guide and does not allow for all isoforms and species variations)
DNA fragmentation factor subunit alpha (DFFA, ICAD, DFF45) is an inhibitor of the caspase-activated DNase (DFFB, CAD, DFF40). DNA fragmentation factor (DFF) consists of two subunits, a 40 kDa caspase-activated nuclease (DFFB, CAD, DFF40) and a 45 kDa inhibitor (DFFA, ICAD, DFF45). In proliferating cells DFFB forms a complex with DFFA. When cells undergo apoptosis, caspase 3 cleaves DFFA at two sites to dissociate the DFFA:DFFB complex (ICAD:CAD), allowing DFFB (CAD) to cleave chromosomal DNA. DFFA is expressed in brain, blood, skin, spleen, adipose tissue. It has 2 isoforms produced by alternative splicing. In addition to blocking the DNase activity of DFFB, the C-terminal region of DFFA is also important for the DFFB-specific folding chaperone activity, as demonstrated by the ability of DFFA to refold DFFB.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human DFFA from the C-terminal region of the protein
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB: 1-2 µg/ml
Category:
Primary Antibodies
Other names:
DNA fragmentation factor subunit alpha, DFFA, inhibitor of caspase-activated Dnase, ICAD, DFF1, DFF-45
Research Areas:
Transcription and Translation, Nucleic Acid Modification, DNA Damage
NS Reagents Product Area:
DNA & Protein Modification
Molecular Weight:
37kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Dickkopf WNT signaling pathway inhibitor 1 (DKK1) is a secreted glycoprotein that inhibits Wnt/Beta-signaling by interaction with low-density lipoprotein receptor-related protein 5/6 (LRP5/6). It is involved in embryonic development and may be important in boone formation in adults. DKK1 has two cysteine rich regions that mediate protein-protein interactions.
Wnt signaling has a vital role in both the development of the nervous system and higher functions including synaptic plasticity and memory. DKK1 may have a role in the development of Alzheimers disease (AD) due to reduced Wnt/Beta-signaling, which leads to synapse vulnerability through reduced regulation of the Wnt signaling pathway.
Elevated DKK1 has also been observed in numerous human cancers with elevated levels in bone marrow plasma and peripheral blood associated with the presence of osteolytic bone lesions in patients with multiple myeloma.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:200-1000.
Category:
Primary Antibodies
Other names:
SK, DKK-1
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
29kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Dickkopf WNT signaling pathway inhibitor 1 (DKK1) is a secreted glycoprotein that inhibits Wnt/Beta-signaling by interaction with low-density lipoprotein receptor-related protein 5/6 (LRP5/6). It is involved in embryonic development and may be important in boone formation in adults. DKK1 has two cysteine rich regions that mediate protein-protein interactions.
Wnt signaling has a vital role in both the development of the nervous system and higher functions including synaptic plasticity and memory. DKK1 may have a role in the development of Alzheimers disease (AD) due to reduced Wnt/Beta-signaling, which leads to synapse vulnerability through reduced regulation of the Wnt signaling pathway.
Elevated DKK1 has also been observed in numerous human cancers with elevated levels in bone marrow plasma and peripheral blood associated with the presence of osteolytic bone lesions in patients with multiple myeloma.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:200-1000.
Category:
Primary Antibodies
Other names:
SK, DKK-1
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
29kDa (Intended as a general guide and does not allow for all isoforms and species variations)
DNA methyltransferase 1-associated protein 1 (DMAP1) is an enzyme consisting of 433 aminoacids. It is involved in transcription repression and activation. DMAP1 interacts with HDAC2 providing a mechanism for histone deacetylation in heterochromatin following replication of DNA at late dismissal origins. DMAP1 can also repress transcription independently of histone deacetylase activity. It participates in the nuclear localization of URI1 and increases its transcriptional co-repressor activity. It is expressed in many tissues including adipose tissue, adrenal gland, amniotic fluid, cerebellar cortex, hippocampus, liver.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 100 µl PBS containing 0.05% BSA and 0.05% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human DMAP1 encompassing the Central and C-terminal regions of the protein
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB: 2-4 µg/ml
Category:
Primary Antibodies
Other names:
DNA methyltransferase 1-associated protein 1, DNMAP1, DNMTAP1
Research Areas:
Transcription and Translation, Protein Modification, Transcription, Chromatin
NS Reagents Product Area:
DNA & Protein Modification
Molecular Weight:
53kDa (Intended as a general guide and does not allow for all isoforms and species variations)
DNA methyltransferase 1-associated protein 1 (DMAP1) is an enzyme consisting of 433 aminoacids. It is involved in transcription repression and activation. DMAP1 interacts with HDAC2 providing a mechanism for histone deacetylation in heterochromatin following replication of DNA at late dismissal origins. DMAP1 can also repress transcription independently of histone deacetylase activity. It participates in the nuclear localization of URI1 and increases its transcriptional co-repressor activity. It is expressed in many tissues including adipose tissue, adrenal gland, amniotic fluid, cerebellar cortex, hippocampus, liver.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human DMAP1 encompassing the Central and C-terminal regions of the protein
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB: 2-4 µg/ml
Category:
Primary Antibodies
Other names:
DNA methyltransferase 1-associated protein 1, DNMAP1, DNMTAP1
Research Areas:
Transcription and Translation, Protein Modification, Transcription, Chromatin
NS Reagents Product Area:
DNA & Protein Modification
Molecular Weight:
53kDa (Intended as a general guide and does not allow for all isoforms and species variations)
DNA methyltransferase 1 (DNMT1) associates with the replication machinery and restores symmetrical methylation at hemimethylated CpG sites generated by the semi-conservative DNA replication process. It maintains methylation patterns with high fidelity and is essential for embryonic development and genome integrity.
DNMT1 is one of the most abundant DNA methyltransferase in mammalian tissues. It comprises a regulatory N-terminal region and a C-terminal catalytic domain connected by a linker of seven glycine-lysine repeats. The C-terminal domains contain all ten catalytic motifs identified in bacterial DNA (cytosine-5) methyltransferases. The N-terminal part contains a PCNA binding domain (PBD), a heterochromatin targeting sequence (TS), a CXXC-type zinc finger domain and two Bromo-Adjacent Homology domains (BAH1 and BAH2).
DNMT1 interacts with RNA polymerase II, some RNA-binding proteins, and some specific Dnmt1-inhibitory RNA molecules involved in chromatin organisation, DNA repair, cell cycle regulation, and apoptosis.
Product Type:
NS Reagents Antibody
Antibody Type:
Monoclonal
Format:
100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human DNMT1 from the N-terminal region of the protein
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
DNA methyltransferase 1 (DNMT1) associates with the replication machinery and restores symmetrical methylation at hemimethylated CpG sites generated by the semi-conservative DNA replication process. It maintains methylation patterns with high fidelity and is essential for embryonic development and genome integrity.
DNMT1 is one of the most abundant DNA methyltransferase in mammalian tissues. It comprises a regulatory N-terminal region and a C-terminal catalytic domain connected by a linker of seven glycine-lysine repeats. The C-terminal domains contain all ten catalytic motifs identified in bacterial DNA (cytosine-5) methyltransferases. The N-terminal part contains a PCNA binding domain (PBD), a heterochromatin targeting sequence (TS), a CXXC-type zinc finger domain and two Bromo-Adjacent Homology domains (BAH1 and BAH2).
DNMT1 interacts with RNA polymerase II, some RNA-binding proteins, and some specific Dnmt1-inhibitory RNA molecules involved in chromatin organisation, DNA repair, cell cycle regulation, and apoptosis.
Product Type:
NS Reagents Antibody
Antibody Type:
Monoclonal
Format:
50 µg in 100 µl PBS containing 0.05% BSA and 0.05% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human DNMT1 from the N-terminal region of the protein
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
DNA methyltransferase 2 (DNMT2) is highly conserved cytosine-C5 methyltransferase that contains all 10 sequence motifs that are conserved among m5C MTases, including the consensus S-adenosyl-L-methionine-binding motifs and the active site ProCys dipeptide. It is a relatively small protein of 391 amino acids and lacks the large N-terminal domains present in the DNMT1 and DNMT3. DNMT2 is ubiquitously expressed with multiple mRNA species in most human and mouse adult tissues. It is variably expressed in human cancer cell lines.
Product Type:
NS Reagents Antibody
Antibody Type:
Monoclonal
Format:
50 µg in 100 µl PBS containing 0.05% BSA and 0.05% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
DNA methyltransferase 2 (DNMT2) is highly conserved cytosine-C5 methyltransferase that contains all 10 sequence motifs that are conserved among m5C MTases, including the consensus S-adenosyl-L-methionine-binding motifs and the active site ProCys dipeptide. It is a relatively small protein of 391 amino acids and lacks the large N-terminal domains present in the DNMT1 and DNMT3. DNMT2 is ubiquitously expressed with multiple mRNA species in most human and mouse adult tissues. It is variably expressed in human cancer cell lines.
Product Type:
NS Reagents Antibody
Antibody Type:
Monoclonal
Format:
100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
DNA methyltransferase 3A (DNMT3A) belongs to the mammalian methyltransferase gene family which is responsible for tissue-specific gene expression. DNMT3A together with other methyltransferases carries out de novo methylation of cytosine residues in CpG islands by the enzymatic addition of methyl residues from S-adenosyl-L-methionine to the 5-carbon atom of the cytosine ring.
DNMT3A also represses key genes enabling the coupling of insulin secretion to glucose levels during beta cell maturation. Loss of Dnmt3a in pancreatic beta cells prevents this developmental metabolic reprogramming, resulting in loss of GSIS (Glucose-Stimulated Insulin Secretion)). Dnmt3a overexpression has been shown in several cancers including AML (Acute Myeloid Leukemia).
Product Type:
NS Reagents Antibody
Antibody Type:
Monoclonal
Format:
100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Clone number:
Clone ABM13G4
Antibody Isotype:
IgG1 kappa
Application Details:
WB: 2-4 ug/ml, FACS: 0.5-1 ug/10^6
Category:
Primary Antibodies
Other names:
DNMT3A, DNA (cytosine-5)-methyltransferase 3A, DNA methyltransferase HsaIIIA, DNA MTase HsaIIIA, M.HsaIIIA, Dnmt3a
Research Areas:
Transcription and Translation, Nucleic Acid Modification, DNA methyltransferase
NS Reagents Product Area:
DNA & Protein Modification
Molecular Weight:
102kDa (Intended as a general guide and does not allow for all isoforms and species variations)
DNA methyltransferase 3A (DNMT3A) belongs to the mammalian methyltransferase gene family which is responsible for tissue-specific gene expression. DNMT3A together with other methyltransferases carries out de novo methylation of cytosine residues in CpG islands by the enzymatic addition of methyl residues from S-adenosyl-L-methionine to the 5-carbon atom of the cytosine ring.
DNMT3A also represses key genes enabling the coupling of insulin secretion to glucose levels during beta cell maturation. Loss of Dnmt3a in pancreatic beta cells prevents this developmental metabolic reprogramming, resulting in loss of GSIS (Glucose-Stimulated Insulin Secretion)). Dnmt3a overexpression has been shown in several cancers including AML (Acute Myeloid Leukemia).
Product Type:
NS Reagents Antibody
Antibody Type:
Monoclonal
Format:
50 µg in 100 µl PBS containing 0.05% BSA and 0.05% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Clone number:
Clone ABM13G4
Antibody Isotype:
IgG1 kappa
Application Details:
WB: 2-4 ug/ml, FACS: 0.5-1 ug/10^6
Category:
Primary Antibodies
Other names:
DNMT3A, DNA (cytosine-5)-methyltransferase 3A, DNA methyltransferase HsaIIIA, DNA MTase HsaIIIA, M.HsaIIIA, Dnmt3a
Research Areas:
Transcription and Translation, Nucleic Acid Modification, DNA methyltransferase
NS Reagents Product Area:
DNA & Protein Modification
Molecular Weight:
102kDa (Intended as a general guide and does not allow for all isoforms and species variations)
DNA methyltransferase 3A (DNMT3A) belongs to the mammalian methyltransferase gene family which is responsible for tissue-specific gene expression. DNMT3A together with other methyltransferases carries out de novo methylation of cytosine residues in CpG islands by the enzymatic addition of methyl residues from S-adenosyl-L-methionine to the 5-carbon atom of the cytosine ring.
DNMT3A also represses key genes enabling the coupling of insulin secretion to glucose levels during beta cell maturation. Loss of Dnmt3a in pancreatic beta cells prevents this developmental metabolic reprogramming, resulting in loss of GSIS (Glucose-Stimulated Insulin Secretion)). Dnmt3a overexpression has been shown in several cancers including AML (Acute Myeloid Leukemia).
Product Type:
NS Reagents Antibody
Antibody Type:
Monoclonal
Format:
100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
DNA methyltransferase 3A (DNMT3A) belongs to the mammalian methyltransferase gene family which is responsible for tissue-specific gene expression. DNMT3A together with other methyltransferases carries out de novo methylation of cytosine residues in CpG islands by the enzymatic addition of methyl residues from S-adenosyl-L-methionine to the 5-carbon atom of the cytosine ring.
DNMT3A also represses key genes enabling the coupling of insulin secretion to glucose levels during beta cell maturation. Loss of Dnmt3a in pancreatic beta cells prevents this developmental metabolic reprogramming, resulting in loss of GSIS (Glucose-Stimulated Insulin Secretion)). Dnmt3a overexpression has been shown in several cancers including AML (Acute Myeloid Leukemia).
Product Type:
NS Reagents Antibody
Antibody Type:
Monoclonal
Format:
50 µg in 100 µl PBS containing 0.05% BSA and 0.05% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
DNA methyltransferase 3 beta (DNMT3B), is a DNA methyltransferase believed to function in de novo methylation, rather than in maintenance methylation. DNMT3B localises to the nucleus and its expression is developmentally regulated. It has been shown to interact with CBX5, DNMT1, DNMT3A, NCAPG, SMC2, KIF4A, SUMO1 and UBE2I.
DNMT3B is has N-terminal regulatory and C-terminal catalytic domains linked by repeated GK dipeptides (Glycine-Lysine-repeats). The N-terminal domain is responsible for nucleus localisation and plays a regulatory role. It also contains a proliferating cell nuclear antigen-binding domain, a cysteine rich zinc finger DNA binding motif (ATRX), a polybromo homology domain (PHD) and a PWWP tetrapeptide chromatin-binding domain.
Product Type:
NS Reagents Antibody
Antibody Type:
Monoclonal
Format:
100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Clone number:
Clone ABM1C25
Antibody Isotype:
IgG1 kappa
Application Details:
WB: 6-8 ?g/ml
Category:
Primary Antibodies
Other names:
DNMT3B, DNA (cytosine-5-)-methyltransferase 3 beta, DNA methyltransferase 3 beta, Dnmt3b
Research Areas:
Transcription and Translation, Nucleic Acid Modification, DNA methyltransferase
NS Reagents Product Area:
DNA & Protein Modification
Molecular Weight:
96kDa (Intended as a general guide and does not allow for all isoforms and species variations)
DNA methyltransferase 3 beta (DNMT3B), is a DNA methyltransferase believed to function in de novo methylation, rather than in maintenance methylation. DNMT3B localises to the nucleus and its expression is developmentally regulated. It has been shown to interact with CBX5, DNMT1, DNMT3A, NCAPG, SMC2, KIF4A, SUMO1 and UBE2I.
DNMT3B is has N-terminal regulatory and C-terminal catalytic domains linked by repeated GK dipeptides (Glycine-Lysine-repeats). The N-terminal domain is responsible for nucleus localisation and plays a regulatory role. It also contains a proliferating cell nuclear antigen-binding domain, a cysteine rich zinc finger DNA binding motif (ATRX), a polybromo homology domain (PHD) and a PWWP tetrapeptide chromatin-binding domain.
Product Type:
NS Reagents Antibody
Antibody Type:
Monoclonal
Format:
50 µg in 100 µl PBS containing 0.05% BSA and 0.05% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Clone number:
Clone ABM1C25
Antibody Isotype:
IgG1 kappa
Application Details:
WB: 6-8 ?g/ml
Category:
Primary Antibodies
Other names:
DNMT3B, DNA (cytosine-5-)-methyltransferase 3 beta, DNA methyltransferase 3 beta, Dnmt3b
Research Areas:
Transcription and Translation, Nucleic Acid Modification, DNA methyltransferase
NS Reagents Product Area:
DNA & Protein Modification
Molecular Weight:
96kDa (Intended as a general guide and does not allow for all isoforms and species variations)
DNA methyltransferase 3-like (DNMT3L) as a catalytically inactive regulatory factor of DNA methyltransferases that can either promote or inhibit DNA methylation. It is not thought to function as a DNA methyltransferase itself as it does not contain the amino acid residues necessary for methyltransferase activity. However, it is essential for the function of DNMT3A and DNMT3B and it is thought to be required for the establishment of maternal genomic imprints. This protein also mediates transcriptional repression through interaction with histone deacetylase 1 and plays a key role in embryonic stem cells and germ cells.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 100 µl PBS containing 0.05% BSA and 0.05% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human Dnmt3L covering the central and C-terminal regions of the protein
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB: 1-2 ug/ml
Category:
Primary Antibodies
Other names:
DNA (cytosine-5-)-methyltransferase 3-like (DNMT3L), DNA methyltransferase 3-like.
Research Areas:
Transcription and Translation, Nucleic Acid Modification, Protein Modification, Transcription, Chromatin
NS Reagents Product Area:
DNA & Protein Modification
Molecular Weight:
44kDa (Intended as a general guide and does not allow for all isoforms and species variations)
DNA methyltransferase 3-like (DNMT3L) as a catalytically inactive regulatory factor of DNA methyltransferases that can either promote or inhibit DNA methylation. It is not thought to function as a DNA methyltransferase itself as it does not contain the amino acid residues necessary for methyltransferase activity. However, it is essential for the function of DNMT3A and DNMT3B and it is thought to be required for the establishment of maternal genomic imprints. This protein also mediates transcriptional repression through interaction with histone deacetylase 1 and plays a key role in embryonic stem cells and germ cells.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human Dnmt3L covering the central and C-terminal regions of the protein
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB: 1-2 ug/ml
Category:
Primary Antibodies
Other names:
DNA (cytosine-5-)-methyltransferase 3-like (DNMT3L), DNA methyltransferase 3-like.
Research Areas:
Transcription and Translation, Nucleic Acid Modification, Protein Modification, Transcription, Chromatin
NS Reagents Product Area:
DNA & Protein Modification
Molecular Weight:
44kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Dynactin subunit 1 (DCTN1) is the largest (approximately 150 kD) subunit of dynactin, a macromolecular complex consisting of multiple subunits ranging in from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein and is involved in a diverse range of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis.
DCTN1 contains N-terminal CAP-Gly and basic domains, followed by the coiled-coil (CC) 1 and 2 domains [1]. The CAP-Gly and basic domains form the microtubule binding domain (MTBD) [2] and the CC1 and CC2 domains mediate the interactions with dynein intermediate chain (DIC) and the other dynactin subunits [1]. The MTBDs of DCTN1 allow microtubule binding during spindle formation and chromosome movement making them essential for cell division[3],
Mutations in the DCTN1 gene are associated with amyotrophic lateral sclerosis (ALS) and distal hereditary motor neuronopathy type VIIB (HMN7B/spinal and bulbar muscular atrophy/dSBMA).
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
142kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Cytoplasm
Purification:
Affinity purification
References:
1: Schroer TA. Dynactin. Annu Rev Cell Dev Biol. 2004;20:75979. 2: Culver-Hanlon TL, Lex SA, Stephens AD, Quintyne NJ, King SJ. A microtubule-binding domain in dynactin increases dynein processivity by skating along microtubules. Nat Cell Biol. 2006;8(3):26470. 3: Robinson RW, Snyder JA. Colocalization studies of Arp1 and p150Glued to spindle microtubules during mitosis: the effect of cytochalasin on the organization of microtubules and motor proteins in PtK1 cells. Cell Biol Int. 2006;30(7):6319.
Dynactin subunit 1 (DCTN1) is the largest (approximately 150 kD) subunit of dynactin, a macromolecular complex consisting of multiple subunits ranging in from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein and is involved in a diverse range of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis.
DCTN1 contains N-terminal CAP-Gly and basic domains, followed by the coiled-coil (CC) 1 and 2 domains [1]. The CAP-Gly and basic domains form the microtubule binding domain (MTBD) [2] and the CC1 and CC2 domains mediate the interactions with dynein intermediate chain (DIC) and the other dynactin subunits [1]. The MTBDs of DCTN1 allow microtubule binding during spindle formation and chromosome movement making them essential for cell division[3],
Mutations in the DCTN1 gene are associated with amyotrophic lateral sclerosis (ALS) and distal hereditary motor neuronopathy type VIIB (HMN7B/spinal and bulbar muscular atrophy/dSBMA).
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
142kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Cytoplasm
Purification:
Affinity purification
References:
1: Schroer TA. Dynactin. Annu Rev Cell Dev Biol. 2004;20:75979. 2: Culver-Hanlon TL, Lex SA, Stephens AD, Quintyne NJ, King SJ. A microtubule-binding domain in dynactin increases dynein processivity by skating along microtubules. Nat Cell Biol. 2006;8(3):26470. 3: Robinson RW, Snyder JA. Colocalization studies of Arp1 and p150Glued to spindle microtubules during mitosis: the effect of cytochalasin on the organization of microtubules and motor proteins in PtK1 cells. Cell Biol Int. 2006;30(7):6319.
Dynactin subunit 1 (DCTN1) is the largest (approximately 150 kD) subunit of dynactin, a macromolecular complex consisting of multiple subunits ranging in from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein and is involved in a diverse range of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis.
DCTN1 contains N-terminal CAP-Gly and basic domains, followed by the coiled-coil (CC) 1 and 2 domains [1]. The CAP-Gly and basic domains form the microtubule binding domain (MTBD) [2] and the CC1 and CC2 domains mediate the interactions with dynein intermediate chain (DIC) and the other dynactin subunits [1]. The MTBDs of DCTN1 allow microtubule binding during spindle formation and chromosome movement making them essential for cell division[3],
Mutations in the DCTN1 gene are associated with amyotrophic lateral sclerosis (ALS) and distal hereditary motor neuronopathy type VIIB (HMN7B/spinal and bulbar muscular atrophy/dSBMA).
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human DCTN1 from the C-terminal region
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
142kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Cytoplasm cytoskeleton
Purification:
Affinity purification
References:
1: Schroer TA. Dynactin. Annu Rev Cell Dev Biol. 2004;20:75979. 2: Culver-Hanlon TL, Lex SA, Stephens AD, Quintyne NJ, King SJ. A microtubule-binding domain in dynactin increases dynein processivity by skating along microtubules. Nat Cell Biol. 2006;8(3):26470. 3: Robinson RW, Snyder JA. Colocalization studies of Arp1 and p150Glued to spindle microtubules during mitosis: the effect of cytochalasin on the organization of microtubules and motor proteins in PtK1 cells. Cell Biol Int. 2006;30(7):6319.
Dynactin subunit 1 (DCTN1) is the largest (approximately 150 kD) subunit of dynactin, a macromolecular complex consisting of multiple subunits ranging in from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein and is involved in a diverse range of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis.
DCTN1 contains N-terminal CAP-Gly and basic domains, followed by the coiled-coil (CC) 1 and 2 domains [1]. The CAP-Gly and basic domains form the microtubule binding domain (MTBD) [2] and the CC1 and CC2 domains mediate the interactions with dynein intermediate chain (DIC) and the other dynactin subunits [1]. The MTBDs of DCTN1 allow microtubule binding during spindle formation and chromosome movement making them essential for cell division[3],
Mutations in the DCTN1 gene are associated with amyotrophic lateral sclerosis (ALS) and distal hereditary motor neuronopathy type VIIB (HMN7B/spinal and bulbar muscular atrophy/dSBMA).
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human DCTN1 from the C-terminal region
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
142kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Cytoplasm cytoskeleton
Purification:
Affinity purification
References:
1: Schroer TA. Dynactin. Annu Rev Cell Dev Biol. 2004;20:75979. 2: Culver-Hanlon TL, Lex SA, Stephens AD, Quintyne NJ, King SJ. A microtubule-binding domain in dynactin increases dynein processivity by skating along microtubules. Nat Cell Biol. 2006;8(3):26470. 3: Robinson RW, Snyder JA. Colocalization studies of Arp1 and p150Glued to spindle microtubules during mitosis: the effect of cytochalasin on the organization of microtubules and motor proteins in PtK1 cells. Cell Biol Int. 2006;30(7):6319.
Excitatory amino acid transporter 2 (EAAT2/SLC1A2) is a membrane-bound protein expressed primarily on astrocytes that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors.
Impaired glutamate uptake by dysfunction or reduced expression of EAAT2 can lead to excitotoxicity, which has been implicated in the pathogenesis of neurodegenerative diseases, including Alzheimers disease, Huntingtons disease and amyotrophic lateral sclerosis. Increased astrocytic EAAT2 expression appears to afford greater neuroprotection under excitotoxic conditions.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the C-terminal region of human SLC1A2
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
IHC 1:25-100.
Category:
Primary Antibodies
Other names:
EAAT2, GLT-1, SLC1A2, Glutamate/aspartate transporter II, Sodium-dependent glutamate/aspartate transporter 2, Solute carrier family 1 member 2, Excitatory amino acid transporter 2
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
62kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Excitatory amino acid transporter 2 (EAAT2/SLC1A2) is a membrane-bound protein expressed primarily on astrocytes that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors.
Impaired glutamate uptake by dysfunction or reduced expression of EAAT2 can lead to excitotoxicity, which has been implicated in the pathogenesis of neurodegenerative diseases, including Alzheimers disease, Huntingtons disease and amyotrophic lateral sclerosis. Increased astrocytic EAAT2 expression appears to afford greater neuroprotection under excitotoxic conditions.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the C-terminal region of human SLC1A2
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
IHC 1:25-100.
Category:
Primary Antibodies
Other names:
EAAT2, GLT-1, SLC1A2, Glutamate/aspartate transporter II, Sodium-dependent glutamate/aspartate transporter 2, Solute carrier family 1 member 2, Excitatory amino acid transporter 2
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
62kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Eukaryotic Translation Initiation Factor 4A-III (EIF4A3) belongs to the Asp-Glu-Ala-Asp (DEAD) box superfamily of proteins that have ATP-dependent RNA helicase activity and are involved in a number of areas of RNA biology, from transcription and translation to mRNA decay. EIF4A3 is named as such because it has homology at the amino-acid level to the translation initiation factors, EIF4A1 and EIF4A2, however it is actually a core component of the exon junction complex (EJC), which is associated with splicing and does not play an essential role in translation initiation (in contrast to EIF4A1 and EIF4A2).
EIF4A3 may have a role in parkinsons disease in relation to the deregulation of mRNA translation.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Eukaryotic Translation Initiation Factor 4A-III (EIF4A3) belongs to the Asp-Glu-Ala-Asp (DEAD) box superfamily of proteins that have ATP-dependent RNA helicase activity and are involved in a number of areas of RNA biology, from transcription and translation to mRNA decay. EIF4A3 is named as such because it has homology at the amino-acid level to the translation initiation factors, EIF4A1 and EIF4A2, however it is actually a core component of the exon junction complex (EJC), which is associated with splicing and does not play an essential role in translation initiation (in contrast to EIF4A1 and EIF4A2).
EIF4A3 may have a role in parkinsons disease in relation to the deregulation of mRNA translation.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Eukaryotic Translation Initiation Factor 4 Gamma 1 (EIF4G1) serves as a scaffold for the assembly of cap-dependent translation components in the formation of the EIF4F complex, which recruits ribosomes to mRNA such that the 5? untranslated region (5? UTR) can be scanned by ribosomes in search of an initiation codon.
A domain at the N-terminal of EIF4G1 can also interact with the poly(A)-binding protein, which may mediate the circularisation of mRNA during translation. Mutations in EIF4G1 have been linked to Parkinson's disease, however reports are conflicting
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Eukaryotic Translation Initiation Factor 4 Gamma 1 (EIF4G1) serves as a scaffold for the assembly of cap-dependent translation components in the formation of the EIF4F complex, which recruits ribosomes to mRNA such that the 5? untranslated region (5? UTR) can be scanned by ribosomes in search of an initiation codon.
A domain at the N-terminal of EIF4G1 can also interact with the poly(A)-binding protein, which may mediate the circularisation of mRNA during translation. Mutations in EIF4G1 have been linked to Parkinson's disease, however reports are conflicting
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Ephrin type-B receptor 2 (EPHB2) is a member of the Eph receptor family of receptor tyrosine kinase transmembrane glycoproteins. These receptors are composed of an N-terminal glycosylated ligand-binding domain, a transmembrane region and an intracellular kinase domain. They bind ligands called ephrins on adjacent cells, leading to contact-dependent bidirectional signalling into neighbouring cells because both receptors and ligands are able to transduce a signalling cascade. Eph receptors are involved in many cellular processes including motility, division, and differentiation. Proteins of the EphB subgroup are distinguished from other members of the Eph receptor family by sequence homology and a preferential binding affinity for membrane-bound ephrin-B ligands. Allelic variants are associated with prostate and brain cancer susceptibility.
Rat, Chicken, Guinea Pig, Japanese quail, Bovine, Goat Rabbit, Sheep, Pig, Horse, Zebrafish, Cat, Dog
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human EPHB2 from the N-terminal half of the protein
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Ephrin type-B receptor 2 (EPHB2) is a member of the Eph receptor family of receptor tyrosine kinase transmembrane glycoproteins. These receptors are composed of an N-terminal glycosylated ligand-binding domain, a transmembrane region and an intracellular kinase domain. They bind ligands called ephrins on adjacent cells, leading to contact-dependent bidirectional signalling into neighbouring cells because both receptors and ligands are able to transduce a signalling cascade. Eph receptors are involved in many cellular processes including motility, division, and differentiation. Proteins of the EphB subgroup are distinguished from other members of the Eph receptor family by sequence homology and a preferential binding affinity for membrane-bound ephrin-B ligands. Allelic variants are associated with prostate and brain cancer susceptibility.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS containing 0.02% sodium azide.
Rat, Chicken, Guinea Pig, Japanese quail, Bovine, Goat Rabbit, Sheep, Pig, Horse, Zebrafish, Cat, Dog
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human EPHB2 from the N-terminal half of the protein
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
The F-box protein family are the substrate-recognition components of the Skp1-Cullin-F-box protein E3 ubiquitin ligase complex (SCF) which catalyses the phosphorylation-dependent ubiquitination of proteins destined for proteasomal degradation.
F-box proteins make up one of the four subunits of the SCF complex, contributing to its specificity by aggregating to target proteins independently of the complex and then binding to the Skp1 component, thereby allowing the target protein to be brought into proximity with the E2 ubiquitin-conjugating enzyme recruited by the E3ubiquitin ligase.
The F-box only protein 7 (Fbxo7) is one of the many FBPs identified in humans and mutations in Fbxo7 have been associated with early-onset parkinsons and cancer.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human FBXO7 from the C-terminal region
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000. IHC 1:50-200. IF 1:50-200.
Category:
Primary Antibodies
Other names:
FBX, FBX07, FBX7, PARK15, PKPS, F-Box Protein 7, F-box only protein 7
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
59kDa (Intended as a general guide and does not allow for all isoforms and species variations)
The F-box protein family are the substrate-recognition components of the Skp1-Cullin-F-box protein E3 ubiquitin ligase complex (SCF) which catalyses the phosphorylation-dependent ubiquitination of proteins destined for proteasomal degradation.
F-box proteins make up one of the four subunits of the SCF complex, contributing to its specificity by aggregating to target proteins independently of the complex and then binding to the Skp1 component, thereby allowing the target protein to be brought into proximity with the E2 ubiquitin-conjugating enzyme recruited by the E3ubiquitin ligase.
The F-box only protein 7 (Fbxo7) is one of the many FBPs identified in humans and mutations in Fbxo7 have been associated with early-onset parkinsons and cancer.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human FBXO7 from the C-terminal region
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000. IHC 1:50-200. IF 1:50-200.
Category:
Primary Antibodies
Other names:
FBX, FBX07, FBX7, PARK15, PKPS, F-Box Protein 7, F-box only protein 7
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
59kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Fragile X Mental Retardation 1 (FRM1) is an RNA binding protein that plays a central role in neuronal development and synaptic plasticity through the regulation of alternative mRNA splicing, mRNA stability, mRNA dendritic transport and postsynaptic local protein synthesis of a subset of mRNAs.
A trinucleotide repeat (CGG) in the gene encoding this protein is normally found at 6-53 copies, but an expansion to 55-230 repeats is the cause of fragile X syndrome. Expansion of the trinucleotide repeat may also cause one form of premature ovarian failure (POF1). Multiple alternatively spliced transcript variants that encode different protein isoforms and which are located in different cellular locations have also been described for this gene.
FRM1 has been shown to play a translation-independent role in the modulation of presynaptic action potential (AP) duration and neurotransmitter release via large-conductance calcium-activated potassium (BK) channels in hippocampal and cortical excitatory neurons [1]. FMR1 may be involved in the control of DNA damage response (DDR) mechanisms through the regulation of ATR-dependent signaling pathways such as histone H2AFX/H2A.x and BRCA1 phosphorylations [2].
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS containing 0.02% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human FMR1 from the N-terminal region of the protein
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Fragile X Mental Retardation 1 (FRM1) is an RNA binding protein that plays a central role in neuronal development and synaptic plasticity through the regulation of alternative mRNA splicing, mRNA stability, mRNA dendritic transport and postsynaptic local protein synthesis of a subset of mRNAs.
A trinucleotide repeat (CGG) in the gene encoding this protein is normally found at 6-53 copies, but an expansion to 55-230 repeats is the cause of fragile X syndrome. Expansion of the trinucleotide repeat may also cause one form of premature ovarian failure (POF1). Multiple alternatively spliced transcript variants that encode different protein isoforms and which are located in different cellular locations have also been described for this gene.
FRM1 has been shown to play a translation-independent role in the modulation of presynaptic action potential (AP) duration and neurotransmitter release via large-conductance calcium-activated potassium (BK) channels in hippocampal and cortical excitatory neurons [1]. FMR1 may be involved in the control of DNA damage response (DDR) mechanisms through the regulation of ATR-dependent signaling pathways such as histone H2AFX/H2A.x and BRCA1 phosphorylations [2].
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human FMR1 from the N-terminal region of the protein
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Furin is a member of the family of proprotein convertases involved in the activation of a large number of zymogens and proproteins. Furin catalyses proteolytic maturation of a diverse repertoire of growth factors, receptors, and enzyme precursors within multiple secretory pathway compartments. Proteolysis by furin is highly specific and occurs at C-terminal to a multibasic recognition motive.
Furin is a type I transmembrane protein composed of a signal peptide, a propeptide terminating in an endoproteolytic cleavage site comprised of a cluster of basic residues, a subtilisin-like catalytic domain, a middle domain (also called P-domain), and a cysteine-rich domain, followed by a C-terminal transmembrane anchor and a cytosolic tail. Furin is synthesized as a precursor protein of about 100 kDa that is converted into a 94 kDa protein by autoproteolytic cleavage of the propeptide. Furin is glycosylated and phosphorylated, which results in an increase of its apparent molecular mass in SDS-PAGE to Mr 100 000.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human Furin from the C-terminal region of the protein
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Furin is a member of the family of proprotein convertases involved in the activation of a large number of zymogens and proproteins. Furin catalyses proteolytic maturation of a diverse repertoire of growth factors, receptors, and enzyme precursors within multiple secretory pathway compartments. Proteolysis by furin is highly specific and occurs at C-terminal to a multibasic recognition motive.
Furin is a type I transmembrane protein composed of a signal peptide, a propeptide terminating in an endoproteolytic cleavage site comprised of a cluster of basic residues, a subtilisin-like catalytic domain, a middle domain (also called P-domain), and a cysteine-rich domain, followed by a C-terminal transmembrane anchor and a cytosolic tail. Furin is synthesized as a precursor protein of about 100 kDa that is converted into a 94 kDa protein by autoproteolytic cleavage of the propeptide. Furin is glycosylated and phosphorylated, which results in an increase of its apparent molecular mass in SDS-PAGE to Mr 100 000.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 100 µl PBS containing 0.05% BSA and 0.05% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human Furin from the C-terminal region of the protein
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
FUS (fused in sarcoma) is a member of the FET/TET (FUS/TLS, EWS, TAF15) family of RNA-binding proteins (RBPs) that have roles in transcription, pre-mRNA splicing, DNA repair, and mRNA transport in neurons.
FUS (like all FET family members) is highly conserved and ubiquitously expressed, with several conserved domains: a serine-tyrosine-glycine-glutamine (SYGQ) domain embedded in the DNA activation domain (AD), 3 glycine-arginine (RGG) rich regions that affect RNA binding, one conserved RNA-binding domain (RBD, formed by a RNA-recognition motif, RRM), and a zinc finger domain that is also involved in nucleic acid binding [1].
FUS binds to single and double stranded DNA as well as RNA and participates in multiple cellular functions. Alternative splicing results in multiple transcript variants. Defects in the FUS gene are associated with amyotrophic lateral sclerosis (ALS). FUS is also implicated in a number of other neurodegenerative disorders.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS containing 0.02% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant protein from the C-terminal region of human FUS
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000.
Category:
Primary Antibodies
Other names:
ALS6, ETM4, HNRNPP2, POMP75, TLS, fused in sarcoma, translocated in liposarcoma
Research Areas:
Neuroscience, Amyotrophic lateral sclerosis
NS Reagents Product Area:
Neuroscience
Molecular Weight:
53kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Nucleus
Purification:
Affinity purification
References:
[1] Role of FET proteins in neurodegenerative disorders Francesca Svetoni, Paola Frisone, Maria Paola Paronetto RNA Biol. 2016; 13(11): 10891102. Published online 2016 Jul 14. doi: 10.1080/15476286.2016.1211225
[2] Functions of FUS/TLS From DNA Repair to Stress Response: Implications for ALS Reddy Ranjith Kumar Sama, Catherine L. Ward, Daryl A. Bosco ASN Neuro. 2014 May-Jun; 6(4): 1759091414544472. doi: 10.1177/1759091414544472
FUS (fused in sarcoma) is a member of the FET/TET (FUS/TLS, EWS, TAF15) family of RNA-binding proteins (RBPs) that have roles in transcription, pre-mRNA splicing, DNA repair, and mRNA transport in neurons.
FUS (like all FET family members) is highly conserved and ubiquitously expressed, with several conserved domains: a serine-tyrosine-glycine-glutamine (SYGQ) domain embedded in the DNA activation domain (AD), 3 glycine-arginine (RGG) rich regions that affect RNA binding, one conserved RNA-binding domain (RBD, formed by a RNA-recognition motif, RRM), and a zinc finger domain that is also involved in nucleic acid binding [1].
FUS binds to single and double stranded DNA as well as RNA and participates in multiple cellular functions. Alternative splicing results in multiple transcript variants. Defects in the FUS gene are associated with amyotrophic lateral sclerosis (ALS). FUS is also implicated in a number of other neurodegenerative disorders.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant protein from the C-terminal region of human FUS
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000.
Category:
Primary Antibodies
Other names:
ALS6, ETM4, HNRNPP2, POMP75, TLS, fused in sarcoma, translocated in liposarcoma
Research Areas:
Neuroscience, Amyotrophic lateral sclerosis
NS Reagents Product Area:
Neuroscience
Molecular Weight:
53kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Nucleus
Purification:
Affinity purification
References:
[1] Role of FET proteins in neurodegenerative disorders Francesca Svetoni, Paola Frisone, Maria Paola Paronetto RNA Biol. 2016; 13(11): 10891102. Published online 2016 Jul 14. doi: 10.1080/15476286.2016.1211225
[2] Functions of FUS/TLS From DNA Repair to Stress Response: Implications for ALS Reddy Ranjith Kumar Sama, Catherine L. Ward, Daryl A. Bosco ASN Neuro. 2014 May-Jun; 6(4): 1759091414544472. doi: 10.1177/1759091414544472
FUS (fused in sarcoma) is a member of the FET/TET (FUS/TLS, EWS, TAF15) family of RNA-binding proteins (RBPs) that have roles in transcription, pre-mRNA splicing, DNA repair, and mRNA transport in neurons.
FUS (like all FET family members) is highly conserved and ubiquitously expressed, with several conserved domains: a serine-tyrosine-glycine-glutamine (SYGQ) domain embedded in the DNA activation domain (AD), 3 glycine-arginine (RGG) rich regions that affect RNA binding, one conserved RNA-binding domain (RBD, formed by a RNA-recognition motif, RRM), and a zinc finger domain that is also involved in nucleic acid binding [1].
FUS binds to single and double stranded DNA as well as RNA and participates in multiple cellular functions. Alternative splicing results in multiple transcript variants. Defects in the FUS gene are associated with amyotrophic lateral sclerosis (ALS). FUS is also implicated in a number of other neurodegenerative disorders.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
IHC 1:30-150.
Category:
Primary Antibodies
Other names:
ALS6, ETM4, HNRNPP2, POMP75, TLS, fused in sarcoma, translocated in liposarcoma
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
53kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Nucleus
Purification:
Affinity purification
References:
[1] Role of FET proteins in neurodegenerative disorders Francesca Svetoni, Paola Frisone, Maria Paola Paronetto RNA Biol. 2016; 13(11): 10891102. Published online 2016 Jul 14. doi: 10.1080/15476286.2016.1211225
[2] Functions of FUS/TLS From DNA Repair to Stress Response: Implications for ALS Reddy Ranjith Kumar Sama, Catherine L. Ward, Daryl A. Bosco ASN Neuro. 2014 May-Jun; 6(4): 1759091414544472. doi: 10.1177/1759091414544472
FUS (fused in sarcoma) is a member of the FET/TET (FUS/TLS, EWS, TAF15) family of RNA-binding proteins (RBPs) that have roles in transcription, pre-mRNA splicing, DNA repair, and mRNA transport in neurons.
FUS (like all FET family members) is highly conserved and ubiquitously expressed, with several conserved domains: a serine-tyrosine-glycine-glutamine (SYGQ) domain embedded in the DNA activation domain (AD), 3 glycine-arginine (RGG) rich regions that affect RNA binding, one conserved RNA-binding domain (RBD, formed by a RNA-recognition motif, RRM), and a zinc finger domain that is also involved in nucleic acid binding [1].
FUS binds to single and double stranded DNA as well as RNA and participates in multiple cellular functions. Alternative splicing results in multiple transcript variants. Defects in the FUS gene are associated with amyotrophic lateral sclerosis (ALS). FUS is also implicated in a number of other neurodegenerative disorders.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
IHC 1:30-150.
Category:
Primary Antibodies
Other names:
ALS6, ETM4, HNRNPP2, POMP75, TLS, fused in sarcoma, translocated in liposarcoma
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
53kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Nucleus
Purification:
Affinity purification
References:
[1] Role of FET proteins in neurodegenerative disorders Francesca Svetoni, Paola Frisone, Maria Paola Paronetto RNA Biol. 2016; 13(11): 10891102. Published online 2016 Jul 14. doi: 10.1080/15476286.2016.1211225
[2] Functions of FUS/TLS From DNA Repair to Stress Response: Implications for ALS Reddy Ranjith Kumar Sama, Catherine L. Ward, Daryl A. Bosco ASN Neuro. 2014 May-Jun; 6(4): 1759091414544472. doi: 10.1177/1759091414544472
Ras GTPase-activating protein-binding protein 1 (G3BP1) is a RNA-binding protein which along with G3BP2 regulates stress granule (SG) formation. Both G3BP1 & 2 contain disordered regions and an ordered nuclear transport factor 2 (NTF2)-like dimerisation domain at the N-terminal that is that is required for SG formation.
G3BP1 has endoribonuclease and helicase activity and is part of the Ras signal transduction pathway, binding specifically to Ras-GTPase-activating protein via its SH3 domain. G3BP1 has multiple phosphorylation sites which may be involved in its function in regulating stress granules. SG-like structures have been reported in neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), so it is believed that G3BP1 may play a role in such neurodegenerative diseases.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Rat, Cow, Chicken, Guinea Pig, Zebra finch, Goat, Dog, Cat
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human G3BP1 from the C-terminal region
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000. IHC 1:50-200. IF 1:50-200.
Category:
Primary Antibodies
Other names:
G3BP, HDH-VIII, ATP-dependent DNA helicase VIII, GAP SH3 domain-binding protein 1, G3BP-1
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
52kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Ras GTPase-activating protein-binding protein 1 (G3BP1) is a RNA-binding protein which along with G3BP2 regulates stress granule (SG) formation. Both G3BP1 & 2 contain disordered regions and an ordered nuclear transport factor 2 (NTF2)-like dimerisation domain at the N-terminal that is that is required for SG formation.
G3BP1 has endoribonuclease and helicase activity and is part of the Ras signal transduction pathway, binding specifically to Ras-GTPase-activating protein via its SH3 domain. G3BP1 has multiple phosphorylation sites which may be involved in its function in regulating stress granules. SG-like structures have been reported in neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), so it is believed that G3BP1 may play a role in such neurodegenerative diseases.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Rat, Cow, Chicken, Guinea Pig, Zebra finch, Goat, Dog, Cat
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human G3BP1 from the C-terminal region
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000. IHC 1:50-200. IF 1:50-200.
Category:
Primary Antibodies
Other names:
G3BP, HDH-VIII, ATP-dependent DNA helicase VIII, GAP SH3 domain-binding protein 1, G3BP-1
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
52kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Glycyl-tRNA synthetase 1 (GARS1) is an aminoacyl-tRNA synthetase that charges tRNAs with glycine. As with all aminoacyl-tRNA synthetases (aaRSs), Glycyl-tRNA synthetase 1 is an essential enzyme, catalysing the first reaction in protein biosynthesis. Glycyl-tRNA synthetase 1 belongs to the class II family of tRNA synthetases and naturally has a glycine binding domain and a WHEP-TRS domain which plays a role in the association of tRNA-synthetases into multienzyme complexes.
Charcot-Marie-Tooth neuropathy (CMT) is an incurable neurodegenerative disease caused by dominant mono-allelic mutations in some aaRSs including Glycyl-tRNA synthetase 1. It has been shown that dominant mutations in GARS1 cause CMT through toxic gain-of-function effects, which also may apply to other aaRS-linked CMT subtypes.
Aminoacyl-tRNA synthetases, including GARS (Glycyl-tRNA synthetase), have been identified as downstream targets of Ubiquitin-like modifier-activating enzyme 1 (UBA1) . Dysregulation of UBA1/GARS pathways in spinal muscular atrophy results in a similar phenotype to GARS-dependent defects (such as Charcot-Marie-Tooth disease), perhaps indicating significant molecular and phenotypic overlap between spinal muscular atrophy and Charcot-Marie-Tooth disease.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Glycyl-tRNA synthetase 1 (GARS1) is an aminoacyl-tRNA synthetase that charges tRNAs with glycine. As with all aminoacyl-tRNA synthetases (aaRSs), Glycyl-tRNA synthetase 1 is an essential enzyme, catalysing the first reaction in protein biosynthesis. Glycyl-tRNA synthetase 1 belongs to the class II family of tRNA synthetases and naturally has a glycine binding domain and a WHEP-TRS domain which plays a role in the association of tRNA-synthetases into multienzyme complexes.
Charcot-Marie-Tooth neuropathy (CMT) is an incurable neurodegenerative disease caused by dominant mono-allelic mutations in some aaRSs including Glycyl-tRNA synthetase 1. It has been shown that dominant mutations in GARS1 cause CMT through toxic gain-of-function effects, which also may apply to other aaRS-linked CMT subtypes.
Aminoacyl-tRNA synthetases, including GARS (Glycyl-tRNA synthetase), have been identified as downstream targets of Ubiquitin-like modifier-activating enzyme 1 (UBA1) . Dysregulation of UBA1/GARS pathways in spinal muscular atrophy results in a similar phenotype to GARS-dependent defects (such as Charcot-Marie-Tooth disease), perhaps indicating significant molecular and phenotypic overlap between spinal muscular atrophy and Charcot-Marie-Tooth disease.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Lysosomal acid glucosylceramidase (GBA or Glucocerebrosidase) is the lysosomal hydrolase that hydrolyzes glucosylceramide (GC) and glucosylsphingosine (GS) to ceramide and sphingosine. It is a 536-amino-acid membrane-associated protein with a 39-amino-acid leader sequence that is cleaved to produce a 497-amino-acid mature protein.
Mutations in the GBA gene cause Gaucher disease, a lysosomal storage disease characterised by an accumulation of glucocerebrosides. Patients with Gaucher disease and heterozygous carriers are at increased risk of developing Parkinson's disease and Dementia with Lewy Bodies.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Lysosomal acid glucosylceramidase (GBA or Glucocerebrosidase) is the lysosomal hydrolase that hydrolyzes glucosylceramide (GC) and glucosylsphingosine (GS) to ceramide and sphingosine. It is a 536-amino-acid membrane-associated protein with a 39-amino-acid leader sequence that is cleaved to produce a 497-amino-acid mature protein.
Mutations in the GBA gene cause Gaucher disease, a lysosomal storage disease characterised by an accumulation of glucocerebrosides. Patients with Gaucher disease and heterozygous carriers are at increased risk of developing Parkinson's disease and Dementia with Lewy Bodies.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Gephyrin is a 93-kDa protein that was initially identified as a tubulin-binding molecule that co-purifies with GlyRs (Glycine Receptors). It is highly expressed in brain tissues, localising to neuronal postsynaptic membranes and is essential for postsynaptic localisation of inhibitory GlyRs and GABA-ARs (GABA-A Receptors). It is thought to anchor the receptors to subsynaptic microtubules.
In vertebrates gephyrin has an N-terminal G-domain and a C-terminal E-domain connected by a central linker region or C-domain. At least five splice variants of Gephyrin have been identified in rat and human brain tissue covering a range of molecular weights.
An accumulation of gephyrin within Beta-amyloid plaques due to a shift in its solubility, has been seen in Alzheimer's disease with an accumulation of a lower molecular weight isoform (a product of gephyrin cleavage), and a reduced amount of the full length gephyrin.
Gephyrin is also required for molybdenum cofactor biosynthesis (in all tissues) and mutations in the Gephyrin gene may be associated with the neurological condition hyperplexia and molybdenum cofactor deficiency.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Gephyrin is a 93-kDa protein that was initially identified as a tubulin-binding molecule that co-purifies with GlyRs (Glycine Receptors). It is highly expressed in brain tissues, localising to neuronal postsynaptic membranes and is essential for postsynaptic localisation of inhibitory GlyRs and GABA-ARs (GABA-A Receptors). It is thought to anchor the receptors to subsynaptic microtubules.
In vertebrates gephyrin has an N-terminal G-domain and a C-terminal E-domain connected by a central linker region or C-domain. At least five splice variants of Gephyrin have been identified in rat and human brain tissue covering a range of molecular weights.
An accumulation of gephyrin within Beta-amyloid plaques due to a shift in its solubility, has been seen in Alzheimer's disease with an accumulation of a lower molecular weight isoform (a product of gephyrin cleavage), and a reduced amount of the full length gephyrin.
Gephyrin is also required for molybdenum cofactor biosynthesis (in all tissues) and mutations in the Gephyrin gene may be associated with the neurological condition hyperplexia and molybdenum cofactor deficiency.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human Gephyrin from the C-terminal region
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Gephyrin is a 93-kDa protein that was initially identified as a tubulin-binding molecule that co-purifies with GlyRs (Glycine Receptors). It is highly expressed in brain tissues, localising to neuronal postsynaptic membranes and is essential for postsynaptic localisation of inhibitory GlyRs and GABA-ARs (GABA-A Receptors). It is thought to anchor the receptors to subsynaptic microtubules.
In vertebrates gephyrin has an N-terminal G-domain and a C-terminal E-domain connected by a central linker region or C-domain. At least five splice variants of Gephyrin have been identified in rat and human brain tissue covering a range of molecular weights.
An accumulation of gephyrin within Beta-amyloid plaques due to a shift in its solubility, has been seen in Alzheimer's disease with an accumulation of a lower molecular weight isoform (a product of gephyrin cleavage), and a reduced amount of the full length gephyrin.
Gephyrin is also required for molybdenum cofactor biosynthesis (in all tissues) and mutations in the Gephyrin gene may be associated with the neurological condition hyperplexia and molybdenum cofactor deficiency.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Gephyrin is a 93-kDa protein that was initially identified as a tubulin-binding molecule that co-purifies with GlyRs (Glycine Receptors). It is highly expressed in brain tissues, localising to neuronal postsynaptic membranes and is essential for postsynaptic localisation of inhibitory GlyRs and GABA-ARs (GABA-A Receptors). It is thought to anchor the receptors to subsynaptic microtubules.
In vertebrates gephyrin has an N-terminal G-domain and a C-terminal E-domain connected by a central linker region or C-domain. At least five splice variants of Gephyrin have been identified in rat and human brain tissue covering a range of molecular weights.
An accumulation of gephyrin within Beta-amyloid plaques due to a shift in its solubility, has been seen in Alzheimer's disease with an accumulation of a lower molecular weight isoform (a product of gephyrin cleavage), and a reduced amount of the full length gephyrin.
Gephyrin is also required for molybdenum cofactor biosynthesis (in all tissues) and mutations in the Gephyrin gene may be associated with the neurological condition hyperplexia and molybdenum cofactor deficiency.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human Gephyrin from the C-terminal region
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Glial fibrillary acidic protein (GFAP), is an intermediate filament (IF) protein belonging to the type III subclass of IF proteins. Like other IF proteins, GFAP is composed of an amino terminal head domain, central rod domain and a carboxy terminal tail domain. GFAP is specifically found in astroglia, a cell type which is highly responsive to neurologic insults. Astrogliosis is found to be a result of mechanical trauma, AIDS dementia, prion infection and inflammatory demyelinating diseases, and is accompanied by an increase in GFAP expression. GFAP is an immunohistochemical marker for localising benign astrocyte and neoplastic cells of glial origin in the central nervous system.
Product Type:
NS Reagents Antibody
Antibody Type:
Monoclonal
Format:
100 µg in 100 µl PBS containing 0.02% sodium azide.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Clone number:
Clone FD19-9
Antibody Isotype:
IgG1
Application Details:
IHC 1:100 - 1: 1000
Category:
Primary Antibodies
Other names:
GFAP, ALXDRD, gfapl, Intermediate filament protein
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
50kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Cytoplasm
Purification:
Protein A Affinity Purified
References:
Yang et al. 2007. J Gastroenterol Hepatol. 22(9):1460-8. PMID: 17645461. ; Hagemann et al. 2006. J Neurosci Methods. 156(1-2):194-202. PMID: 16621008. ; Coakham et al. 1984. Lancet. 1(8386):1095-8. PMID: 6202990. ; Garson JA. The development and characterisation of monoclonal antibodies for use in neuropathology. MD thesis. University of Birmingham, 1983
Glial fibrillary acidic protein (GFAP), is an intermediate filament (IF) protein belonging to the type III subclass of IF proteins. Like other IF proteins, GFAP is composed of an amino terminal head domain, central rod domain and a carboxy terminal tail domain. GFAP is specifically found in astroglia, a cell type which is highly responsive to neurologic insults. Astrogliosis is found to be a result of mechanical trauma, AIDS dementia, prion infection and inflammatory demyelinating diseases, and is accompanied by an increase in GFAP expression. GFAP is an immunohistochemical marker for localising benign astrocyte and neoplastic cells of glial origin in the central nervous system.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Clone number:
Clone FD19-9
Antibody Isotype:
IgG1
Application Details:
IHC 1:100 - 1: 1000
Category:
Primary Antibodies
Other names:
GFAP, ALXDRD, gfapl, Intermediate filament protein
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
50kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Cytoplasm
Purification:
Protein A Affinity Purified
References:
Yang et al. 2007. J Gastroenterol Hepatol. 22(9):1460-8. PMID: 17645461. ; Hagemann et al. 2006. J Neurosci Methods. 156(1-2):194-202. PMID: 16621008. ; Coakham et al. 1984. Lancet. 1(8386):1095-8. PMID: 6202990. ; Garson JA. The development and characterisation of monoclonal antibodies for use in neuropathology. MD thesis. University of Birmingham, 1983
Glucagon-like peptide-1 receptor (GLP1R) is a 7-transmembrane receptor protein found on beta cells of the pancreas. It functions as a receptor for glucagon-like peptide 1 (GLP-1) hormone, which stimulates glucose-induced insulin secretion. GLP1R functions at the cell surface and becomes internalised in response to GLP-1 and GLP-1 analogs, playing an important role in the signalling cascades leading to insulin secretion. It is a member of the glucagon receptor family of G protein-coupled receptors [1]. GLP1R is composed of two domains, an extracellular domain that binds the C-terminal helix of GLP-1 [2], and a transmembrane domain [3] that binds the N-terminal region of GLP-1 [4][5][6].
GLP1R also displays neuroprotective effects in animal models. Polymorphisms in this gene are associated with diabetes, making it an important drug target for the treatment of type 2 diabetes. Alternative splicing of the GLP1R gene results in multiple transcript variants.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS containing 0.02% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the N-terminal region of Human GLP1R
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
53kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Cell membrane, Multi-pass membrane protein
Purification:
Affinity purification
References:
1. Brubaker PL, Drucker DJ (2002). "Structure-function of the glucagon receptor family of the G protein-coupled receptors: the glucagon, GIP, GLP-1, and GLP-2 receptors". Recept. Channels. 8 (34): 17988.
2. Underwood CR, Garibay P, Knudsen LB, Hastrup S, Peters GH, Rudolph R, Reedtz-Runge S (June 2010). "Crystal structure of glucagon-like peptide-1 in complex with the extracellular domain of the glucagon-like peptide-1 receptor". Journal of Biological Chemistry. 285 (1): 723730.
3. Song G, Yang D, Wang Y, de Graaf C, Zhou Q, Jiang S, Liu K, Cai X, Dai A, Lin G, Liu D, Wu F, Wu Y, Zhao S, Ye L, Han GW, Lau J, Wu B, Hanson MA, Liu ZJ, Wang MW, Stevens RC (2017). "Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators)". Nature. 546: 312315.
4. Wooten D, Reynolds CA, Koole C, Smith KJ, Mobarec JC, Simms J, Quon T, Coudrat T, Furness SG, Miller LJ, Christopolous A, Sexton PM (March 2016). "A Hydrogen-Bonded Polar Network in the Core of the Glucagon-Like Peptide-1 Receptor Is a Fulcrum for Biased Agonism: Lessons from Class B Crystal Structures". Molecular Pharmacology. 89 (3): 335347.
5. Wooten D, Reynolds CA, Smith KJ, Mobarec JC, Koole C, Savage EE, Pabreja K, Simms J, Sridhar R, Furness SG, Liu M, Thompson PE, Miller LJ, Christopolous A, Sexton PM (June 2016). "The extracellular surface of the GLP-1 receptor is a molecular trigger for biased agonism". Cell. 165 (7): 16321643.
6. Yang D, de Graaf C, Yang L, Song G, Dai A, Cai X, Feng Y, Reedtz-Runge S, Hanson MA, Yang H, Jiang H, Stevens RC, Wang MW (June 2016). "Structural Determinants of Binding the Seven-transmembrane Domain of the Glucagon-like Peptide-1 Receptor (GLP-1R)". Journal of Biological Chemistry. 291 (25): 129913004.
7. Wooten D, Reynolds CA, Smith KJ, Mobarec JC, Furness SG, Miller LJ, Christopolous A, Sexton PM (August 2016). "Key interactions by conserved polar amino acids located at the transmembrane helical boundaries in Class B GPCRs modulate activation, effector specificity and biased signalling in the glucagon-like peptide-1 receptor". Biochemical Pharmacology. 118: 6887.
Glucagon-like peptide-1 receptor (GLP1R) is a 7-transmembrane receptor protein found on beta cells of the pancreas. It functions as a receptor for glucagon-like peptide 1 (GLP-1) hormone, which stimulates glucose-induced insulin secretion. GLP1R functions at the cell surface and becomes internalised in response to GLP-1 and GLP-1 analogs, playing an important role in the signalling cascades leading to insulin secretion. It is a member of the glucagon receptor family of G protein-coupled receptors [1]. GLP1R is composed of two domains, an extracellular domain that binds the C-terminal helix of GLP-1 [2], and a transmembrane domain [3] that binds the N-terminal region of GLP-1 [4][5][6].
GLP1R also displays neuroprotective effects in animal models. Polymorphisms in this gene are associated with diabetes, making it an important drug target for the treatment of type 2 diabetes. Alternative splicing of the GLP1R gene results in multiple transcript variants.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the N-terminal region of Human GLP1R
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
53kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Cell membrane, Multi-pass membrane protein
Purification:
Affinity purification
References:
1. Brubaker PL, Drucker DJ (2002). "Structure-function of the glucagon receptor family of the G protein-coupled receptors: the glucagon, GIP, GLP-1, and GLP-2 receptors". Recept. Channels. 8 (34): 17988.
2. Underwood CR, Garibay P, Knudsen LB, Hastrup S, Peters GH, Rudolph R, Reedtz-Runge S (June 2010). "Crystal structure of glucagon-like peptide-1 in complex with the extracellular domain of the glucagon-like peptide-1 receptor". Journal of Biological Chemistry. 285 (1): 723730.
3. Song G, Yang D, Wang Y, de Graaf C, Zhou Q, Jiang S, Liu K, Cai X, Dai A, Lin G, Liu D, Wu F, Wu Y, Zhao S, Ye L, Han GW, Lau J, Wu B, Hanson MA, Liu ZJ, Wang MW, Stevens RC (2017). "Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators)". Nature. 546: 312315.
4. Wooten D, Reynolds CA, Koole C, Smith KJ, Mobarec JC, Simms J, Quon T, Coudrat T, Furness SG, Miller LJ, Christopolous A, Sexton PM (March 2016). "A Hydrogen-Bonded Polar Network in the Core of the Glucagon-Like Peptide-1 Receptor Is a Fulcrum for Biased Agonism: Lessons from Class B Crystal Structures". Molecular Pharmacology. 89 (3): 335347.
5. Wooten D, Reynolds CA, Smith KJ, Mobarec JC, Koole C, Savage EE, Pabreja K, Simms J, Sridhar R, Furness SG, Liu M, Thompson PE, Miller LJ, Christopolous A, Sexton PM (June 2016). "The extracellular surface of the GLP-1 receptor is a molecular trigger for biased agonism". Cell. 165 (7): 16321643.
6. Yang D, de Graaf C, Yang L, Song G, Dai A, Cai X, Feng Y, Reedtz-Runge S, Hanson MA, Yang H, Jiang H, Stevens RC, Wang MW (June 2016). "Structural Determinants of Binding the Seven-transmembrane Domain of the Glucagon-like Peptide-1 Receptor (GLP-1R)". Journal of Biological Chemistry. 291 (25): 129913004.
7. Wooten D, Reynolds CA, Smith KJ, Mobarec JC, Furness SG, Miller LJ, Christopolous A, Sexton PM (August 2016). "Key interactions by conserved polar amino acids located at the transmembrane helical boundaries in Class B GPCRs modulate activation, effector specificity and biased signalling in the glucagon-like peptide-1 receptor". Biochemical Pharmacology. 118: 6887.
Anti-G protein-coupled estrogen receptor 1 (GPER1/GPR30) is a novel estrogenic receptor that binds to 17-beta-estradiol (E2) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. Different from traditional estrogen nuclear receptors, GPR30 exerts its biological effects through rapid non-genomic mechanisms [1].
GPR30 is involved in several physiopathological disorders and especially in estrogen-dependent diseases such as breast cancer and also has a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a RAMP3-dependent manner. It is highly expressed in the brain [2,3] and activation of GPR30 has neuroprotective effects on ischemic brain injury [4]. In Humans GPR30 is 375 amino acids in length, contains an N-terminal extracellular region (1?62), a series of seven TM domains (63?327), and a C-terminal cytoplasmic tail (328?375).
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the C-terminal region of human GPER1
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
1. Prossnitz E.R., Barton M. The G-protein-coupled estrogen receptor GPER in health and disease. Nat Rev Endocrinol. 2011;7:715726
2. Brailoiu E, Dun SL, Brailoiu GC, Mizuo K, Sklar LA, Oprea TI, et al. Distribution and characterization of estrogen receptor G protein-coupled receptor 30 in the rat central nervous system. J Endocrinol. 2007;193:311321. doi: 10.1677/JOE-07-0017. [PubMed] [CrossRef]
3. Tang H, Zhang Q, Yang L, Dong Y, Khan M, Yang F, et al. GPR30 mediates estrogen rapid signaling and neuroprotection. Mol Cell Endocrinol. 2014;387:528. doi: 10.1016/j.mce.2014.01.024.
4. Kosaka Y., Quillinan N., Bond C. GPER1/GPR30 activation improves neuronal survival following global cerebral ischemia induced by cardiac arrest in mice. Transl Stroke Res. 2012;3:500507.
Anti-G protein-coupled estrogen receptor 1 (GPER1/GPR30) is a novel estrogenic receptor that binds to 17-beta-estradiol (E2) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. Different from traditional estrogen nuclear receptors, GPR30 exerts its biological effects through rapid non-genomic mechanisms [1].
GPR30 is involved in several physiopathological disorders and especially in estrogen-dependent diseases such as breast cancer and also has a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a RAMP3-dependent manner. It is highly expressed in the brain [2,3] and activation of GPR30 has neuroprotective effects on ischemic brain injury [4]. In Humans GPR30 is 375 amino acids in length, contains an N-terminal extracellular region (1?62), a series of seven TM domains (63?327), and a C-terminal cytoplasmic tail (328?375).
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the C-terminal region of human GPER1
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
1. Prossnitz E.R., Barton M. The G-protein-coupled estrogen receptor GPER in health and disease. Nat Rev Endocrinol. 2011;7:715726
2. Brailoiu E, Dun SL, Brailoiu GC, Mizuo K, Sklar LA, Oprea TI, et al. Distribution and characterization of estrogen receptor G protein-coupled receptor 30 in the rat central nervous system. J Endocrinol. 2007;193:311321. doi: 10.1677/JOE-07-0017. [PubMed] [CrossRef]
3. Tang H, Zhang Q, Yang L, Dong Y, Khan M, Yang F, et al. GPR30 mediates estrogen rapid signaling and neuroprotection. Mol Cell Endocrinol. 2014;387:528. doi: 10.1016/j.mce.2014.01.024.
4. Kosaka Y., Quillinan N., Bond C. GPER1/GPR30 activation improves neuronal survival following global cerebral ischemia induced by cardiac arrest in mice. Transl Stroke Res. 2012;3:500507.
GPR83 is an orphan G protein-coupled receptor highly expressed in brain and thymus. It is most homologous to the tachykinin and neuropeptide Y (NPY) receptors. GPR83 is selectively up-regulated by both murine and human CD4(+)CD25(+) regulatory T cells. It was also identified as the receptor for neuroendocrine peptide PEN(1)
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 100 µl PBS containing 0.05% BSA and 0.05% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human GPR83 from the central region of the protein
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB: 1-2ug/ml
Category:
Primary Antibodies
Other names:
GPR83, GIR/ GPR72
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
48kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Plasma membrane
Purification:
Protein A Purified
References:
(1) Identification of GPR83 as the receptor for the neuroendocrine peptide PEN, Ivone Gomes et al. DOI:10.1126/scisignal.aad0694
GPR83 is an orphan G protein-coupled receptor highly expressed in brain and thymus. It is most homologous to the tachykinin and neuropeptide Y (NPY) receptors. GPR83 is selectively up-regulated by both murine and human CD4(+)CD25(+) regulatory T cells. It was also identified as the receptor for neuroendocrine peptide PEN(1)
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human GPR83 from the central region of the protein
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB: 1-2ug/ml
Category:
Primary Antibodies
Other names:
GPR83, GIR/ GPR72
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
48kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Plasma membrane
Purification:
Protein A Purified
References:
(1) Identification of GPR83 as the receptor for the neuroendocrine peptide PEN, Ivone Gomes et al. DOI:10.1126/scisignal.aad0694
G protein-coupled receptor class C group 6 member A (GPRC6A) is a widely expressed G-protein coupled receptor, believed to be a master regulator of complex endocrine networks and metabolic processes. GPRC6A is activated by multiple ligands, including osteocalcin (Ocn), testosterone (T), basic amino acids, and various cations. [1]
Members of family C of the G protein-coupled receptor (GPCR) superfamily, such as GPRC6A, are characterised by an evolutionarily conserved amino acid-sensing motif linked to an intramembranous 7-transmembrane loop region. Several members of GPCR family C, including GPRC6A, also have a long N-terminal domain.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human GPRC6A from the central region of the protein
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000. IHC 1:50-200.
Category:
Primary Antibodies
Other names:
G-protein coupled receptor family C group 6 member A, hGPRC6A, GPRC6A, GPCR, bA86F4.3, GPCR33, hGPCR33
Research Areas:
Cell Signalling and Transport, calcitonin-receptor-like receptor
NS Reagents Product Area:
Cell Signalling
Molecular Weight:
105kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Cell membrane, Multi-pass membrane protein
Purification:
Affinity purification
References:
1. Min Pi, Satoru Kenneth Nishimoto, L. Darryl Quarles. Mol Metab. 2017 Feb; 6(2): 185193.
G protein-coupled receptor class C group 6 member A (GPRC6A) is a widely expressed G-protein coupled receptor, believed to be a master regulator of complex endocrine networks and metabolic processes. GPRC6A is activated by multiple ligands, including osteocalcin (Ocn), testosterone (T), basic amino acids, and various cations. [1]
Members of family C of the G protein-coupled receptor (GPCR) superfamily, such as GPRC6A, are characterised by an evolutionarily conserved amino acid-sensing motif linked to an intramembranous 7-transmembrane loop region. Several members of GPCR family C, including GPRC6A, also have a long N-terminal domain.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS containing 0.02% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human GPRC6A from the central region of the protein
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000. IHC 1:50-200.
Category:
Primary Antibodies
Other names:
G-protein coupled receptor family C group 6 member A, hGPRC6A, GPRC6A, GPCR, bA86F4.3, GPCR33, hGPCR33
Research Areas:
Cell Signalling and Transport, calcitonin-receptor-like receptor
NS Reagents Product Area:
Cell Signalling
Molecular Weight:
105kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Cell membrane, Multi-pass membrane protein
Purification:
Affinity purification
References:
1. Min Pi, Satoru Kenneth Nishimoto, L. Darryl Quarles. Mol Metab. 2017 Feb; 6(2): 185193.
Glycogen synthase kinase-3 beta (GSK3B) is a proline-directed serine threonine kinase which has been implicated in multiple biological processes including embryonic development, cell differentiation, apoptosis and insulin response. More than 40 proteins have been reported to be phosphorylated by GSK3B including glycogen synthase, Acetyl CoA carboxylase, Axin, Cyclin D1, structural proteins like Tau, neural cell adhesion protein (NCAM) many transcription factors. GSK3B also regulates various cellular processes by binding to protein complexes.
GSK3B is expressed in almost all the tissues. However the highest expression is in brain tissue due to its vital role in the neuronal signaling. Dysregulation of GSK3B expression leads to various pathological conditions such as diabetes or insulin resistance, neuronal dysfunction and neuronal diseases. GSK3B is generally a cytosolic protein, but may also be seen in the nucleus and mitochondria.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the N-terminal region of human Glycogen synthase kinase-3 beta
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Glycogen synthase kinase-3 beta (GSK3B) is a proline-directed serine threonine kinase which has been implicated in multiple biological processes including embryonic development, cell differentiation, apoptosis and insulin response. More than 40 proteins have been reported to be phosphorylated by GSK3B including glycogen synthase, Acetyl CoA carboxylase, Axin, Cyclin D1, structural proteins like Tau, neural cell adhesion protein (NCAM) many transcription factors. GSK3B also regulates various cellular processes by binding to protein complexes.
GSK3B is expressed in almost all the tissues. However the highest expression is in brain tissue due to its vital role in the neuronal signaling. Dysregulation of GSK3B expression leads to various pathological conditions such as diabetes or insulin resistance, neuronal dysfunction and neuronal diseases. GSK3B is generally a cytosolic protein, but may also be seen in the nucleus and mitochondria.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the N-terminal region of human Glycogen synthase kinase-3 beta
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
GTP cyclohydrolase 1 (GCH1) is an essential enzyme for dopamine production in nigrostriatal cells. It is required for BH4 synthesis (6(R)-l-erythro-5,6,7,8-tetrahydrobiopterin), a cofactor required for the production of aromatic amino acids, neurotransmitters, and nitric oxide. Through this requirement, GCH1 is implicated in neurological disorders such as DOPA-responsive dystonia and Parkinsons disease.
GCH1 is also relevant in pain sensitivity, cardiovascular risk, some cancers and chronic diseases such as hypertension, diabetes and atherosclerosis.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
GTP cyclohydrolase 1 (GCH1) is an essential enzyme for dopamine production in nigrostriatal cells. It is required for BH4 synthesis (6(R)-l-erythro-5,6,7,8-tetrahydrobiopterin), a cofactor required for the production of aromatic amino acids, neurotransmitters, and nitric oxide. Through this requirement, GCH1 is implicated in neurological disorders such as DOPA-responsive dystonia and Parkinsons disease.
GCH1 is also relevant in pain sensitivity, cardiovascular risk, some cancers and chronic diseases such as hypertension, diabetes and atherosclerosis.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Histone deacetylase 6 (HDAC6) is a member of the HDAC family of enzymes that remove acetyl groups from lysines of histones thereby acting as gene transcription regulators. HDAC6 is more specifically a member of the class IIB HDAC family and contains two catalytic domains and a C-terminal zinc finger domain that binds free ubiquitin as well as ubiquitinated proteins with high affinity. As a cytoplasmic deacetylase, HDAC6 can deacetylate substrates such as tubulin, heat shock protein 90 (HSP90).
HDAC6 plays an important role in protein degradation, alongside roles in cell morphology, adhesion, migration, and tumor cell invasion/metastasis.
Inhibition of Histone deacetylases (HDACs) has been shown to be neuroprotective in animal models of neurodegenerative diseases and HDAC6 is one possible target, however theoretically HDAC6 should actually contribute to the degradation of protein aggregates seen in neurodegenerative disorders such as Alzheimers, Parkinsons and Hutingtons diseases, So HDAC6 as a target for neurodegenerative disorders remains controversial.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Histone deacetylase 6 (HDAC6) is a member of the HDAC family of enzymes that remove acetyl groups from lysines of histones thereby acting as gene transcription regulators. HDAC6 is more specifically a member of the class IIB HDAC family and contains two catalytic domains and a C-terminal zinc finger domain that binds free ubiquitin as well as ubiquitinated proteins with high affinity. As a cytoplasmic deacetylase, HDAC6 can deacetylate substrates such as tubulin, heat shock protein 90 (HSP90).
HDAC6 plays an important role in protein degradation, alongside roles in cell morphology, adhesion, migration, and tumor cell invasion/metastasis.
Inhibition of Histone deacetylases (HDACs) has been shown to be neuroprotective in animal models of neurodegenerative diseases and HDAC6 is one possible target, however theoretically HDAC6 should actually contribute to the degradation of protein aggregates seen in neurodegenerative disorders such as Alzheimers, Parkinsons and Hutingtons diseases, So HDAC6 as a target for neurodegenerative disorders remains controversial.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Histone H2A is a core histone (along with H2B, H3 and H4). Core formation takes place through the interaction of two H2A molecules after which H2A forms a dimer with H2B; the core molecule is complete when H3-H4 also attaches to form a tetramer. H2A refers to a number of closely related proteins that vary by only a few amino acids including H2A.1, H2A.2, H2AX, and H2AZ. H2A undergoes various post-translational modifications, including acetylation, phosphorylation, methylation, and ubiquitination, which occur in response to various stimuli and directly affect the accessibility of chromatin to transcription factors. Changes in variant composition occur in differentiating cells. H2A consists of a main globular domain and a long N-terminal tail or C-terminal on one end of the molecule. The N-terminal tail or C-terminal tail is the location of post-translational modification.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 100 µl PBS containing 0.05% BSA and 0.05% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB: 2-4ug/ml,Immunohistochemical analysis: 5ug/ml
Category:
Primary Antibodies
Other names:
H2A
Research Areas:
Histone, Transcription and Translation, Protein Modification, Transcription, Chromatin
NS Reagents Product Area:
DNA & Protein Modification
Molecular Weight:
14kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Histone H2A is a core histone (along with H2B, H3 and H4). Core formation takes place through the interaction of two H2A molecules after which H2A forms a dimer with H2B; the core molecule is complete when H3-H4 also attaches to form a tetramer. H2A refers to a number of closely related proteins that vary by only a few amino acids including H2A.1, H2A.2, H2AX, and H2AZ. H2A undergoes various post-translational modifications, including acetylation, phosphorylation, methylation, and ubiquitination, which occur in response to various stimuli and directly affect the accessibility of chromatin to transcription factors. Changes in variant composition occur in differentiating cells. H2A consists of a main globular domain and a long N-terminal tail or C-terminal on one end of the molecule. The N-terminal tail or C-terminal tail is the location of post-translational modification.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB: 2-4ug/ml,Immunohistochemical analysis: 5ug/ml
Category:
Primary Antibodies
Other names:
H2A
Research Areas:
Histone, Transcription and Translation, Protein Modification, Transcription, Chromatin
NS Reagents Product Area:
DNA & Protein Modification
Molecular Weight:
14kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Histone H2AX is expressed in all eukaryotic cells and in humans constitutes about 10% of the H2A histones in chromatin. It is a 15 kDa variant of Histone H2 required for the repair of double-stranded DNA breaks. In response to DNA double-strand break formation it is phosphorylated in the position of Ser139 producing gamma-H2AX. Histone H2AX is a substrate of several phosphoinositide 3-kinase-related protein kinases (PIKKs), such as ATM (ataxia teleangiectasia mutated), ATR (ATM and Rad3-related), or DNA-dependent protein kinase (DNA-PK).
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide.
Mouse, Rat, Zebrafish, Canine, Horse, Sheep, Goat.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB: 2-4 µg/ml
Category:
Primary Antibodies
Other names:
gamma-H2AX, H2A, H2A.X
Research Areas:
Histone, Transcription and Translation, Protein Modification, Transcription, Chromatin
NS Reagents Product Area:
DNA & Protein Modification
Molecular Weight:
15kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Histone H2AX is expressed in all eukaryotic cells and in humans constitutes about 10% of the H2A histones in chromatin. It is a 15 kDa variant of Histone H2 required for the repair of double-stranded DNA breaks. In response to DNA double-strand break formation it is phosphorylated in the position of Ser139 producing gamma-H2AX. Histone H2AX is a substrate of several phosphoinositide 3-kinase-related protein kinases (PIKKs), such as ATM (ataxia teleangiectasia mutated), ATR (ATM and Rad3-related), or DNA-dependent protein kinase (DNA-PK).
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide.
Mouse, Rat, Zebrafish, Canine, Horse, Sheep, Goat.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB: 2-4 µg/ml
Category:
Primary Antibodies
Other names:
gamma-H2AX, H2A, H2A.X
Research Areas:
Histone, Transcription and Translation, Protein Modification, Transcription, Chromatin
NS Reagents Product Area:
DNA & Protein Modification
Molecular Weight:
15kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Histone H2AX is expressed in all eukaryotic cells and in humans constitutes about 10% of the H2A histones in chromatin. It is a 15 kDa variant of Histone H2 required for the repair of double-stranded DNA breaks. In response to DNA double-strand break formation it is phosphorylated in the position of Ser139 producing gamma-H2AX. Histone H2AX is a substrate of several phosphoinositide 3-kinase-related protein kinases (PIKKs), such as ATM (ataxia teleangiectasia mutated), ATR (ATM and Rad3-related), or DNA-dependent protein kinase (DNA-PK).
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 100 µl PBS containing 0.05% BSA and 0.05% sodium azide.
Mouse, Rat, Zebrafish, Canine, Horse, Sheep, Goat.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB: 2-4 µg/ml
Category:
Primary Antibodies
Other names:
gamma-H2AX, H2A, H2A.X
Research Areas:
Histone, Transcription and Translation, Protein Modification, Transcription, Chromatin
NS Reagents Product Area:
DNA & Protein Modification
Molecular Weight:
15kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Histone H2AX is expressed in all eukaryotic cells and in humans constitutes about 10% of the H2A histones in chromatin. It is a 15 kDa variant of Histone H2 required for the repair of double-stranded DNA breaks. In response to DNA double-strand break formation it is phosphorylated in the position of Ser139 producing gamma-H2AX. Histone H2AX is a substrate of several phosphoinositide 3-kinase-related protein kinases (PIKKs), such as ATM (ataxia teleangiectasia mutated), ATR (ATM and Rad3-related), or DNA-dependent protein kinase (DNA-PK).
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 100 µl PBS containing 0.05% BSA and 0.05% sodium azide.
Mouse, Rat, Zebrafish, Canine, Horse, Sheep, Goat.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB: 2-4 µg/ml
Category:
Primary Antibodies
Other names:
gamma-H2AX, H2A, H2A.X
Research Areas:
Histone, Transcription and Translation, Protein Modification, Transcription, Chromatin
NS Reagents Product Area:
DNA & Protein Modification
Molecular Weight:
15kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Histone H3.3 is a replication independent variant of Histone H3 which is generally expressed in quiescent or terminally differentiated cells. It constitutes the predominant form of histone H3 in such cells and replaces conventional H3 in a wide range of nucleosomes in active genes. It is incorporated into chromatin independently of DNA synthesis. Modifications in Histone H3.3 are associated with transcriptional activation and act as an epigenetic mark of transcriptionally active chromatin. Histone H3.3 has been found to play an important role in maintaining genome integrity during mammalian development. Histone H3.3 is a 15 kDa protein which is expressed throughout the cell cycle independently of DNA synthesis in all eukaryotic genomes. H3.3 differs from the canonical replication-coupled H3 histones (H3.1/H3.2 in mammals) by only four to five amino acids, respectively, but has distinct expression patterns and chromatin incorporation mechanisms. Canonical H3 variants are expressed only during S phase.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB: 2-4 µg/ml
Category:
Primary Antibodies
Other names:
H3 histone family 3A, H3 histone family member 3A
Research Areas:
Histone, Transcription and Translation, Protein Modification, Transcription, Chromatin
NS Reagents Product Area:
DNA & Protein Modification
Molecular Weight:
15kDa (Intended as a general guide and does not allow for all isoforms and species variations)
