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Product Search Results: R-1751-50

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Product Search Results: R-1751-50

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Biosensis R-1751-50 50 µg £270.00
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Product Detail: FUNCTION: Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum. SUBUNIT: Heterodimer. Interacts with DSIPI; this interaction inhibits the binding of active AP1 to its target DNA. Interacts with MAFB. SUBCELLULAR LOCATION: Nucleus. INDUCTION: C-fos expression increases upon a variety of stimuli, including growth factors, cytokines, neurotransmitters, polypeptide hormones, stress and cell injury. SIMILARITY: Belongs to the bZIP family. Fos subfamily. SIMILARITY: Contains 1 bZIP domain (Ref: uniprot.org).
Product Type: Antibody
Antibody Type: Polyclonal
Format: Lyophilized from a solution containing 3% trehalose in PBS, pH 7.4, without preservatives.
Storage Temp: Store lyophilised, unopened vial at 2- 8 °C or lower. After reconstitution, prepare aliquots and store at -20 °C for a higher stability. Avoid freeze-thaw cycles.
Host Animal: Rabbit
Species Reactivity: Horse, Cow, Pig, Chicken, Rat, Mouse
Immunogen: Full length, E.coli-derived recombinant human c-FOS protein.
Applications: IH,Frozen, IC; WB
Data Sheet: PLEASE CLICK HERE TO DOWNLOAD
Antibody Isotype: IgG
Application Details: Immunohistochemistry (IHC) and immunocytochemistry (ICC): 0.2-1.0 µg/mL. This antibody has been shown to work on 4% PFA fixed mouse brain sections.Western blotting (WB): 0.5-1.0 µg/mL. This antibody detects bands between 50-65 kDa, which only appear in stimulated cells. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.
Alternative Names: Cellular oncogene fos; G0/G1 switch regulatory protein 7; cFOS
Accession Number: FOS_HUMAN
Reconstitution: Reconstitute with 50 µL sterile-filtered, ultrapure water, to achieve an antibody concentration of 1 mg/mL. Centrifuge briefly to remove any insoluble material.
Shelf Life: 12 months after purchase if unopened and stored as indicated.
Specificity: Human. | Horse, cow, pig, chicken, rat, mouse.
Purity: Affinity purified.