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Product Search Results: AB19-10126

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Product Search Results: AB19-10126

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Newmarket Scientific - NS Reagents AB19-10126-50ug 50 µg £220.00
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Product Detail: Anti-CDK5 Antibody (NSR-256)
Background Info: Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine-threonine kinase belonging to the Cdc2/Cdk1 family that regulates various neuronal processes such as neurogenesis, neuronal migration, and axon guidance. It is essential for the development of the central nervous system, being highly expressed in the brain. Cdk5 is controlled by the neural specific activators p35, p39. Outside of the nervous system CDK5 regulates vesicular transport, apoptosis, cell adhesion, and migration in many cell types.

Cdk5 has been implicated in the pathology of multiple types of cancers and is a potential target for Glioblastoma. Deregulation of Cdk5 is also linked to neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), and Hungtington's disease (HD) and additionally it has been proposed that Cdk5 modulates the brain reward system and therefore it has consequently also been linked to psychiatric diseases.
Product Type: NS Reagents Antibody
Antibody Type: Monoclonal
Format: 50 µg in 50 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage Temp: 6 months: 4°C. Long-term storage: -20°C. Avoid multiple freeze and thaw cycles.
Host Animal: Mouse
Species Reactivity: Human, Mouse, Rat, Monkey
Expected Species: If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen: Partial length recombinant human CDK5 from the N-terminal region (expressed in E.coli)
Applications: WB ¦ ICC
Additional Info: If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Clone number: NSR-256
Antibody Isotype: IgG1
Application Details: WB 1:500. IHC 1:150.
Category: Primary Antibodies
Other names: LIS7, PSSALRE, Cyclin-dependent-like kinase 5, Cell division protein kinase 5, Serine/threonine-protein kinase PSSALRE, Tau protein kinase II catalytic subunit, CDKN5, TPKII Catalytic Subunit, Epididymis Secretory Sperm Binding Protein
Research Areas: Neuroscience
NS Reagents Product Area: Neuroscience
Molecular Weight: 33kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location: Cell junction Cell membrane, Nucleus, Postsynaptic cell membrane presynapse
Purification: Affinity purification
Uniprot ID: Q00535
Gene ID: 1020
Gene symbol: CDK5
Release Date: Nov-19