FUS (fused in sarcoma) is a member of the FET/TET (FUS/TLS, EWS, TAF15) family of RNA-binding proteins (RBPs) that have roles in transcription, pre-mRNA splicing, DNA repair, and mRNA transport in neurons.
FUS (like all FET family members) is highly conserved and ubiquitously expressed, with several conserved domains: a serine-tyrosine-glycine-glutamine (SYGQ) domain embedded in the DNA activation domain (AD), 3 glycine-arginine (RGG) rich regions that affect RNA binding, one conserved RNA-binding domain (RBD, formed by a RNA-recognition motif, RRM), and a zinc finger domain that is also involved in nucleic acid binding [1].
FUS binds to single and double stranded DNA as well as RNA and participates in multiple cellular functions. Alternative splicing results in multiple transcript variants. Defects in the FUS gene are associated with amyotrophic lateral sclerosis (ALS). FUS is also implicated in a number of other neurodegenerative disorders.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS containing 0.02% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant protein from the C-terminal region of human FUS
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000.
Antibody Number:
10074
Category:
Primary Antibodies
Other names:
ALS6, ETM4, HNRNPP2, POMP75, TLS, fused in sarcoma, translocated in liposarcoma
Research Areas:
Neuroscience, Amyotrophic lateral sclerosis
NS Reagents Product Area:
Neuroscience
Molecular Weight:
53kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Nucleus
Purification:
Affinity purification
References:
[1] Role of FET proteins in neurodegenerative disorders Francesca Svetoni, Paola Frisone, Maria Paola Paronetto RNA Biol. 2016; 13(11): 10891102. Published online 2016 Jul 14. doi: 10.1080/15476286.2016.1211225
[2] Functions of FUS/TLS From DNA Repair to Stress Response: Implications for ALS Reddy Ranjith Kumar Sama, Catherine L. Ward, Daryl A. Bosco ASN Neuro. 2014 May-Jun; 6(4): 1759091414544472. doi: 10.1177/1759091414544472
FUS (fused in sarcoma) is a member of the FET/TET (FUS/TLS, EWS, TAF15) family of RNA-binding proteins (RBPs) that have roles in transcription, pre-mRNA splicing, DNA repair, and mRNA transport in neurons.
FUS (like all FET family members) is highly conserved and ubiquitously expressed, with several conserved domains: a serine-tyrosine-glycine-glutamine (SYGQ) domain embedded in the DNA activation domain (AD), 3 glycine-arginine (RGG) rich regions that affect RNA binding, one conserved RNA-binding domain (RBD, formed by a RNA-recognition motif, RRM), and a zinc finger domain that is also involved in nucleic acid binding [1].
FUS binds to single and double stranded DNA as well as RNA and participates in multiple cellular functions. Alternative splicing results in multiple transcript variants. Defects in the FUS gene are associated with amyotrophic lateral sclerosis (ALS). FUS is also implicated in a number of other neurodegenerative disorders.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant protein from the C-terminal region of human FUS
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000.
Antibody Number:
10074
Category:
Primary Antibodies
Other names:
ALS6, ETM4, HNRNPP2, POMP75, TLS, fused in sarcoma, translocated in liposarcoma
Research Areas:
Neuroscience, Amyotrophic lateral sclerosis
NS Reagents Product Area:
Neuroscience
Molecular Weight:
53kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Nucleus
Purification:
Affinity purification
References:
[1] Role of FET proteins in neurodegenerative disorders Francesca Svetoni, Paola Frisone, Maria Paola Paronetto RNA Biol. 2016; 13(11): 10891102. Published online 2016 Jul 14. doi: 10.1080/15476286.2016.1211225
[2] Functions of FUS/TLS From DNA Repair to Stress Response: Implications for ALS Reddy Ranjith Kumar Sama, Catherine L. Ward, Daryl A. Bosco ASN Neuro. 2014 May-Jun; 6(4): 1759091414544472. doi: 10.1177/1759091414544472
FUS (fused in sarcoma) is a member of the FET/TET (FUS/TLS, EWS, TAF15) family of RNA-binding proteins (RBPs) that have roles in transcription, pre-mRNA splicing, DNA repair, and mRNA transport in neurons.
FUS (like all FET family members) is highly conserved and ubiquitously expressed, with several conserved domains: a serine-tyrosine-glycine-glutamine (SYGQ) domain embedded in the DNA activation domain (AD), 3 glycine-arginine (RGG) rich regions that affect RNA binding, one conserved RNA-binding domain (RBD, formed by a RNA-recognition motif, RRM), and a zinc finger domain that is also involved in nucleic acid binding [1].
FUS binds to single and double stranded DNA as well as RNA and participates in multiple cellular functions. Alternative splicing results in multiple transcript variants. Defects in the FUS gene are associated with amyotrophic lateral sclerosis (ALS). FUS is also implicated in a number of other neurodegenerative disorders.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
Storage Temp:
Store at -20°C. Avoid freeze / thaw cycles.
Host Animal:
Rabbit
Species Reactivity:
Human, Mouse
Expected Species:
Rat, Bovine
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
IHC 1:30-150.
Antibody Number:
10104
Category:
Primary Antibodies
Other names:
ALS6, ETM4, HNRNPP2, POMP75, TLS, fused in sarcoma, translocated in liposarcoma
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
53kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Nucleus
Purification:
Affinity purification
References:
[1] Role of FET proteins in neurodegenerative disorders Francesca Svetoni, Paola Frisone, Maria Paola Paronetto RNA Biol. 2016; 13(11): 10891102. Published online 2016 Jul 14. doi: 10.1080/15476286.2016.1211225
[2] Functions of FUS/TLS From DNA Repair to Stress Response: Implications for ALS Reddy Ranjith Kumar Sama, Catherine L. Ward, Daryl A. Bosco ASN Neuro. 2014 May-Jun; 6(4): 1759091414544472. doi: 10.1177/1759091414544472
FUS (fused in sarcoma) is a member of the FET/TET (FUS/TLS, EWS, TAF15) family of RNA-binding proteins (RBPs) that have roles in transcription, pre-mRNA splicing, DNA repair, and mRNA transport in neurons.
FUS (like all FET family members) is highly conserved and ubiquitously expressed, with several conserved domains: a serine-tyrosine-glycine-glutamine (SYGQ) domain embedded in the DNA activation domain (AD), 3 glycine-arginine (RGG) rich regions that affect RNA binding, one conserved RNA-binding domain (RBD, formed by a RNA-recognition motif, RRM), and a zinc finger domain that is also involved in nucleic acid binding [1].
FUS binds to single and double stranded DNA as well as RNA and participates in multiple cellular functions. Alternative splicing results in multiple transcript variants. Defects in the FUS gene are associated with amyotrophic lateral sclerosis (ALS). FUS is also implicated in a number of other neurodegenerative disorders.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
Storage Temp:
Store at -20°C. Avoid freeze / thaw cycles.
Host Animal:
Rabbit
Species Reactivity:
Human, Mouse
Expected Species:
Rat, Bovine
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
IHC 1:30-150.
Antibody Number:
10104
Category:
Primary Antibodies
Other names:
ALS6, ETM4, HNRNPP2, POMP75, TLS, fused in sarcoma, translocated in liposarcoma
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
53kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Nucleus
Purification:
Affinity purification
References:
[1] Role of FET proteins in neurodegenerative disorders Francesca Svetoni, Paola Frisone, Maria Paola Paronetto RNA Biol. 2016; 13(11): 10891102. Published online 2016 Jul 14. doi: 10.1080/15476286.2016.1211225
[2] Functions of FUS/TLS From DNA Repair to Stress Response: Implications for ALS Reddy Ranjith Kumar Sama, Catherine L. Ward, Daryl A. Bosco ASN Neuro. 2014 May-Jun; 6(4): 1759091414544472. doi: 10.1177/1759091414544472
Uniprot ID:
P35637
Gene ID:
2521
Gene symbol:
FUS
Release Date:
May-19
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