Mitochondrial serine protease HtrA2 is expressed as a 49-kDa proenzyme that is targeted to the mitochondrial intermembrane space. Full-length HtrA2 consists of five functional regions: an N-terminal mitochondrial localisation signal, a transmembrane segment, an inhibitor of apoptosis protein binding motif, a serine protease domain and a C-terminal PDZ domain. It is believed that the transmembrane anchor attaches the precursor protein to the mitochondrial inner membrane, where it undergoes maturation. The fully processed protein loses 133 amino acids from the N-terminal (the localisation signal and the transmembrane anchor), exposing an N-terminal inhibitor of apoptosis protein binding motif.
The protease activity of the HtrA2 is required for mitochondrial homeostasis and mutations inactivating HtrA2 have been linked to neurodegenerative disorders such as Parkinson's disease. Additionally HtrA2 released into the cytosol is involved in apoptosis.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the C-terminal region of human HTRA2
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:2000-5000. IHC 1:50-200.
Category:
Primary Antibodies
Other names:
HTRA2, MGCA8, OMI, PARK13, PRSS25, HtrA Serine Peptidase 2, High Temperature Requirement Protein A2, Serine Protease HTRA2 Mitochondrial, Omi Stress-Regulated Endoprotease, Serine Proteinase OMI, Protease Serine 25, EC 3.4.21.108, Epididymis Secretory Sperm Binding Protein, HtrA-Like Serine Protease 3
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
49kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Mitochondrial serine protease HtrA2 is expressed as a 49-kDa proenzyme that is targeted to the mitochondrial intermembrane space. Full-length HtrA2 consists of five functional regions: an N-terminal mitochondrial localisation signal, a transmembrane segment, an inhibitor of apoptosis protein binding motif, a serine protease domain and a C-terminal PDZ domain. It is believed that the transmembrane anchor attaches the precursor protein to the mitochondrial inner membrane, where it undergoes maturation. The fully processed protein loses 133 amino acids from the N-terminal (the localisation signal and the transmembrane anchor), exposing an N-terminal inhibitor of apoptosis protein binding motif.
The protease activity of the HtrA2 is required for mitochondrial homeostasis and mutations inactivating HtrA2 have been linked to neurodegenerative disorders such as Parkinson's disease. Additionally HtrA2 released into the cytosol is involved in apoptosis.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the C-terminal region of human HTRA2
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:2000-5000. IHC 1:50-200.
Category:
Primary Antibodies
Other names:
HTRA2, MGCA8, OMI, PARK13, PRSS25, HtrA Serine Peptidase 2, High Temperature Requirement Protein A2, Serine Protease HTRA2 Mitochondrial, Omi Stress-Regulated Endoprotease, Serine Proteinase OMI, Protease Serine 25, EC 3.4.21.108, Epididymis Secretory Sperm Binding Protein, HtrA-Like Serine Protease 3
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
49kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Mitochondrion intermembrane space
Purification:
Affinity purification
Uniprot ID:
O43464
Gene ID:
27429
Gene symbol:
HTRA2
Release Date:
Sep-19
Cookies:
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