| Product Detail: |
Anti-Daxx Antibody (Polyclonal - Sera) |
| Background Info: |
Death-domain-associated protein (DAXX) is a transcription regulator, that interacts with proteins involved in transcriptional silencing, such as histone deacetylases (HDAC1 and HDAC2) and DNA methyltransferase DNMT1. It represses the activity of several transcriptional factors, including C/EBP beta, c-Met, Pax3, Ets1, p53, p73, p63, glucocorticoid receptor, androgen receptor, and SMAD4.
DAXX is a nuclear protein associated with the promyelocytic leukaemia nuclear body (PML-NB) and other subnuclear domains. It can be either a pro-apoptotic or an anti-apoptotic factor, depending on the cell type and context. Daxx is thought to play a role in the pathology of human diseases including cancer and neurodegenerative disorders. |
| Product Type: |
NS Reagents Antibody |
| Antibody Type: |
Polyclonal |
| Format: |
Sera with Sodium Azide |
| Storage Temp: |
6 months: 4°C. Long-term storage: -20°C. Avoid multiple freeze and thaw cycles. |
| Host Animal: |
Rabbit |
| Species Reactivity: |
Bovine, Dog, Human, Monkey, Rat, Dog, Cat, Pig, Sheep, Rabbit, Guinea pig |
| Expected Species: |
Mouse (single amino acid difference with the immunogen/human peptide sequence).
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you. |
| Immunogen: |
A synthetic peptide from the central region of Human Daxx |
| Applications: |
IP ¦ IHC ¦ WB |
| Data Sheet: |
PLEASE CLICK HERE TO DOWNLOAD |
| Additional Info: |
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you. |
| Antibody Isotype: |
IgG |
| Application Details: |
WB: 1:1000-1:2000
IHC (paraffin): 1:1000-1:5000
IHC (frozen): 1:1000-1:2000
IP: 1:50-1:200 |
| Category: |
Primary Antibodies |
| Other names: |
DAXX, DAP6, Death domain-associated protein 6, Fas-binding protein, ETS1-associated protein 1 |
| Research Areas: |
Transcription and Translation, DNA Damage and Methylation, Protein and Nucleic Acid Modification |
| NS Reagents Product Area: |
DNA & Protein Modification |
| Molecular Weight: |
82kDa (Intended as a general guide and does not allow for all isoforms and species variations) |
| Subcellular location: |
Nucleoplasm, PML body, nucleolus, cytoplasm, centromere |
| Purification: |
Sera |
| Uniprot ID: |
Q9UER7 |
| Gene ID: |
1616 |
| Gene symbol: |
DAXX |
| Release Date: |
Dec-17 |
