Optineurin (OPTN) is an autophagy receptor that interacts with numerous proteins. It is involved in regulating many cellular functions, including vesicular trafficking from the Golgi to plasma membrane, endocytic trafficking, and signaling leading to NF-kappa-B (see 164011) activation [1]
Optineurin has been shown to interact with huntingtin [2], transcription factor IIIA [3], and RAB8 [4] and may therefore function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation. Alternative splicing of the gene results in multiple transcript variants encoding the same protein.
Optineurin mutations are associated with Glaucoma and Amyotrophic lateral sclerosis (ALS).
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
[1] Vaibhava, V., Nagabhushana, A., Chalasani, M. L. S., Sudhakar, C., Kumari, A., Swarup, G. Optineurin mediates a negative regulation of Rab8 by the GTPase-activating protein TBC1D17. J. Cell Sci. 125: 5026-5039, 2012. [2]Faber, P. W., Barnes, G. T., Srinidhi, J., Chen, J., Gusella, J. F., MacDonald, M. E. Huntingtin interacts with a family of WW domain proteins. Hum. Molec. Genet. 7: 1463-1474, 1998. [3] Moreland, R. J., Dresser, M. E., Rodgers, J. S., Roe, B. A., Conaway, J. W., Conaway, R. C., Hanas, J. S. Identification of a transcription factor IIIA-interacting protein. Nucleic Acids Res. 28: 1986-1993, 2000. [4] Hattula, K., Peranen, J. FIP-2, a coiled-coil protein, links huntingtin to Rab8 and modulates cellular morphogenesis. Curr. Biol. 10: 1603-1606, 2000.
Optineurin (OPTN) is an autophagy receptor that interacts with numerous proteins. It is involved in regulating many cellular functions, including vesicular trafficking from the Golgi to plasma membrane, endocytic trafficking, and signaling leading to NF-kappa-B (see 164011) activation [1]
Optineurin has been shown to interact with huntingtin [2], transcription factor IIIA [3], and RAB8 [4] and may therefore function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation. Alternative splicing of the gene results in multiple transcript variants encoding the same protein.
Optineurin mutations are associated with Glaucoma and Amyotrophic lateral sclerosis (ALS).
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS containing 0.02% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
[1] Vaibhava, V., Nagabhushana, A., Chalasani, M. L. S., Sudhakar, C., Kumari, A., Swarup, G. Optineurin mediates a negative regulation of Rab8 by the GTPase-activating protein TBC1D17. J. Cell Sci. 125: 5026-5039, 2012. [2]Faber, P. W., Barnes, G. T., Srinidhi, J., Chen, J., Gusella, J. F., MacDonald, M. E. Huntingtin interacts with a family of WW domain proteins. Hum. Molec. Genet. 7: 1463-1474, 1998. [3] Moreland, R. J., Dresser, M. E., Rodgers, J. S., Roe, B. A., Conaway, J. W., Conaway, R. C., Hanas, J. S. Identification of a transcription factor IIIA-interacting protein. Nucleic Acids Res. 28: 1986-1993, 2000. [4] Hattula, K., Peranen, J. FIP-2, a coiled-coil protein, links huntingtin to Rab8 and modulates cellular morphogenesis. Curr. Biol. 10: 1603-1606, 2000.
Sequestosome-1 (SQSTM1) is an autophagy receptor that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. SQSTM1 functions as a scaffolding/adaptor protein with TNF receptor-associated factor 6 (TRAF6). Mutations in SQSTM1 are also observed in familial ALS cases associated with aberrant TDP-43 inclusions and additionally mutations in SQSTM1 may result in Paget disease of bone. SQSTM1 may also be involved in cell differentiation, apoptosis, immune response and regulation of K+ channels.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the C-terminal region of Human Sequestosome-1 (SQSTM1)
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:3000.
Category:
Primary Antibodies
Other names:
Sequestosome-1, A170, DMRV, FTDALS3, NADGP, OSIL, p60, p62, p62B, PDB3, ZIP3, A170, FTDALS3, OSIL, p60, p62, p62B, PDB3, ZIP3, EBI3-associated protein of 60 kDa, EBIAP, Ubiquitin-binding protein p62
Sequestosome-1 (SQSTM1) is an autophagy receptor that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. SQSTM1 functions as a scaffolding/adaptor protein with TNF receptor-associated factor 6 (TRAF6). Mutations in SQSTM1 are also observed in familial ALS cases associated with aberrant TDP-43 inclusions and additionally mutations in SQSTM1 may result in Paget disease of bone. SQSTM1 may also be involved in cell differentiation, apoptosis, immune response and regulation of K+ channels.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the C-terminal region of Human Sequestosome-1 (SQSTM1)
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:3000.
Category:
Primary Antibodies
Other names:
Sequestosome-1, A170, DMRV, FTDALS3, NADGP, OSIL, p60, p62, p62B, PDB3, ZIP3, A170, FTDALS3, OSIL, p60, p62, p62B, PDB3, ZIP3, EBI3-associated protein of 60 kDa, EBIAP, Ubiquitin-binding protein p62
Sequestosome-1 (SQSTM1) is an autophagy receptor that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. SQSTM1 functions as a scaffolding/adaptor protein with TNF receptor-associated factor 6 (TRAF6). Mutations in SQSTM1 are also observed in familial ALS cases associated with aberrant TDP-43 inclusions and additionally mutations in SQSTM1 may result in Paget disease of bone. SQSTM1 may also be involved in cell differentiation, apoptosis, immune response and regulation of K+ channels.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000. IHC 1:50-200. IF 1:50-200. IP 1:50-100.
Category:
Primary Antibodies
Other names:
Sequestosome-1, A170, DMRV, FTDALS3, NADGP, OSIL, p60, p62, p62B, PDB3, ZIP3, A170, FTDALS3, OSIL, p60, p62, p62B, PDB3, ZIP3, EBI3-associated protein of 60 kDa, EBIAP, Ubiquitin-binding protein p62
Sequestosome-1 (SQSTM1) is an autophagy receptor that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. SQSTM1 functions as a scaffolding/adaptor protein with TNF receptor-associated factor 6 (TRAF6). Mutations in SQSTM1 are also observed in familial ALS cases associated with aberrant TDP-43 inclusions and additionally mutations in SQSTM1 may result in Paget disease of bone. SQSTM1 may also be involved in cell differentiation, apoptosis, immune response and regulation of K+ channels.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS containing 0.02% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000. IHC 1:50-200. IF 1:50-200. IP 1:50-100.
Category:
Primary Antibodies
Other names:
Sequestosome-1, A170, DMRV, FTDALS3, NADGP, OSIL, p60, p62, p62B, PDB3, ZIP3, A170, FTDALS3, OSIL, p60, p62, p62B, PDB3, ZIP3, EBI3-associated protein of 60 kDa, EBIAP, Ubiquitin-binding protein p62
Ubiquilin-2 (UBQLN2) is a 624-amino acid multi-domain adaptor protein and a member of the ubiquilin family of proteins that regulate the degradation of ubiquitinated proteins by the ubiquitin-proteasome system (UPS), autophagy and the endoplasmic reticulum-associated protein degradation (ERAD) pathway. Ubiquilins are characterised by the presence of an N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. The central portion is highly variable.
UBQLN2 Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding to their polyubiquitin chains, through the ubiquitin-associated domain (UBA) and by interacting with the subunits of the proteasome through the ubiquitin-like domain (ULD).
Mutations in UBQLN2 are associated with Amyotrophic Lateral Sclerosis with most ALS-linked mutations localised to the proline-rich repeat (Pxx) region that is unique to ubiquilin-2 and not present in the other members of the ubiquilin protein family. UBQLN2 has also been shown to bind the ATPase domain of the Hsp70-like Stch protein. Mutations in UBQLN2 are also observed in familial ALS (FALS) cases associated with aberrant TDP-43 inclusions.
Rat, Golden hamster, Guinea Pig, Pig, Horse, Ord's kangaroo rat, Cat, Dog
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human UBQLN2 from the N-terminal region
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Ubiquilin-2 (UBQLN2) is a 624-amino acid multi-domain adaptor protein and a member of the ubiquilin family of proteins that regulate the degradation of ubiquitinated proteins by the ubiquitin-proteasome system (UPS), autophagy and the endoplasmic reticulum-associated protein degradation (ERAD) pathway. Ubiquilins are characterised by the presence of an N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. The central portion is highly variable.
UBQLN2 Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding to their polyubiquitin chains, through the ubiquitin-associated domain (UBA) and by interacting with the subunits of the proteasome through the ubiquitin-like domain (ULD).
Mutations in UBQLN2 are associated with Amyotrophic Lateral Sclerosis with most ALS-linked mutations localised to the proline-rich repeat (Pxx) region that is unique to ubiquilin-2 and not present in the other members of the ubiquilin protein family. UBQLN2 has also been shown to bind the ATPase domain of the Hsp70-like Stch protein. Mutations in UBQLN2 are also observed in familial ALS (FALS) cases associated with aberrant TDP-43 inclusions.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS containing 0.02% sodium azide.
Rat, Golden hamster, Guinea Pig, Pig, Horse, Ord's kangaroo rat, Cat, Dog
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human UBQLN2 from the N-terminal region
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Mitofusin-2 (MFN2) is a mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion and contributes to the maintenance and operation of the mitochondrial network. MFN2 is involved in the regulation of vascular smooth muscle cell proliferation, and it may play a role in the pathophysiology of obesity. Mutations in this gene cause Charcot-Marie-Tooth disease type 2A2, and hereditary motor and sensory neuropathy VI, which are both disorders of the peripheral nervous system. Defects in this gene have also been associated with early-onset stroke.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
Mouse, Rat, Rabbit, Chicken, Guinea Pig, Chinese Hamster, Cat, Rainbow Trout, Turbot, Naked Mole Rat, Cuckoo and many other species
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide of 13 aa taken from human MFN2 between aa 100 and 300
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Mitofusin-2 (MFN2) is a mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion and contributes to the maintenance and operation of the mitochondrial network. MFN2 is involved in the regulation of vascular smooth muscle cell proliferation, and it may play a role in the pathophysiology of obesity. Mutations in this gene cause Charcot-Marie-Tooth disease type 2A2, and hereditary motor and sensory neuropathy VI, which are both disorders of the peripheral nervous system. Defects in this gene have also been associated with early-onset stroke.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
Mouse, Rat, Rabbit, Chicken, Guinea Pig, Chinese Hamster, Cat, Rainbow Trout, Turbot, Naked Mole Rat, Cuckoo and many other species
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide of 13 aa taken from human MFN2 between aa 100 and 300
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Fragile X Mental Retardation 1 (FRM1) is an RNA binding protein that plays a central role in neuronal development and synaptic plasticity through the regulation of alternative mRNA splicing, mRNA stability, mRNA dendritic transport and postsynaptic local protein synthesis of a subset of mRNAs.
A trinucleotide repeat (CGG) in the gene encoding this protein is normally found at 6-53 copies, but an expansion to 55-230 repeats is the cause of fragile X syndrome. Expansion of the trinucleotide repeat may also cause one form of premature ovarian failure (POF1). Multiple alternatively spliced transcript variants that encode different protein isoforms and which are located in different cellular locations have also been described for this gene.
FRM1 has been shown to play a translation-independent role in the modulation of presynaptic action potential (AP) duration and neurotransmitter release via large-conductance calcium-activated potassium (BK) channels in hippocampal and cortical excitatory neurons [1]. FMR1 may be involved in the control of DNA damage response (DDR) mechanisms through the regulation of ATR-dependent signaling pathways such as histone H2AFX/H2A.x and BRCA1 phosphorylations [2].
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human FMR1 from the N-terminal region of the protein
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Fragile X Mental Retardation 1 (FRM1) is an RNA binding protein that plays a central role in neuronal development and synaptic plasticity through the regulation of alternative mRNA splicing, mRNA stability, mRNA dendritic transport and postsynaptic local protein synthesis of a subset of mRNAs.
A trinucleotide repeat (CGG) in the gene encoding this protein is normally found at 6-53 copies, but an expansion to 55-230 repeats is the cause of fragile X syndrome. Expansion of the trinucleotide repeat may also cause one form of premature ovarian failure (POF1). Multiple alternatively spliced transcript variants that encode different protein isoforms and which are located in different cellular locations have also been described for this gene.
FRM1 has been shown to play a translation-independent role in the modulation of presynaptic action potential (AP) duration and neurotransmitter release via large-conductance calcium-activated potassium (BK) channels in hippocampal and cortical excitatory neurons [1]. FMR1 may be involved in the control of DNA damage response (DDR) mechanisms through the regulation of ATR-dependent signaling pathways such as histone H2AFX/H2A.x and BRCA1 phosphorylations [2].
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS containing 0.02% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human FMR1 from the N-terminal region of the protein
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Glucagon-like peptide-1 receptor (GLP1R) is a 7-transmembrane receptor protein found on beta cells of the pancreas. It functions as a receptor for glucagon-like peptide 1 (GLP-1) hormone, which stimulates glucose-induced insulin secretion. GLP1R functions at the cell surface and becomes internalised in response to GLP-1 and GLP-1 analogs, playing an important role in the signalling cascades leading to insulin secretion. It is a member of the glucagon receptor family of G protein-coupled receptors [1]. GLP1R is composed of two domains, an extracellular domain that binds the C-terminal helix of GLP-1 [2], and a transmembrane domain [3] that binds the N-terminal region of GLP-1 [4][5][6].
GLP1R also displays neuroprotective effects in animal models. Polymorphisms in this gene are associated with diabetes, making it an important drug target for the treatment of type 2 diabetes. Alternative splicing of the GLP1R gene results in multiple transcript variants.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the N-terminal region of Human GLP1R
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
53kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Cell membrane, Multi-pass membrane protein
Purification:
Affinity purification
References:
1. Brubaker PL, Drucker DJ (2002). "Structure-function of the glucagon receptor family of the G protein-coupled receptors: the glucagon, GIP, GLP-1, and GLP-2 receptors". Recept. Channels. 8 (34): 17988.
2. Underwood CR, Garibay P, Knudsen LB, Hastrup S, Peters GH, Rudolph R, Reedtz-Runge S (June 2010). "Crystal structure of glucagon-like peptide-1 in complex with the extracellular domain of the glucagon-like peptide-1 receptor". Journal of Biological Chemistry. 285 (1): 723730.
3. Song G, Yang D, Wang Y, de Graaf C, Zhou Q, Jiang S, Liu K, Cai X, Dai A, Lin G, Liu D, Wu F, Wu Y, Zhao S, Ye L, Han GW, Lau J, Wu B, Hanson MA, Liu ZJ, Wang MW, Stevens RC (2017). "Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators)". Nature. 546: 312315.
4. Wooten D, Reynolds CA, Koole C, Smith KJ, Mobarec JC, Simms J, Quon T, Coudrat T, Furness SG, Miller LJ, Christopolous A, Sexton PM (March 2016). "A Hydrogen-Bonded Polar Network in the Core of the Glucagon-Like Peptide-1 Receptor Is a Fulcrum for Biased Agonism: Lessons from Class B Crystal Structures". Molecular Pharmacology. 89 (3): 335347.
5. Wooten D, Reynolds CA, Smith KJ, Mobarec JC, Koole C, Savage EE, Pabreja K, Simms J, Sridhar R, Furness SG, Liu M, Thompson PE, Miller LJ, Christopolous A, Sexton PM (June 2016). "The extracellular surface of the GLP-1 receptor is a molecular trigger for biased agonism". Cell. 165 (7): 16321643.
6. Yang D, de Graaf C, Yang L, Song G, Dai A, Cai X, Feng Y, Reedtz-Runge S, Hanson MA, Yang H, Jiang H, Stevens RC, Wang MW (June 2016). "Structural Determinants of Binding the Seven-transmembrane Domain of the Glucagon-like Peptide-1 Receptor (GLP-1R)". Journal of Biological Chemistry. 291 (25): 129913004.
7. Wooten D, Reynolds CA, Smith KJ, Mobarec JC, Furness SG, Miller LJ, Christopolous A, Sexton PM (August 2016). "Key interactions by conserved polar amino acids located at the transmembrane helical boundaries in Class B GPCRs modulate activation, effector specificity and biased signalling in the glucagon-like peptide-1 receptor". Biochemical Pharmacology. 118: 6887.
Glucagon-like peptide-1 receptor (GLP1R) is a 7-transmembrane receptor protein found on beta cells of the pancreas. It functions as a receptor for glucagon-like peptide 1 (GLP-1) hormone, which stimulates glucose-induced insulin secretion. GLP1R functions at the cell surface and becomes internalised in response to GLP-1 and GLP-1 analogs, playing an important role in the signalling cascades leading to insulin secretion. It is a member of the glucagon receptor family of G protein-coupled receptors [1]. GLP1R is composed of two domains, an extracellular domain that binds the C-terminal helix of GLP-1 [2], and a transmembrane domain [3] that binds the N-terminal region of GLP-1 [4][5][6].
GLP1R also displays neuroprotective effects in animal models. Polymorphisms in this gene are associated with diabetes, making it an important drug target for the treatment of type 2 diabetes. Alternative splicing of the GLP1R gene results in multiple transcript variants.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS containing 0.02% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the N-terminal region of Human GLP1R
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
53kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Cell membrane, Multi-pass membrane protein
Purification:
Affinity purification
References:
1. Brubaker PL, Drucker DJ (2002). "Structure-function of the glucagon receptor family of the G protein-coupled receptors: the glucagon, GIP, GLP-1, and GLP-2 receptors". Recept. Channels. 8 (34): 17988.
2. Underwood CR, Garibay P, Knudsen LB, Hastrup S, Peters GH, Rudolph R, Reedtz-Runge S (June 2010). "Crystal structure of glucagon-like peptide-1 in complex with the extracellular domain of the glucagon-like peptide-1 receptor". Journal of Biological Chemistry. 285 (1): 723730.
3. Song G, Yang D, Wang Y, de Graaf C, Zhou Q, Jiang S, Liu K, Cai X, Dai A, Lin G, Liu D, Wu F, Wu Y, Zhao S, Ye L, Han GW, Lau J, Wu B, Hanson MA, Liu ZJ, Wang MW, Stevens RC (2017). "Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators)". Nature. 546: 312315.
4. Wooten D, Reynolds CA, Koole C, Smith KJ, Mobarec JC, Simms J, Quon T, Coudrat T, Furness SG, Miller LJ, Christopolous A, Sexton PM (March 2016). "A Hydrogen-Bonded Polar Network in the Core of the Glucagon-Like Peptide-1 Receptor Is a Fulcrum for Biased Agonism: Lessons from Class B Crystal Structures". Molecular Pharmacology. 89 (3): 335347.
5. Wooten D, Reynolds CA, Smith KJ, Mobarec JC, Koole C, Savage EE, Pabreja K, Simms J, Sridhar R, Furness SG, Liu M, Thompson PE, Miller LJ, Christopolous A, Sexton PM (June 2016). "The extracellular surface of the GLP-1 receptor is a molecular trigger for biased agonism". Cell. 165 (7): 16321643.
6. Yang D, de Graaf C, Yang L, Song G, Dai A, Cai X, Feng Y, Reedtz-Runge S, Hanson MA, Yang H, Jiang H, Stevens RC, Wang MW (June 2016). "Structural Determinants of Binding the Seven-transmembrane Domain of the Glucagon-like Peptide-1 Receptor (GLP-1R)". Journal of Biological Chemistry. 291 (25): 129913004.
7. Wooten D, Reynolds CA, Smith KJ, Mobarec JC, Furness SG, Miller LJ, Christopolous A, Sexton PM (August 2016). "Key interactions by conserved polar amino acids located at the transmembrane helical boundaries in Class B GPCRs modulate activation, effector specificity and biased signalling in the glucagon-like peptide-1 receptor". Biochemical Pharmacology. 118: 6887.
Uniprot ID:
P43220
Gene ID:
2740
Gene symbol:
GLP1R
Release Date:
Oct-18
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