Newmarket Scientific Product Search Results for AB20-10132

Product Search Results: AB20-10132
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Product Search Results: AB20-10132	Num Products Matched: 2	2

Newmarket Scientific - NS Reagents

AB20-10132-50ug

50 µg

£220.00

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Product Detail:	Anti-Lipocalin-2 Antibody (Polyclonal)
Background Info:	Lipocalin-2 (LCN2) is a secreted glycoprotein involved in innate immunity that has roles in iron homeostasis, infection, and inflammation. It was originally identified as a major constituent of the neutrophil secondary granules, so it is also known as neutrophil gelatinase-associated lipocalin (NGAL). It is highly expressed in the central nervous system in response to injury and inflammation and has also been identified as a potential marker for Alzheimers disease. Increased levels of Lipocalin-2 have been seen in plasma from patients with mild cognitive impairment (MCI) and in CSF from patients with multiple sclerosis. Experimental models of Vascular dementia have shown that Lipocalin-2 mediates hippocampal damage and that decreased levels are associated with less white matter damage and cognitive decline.
Product Type:	NS Reagents Antibody
Antibody Type:	Polyclonal Antibody
Format:	50 µg in 50 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
Storage Temp:	6 months: 4°C. Long-term storage: -20°C. Avoid multiple freeze and thaw cycles.
Host Animal:	Rabbit
Species Reactivity:	Human
Expected Species:	If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:	A synthetic peptide from human LCN2
Applications:	WB ¦ IHC
Data Sheet:	PLEASE CLICK HERE TO DOWNLOAD
Additional Info:	If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:	IgG
Application Details:	WB 1:1000-5000. IHC 1:50-200.
Category:	Primary Antibodies
Other names:	24p3, MSFI, NGAL, p25, 25 kDa alpha-2-microglobulin-related subunit of MMP-9, Oncogene 24p3, Siderocalin, Lipocalin-2, LCN2
Research Areas:	Neuroscience
NS Reagents Product Area:	Neuroscience
Molecular Weight:	23kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:	Secreted, Cytosol
Purification:	Affinity purification
References:	Franc Llorens, Peter Hermann, Anna Villar-Piqué et al - Cerebrospinal fluid lipocalin 2 as a novel biomarker for the differential diagnosis of vascular dementia. Nat Commun. 2020; 11: 619.
Uniprot ID:	P80188
Gene ID:	3934
Gene symbol:	LCN2
Release Date:	Mar-20

Newmarket Scientific - NS Reagents

AB20-10132-100ug

100ug

£275.00

Please sign in or sign up to order this product online.

Product Detail:	Anti-Lipocalin-2 Antibody (Polyclonal)
Background Info:	Lipocalin-2 (LCN2) is a secreted glycoprotein involved in innate immunity that has roles in iron homeostasis, infection, and inflammation. It was originally identified as a major constituent of the neutrophil secondary granules, so it is also known as neutrophil gelatinase-associated lipocalin (NGAL). It is highly expressed in the central nervous system in response to injury and inflammation and has also been identified as a potential marker for Alzheimers disease. Increased levels of Lipocalin-2 have been seen in plasma from patients with mild cognitive impairment (MCI) and in CSF from patients with multiple sclerosis. Experimental models of Vascular dementia have shown that Lipocalin-2 mediates hippocampal damage and that decreased levels are associated with less white matter damage and cognitive decline.
Product Type:	NS Reagents Antibody
Antibody Type:	Polyclonal Antibody
Format:	100 µg in 100 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
Storage Temp:	6 months: 4°C. Long-term storage: -20°C. Avoid multiple freeze and thaw cycles.
Host Animal:	Rabbit
Species Reactivity:	Human
Expected Species:	If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:	A synthetic peptide from human LCN2
Applications:	WB ¦ IHC
Data Sheet:	PLEASE CLICK HERE TO DOWNLOAD
Additional Info:	If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:	IgG
Application Details:	WB 1:1000-5000. IHC 1:50-200.
Category:	Primary Antibodies
Other names:	24p3, MSFI, NGAL, p25, 25 kDa alpha-2-microglobulin-related subunit of MMP-9, Oncogene 24p3, Siderocalin, Lipocalin-2, LCN2
Research Areas:	Neuroscience
NS Reagents Product Area:	Neuroscience
Molecular Weight:	23kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:	Secreted, Cytosol
Purification:	Affinity purification
References:	Franc Llorens, Peter Hermann, Anna Villar-Piqué et al - Cerebrospinal fluid lipocalin 2 as a novel biomarker for the differential diagnosis of vascular dementia. Nat Commun. 2020; 11: 619.
Uniprot ID:	P80188
Gene ID:	3934
Gene symbol:	LCN2
Release Date:	Mar-20

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Product Search Results: AB20-10132

Product Search Results: AB20-10132

Anti-Lipocalin-2 Antibody

Anti-Lipocalin-2 Antibody