Apoptosis inducing factor (AIFM1/AIF) is a mitochondrial flavoprotein that has a fundamental housekeeping role in mitochondrial bioenergetics. It is also involved in caspase-independent cell death, where following an apoptotic trigger, proteolysis of the membrane-tethered precursor AIF, causes AIF to translocate to the nucleus, where it participates in chromatin condensation and DNA degradation.
Mutations in the AIFM1 gene cause combined oxidative phosphorylation deficiency 6 (COXPD6), a severe mitochondrial encephalomyopathy and X-linked recessive Charcot-Marie-Tooth disease-4 (CMTX-4), a disorder resulting in neuropathy, and axonal and motor-sensory defects with deafness and mental retardation.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the N-terminal region of human AIFM1
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:3000.
Category:
Primary Antibodies
Other names:
AIF, CMT2D, CMTX4, COWCK, COXPD6, DFNX5, NADMR, NAMSD, PDCD8, Apoptosis Inducing Factor Mitochondria Associated 1, Apoptosis-Inducing Factor, Mitochondrion-Associated 1, Programmed Cell Death 8 (Apoptosis-Inducing Factor), Auditory Neuropathy, X-Linked Recessive 1, PDCD8, Neuropathy, Axonal, Motor-Sensory With Deafness And Mental Retardation (Cowchock Syndrome), Striatal Apoptosis-Inducing Factor, Testicular Secretory Protein Li
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
67kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Apoptosis inducing factor (AIFM1/AIF) is a mitochondrial flavoprotein that has a fundamental housekeeping role in mitochondrial bioenergetics. It is also involved in caspase-independent cell death, where following an apoptotic trigger, proteolysis of the membrane-tethered precursor AIF, causes AIF to translocate to the nucleus, where it participates in chromatin condensation and DNA degradation.
Mutations in the AIFM1 gene cause combined oxidative phosphorylation deficiency 6 (COXPD6), a severe mitochondrial encephalomyopathy and X-linked recessive Charcot-Marie-Tooth disease-4 (CMTX-4), a disorder resulting in neuropathy, and axonal and motor-sensory defects with deafness and mental retardation.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the N-terminal region of human AIFM1
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:3000.
Category:
Primary Antibodies
Other names:
AIF, CMT2D, CMTX4, COWCK, COXPD6, DFNX5, NADMR, NAMSD, PDCD8, Apoptosis Inducing Factor Mitochondria Associated 1, Apoptosis-Inducing Factor, Mitochondrion-Associated 1, Programmed Cell Death 8 (Apoptosis-Inducing Factor), Auditory Neuropathy, X-Linked Recessive 1, PDCD8, Neuropathy, Axonal, Motor-Sensory With Deafness And Mental Retardation (Cowchock Syndrome), Striatal Apoptosis-Inducing Factor, Testicular Secretory Protein Li
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
67kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Nucleus, Mitochondrion
Purification:
Affinity purification
Uniprot ID:
O95831
Gene ID:
9131
Gene symbol:
AIFM1
Release Date:
Sep-19
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