Anti-cytokeratin 7 reacts with proteins that are found in most ductal, glandular, transitional, and biliary duct epithelial cells. Cytokeratin 7 (CK7) labeling can help distinguish between lung,breast carcinomas, and urothelial carcinomas that typically stain positive, and colon and prostate carcinomas that typically lack CK7 expression.CK 7 is a common marker of primary lung adenocarcinomas (almost all cases) with a lower specificity since it is also observed in other primary lung carcinomas and non-pulmonary carcinomas.1 Anti-cytokeratin 7 has also been useful in the differential diagnosis of ovarian neoplasms.This antibody does not recognize intermediate filament proteins.
Antibody Isotype:
IgG1-k
Monosan Range:
MONOSAN Ready To Use
Clone:
OV-TL 12/30
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Jerome MV, et al. Histopathology. 2004; 45:125-34
References 2:
Murray SK, et al. Am J Surg Pathol. 2004; 28:1154-62
References 3:
Ramalingam P, et al. Ann Diagn Pathol. 2003; 7:112-9
References 4:
McCluggage WG, et al. Histopathology. 2005; 47:231-247
References 5:
Roy S, et al. Arch Pathol Lab Med. 2011; 135:1601-5
Cytokeratins are a subfamily of intermediate filament proteins and are characterized by a remarkable biochemical diversity, represented in Human epithelial tissues by at least 20 different polypeptides. They range in molecular weight between 40 kDa and 68 kDa and isoelectric pH between 4.9 7.8. The individual Human Cytokeratins are numbered 1 to 20. The various epithelia in the Human body usually express Cytokeratins which are not only characteristic of the type of epithelium, but also related to the degree of maturation or differentiation within an epithelium. Cytokeratin subtype expression patterns are used in the distinction of different types of epithelial malignancies. The Cytokeratin antibodies are not only of assistance in the differential diagnosis of tumors using immunohistochemistry on tissue sections, but are also a useful tool in cytopathology and flow cytometric assays.
Antibody Isotype:
IgG1
Monosan Range:
MONOSAN
Clone:
OVTL12/30
Concentration:
100 ug/ ml
Storage buffer:
PBS with 0.1% BSA and 0.02% sodium azide
Storage:
2-8°C
References 1:
Ramaekers, F. et al. 1990 Am J Pathol 136, 641-55
References 2:
van Niekerk, CC et al. 1991 J Pathol 165, 145-52
References 3:
van de Molengraft, F.J et al. 1993 Histopathology 22, 35-8
References 4:
van Niekerk, CC et al. 1997 Cancer Detect Prev 21, 247-57
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