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Newmarket Scientific

Product Search Results: HBM-TFF-MV

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Product Search Results: HBM-TFF-MV

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HansaBioMed HBM-TFF-MV 1 concentrator £238.00
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Background Info: Exosomes are small endosome derived lipid nanoparticles (50-120 nm) actively secreted by exocytosis by most living cells. Exosome release occurs either constitutively or upon induction, under both normal and pathological conditions, in a dynamic, regulated and functionally relevant manner. Both amount and molecular composition of released exosomes depend on the state of a parent cell. Exosomes have been isolated from diverse cell lines (hematopoietic cells, tumor lines, primary cultures, virus infected cells) as well as from biological fluids in particular blood (e.g. serum and plasma from cancer patients) and other body fluids (bronchoalveolar lavage fluid, pleural effusions, synovial fluid, urine, amniotic fluid, semen, saliva etc). Exosomes have pleiotropic physiological and pathological functions and an emerging role in diverse pathological conditions such as cancer, infectious and neurodegenerative diseases.
Product Type: Concentrator
Storage Temp: RT
Applications: Concentrator
Additional Info: TFF-MV is a filter cartridge in hollow fibers made of polysulfone. The filter is very useful for separating different EVs by size. Indeed, microvesicles bigger than 150 nm are retained inside the hollow fibers, while small EVs and molecules easily permeate the filter. Microvesicles can be recovered with a syringe in PBS buffer without additional purification steps.

Filter cartridge: Polysulfone hollow fibres

Sample volume per reaction: Recommended sample volume from 10 ml up to several liters if connected to mechanical pump
Application Details: Applications:
Concentration of solutions containing EVs, exosomes or nanoparticles.
Concentration of diluted matrices as cell media or urine prior to EV isolation.
Removal of small molecules and unbound dyes from solution containing EVs/exosomes and nanoparticles.
EV and exosomes dialysis.
Concentration of EV suspensions post SEC isolation.
Shelf life: not indicated