Ephrin type-B receptor 2 (EPHB2) is a member of the Eph receptor family of receptor tyrosine kinase transmembrane glycoproteins. These receptors are composed of an N-terminal glycosylated ligand-binding domain, a transmembrane region and an intracellular kinase domain. They bind ligands called ephrins on adjacent cells, leading to contact-dependent bidirectional signalling into neighbouring cells because both receptors and ligands are able to transduce a signalling cascade. Eph receptors are involved in many cellular processes including motility, division, and differentiation. Proteins of the EphB subgroup are distinguished from other members of the Eph receptor family by sequence homology and a preferential binding affinity for membrane-bound ephrin-B ligands. Allelic variants are associated with prostate and brain cancer susceptibility.
Rat, Chicken, Guinea Pig, Japanese quail, Bovine, Goat Rabbit, Sheep, Pig, Horse, Zebrafish, Cat, Dog
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human EPHB2 from the N-terminal half of the protein
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Ephrin type-B receptor 2 (EPHB2) is a member of the Eph receptor family of receptor tyrosine kinase transmembrane glycoproteins. These receptors are composed of an N-terminal glycosylated ligand-binding domain, a transmembrane region and an intracellular kinase domain. They bind ligands called ephrins on adjacent cells, leading to contact-dependent bidirectional signalling into neighbouring cells because both receptors and ligands are able to transduce a signalling cascade. Eph receptors are involved in many cellular processes including motility, division, and differentiation. Proteins of the EphB subgroup are distinguished from other members of the Eph receptor family by sequence homology and a preferential binding affinity for membrane-bound ephrin-B ligands. Allelic variants are associated with prostate and brain cancer susceptibility.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS containing 0.02% sodium azide.
Rat, Chicken, Guinea Pig, Japanese quail, Bovine, Goat Rabbit, Sheep, Pig, Horse, Zebrafish, Cat, Dog
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human EPHB2 from the N-terminal half of the protein
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
117kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Cell membrane, Cell projection, Single-pass type I membrane protein, axon, dendrite
Purification:
Affinity purification
Uniprot ID:
P29323
Gene ID:
2048
Gene symbol:
EPHB2
Release Date:
Oct-18
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