Newmarket Scientific Product Search Results for Anti-taf15

Product Search Results: Anti-taf15
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Product Search Results: Anti-taf15	Num Products Matched: 2	2

Newmarket Scientific - NS Reagents

AB19-10108-100ug

100 µg

£275.00

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Product Detail:	Anti-TAF15 Antibody (Polyclonal)
Background Info:	TATA-binding protein-associated factor 2N (TAF15) is a member of the FET/TET (FUS/TLS, EWS, TAF15) family of RNA-binding proteins (RBPs) that have roles in transcription, pre-mRNA splicing, DNA repair, and mRNA transport in neurons. TAF15 (like all FET family members) is highly conserved and ubiquitously expressed, with several conserved domains: a serine-tyrosine-glycine-glutamine (SYGQ) domain embedded in the DNA activation domain (AD), 3 glycine-arginine (RGG) rich regions that affect RNA binding, one conserved RNA-binding domain (RBD, formed by a RNA-recognition motif, RRM), and a zinc finger domain that is also involved in nucleic acid binding [1]. Mutations in the TAF15 gene may have a role in the pathogenesis of Amyotrophic lateral sclerosis (ALS) with TAF15 accumulating as cytoplasmic aggregates in neuronal cells. It has also been shown that parkin directly binds to TAF15 and may suppress the defective TAF15 genotype in ALS. TAF15 is also implicated in a number of other neurodegenerative disorders.
Product Type:	NS Reagents Antibody
Antibody Type:	Polyclonal
Format:	100 µg in 100 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage Temp:	Store at -20?. Avoid freeze / thaw cycles.
Host Animal:	Rabbit
Species Reactivity:	Human
Expected Species:	Mouse Pig Rat, Chicken, Horse
Immunogen:	Partial length recombinant human TAF15 from the N-terminal region
Applications:	WB IHC
Data Sheet:	PLEASE CLICK HERE TO DOWNLOAD
Additional Info:	If you would like further information regarding the immunogen used in the productiion of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:	IgG
Application Details:	WB 1:500-2000. IHC 1:50-100.
Antibody Number:	10108
Category:	Primary Antibodies
Other names:	Npl3, RBP56, TAF2N, TAFII68, TATA-binding protein-associated factor 2N
Research Areas:	Neuroscience
NS Reagents Product Area:	Neuroscience
Molecular Weight:	62kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:	Cytoplasm, Nucleus
Purification:	Affinity purification
References:	[1] Role of FET proteins in neurodegenerative disorders Francesca Svetoni, Paola Frisone, Maria Paola Paronetto RNA Biol. 2016; 13(11): 10891102. Published online 2016 Jul 14. doi: 10.1080/15476286.2016.1211225
Uniprot ID:	Q92804
Gene ID:	8148
Gene symbol:	TAF15
Release Date:	Sep-19

Newmarket Scientific - NS Reagents

AB19-10108-50ug

50 µg

£220.00

Please sign in or sign up to order this product online.

Product Detail:	Anti-TAF15 Antibody (Polyclonal)
Background Info:	TATA-binding protein-associated factor 2N (TAF15) is a member of the FET/TET (FUS/TLS, EWS, TAF15) family of RNA-binding proteins (RBPs) that have roles in transcription, pre-mRNA splicing, DNA repair, and mRNA transport in neurons. TAF15 (like all FET family members) is highly conserved and ubiquitously expressed, with several conserved domains: a serine-tyrosine-glycine-glutamine (SYGQ) domain embedded in the DNA activation domain (AD), 3 glycine-arginine (RGG) rich regions that affect RNA binding, one conserved RNA-binding domain (RBD, formed by a RNA-recognition motif, RRM), and a zinc finger domain that is also involved in nucleic acid binding [1]. Mutations in the TAF15 gene may have a role in the pathogenesis of Amyotrophic lateral sclerosis (ALS) with TAF15 accumulating as cytoplasmic aggregates in neuronal cells. It has also been shown that parkin directly binds to TAF15 and may suppress the defective TAF15 genotype in ALS. TAF15 is also implicated in a number of other neurodegenerative disorders.
Product Type:	NS Reagents Antibody
Antibody Type:	Polyclonal
Format:	50 µg in 50 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage Temp:	Store at -20?. Avoid freeze / thaw cycles.
Host Animal:	Rabbit
Species Reactivity:	Human
Expected Species:	Mouse Pig Rat, Chicken, Horse
Immunogen:	Partial length recombinant human TAF15 from the N-terminal region
Applications:	WB IHC
Data Sheet:	PLEASE CLICK HERE TO DOWNLOAD
Additional Info:	If you would like further information regarding the immunogen used in the productiion of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:	IgG
Application Details:	WB 1:500-2000. IHC 1:50-100.
Antibody Number:	10108
Category:	Primary Antibodies
Other names:	Npl3, RBP56, TAF2N, TAFII68, TATA-binding protein-associated factor 2N
Research Areas:	Neuroscience
NS Reagents Product Area:	Neuroscience
Molecular Weight:	62kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:	Cytoplasm, Nucleus
Purification:	Affinity purification
References:	[1] Role of FET proteins in neurodegenerative disorders Francesca Svetoni, Paola Frisone, Maria Paola Paronetto RNA Biol. 2016; 13(11): 10891102. Published online 2016 Jul 14. doi: 10.1080/15476286.2016.1211225
Uniprot ID:	Q92804
Gene ID:	8148
Gene symbol:	TAF15
Release Date:	Sep-19

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Product Search Results: Anti-taf15

Product Search Results: Anti-taf15

Anti-TAF15 Antibody

Anti-TAF15 Antibody