Newmarket Scientific Product Search Results for AB21-10139

Product Search Results: AB21-10139
Num Products Matched:
Product Search Results: AB21-10139	Num Products Matched: 2	2

Newmarket Scientific - NS Reagents

AB21-10139-50ug

50 µg

£225.00

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Product Detail:	Anti-PLCG2 Antibody (Polyclonal)
Background Info:	Phospholipase C-gamma2 (PLCG2) PLCG2 is an enzyme mainly expressed in immune cells (including microglia) which are involved in innate immunity. It is involved in the transmembrane transduction of immune signals that determine the fate and function of various immune cell types. PLCG2 has higher expression levels in pathologically afected brain regions in Alzheimers disease indicating that the immune system may play a key role in the development of Alzheimers disease and a polymorphism in phospholipase C-gamma 2 (PLCG2) has been reported to be protective against late onset Alzheimers disease (LOAD) [1].
Product Type:	NS Reagents Antibody
Antibody Type:	Polyclonal Antibody
Format:	50 µg in 50 µl Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
Storage Temp:	Store at -20°C. Avoid freeze / thaw cycles.
Host Animal:	Rabbit
Species Reactivity:	Human, Mouse, Rat
Expected Species:	Cat, Dog, Chimpanzee, Pig, Bovine
Immunogen:	Partial length recombinant human PLCG2 from the N-terminal region
Applications:	WB IHC IF
Data Sheet:	PLEASE CLICK HERE TO DOWNLOAD
Additional Info:	If you would like further information regarding the immunogen used in the production of this antibody or have a query about if this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:	IgG
Application Details:	WB 1:500-2000. IHC 1:50-200. IF 1:20-100.
Category:	Primary Antibodies
Other names:	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2, Phospholipase C-IV, PLC-IV, Phospholipase C-gamma-2, PLC-gamma-2
Research Areas:	Neuroscience
NS Reagents Product Area:	Neuroscience
Molecular Weight:	148kDa
Subcellular location:	Secreted/Extracellular region, Plasma Membrane
Purification:	Affinity purification
References:	[1] Sims R, van der Lee SJ, Naj AC, Bellenguez C, Badarinarayan N, Jakobsdottir J et al (2017) Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimers disease. Nat Genet 49:13731384.
Uniprot ID:	P16885
Gene ID:	5336
Gene symbol:	PLCG2
Release Date:	Apr-21

Newmarket Scientific - NS Reagents

AB21-10139-100ug

100 µg

£295.00

Please sign in or sign up to order this product online.

Product Detail:	Anti-PLCG2 Antibody (Polyclonal)
Background Info:	Phospholipase C-gamma2 (PLCG2) PLCG2 is an enzyme mainly expressed in immune cells (including microglia) which are involved in innate immunity. It is involved in the transmembrane transduction of immune signals that determine the fate and function of various immune cell types. PLCG2 has higher expression levels in pathologically afected brain regions in Alzheimers disease indicating that the immune system may play a key role in the development of Alzheimers disease and a polymorphism in phospholipase C-gamma 2 (PLCG2) has been reported to be protective against late onset Alzheimers disease (LOAD) [1].
Product Type:	NS Reagents Antibody
Antibody Type:	Polyclonal Antibody
Format:	100 µg in 100 µl Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
Storage Temp:	Store at -20°C. Avoid freeze / thaw cycles.
Host Animal:	Rabbit
Species Reactivity:	Human, Mouse, Rat
Expected Species:	Cat, Dog, Chimpanzee, Pig, Bovine
Immunogen:	Partial length recombinant human PLCG2 from the N-terminal region
Applications:	WB IHC IF
Data Sheet:	PLEASE CLICK HERE TO DOWNLOAD
Additional Info:	If you would like further information regarding the immunogen used in the production of this antibody or have a query about if this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:	IgG
Application Details:	WB 1:500-2000. IHC 1:50-200. IF 1:20-100.
Category:	Primary Antibodies
Other names:	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2, Phospholipase C-IV, PLC-IV, Phospholipase C-gamma-2, PLC-gamma-2
Research Areas:	Neuroscience
NS Reagents Product Area:	Neuroscience
Molecular Weight:	148kDa
Subcellular location:	Secreted/Extracellular region, Plasma Membrane
Purification:	Affinity purification
References:	[1] Sims R, van der Lee SJ, Naj AC, Bellenguez C, Badarinarayan N, Jakobsdottir J et al (2017) Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimers disease. Nat Genet 49:13731384.
Uniprot ID:	P16885
Gene ID:	5336
Gene symbol:	PLCG2
Release Date:	Apr-21

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Product Search Results: AB21-10139

Product Search Results: AB21-10139

Anti-PLCG2 Antibody

Anti-PLCG2 Antibody