The NSR Prestained Protein Ladder is a three colour protein standard with 13 prestained proteins covering molecular weights from 3.5 to 245 kilodaltons. It has been designed for use in most general applications for a protein ladder with a broad range of protein sizes, key reference bands and excellent Western transfer efficiency (tested with PVDF, nylon and nitrocellulose membranes).
Background Info:
Most of the proteins are covalently coupled with a blue chromophore apart from two reference bands, one stained red at 75 kDa and one stained green at 25 kDa for easy reading of the ladder and to aid in the monitoring of protein separation.
The NSR Prestained Protein Ladder is supplied ready to use in gel loading buffer.
PLEASE E-MAIL US TO REQUEST A FREE SAMPLE.
Arrange for our Protein ladder to be in your stores and receive a free vial. Email us for more details - tech@nktscientific.com.
Product Type:
NS Reagents Protein Ladder
Format:
Buffer: 20 mM Tris-phosphate, pH 7.5, 2% SDS, 0.2 mM Dithiothreitol, 3.6 M Urea, 15 % (v/v) Glycerol.
Storage Temp:
Store at 25°C, for 2 weeks or 4°C for 3 months. For long-term storage, store at -20°C.
The shelf life is 1 year from receipt when stored frozen, however the NSR Prestained Protein Ladder should be stable for many years if stored frozen and excessive freeze thaw cycles are avoided.
The fragments in our 50bp ladder range from 50-1,500 base pairs, with the 200, 500 and 1,200 base pair bands having increased intensity to act as key reference points. There are 17 bands in total.
The expected mass of DNA in each band (based on a total of 0.56 ug in a 5ul load) is provided for approximating the mass of DNA in sample bands of a similar size.
Our DNA ladders are a combination of a plasmid digested DNA and PCR products, providing precise fragments.
PLEASE E-MAIL US TO REQUEST A FREE SAMPLE. .
Arrange for our DNA ladders to be in your stores and receive 5 vials of any of our DNA ladders for free. Email us for more details - tech@nktscientific.com.
Background Info:
Our 50bp ladder is provided ready to use with orange G as the tracking dye.
Product Type:
NS Reagents DNA Ladder
Format:
Buffer: 10mM Tris-HCl (pH 8.0) and 10mM EDTA
Storage Temp:
Store at 25°C, for 6 months or 4°C for a year. For long-term storage, store at -20°C.
The fragments in our 50bp ladder range from 50-1,500 base pairs, with the 200, 500 and 1,200 base pair bands having increased intensity to act as key reference points. There are 17 bands in total.
The expected mass of DNA in each band (based on a total of 0.56 ug in a 5ul load) is provided for approximating the mass of DNA in sample bands of a similar size.
Our DNA ladders are a combination of a plasmid digested DNA and PCR products, providing precise fragments.
PLEASE E-MAIL US TO REQUEST A FREE SAMPLE. .
Arrange for our DNA ladders to be in your stores and receive 5 vials of any of our DNA ladders for free. Email us for more details - tech@nktscientific.com.
Background Info:
Our 50bp ladder is provided ready to use with orange G as the tracking dye.
Product Type:
NS Reagents DNA Ladder
Format:
Buffer: 10mM Tris-HCl (pH 8.0) and 10mM EDTA
Storage Temp:
Store at 25°C, for 6 months or 4°C for a year. For long-term storage, store at -20°C.
The fragments in our 1Kbp ladder range from 250-10,000 base pairs, with the 1K and 3K base pair bands having increased intensity to act as key reference points. There are 13 bands in total.
The expected mass of DNA in each band (based on a total of 0.5 ug in a 5ul load) is provided for approximating the mass of DNA in sample bands of a similar size.
Our DNA ladders are a combination of a plasmid digested DNA and PCR products, providing precise fragments.
PLEASE E-MAIL US TO REQUEST A FREE SAMPLE. .
Arrange for our DNA ladders to be in your stores and receive 5 vials of any of our DNA ladders for free. Email us for more details - tech@nktscientific.com.
Background Info:
Our 1Kbp ladder is provided ready to use with bromophenol blue & xylene cyanol FF included as tracking dyes.
Product Type:
NS Reagents DNA Ladder
Format:
Buffer: 10mM Tris-HCl (pH 8.0) and 10mM EDTA
Storage Temp:
Store at 25°C, for 6 months or 4°C for a year. For long-term storage, store at -20°C.
The fragments in our 1Kbp ladder range from 250-10,000 base pairs, with the 1K and 3K base pair bands having increased intensity to act as key reference points. There are 13 bands in total.
The expected mass of DNA in each band (based on a total of 0.5 ug in a 5ul load) is provided for approximating the mass of DNA in sample bands of a similar size.
Our DNA ladders are a combination of a plasmid digested DNA and PCR products, providing precise fragments.
PLEASE E-MAIL US TO REQUEST A FREE SAMPLE.
Arrange for our DNA ladders to be in your stores and receive 5 vials of any of our DNA ladders for free. Email us for more details - tech@nktscientific.com.
Background Info:
Our 1Kbp ladder is provided ready to use with bromophenol blue & xylene cyanol FF included as tracking dyes.
Product Type:
NS Reagents DNA Ladder
Format:
Buffer: 10mM Tris-HCl (pH 8.0) and 10mM EDTA
Storage Temp:
Store at 25°C, for 6 months or 4°C for a year. For long-term storage, store at -20°C.
The fragments in our 100bp ladder range from 100-1,500 base pairs, with the 500 and 1,500 base pair bands having increased intensity to act as key reference points. There are 11 bands in total.
The expected mass of DNA in each band (based on a total of 0.5 ug in a 5ul load) is provided for approximating the mass of DNA in sample bands of a similar size.
Our DNA ladders are a combination of a plasmid digested DNA and PCR products, providing precise fragments.
PLEASE E-MAIL US TO REQUEST A FREE SAMPLE. .
Arrange for our DNA ladders to be in your stores and receive 5 vials of any of our DNA ladders for free. Email us for more details - tech@nktscientific.com.
Background Info:
Our 100bp ladder is provided ready to use with orange G & xylene cyanol FF included as tracking dyes.
Product Type:
NS Reagents DNA Ladder
Format:
Buffer: 10mM Tris-HCl (pH 8.0) and 10mM EDTA
Storage Temp:
Store at 25°C, for 6 months or 4°C for a year. For long-term storage, store at -20°C.
The fragments in our 100bp ladder range from 100-1,500 base pairs, with the 500 and 1,500 base pair bands having increased intensity to act as key reference points. There are 11 bands in total.
The expected mass of DNA in each band (based on a total of 0.5 ug in a 5ul load) is provided for approximating the mass of DNA in sample bands of a similar size.
Our DNA ladders are a combination of a plasmid digested DNA and PCR products, providing precise fragments.
PLEASE E-MAIL US TO REQUEST A FREE SAMPLE.
Arrange for our DNA ladders to be in your stores and receive 5 vials of any of our DNA ladders for free. Email us for more details - tech@nktscientific.com.
Background Info:
Our 100bp ladder is provided ready to use with orange G & xylene cyanol FF included as tracking dyes.
Product Type:
NS Reagents DNA Ladder
Format:
Buffer: 10mM Tris-HCl (pH 8.0) and 10mM EDTA
Storage Temp:
Store at 25°C, for 6 months or 4°C for a year. For long-term storage, store at -20°C.
Superoxide dismutase 1 (SOD1) is one of three superoxide dismutases with SOD1 being the principal cytoplasmic superoxide dismutase in humans. It binds copper and zinc ions for its activity and stability and plays a major role in redox potential regulation. It catalyses the transformation of the superoxide anion (O2?) into hydrogen peroxide. SOD1 variants are a common cause of familial amyotrophic lateral sclerosis (ALS).
The Immunogen for this antibody is taken from a region of very high sequence conservation within the Zn-binding loop.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the Zn-binding loop of Human SOD1
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:3000.
Category:
Primary Antibodies
Other names:
hSod1, ALS, ALS1, SODC, SOD2
Research Areas:
Neuroscience, Amyotrophic lateral sclerosis
NS Reagents Product Area:
Neuroscience
Molecular Weight:
16kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Superoxide dismutase 1 (SOD1) is one of three superoxide dismutases with SOD1 being the principal cytoplasmic superoxide dismutase in humans. It binds copper and zinc ions for its activity and stability and plays a major role in redox potential regulation. It catalyses the transformation of the superoxide anion (O2?) into hydrogen peroxide. SOD1 variants are a common cause of familial amyotrophic lateral sclerosis (ALS).
The Immunogen for this antibody is taken from a region of very high sequence conservation within the Zn-binding loop.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the Zn-binding loop of Human SOD1
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Phospholipase C-gamma2 (PLCG2) PLCG2 is an enzyme mainly expressed in immune cells (including microglia) which are involved in innate immunity. It is involved in the transmembrane transduction of immune signals that determine the fate and function of various immune cell types.
PLCG2 has higher expression levels in pathologically afected brain regions in Alzheimers disease indicating that the immune system may play a key role in the development of Alzheimers disease and a polymorphism in phospholipase C-gamma 2 (PLCG2) has been reported to be protective against late onset Alzheimers disease (LOAD) [1].
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal Antibody
Format:
50 µg in 50 µl Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
Storage Temp:
Store at -20°C. Avoid freeze / thaw cycles.
Host Animal:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Expected Species:
Cat, Dog, Chimpanzee, Pig, Bovine
Immunogen:
Partial length recombinant human PLCG2 from the N-terminal region
If you would like further information regarding the immunogen used in the production of this antibody or have a query about if this antibody will bind to your protein/species please contact us and we can do the analysis for you.
[1] Sims R, van der Lee SJ, Naj AC, Bellenguez C, Badarinarayan N, Jakobsdottir J et al (2017) Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimers disease. Nat Genet 49:13731384.
Phospholipase C-gamma2 (PLCG2) PLCG2 is an enzyme mainly expressed in immune cells (including microglia) which are involved in innate immunity. It is involved in the transmembrane transduction of immune signals that determine the fate and function of various immune cell types.
PLCG2 has higher expression levels in pathologically afected brain regions in Alzheimers disease indicating that the immune system may play a key role in the development of Alzheimers disease and a polymorphism in phospholipase C-gamma 2 (PLCG2) has been reported to be protective against late onset Alzheimers disease (LOAD) [1].
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal Antibody
Format:
100 µg in 100 µl Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
Storage Temp:
Store at -20°C. Avoid freeze / thaw cycles.
Host Animal:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Expected Species:
Cat, Dog, Chimpanzee, Pig, Bovine
Immunogen:
Partial length recombinant human PLCG2 from the N-terminal region
If you would like further information regarding the immunogen used in the production of this antibody or have a query about if this antibody will bind to your protein/species please contact us and we can do the analysis for you.
[1] Sims R, van der Lee SJ, Naj AC, Bellenguez C, Badarinarayan N, Jakobsdottir J et al (2017) Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimers disease. Nat Genet 49:13731384.
Apolipoprotein E (APOE) is a 34-kDa glycoprotein that mediates lipid metabolism. There are 3 common variants (APOE2, APOE3 and APOE4) that differ in two amino acid positions, 112 and 158. The N-terminal of APOE forms an anti-parallel four-helix bundle with the non-polar sides facing internally and the C-terminal domain contains three helices which form a large exposed hydrophobic surface, interacting with those in the N-terminal helix bundle. The C-terminal region also contains a low density lipoprotein receptor (LDLR)-binding site. The N and C terminal regions of the protein are connected by a hinge region.
In the brain, APOE is produced predominantly by astrocytes, microglia, vascular mural cells, and the choroid plexus. APOE functions through binding to cell surface receptors, including low-density lipoprotein receptor (LDLR) and a number of others [1]. Additionally recent studies have shown that triggering receptor expressed on myeloid cells 2 (TREM2), expressed by microglia in the brain, is also a receptor for APOE [2,3] APOE is the strongest genetic risk modifier of late-onset Alzheimers disease with APOE4 increasing risk through earlier and more abundant amyloid pathology.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal Antibody
Format:
50 µg in 50 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage Temp:
Store at -20°C. Avoid freeze / thaw cycles.
Host Animal:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Expected Species:
Dog, Sheep, Pig
Immunogen:
Partial length recombinant human ApoE from the C-terminal region
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:1000-3000. IHC 1:50-200. IF 1:50-100.
Category:
Primary Antibodies
Other names:
Apolipoprotein E, Apo-E4, LDLCQ5
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
36kDa
Subcellular location:
Secreted/Extracellular region
Purification:
Affinity purification
References:
[1] Holtzman DM, Herz J, Bu G. Apolipoprotein E and apolipoprotein E receptors: normal biology and roles in Alzheimer disease. Cold Spring Harb Perspect Med. 2012;2(3):a006312. [2] Atagi Y, et al. Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2). J Biol Chem. 2015;290(43):2604350. [3] Yeh FL, et al. TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia. Neuron. 2016;91(2):32840.
Apolipoprotein E (APOE) is a 34-kDa glycoprotein that mediates lipid metabolism. There are 3 common variants (APOE2, APOE3 and APOE4) that differ in two amino acid positions, 112 and 158. The N-terminal of APOE forms an anti-parallel four-helix bundle with the non-polar sides facing internally and the C-terminal domain contains three helices which form a large exposed hydrophobic surface, interacting with those in the N-terminal helix bundle. The C-terminal region also contains a low density lipoprotein receptor (LDLR)-binding site. The N and C terminal regions of the protein are connected by a hinge region.
In the brain, APOE is produced predominantly by astrocytes, microglia, vascular mural cells, and the choroid plexus. APOE functions through binding to cell surface receptors, including low-density lipoprotein receptor (LDLR) and a number of others [1]. Additionally recent studies have shown that triggering receptor expressed on myeloid cells 2 (TREM2), expressed by microglia in the brain, is also a receptor for APOE [2,3] APOE is the strongest genetic risk modifier of late-onset Alzheimers disease with APOE4 increasing risk through earlier and more abundant amyloid pathology.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal Antibody
Format:
100 µg in 100 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage Temp:
Store at -20°C. Avoid freeze / thaw cycles.
Host Animal:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Expected Species:
Dog, Sheep, Pig
Immunogen:
Partial length recombinant human ApoE from the C-terminal region
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:1000-3000. IHC 1:50-200. IF 1:50-100.
Category:
Primary Antibodies
Other names:
Apolipoprotein E, Apo-E4, LDLCQ5
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
36kDa
Subcellular location:
Secreted/Extracellular region
Purification:
Affinity purification
References:
[1] Holtzman DM, Herz J, Bu G. Apolipoprotein E and apolipoprotein E receptors: normal biology and roles in Alzheimer disease. Cold Spring Harb Perspect Med. 2012;2(3):a006312. [2] Atagi Y, et al. Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2). J Biol Chem. 2015;290(43):2604350. [3] Yeh FL, et al. TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia. Neuron. 2016;91(2):32840.
Histamine is an important messenger molecule and neuromodulator with four known G protein-coupled receptors (GPCRs), H1, H2, H3 and H4. Histamine receptor H3 (HRH3) is a presynaptic autoreceptor that regulates histamine release from histaminergic neurons via negative feedback [1] as well as a heteroreceptor that regulates the release of other neurotransmitters [2,3,4]. It is also expressed postsynaptically in the modulation of dopamine signalling.
HRH3 is expressed predominantly in the cortex, thalamus, hypothalamus, hippocampus, amygdala and basal ganglia. Dysregulated central histaminergic signalling has been associated with a number of psychiatric disorders including sleep disorders, ADHD, Alzheimer's disease, Parkinson's disease and schizophrenia.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal Antibody
Format:
50 µg in 50 µl Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
Storage Temp:
Store at -20°C. Avoid freeze / thaw cycles.
Host Animal:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Expected Species:
Guinae Pig, Cat
Immunogen:
A synthetic peptide from the C-terminal region of human HRH3
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:2000-5000. IHC 1:10-100.
Category:
Primary Antibodies
Other names:
HH3R, G-protein coupled receptor 97, GPCR97, H3R
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
49kDa
Subcellular location:
Plasma Membrane
Purification:
Affinity purification
References:
[1] Morisset S, Rouleau A, Ligneau X, Gbahou F, Tardivel-Lacombe J, Stark H, Schunack W, Ganellin CR, Schwartz JC, Arrang JM. High constitutive activity of native H3 receptors regulates histamine neurons in brain. Nature. 2000; 408:860-4. [2] Schlicker E, Betz R, Gothert M. Histamine H3 receptor-mediated inhibition of serotonin release in the rat brain cortex. Naunyn Schmiedebergs Arch Pharmacol. 1988; 337:588-90. [3] Schlicker E, Fink K, Hinterthaner M, Gothert M. Inhibition of noradrenaline release in the rat brain cortex via presynaptic H3 receptors. Naunyn Schmiedebergs Arch Pharmacol. 1989; 340:633-8. [4] Schlicker E, Fink K, Detzner M, Gothert M. Histamine inhibits dopamine release in the mouse striatum via presynaptic H3 receptors. J Neural Transm Gen Sect. 1993; 93:1-10.
Histamine is an important messenger molecule and neuromodulator with four known G protein-coupled receptors (GPCRs), H1, H2, H3 and H4. Histamine receptor H3 (HRH3) is a presynaptic autoreceptor that regulates histamine release from histaminergic neurons via negative feedback [1] as well as a heteroreceptor that regulates the release of other neurotransmitters [2,3,4]. It is also expressed postsynaptically in the modulation of dopamine signalling.
HRH3 is expressed predominantly in the cortex, thalamus, hypothalamus, hippocampus, amygdala and basal ganglia. Dysregulated central histaminergic signalling has been associated with a number of psychiatric disorders including sleep disorders, ADHD, Alzheimer's disease, Parkinson's disease and schizophrenia.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal Antibody
Format:
100 µg in 100 µl Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
Storage Temp:
Store at -20°C. Avoid freeze / thaw cycles.
Host Animal:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Expected Species:
Guinae Pig, Cat
Immunogen:
A synthetic peptide from the C-terminal region of human HRH3
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
[1] Morisset S, Rouleau A, Ligneau X, Gbahou F, Tardivel-Lacombe J, Stark H, Schunack W, Ganellin CR, Schwartz JC, Arrang JM. High constitutive activity of native H3 receptors regulates histamine neurons in brain. Nature. 2000; 408:860-4. [2] Schlicker E, Betz R, Gothert M. Histamine H3 receptor-mediated inhibition of serotonin release in the rat brain cortex. Naunyn Schmiedebergs Arch Pharmacol. 1988; 337:588-90. [3] Schlicker E, Fink K, Hinterthaner M, Gothert M. Inhibition of noradrenaline release in the rat brain cortex via presynaptic H3 receptors. Naunyn Schmiedebergs Arch Pharmacol. 1989; 340:633-8. [4] Schlicker E, Fink K, Detzner M, Gothert M. Histamine inhibits dopamine release in the mouse striatum via presynaptic H3 receptors. J Neural Transm Gen Sect. 1993; 93:1-10.
CD38 is a widely expressed 45 kDa transmembrane glycoprotein with a short cytoplasmic tail (aa 121), a transmembrane domain (aa 2242) and an extracellular domain (aa 43300) [1]. It is a multifunctional ectoenzyme catalysing multiple reactions and also has a role in signal transduction and calcium signaling.
In the brain CD38 is expressed in neurons, astrocytes and microglial cells and expression was found to increase under neuroinflammatory conditions indicating that it may have a role in the regulation of neuroinflammation. In Alzheimers disease, CD38 immunoreactivity is seen in intracellular tangles and neuropil threads [2].
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal Antibody
Format:
50 µg in 50 µl Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
Storage Temp:
Store at -20°C. Avoid freeze / thaw cycles.
Host Animal:
Rabbit
Species Reactivity:
Human, Rat
Immunogen:
A synthetic peptide from the C-terminal region of human CD38
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
[1] Malavasi, F.; Deaglio, S.; Funaro, A.; Ferrero, E.; Horenstein, A.L.; Ortolan, E.; Vaisitti, T.; Aydin, S. Evolution and Function of the ADP Ribosyl Cyclase/CD38 Gene Family in Physiology and Pathology. Physiol. Rev. 2008, 88, 841886. [2] Otsuka K., Mizuguchi M., Aizawa T., Haga S., Sato M., Inoya H., Namba Y., Machinami R. Immunoreactivity in Alzheimers neurofibrillary tangles (abstract) Brain Pathol. 1994;4:558.
CD38 is a widely expressed 45 kDa transmembrane glycoprotein with a short cytoplasmic tail (aa 121), a transmembrane domain (aa 2242) and an extracellular domain (aa 43300) [1]. It is a multifunctional ectoenzyme catalysing multiple reactions and also has a role in signal transduction and calcium signaling.
In the brain CD38 is expressed in neurons, astrocytes and microglial cells and expression was found to increase under neuroinflammatory conditions indicating that it may have a role in the regulation of neuroinflammation. In Alzheimers disease, CD38 immunoreactivity is seen in intracellular tangles and neuropil threads [2].
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal Antibody
Format:
100 µg in 100 µl Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
Storage Temp:
Store at -20°C. Avoid freeze / thaw cycles.
Host Animal:
Rabbit
Species Reactivity:
Human, Rat
Immunogen:
A synthetic peptide from the C-terminal region of human CD38
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
[1] Malavasi, F.; Deaglio, S.; Funaro, A.; Ferrero, E.; Horenstein, A.L.; Ortolan, E.; Vaisitti, T.; Aydin, S. Evolution and Function of the ADP Ribosyl Cyclase/CD38 Gene Family in Physiology and Pathology. Physiol. Rev. 2008, 88, 841886. [2] Otsuka K., Mizuguchi M., Aizawa T., Haga S., Sato M., Inoya H., Namba Y., Machinami R. Immunoreactivity in Alzheimers neurofibrillary tangles (abstract) Brain Pathol. 1994;4:558.
CYFIP1 (Cytoplasmic FMRP interacting protein 1) is a synaptic protein involved in multiple biological pathways. It binds FMRP (fragile-X mental retardation protein) and the resulting CYFIP1-FMRP complex represses translation at dendritic and synaptic sites [1]. CYFIP1 is also part of the Wave Regulatory Complex (WRC) formed by WAVE1/2/3, CYFIP1, ABI1/2, NCKAP1 and HPSC300 [2], involved in the formation of the actin cytoskeleton. CYFIP1 inhibits the WAVE complex in an inhibited state through interaction with the Arp2/3 complex. Both processes, actin dynamics and regulated protein synthesis, are crucial for synaptic development and brain functioning. Synaptic activation changes the protein conformation of CYFIP1, from globular to planar, pushing CYFIP1 more towards the WAVE complex, thereby inhibiting actin remodelling. A loss of CYFIP1 leads to defective axonal growth and motor function showing that CYFIP1 is essential for synaptic plasticity.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal Antibody
Format:
50 µg in 50 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage Temp:
Store at -20°C. Avoid freeze / thaw cycles.
Host Animal:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Expected Species:
Cat, Dog, Chimpanzee, Zebrafish
Immunogen:
Partial length recombinant human CYFIP1 from the N-terminal region
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:1000-2000. IHC 1:50-200.
Category:
Primary Antibodies
Other names:
Specifically Rac1-associated protein 1, Cytoplasmic FMR1-interacting protein 1, Sra-1, Specifically Rac1-associated (Sra-1) protein36, p140sra-1
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
145kDa (Intended as a general guide and does not allow for all isoforms and species variations)
[1] Napoli I, Mercaldo V, Boyl PP, Eleuteri B, Zalfa F, De Rubeis S, et al. The fragile X syndrome protein represses activity-dependent translation through CYFIP1, a new 4E-BP. Cell. 2008;134(6):104254. [2] Chen, Z. et al. Structure and control of the actin regulatory WAVE complex. Nature 468, 533538 (2010). [3] De Rubeis S, Pasciuto E, Li KW, Fernández E, Di Marino D, Buzzi A, et al. CYFIP1 coordinates mRNA translation and cytoskeleton remodeling to ensure proper dendritic Spine formation. Neuron. 2013;79(6):116982.
CYFIP1 (Cytoplasmic FMRP interacting protein 1) is a synaptic protein involved in multiple biological pathways. It binds FMRP (fragile-X mental retardation protein) and the resulting CYFIP1-FMRP complex represses translation at dendritic and synaptic sites [1]. CYFIP1 is also part of the Wave Regulatory Complex (WRC) formed by WAVE1/2/3, CYFIP1, ABI1/2, NCKAP1 and HPSC300 [2], involved in the formation of the actin cytoskeleton. CYFIP1 inhibits the WAVE complex in an inhibited state through interaction with the Arp2/3 complex. Both processes, actin dynamics and regulated protein synthesis, are crucial for synaptic development and brain functioning. Synaptic activation changes the protein conformation of CYFIP1, from globular to planar, pushing CYFIP1 more towards the WAVE complex, thereby inhibiting actin remodelling. A loss of CYFIP1 leads to defective axonal growth and motor function showing that CYFIP1 is essential for synaptic plasticity.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal Antibody
Format:
100 µg in 100 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage Temp:
Store at -20°C. Avoid freeze / thaw cycles.
Host Animal:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Expected Species:
Cat, Dog, Chimpanzee, Zebrafish
Immunogen:
Partial length recombinant human CYFIP1 from the N-terminal region
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:1000-2000. IHC 1:50-200.
Category:
Primary Antibodies
Other names:
Specifically Rac1-associated protein 1, Cytoplasmic FMR1-interacting protein 1, Sra-1, Specifically Rac1-associated (Sra-1) protein36, p140sra-1
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
145kDa (Intended as a general guide and does not allow for all isoforms and species variations)
[1] Napoli I, Mercaldo V, Boyl PP, Eleuteri B, Zalfa F, De Rubeis S, et al. The fragile X syndrome protein represses activity-dependent translation through CYFIP1, a new 4E-BP. Cell. 2008;134(6):104254. [2] Chen, Z. et al. Structure and control of the actin regulatory WAVE complex. Nature 468, 533538 (2010). [3] De Rubeis S, Pasciuto E, Li KW, Fernández E, Di Marino D, Buzzi A, et al. CYFIP1 coordinates mRNA translation and cytoskeleton remodeling to ensure proper dendritic Spine formation. Neuron. 2013;79(6):116982.
TREM2 (Triggering receptor expressed on myeloid cells 2) is a cell surface transmembrane glycoprotein with an immunoglobulin like extracellular domain and a cytoplasmic tail [1]. It is expressed in myeloid cells including dendritic cells, granulocytes, and tissue-specific macrophages such as osteoclasts. In the brain, TREM2 is only expressed by microglia and in the central nervous system expression of TREM2 varies with higher expression in the hippocampus, spinal cord and white matter.
TREM2 plays a complex role in neuroinflammation with expression of TREM2 being upregulated in pathological conditions such as Parkinson's disease, Amyotrophic lateral sclerosis (ALS), stroke, traumatic brain injury and Alzheimer's Disease [2]. TREM2 has also been shown to have a role in potential mechanisms linking urban air pollution to Alzheimer's Disease through its involvement in the regulation of neuroinflammation [3].
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
KLH conjugated synthetic peptide from the N-terminal region of human TREM2
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
TREM-2, TREM2a, TREM2b, TREM2c, Trggering receptor expressed on myeloid cells 2, Trggering receptor expressed on myeloid cells 2a, Triggering receptor expressed on monocytes 2
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
25kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Cell membrane, Secreted
Purification:
Affinity purification
References:
[1] Bouchon A, Dietrich J, Colonna M. Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes. J Immunol. 2000;164:49915.
[2] Gratuze, M., Leyns, C.E.G. & Holtzman, D.M. New insights into the role of TREM2 in Alzheimers disease. Mol Neurodegeneration 13, 66 (2018).
[3] Hendrik J. Greve, Christen L. Mumaw, Evan J. Messenger, Prasada R. S. Kodavanti, Joyce L. Royland, Urmila P. Kodavanti and Michelle L. Block. Diesel exhaust impairs TREM2 to dysregulate neuroinflammation. J Neuroinflammation. 2020; 17: 351.
TREM2 (Triggering receptor expressed on myeloid cells 2) is a cell surface transmembrane glycoprotein with an immunoglobulin like extracellular domain and a cytoplasmic tail [1]. It is expressed in myeloid cells including dendritic cells, granulocytes, and tissue-specific macrophages such as osteoclasts. In the brain, TREM2 is only expressed by microglia and in the central nervous system expression of TREM2 varies with higher expression in the hippocampus, spinal cord and white matter.
TREM2 plays a complex role in neuroinflammation with expression of TREM2 being upregulated in pathological conditions such as Parkinson's disease, Amyotrophic lateral sclerosis (ALS), stroke, traumatic brain injury and Alzheimer's Disease [2]. TREM2 has also been shown to have a role in potential mechanisms linking urban air pollution to Alzheimer's Disease through its involvement in the regulation of neuroinflammation [3].
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
KLH conjugated synthetic peptide from the N-terminal region of human TREM2
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
TREM-2, TREM2a, TREM2b, TREM2c, Trggering receptor expressed on myeloid cells 2, Trggering receptor expressed on myeloid cells 2a, Triggering receptor expressed on monocytes 2
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
25kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Cell membrane, Secreted
Purification:
Affinity purification
References:
[1] Bouchon A, Dietrich J, Colonna M. Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes. J Immunol. 2000;164:49915.
[2] Gratuze, M., Leyns, C.E.G. & Holtzman, D.M. New insights into the role of TREM2 in Alzheimers disease. Mol Neurodegeneration 13, 66 (2018).
[3] Hendrik J. Greve, Christen L. Mumaw, Evan J. Messenger, Prasada R. S. Kodavanti, Joyce L. Royland, Urmila P. Kodavanti and Michelle L. Block. Diesel exhaust impairs TREM2 to dysregulate neuroinflammation. J Neuroinflammation. 2020; 17: 351.
Lipocalin-2 (LCN2) is a secreted glycoprotein involved in innate immunity that has roles in iron homeostasis, infection, and inflammation. It was originally identified as a major constituent of the neutrophil secondary granules, so it is also known as neutrophil gelatinase-associated lipocalin (NGAL).
It is highly expressed in the central nervous system in response to injury and inflammation and has also been identified as a potential marker for Alzheimers disease. Increased levels of Lipocalin-2 have been seen in plasma from patients with mild cognitive impairment (MCI) and in CSF from patients with multiple sclerosis. Experimental models of Vascular dementia have shown that Lipocalin-2 mediates hippocampal damage and that decreased levels are associated with less white matter damage and cognitive decline.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal Antibody
Format:
50 µg in 50 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
23kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Secreted, Cytosol
Purification:
Affinity purification
References:
Franc Llorens, Peter Hermann, Anna Villar-Piqué et al - Cerebrospinal fluid lipocalin 2 as a novel biomarker for the differential diagnosis of vascular dementia. Nat Commun. 2020; 11: 619.
Lipocalin-2 (LCN2) is a secreted glycoprotein involved in innate immunity that has roles in iron homeostasis, infection, and inflammation. It was originally identified as a major constituent of the neutrophil secondary granules, so it is also known as neutrophil gelatinase-associated lipocalin (NGAL).
It is highly expressed in the central nervous system in response to injury and inflammation and has also been identified as a potential marker for Alzheimers disease. Increased levels of Lipocalin-2 have been seen in plasma from patients with mild cognitive impairment (MCI) and in CSF from patients with multiple sclerosis. Experimental models of Vascular dementia have shown that Lipocalin-2 mediates hippocampal damage and that decreased levels are associated with less white matter damage and cognitive decline.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal Antibody
Format:
100 µg in 100 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
23kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Secreted, Cytosol
Purification:
Affinity purification
References:
Franc Llorens, Peter Hermann, Anna Villar-Piqué et al - Cerebrospinal fluid lipocalin 2 as a novel biomarker for the differential diagnosis of vascular dementia. Nat Commun. 2020; 11: 619.
Lipocalin-2 (LCN2) is a secreted glycoprotein involved in innate immunity that has roles in iron homeostasis, infection, and inflammation. It was originally identified as a major constituent of the neutrophil secondary granules, so it is also known as neutrophil gelatinase-associated lipocalin (NGAL).
It is highly expressed in the central nervous system in response to injury and inflammation and has also been identified as a potential marker for Alzheimers disease. Increased levels of Lipocalin-2 have been seen in plasma from patients with mild cognitive impairment (MCI) and in CSF from patients with multiple sclerosis. Experimental models of Vascular dementia have shown that Lipocalin-2 mediates hippocampal damage and that decreased levels are associated with less white matter damage and cognitive decline.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal Antibody
Format:
50 µg in 50 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
23kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Secreted, Cytosol
Purification:
Affinity purification
References:
Franc Llorens, Peter Hermann, Anna Villar-Piqué et al - Cerebrospinal fluid lipocalin 2 as a novel biomarker for the differential diagnosis of vascular dementia. Nat Commun. 2020; 11: 619.
Lipocalin-2 (LCN2) is a secreted glycoprotein involved in innate immunity that has roles in iron homeostasis, infection, and inflammation. It was originally identified as a major constituent of the neutrophil secondary granules, so it is also known as neutrophil gelatinase-associated lipocalin (NGAL).
It is highly expressed in the central nervous system in response to injury and inflammation and has also been identified as a potential marker for Alzheimers disease. Increased levels of Lipocalin-2 have been seen in plasma from patients with mild cognitive impairment (MCI) and in CSF from patients with multiple sclerosis. Experimental models of Vascular dementia have shown that Lipocalin-2 mediates hippocampal damage and that decreased levels are associated with less white matter damage and cognitive decline.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal Antibody
Format:
100 µg in 100 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
23kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Secreted, Cytosol
Purification:
Affinity purification
References:
Franc Llorens, Peter Hermann, Anna Villar-Piqué et al - Cerebrospinal fluid lipocalin 2 as a novel biomarker for the differential diagnosis of vascular dementia. Nat Commun. 2020; 11: 619.
Lipocalin-2 (LCN2) is a secreted glycoprotein involved in innate immunity that has roles in iron homeostasis, infection, and inflammation. It was originally identified as a major constituent of the neutrophil secondary granules, so it is also known as neutrophil gelatinase-associated lipocalin (NGAL).
It is highly expressed in the central nervous system in response to injury and inflammation and has also been identified as a potential marker for Alzheimers disease. Increased levels of Lipocalin-2 have been seen in plasma from patients with mild cognitive impairment (MCI) and in CSF from patients with multiple sclerosis. Experimental models of Vascular dementia have shown that Lipocalin-2 mediates hippocampal damage and that decreased levels are associated with less white matter damage and cognitive decline.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal Antibody
Format:
50 µg in 50 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
23kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Secreted, Cytosol
Purification:
Affinity purification
References:
Franc Llorens, Peter Hermann, Anna Villar-Piqué et al - Cerebrospinal fluid lipocalin 2 as a novel biomarker for the differential diagnosis of vascular dementia. Nat Commun. 2020; 11: 619.
Lipocalin-2 (LCN2) is a secreted glycoprotein involved in innate immunity that has roles in iron homeostasis, infection, and inflammation. It was originally identified as a major constituent of the neutrophil secondary granules, so it is also known as neutrophil gelatinase-associated lipocalin (NGAL).
It is highly expressed in the central nervous system in response to injury and inflammation and has also been identified as a potential marker for Alzheimers disease. Increased levels of Lipocalin-2 have been seen in plasma from patients with mild cognitive impairment (MCI) and in CSF from patients with multiple sclerosis. Experimental models of Vascular dementia have shown that Lipocalin-2 mediates hippocampal damage and that decreased levels are associated with less white matter damage and cognitive decline.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal Antibody
Format:
100 µg in 100 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
23kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Secreted, Cytosol
Purification:
Affinity purification
References:
Franc Llorens, Peter Hermann, Anna Villar-Piqué et al - Cerebrospinal fluid lipocalin 2 as a novel biomarker for the differential diagnosis of vascular dementia. Nat Commun. 2020; 11: 619.
Nogo receptor 3 (NgR3) is a 441 amino acid protein that belongs to the Nogo receptor family. Nogo receptors NgR1, NgR2 and NgR3 are Glycosylphosphatidylinositol-anchored proteins (GPI-APs) that share similar structures, including eight leucine-rich repeats (LRRs) between N-terminal and C-terminal LRR-capping domains, connected via a stalk region to the GPI anchor.
NgR3 is predominantly expressed in brain, where it localises to the surface of neurons, but is also found at lower levels in lung, placenta, kidney, mammary gland, skeletal muscle, spleen and salivary gland.
NgR1 binds to three myelin inhibitors Nogo, OMgp, and Myelin-associated-glycoprotein (MAG), whereas NgR2 interacts with MAG. The ligands that bind to NgR3 are less clear.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal Antibody
Format:
50 µg in 50 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Nogo receptor 3 (NgR3) is a 441 amino acid protein that belongs to the Nogo receptor family. Nogo receptors NgR1, NgR2 and NgR3 are Glycosylphosphatidylinositol-anchored proteins (GPI-APs) that share similar structures, including eight leucine-rich repeats (LRRs) between N-terminal and C-terminal LRR-capping domains, connected via a stalk region to the GPI anchor.
NgR3 is predominantly expressed in brain, where it localises to the surface of neurons, but is also found at lower levels in lung, placenta, kidney, mammary gland, skeletal muscle, spleen and salivary gland.
NgR1 binds to three myelin inhibitors Nogo, OMgp, and Myelin-associated-glycoprotein (MAG), whereas NgR2 interacts with MAG. The ligands that bind to NgR3 are less clear.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal Antibody
Format:
100 µg in 100 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Oligodendrocyte-myelin glycoprotein (OMG) is one of three myelin-associated proteins (along with Nogo-A and MAG) that inhibit neurite outgrowth by binding to the Nogo receptor (NgR1). OMG is expressed by neurons and oligodendrocytes and influences the development of the adult central nervous system. The binding of OMG (along with Nogo-A and MAG) to Nogo Receptor (NgR1) activates a signalling cascade via the Rho family GTPases which leads to growth cone collapse.
NB: Do not confuse oligodendrocyte-myelin glycoprotein (OMG) with myelin-oligodendrocyte glycoprotein (MOG) which is a myelin glycoprotein expressed only at the outermost surface of myelin sheaths and oligodendrocyte membranes and is believed to act as a cell adhesion molecule, a regulator of microtubule stability, and a mediator of myelin and immune interactions.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal Antibody
Format:
50 µg in 50 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:200-1000. IHC 1:50-200.
Category:
Primary Antibodies
Other names:
OMGP, OMG
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
50kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Oligodendrocyte-myelin glycoprotein (OMG) is one of three myelin-associated proteins (along with Nogo-A and MAG) that inhibit neurite outgrowth by binding to the Nogo receptor (NgR1). OMG is expressed by neurons and oligodendrocytes and influences the development of the adult central nervous system. The binding of OMG (along with Nogo-A and MAG) to Nogo Receptor (NgR1) activates a signalling cascade via the Rho family GTPases which leads to growth cone collapse.
NB: Do not confuse oligodendrocyte-myelin glycoprotein (OMG) with myelin-oligodendrocyte glycoprotein (MOG) which is a myelin glycoprotein expressed only at the outermost surface of myelin sheaths and oligodendrocyte membranes and is believed to act as a cell adhesion molecule, a regulator of microtubule stability, and a mediator of myelin and immune interactions.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal Antibody
Format:
100 µg in 100 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Nogo (Reticulon-4) exists in 3 isoforms (Nogo-A, Nogo-B, and Nogo-C) that share a C-terminal domain of 188 amino acid residues, known as the highly conserved reticulon homology domain. It was originally identified as an inhibitor of neurite outgrowth and axonal regeneration in the central nervous system [1].
Nogo-A (the largest isoform) is a neurite outgrowth inhibitor and is mainly secreted in the central nervous system. Nogo-B is expressed in tissues including vessel walls, smooth muscles, skeletal muscles, and endothelium, and Nogo-C is secreted in the liver, vascular smooth muscles, skeletal muscles, heart, and neurons.
This antibody binds all 3 isoforms.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal Antibody
Format:
50 µg in 50 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
129 kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Endoplasmic reticulum (membrane), Plasma membrane
Purification:
Affinity purification
References:
[1] Chen MS, Huber AB, van der Haar ME, Frank M, Schnell L, Spillmann AA, Christ F, Schwab ME (2000). Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1. Nature 403, 434439.
Nogo (Reticulon-4) exists in 3 isoforms (Nogo-A, Nogo-B, and Nogo-C) that share a C-terminal domain of 188 amino acid residues, known as the highly conserved reticulon homology domain. It was originally identified as an inhibitor of neurite outgrowth and axonal regeneration in the central nervous system [1].
Nogo-A (the largest isoform) is a neurite outgrowth inhibitor and is mainly secreted in the central nervous system. Nogo-B is expressed in tissues including vessel walls, smooth muscles, skeletal muscles, and endothelium, and Nogo-C is secreted in the liver, vascular smooth muscles, skeletal muscles, heart, and neurons.
This antibody binds all 3 isoforms.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal Antibody
Format:
100 µg in 100 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
129 kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Endoplasmic reticulum (membrane), Plasma membrane
Purification:
Affinity purification
References:
[1] Chen MS, Huber AB, van der Haar ME, Frank M, Schnell L, Spillmann AA, Christ F, Schwab ME (2000). Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1. Nature 403, 434439.
Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine-threonine kinase belonging to the Cdc2/Cdk1 family that regulates various neuronal processes such as neurogenesis, neuronal migration, and axon guidance. It is essential for the development of the central nervous system, being highly expressed in the brain. Cdk5 is controlled by the neural specific activators p35, p39. Outside of the nervous system CDK5 regulates vesicular transport, apoptosis, cell adhesion, and migration in many cell types.
Cdk5 has been implicated in the pathology of multiple types of cancers and is a potential target for Glioblastoma. Deregulation of Cdk5 is also linked to neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), and Hungtington's disease (HD) and additionally it has been proposed that Cdk5 modulates the brain reward system and therefore it has consequently also been linked to psychiatric diseases.
Product Type:
NS Reagents Antibody
Antibody Type:
Monoclonal
Format:
50 µg in 50 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human CDK5 from the N-terminal region (expressed in E.coli)
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Clone number:
NSR-256
Antibody Isotype:
IgG1
Application Details:
WB 1:500. IHC 1:150.
Category:
Primary Antibodies
Other names:
LIS7, PSSALRE, Cyclin-dependent-like kinase 5, Cell division protein kinase 5, Serine/threonine-protein kinase PSSALRE, Tau protein kinase II catalytic subunit, CDKN5, TPKII Catalytic Subunit, Epididymis Secretory Sperm Binding Protein
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
33kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine-threonine kinase belonging to the Cdc2/Cdk1 family that regulates various neuronal processes such as neurogenesis, neuronal migration, and axon guidance. It is essential for the development of the central nervous system, being highly expressed in the brain. Cdk5 is controlled by the neural specific activators p35, p39. Outside of the nervous system CDK5 regulates vesicular transport, apoptosis, cell adhesion, and migration in many cell types.
Cdk5 has been implicated in the pathology of multiple types of cancers and is a potential target for Glioblastoma. Deregulation of Cdk5 is also linked to neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), and Hungtington's disease (HD) and additionally it has been proposed that Cdk5 modulates the brain reward system and therefore it has consequently also been linked to psychiatric diseases.
Product Type:
NS Reagents Antibody
Antibody Type:
Monoclonal
Format:
100 µg in 100 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human CDK5 from the N-terminal region (expressed in E.coli)
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Clone number:
NSR-256
Antibody Isotype:
IgG1
Application Details:
WB 1:500. IHC 1:150.
Category:
Primary Antibodies
Other names:
LIS7, PSSALRE, Cyclin-dependent-like kinase 5, Cell division protein kinase 5, Serine/threonine-protein kinase PSSALRE, Tau protein kinase II catalytic subunit, CDKN5, TPKII Catalytic Subunit, Epididymis Secretory Sperm Binding Protein
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
33kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Apoptosis inducing factor (AIFM1/AIF) is a mitochondrial flavoprotein that has a fundamental housekeeping role in mitochondrial bioenergetics. It is also involved in caspase-independent cell death, where following an apoptotic trigger, proteolysis of the membrane-tethered precursor AIF, causes AIF to translocate to the nucleus, where it participates in chromatin condensation and DNA degradation.
Mutations in the AIFM1 gene cause combined oxidative phosphorylation deficiency 6 (COXPD6), a severe mitochondrial encephalomyopathy and X-linked recessive Charcot-Marie-Tooth disease-4 (CMTX-4), a disorder resulting in neuropathy, and axonal and motor-sensory defects with deafness and mental retardation.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the N-terminal region of human AIFM1
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:3000.
Category:
Primary Antibodies
Other names:
AIF, CMT2D, CMTX4, COWCK, COXPD6, DFNX5, NADMR, NAMSD, PDCD8, Apoptosis Inducing Factor Mitochondria Associated 1, Apoptosis-Inducing Factor, Mitochondrion-Associated 1, Programmed Cell Death 8 (Apoptosis-Inducing Factor), Auditory Neuropathy, X-Linked Recessive 1, PDCD8, Neuropathy, Axonal, Motor-Sensory With Deafness And Mental Retardation (Cowchock Syndrome), Striatal Apoptosis-Inducing Factor, Testicular Secretory Protein Li
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
67kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Apoptosis inducing factor (AIFM1/AIF) is a mitochondrial flavoprotein that has a fundamental housekeeping role in mitochondrial bioenergetics. It is also involved in caspase-independent cell death, where following an apoptotic trigger, proteolysis of the membrane-tethered precursor AIF, causes AIF to translocate to the nucleus, where it participates in chromatin condensation and DNA degradation.
Mutations in the AIFM1 gene cause combined oxidative phosphorylation deficiency 6 (COXPD6), a severe mitochondrial encephalomyopathy and X-linked recessive Charcot-Marie-Tooth disease-4 (CMTX-4), a disorder resulting in neuropathy, and axonal and motor-sensory defects with deafness and mental retardation.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the N-terminal region of human AIFM1
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:3000.
Category:
Primary Antibodies
Other names:
AIF, CMT2D, CMTX4, COWCK, COXPD6, DFNX5, NADMR, NAMSD, PDCD8, Apoptosis Inducing Factor Mitochondria Associated 1, Apoptosis-Inducing Factor, Mitochondrion-Associated 1, Programmed Cell Death 8 (Apoptosis-Inducing Factor), Auditory Neuropathy, X-Linked Recessive 1, PDCD8, Neuropathy, Axonal, Motor-Sensory With Deafness And Mental Retardation (Cowchock Syndrome), Striatal Apoptosis-Inducing Factor, Testicular Secretory Protein Li
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
67kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Apoptosis inducing factor (AIFM1/AIF) is a mitochondrial flavoprotein that has a fundamental housekeeping role in mitochondrial bioenergetics. It is also involved in caspase-independent cell death, where following an apoptotic trigger, proteolysis of the membrane-tethered precursor AIF, causes AIF to translocate to the nucleus, where it participates in chromatin condensation and DNA degradation.
Mutations in the AIFM1 gene cause combined oxidative phosphorylation deficiency 6 (COXPD6), a severe mitochondrial encephalomyopathy and X-linked recessive Charcot-Marie-Tooth disease-4 (CMTX-4), a disorder resulting in neuropathy, and axonal and motor-sensory defects with deafness and mental retardation.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human AIFM1 from the C-terminal region
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000. IHC 1:50-200. IF 1:50-200.
Category:
Primary Antibodies
Other names:
AIF, CMT2D, CMTX4, COWCK, COXPD6, DFNX5, NADMR, NAMSD, PDCD8, Apoptosis Inducing Factor Mitochondria Associated 1, Apoptosis-Inducing Factor, Mitochondrion-Associated 1, Programmed Cell Death 8 (Apoptosis-Inducing Factor), Auditory Neuropathy, X-Linked Recessive 1, PDCD8, Neuropathy, Axonal, Motor-Sensory With Deafness And Mental Retardation (Cowchock Syndrome), Striatal Apoptosis-Inducing Factor, Testicular Secretory Protein Li
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
67kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Apoptosis inducing factor (AIFM1/AIF) is a mitochondrial flavoprotein that has a fundamental housekeeping role in mitochondrial bioenergetics. It is also involved in caspase-independent cell death, where following an apoptotic trigger, proteolysis of the membrane-tethered precursor AIF, causes AIF to translocate to the nucleus, where it participates in chromatin condensation and DNA degradation.
Mutations in the AIFM1 gene cause combined oxidative phosphorylation deficiency 6 (COXPD6), a severe mitochondrial encephalomyopathy and X-linked recessive Charcot-Marie-Tooth disease-4 (CMTX-4), a disorder resulting in neuropathy, and axonal and motor-sensory defects with deafness and mental retardation.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human AIFM1 from the C-terminal region
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000. IHC 1:50-200. IF 1:50-200.
Category:
Primary Antibodies
Other names:
AIF, CMT2D, CMTX4, COWCK, COXPD6, DFNX5, NADMR, NAMSD, PDCD8, Apoptosis Inducing Factor Mitochondria Associated 1, Apoptosis-Inducing Factor, Mitochondrion-Associated 1, Programmed Cell Death 8 (Apoptosis-Inducing Factor), Auditory Neuropathy, X-Linked Recessive 1, PDCD8, Neuropathy, Axonal, Motor-Sensory With Deafness And Mental Retardation (Cowchock Syndrome), Striatal Apoptosis-Inducing Factor, Testicular Secretory Protein Li
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
67kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Ubiquitin-like modifier-activating enzyme 1 (UBA1) is a multidomain enzyme and regulator of the ubiquitin proteasome system (UPS). It effectively marks proteins for degradation by the proteasome, acting as a gatekeeper of the Ub conjugation cascade by activating ubiquitin in a two-step process involving adenylation and thioester bond formation followed by transfer of ubiquitin to Cdc34 (an E2 ubiquitin-conjugating enzyme).
Mutations in the ubiquitin-like modifier activating enzyme 1 gene (UBA1), leading to reduced UBA1 expression, cause a rare form of Spinal Muscular Atrophy (SMA) known as X-linked SMA (XL-SMA).
Aminoacyl-tRNA synthetases, including GARS (Glycyl-tRNA synthetase), havebeen identified as downstream targets of UBA1. Dysregulation of UBA1/GARS pathways in spinal muscular atrophy results in a similar phenotype to GARS-dependent defects (such as Charcot-Marie-Tooth disease), perhaps indicating significant molecular and phenotypic overlap between spinal muscular atrophy and Charcot-Marie-Tooth disease.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human UBA1 from the central region (less than 100 aa in length)
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000.
Category:
Primary Antibodies
Other names:
A1S9, A1ST, GXP1, UBE1, A1S9T, AMCX1, POC20, SMAX2, UBA1A, UBE1X, CFAP124, Ubiquitin Like Modifier Activating Enzyme, Ubiquitin-Activating Enzyme E1, A1S9T And BN75 Temperature Sensitivity Complementing, Ubiquitin-Activating Enzyme E1 Homolog, Testicular Secretory Protein Li 63, POC20 Centriolar Protein Homolog, Protein A1S9.
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
118kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Ubiquitin-like modifier-activating enzyme 1 (UBA1) is a multidomain enzyme and regulator of the ubiquitin proteasome system (UPS). It effectively marks proteins for degradation by the proteasome, acting as a gatekeeper of the Ub conjugation cascade by activating ubiquitin in a two-step process involving adenylation and thioester bond formation followed by transfer of ubiquitin to Cdc34 (an E2 ubiquitin-conjugating enzyme).
Mutations in the ubiquitin-like modifier activating enzyme 1 gene (UBA1), leading to reduced UBA1 expression, cause a rare form of Spinal Muscular Atrophy (SMA) known as X-linked SMA (XL-SMA).
Aminoacyl-tRNA synthetases, including GARS (Glycyl-tRNA synthetase), havebeen identified as downstream targets of UBA1. Dysregulation of UBA1/GARS pathways in spinal muscular atrophy results in a similar phenotype to GARS-dependent defects (such as Charcot-Marie-Tooth disease), perhaps indicating significant molecular and phenotypic overlap between spinal muscular atrophy and Charcot-Marie-Tooth disease.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human UBA1 from the central region (less than 100 aa in length)
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000.
Category:
Primary Antibodies
Other names:
A1S9, A1ST, GXP1, UBE1, A1S9T, AMCX1, POC20, SMAX2, UBA1A, UBE1X, CFAP124, Ubiquitin Like Modifier Activating Enzyme, Ubiquitin-Activating Enzyme E1, A1S9T And BN75 Temperature Sensitivity Complementing, Ubiquitin-Activating Enzyme E1 Homolog, Testicular Secretory Protein Li 63, POC20 Centriolar Protein Homolog, Protein A1S9.
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
118kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Ubiquitin-like modifier-activating enzyme 1 (UBA1) is a multidomain enzyme and regulator of the ubiquitin proteasome system (UPS). It effectively marks proteins for degradation by the proteasome, acting as a gatekeeper of the Ub conjugation cascade by activating ubiquitin in a two-step process involving adenylation and thioester bond formation followed by transfer of ubiquitin to Cdc34 (an E2 ubiquitin-conjugating enzyme).
Mutations in the ubiquitin-like modifier activating enzyme 1 gene (UBA1), leading to reduced UBA1 expression, cause a rare form of Spinal Muscular Atrophy (SMA) known as X-linked SMA (XL-SMA).
Aminoacyl-tRNA synthetases, including GARS (Glycyl-tRNA synthetase), havebeen identified as downstream targets of UBA1. Dysregulation of UBA1/GARS pathways in spinal muscular atrophy results in a similar phenotype to GARS-dependent defects (such as Charcot-Marie-Tooth disease), perhaps indicating significant molecular and phenotypic overlap between spinal muscular atrophy and Charcot-Marie-Tooth disease.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000. IHC 1:30-150.
Category:
Primary Antibodies
Other names:
A1S9, A1ST, GXP1, UBE1, A1S9T, AMCX1, POC20, SMAX2, UBA1A, UBE1X, CFAP124, Ubiquitin Like Modifier Activating Enzyme, Ubiquitin-Activating Enzyme E1, A1S9T And BN75 Temperature Sensitivity Complementing, Ubiquitin-Activating Enzyme E1 Homolog, Testicular Secretory Protein Li 63, POC20 Centriolar Protein Homolog, Protein A1S9.
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
118kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Ubiquitin-like modifier-activating enzyme 1 (UBA1) is a multidomain enzyme and regulator of the ubiquitin proteasome system (UPS). It effectively marks proteins for degradation by the proteasome, acting as a gatekeeper of the Ub conjugation cascade by activating ubiquitin in a two-step process involving adenylation and thioester bond formation followed by transfer of ubiquitin to Cdc34 (an E2 ubiquitin-conjugating enzyme).
Mutations in the ubiquitin-like modifier activating enzyme 1 gene (UBA1), leading to reduced UBA1 expression, cause a rare form of Spinal Muscular Atrophy (SMA) known as X-linked SMA (XL-SMA).
Aminoacyl-tRNA synthetases, including GARS (Glycyl-tRNA synthetase), havebeen identified as downstream targets of UBA1. Dysregulation of UBA1/GARS pathways in spinal muscular atrophy results in a similar phenotype to GARS-dependent defects (such as Charcot-Marie-Tooth disease), perhaps indicating significant molecular and phenotypic overlap between spinal muscular atrophy and Charcot-Marie-Tooth disease.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000. IHC 1:30-150.
Category:
Primary Antibodies
Other names:
A1S9, A1ST, GXP1, UBE1, A1S9T, AMCX1, POC20, SMAX2, UBA1A, UBE1X, CFAP124, Ubiquitin Like Modifier Activating Enzyme, Ubiquitin-Activating Enzyme E1, A1S9T And BN75 Temperature Sensitivity Complementing, Ubiquitin-Activating Enzyme E1 Homolog, Testicular Secretory Protein Li 63, POC20 Centriolar Protein Homolog, Protein A1S9.
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
118kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Glycyl-tRNA synthetase 1 (GARS1) is an aminoacyl-tRNA synthetase that charges tRNAs with glycine. As with all aminoacyl-tRNA synthetases (aaRSs), Glycyl-tRNA synthetase 1 is an essential enzyme, catalysing the first reaction in protein biosynthesis. Glycyl-tRNA synthetase 1 belongs to the class II family of tRNA synthetases and naturally has a glycine binding domain and a WHEP-TRS domain which plays a role in the association of tRNA-synthetases into multienzyme complexes.
Charcot-Marie-Tooth neuropathy (CMT) is an incurable neurodegenerative disease caused by dominant mono-allelic mutations in some aaRSs including Glycyl-tRNA synthetase 1. It has been shown that dominant mutations in GARS1 cause CMT through toxic gain-of-function effects, which also may apply to other aaRS-linked CMT subtypes.
Aminoacyl-tRNA synthetases, including GARS (Glycyl-tRNA synthetase), have been identified as downstream targets of Ubiquitin-like modifier-activating enzyme 1 (UBA1) . Dysregulation of UBA1/GARS pathways in spinal muscular atrophy results in a similar phenotype to GARS-dependent defects (such as Charcot-Marie-Tooth disease), perhaps indicating significant molecular and phenotypic overlap between spinal muscular atrophy and Charcot-Marie-Tooth disease.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Glycyl-tRNA synthetase 1 (GARS1) is an aminoacyl-tRNA synthetase that charges tRNAs with glycine. As with all aminoacyl-tRNA synthetases (aaRSs), Glycyl-tRNA synthetase 1 is an essential enzyme, catalysing the first reaction in protein biosynthesis. Glycyl-tRNA synthetase 1 belongs to the class II family of tRNA synthetases and naturally has a glycine binding domain and a WHEP-TRS domain which plays a role in the association of tRNA-synthetases into multienzyme complexes.
Charcot-Marie-Tooth neuropathy (CMT) is an incurable neurodegenerative disease caused by dominant mono-allelic mutations in some aaRSs including Glycyl-tRNA synthetase 1. It has been shown that dominant mutations in GARS1 cause CMT through toxic gain-of-function effects, which also may apply to other aaRS-linked CMT subtypes.
Aminoacyl-tRNA synthetases, including GARS (Glycyl-tRNA synthetase), have been identified as downstream targets of Ubiquitin-like modifier-activating enzyme 1 (UBA1) . Dysregulation of UBA1/GARS pathways in spinal muscular atrophy results in a similar phenotype to GARS-dependent defects (such as Charcot-Marie-Tooth disease), perhaps indicating significant molecular and phenotypic overlap between spinal muscular atrophy and Charcot-Marie-Tooth disease.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Lysosomal acid glucosylceramidase (GBA or Glucocerebrosidase) is the lysosomal hydrolase that hydrolyzes glucosylceramide (GC) and glucosylsphingosine (GS) to ceramide and sphingosine. It is a 536-amino-acid membrane-associated protein with a 39-amino-acid leader sequence that is cleaved to produce a 497-amino-acid mature protein.
Mutations in the GBA gene cause Gaucher disease, a lysosomal storage disease characterised by an accumulation of glucocerebrosides. Patients with Gaucher disease and heterozygous carriers are at increased risk of developing Parkinson's disease and Dementia with Lewy Bodies.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Lysosomal acid glucosylceramidase (GBA or Glucocerebrosidase) is the lysosomal hydrolase that hydrolyzes glucosylceramide (GC) and glucosylsphingosine (GS) to ceramide and sphingosine. It is a 536-amino-acid membrane-associated protein with a 39-amino-acid leader sequence that is cleaved to produce a 497-amino-acid mature protein.
Mutations in the GBA gene cause Gaucher disease, a lysosomal storage disease characterised by an accumulation of glucocerebrosides. Patients with Gaucher disease and heterozygous carriers are at increased risk of developing Parkinson's disease and Dementia with Lewy Bodies.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
The F-box protein family are the substrate-recognition components of the Skp1-Cullin-F-box protein E3 ubiquitin ligase complex (SCF) which catalyses the phosphorylation-dependent ubiquitination of proteins destined for proteasomal degradation.
F-box proteins make up one of the four subunits of the SCF complex, contributing to its specificity by aggregating to target proteins independently of the complex and then binding to the Skp1 component, thereby allowing the target protein to be brought into proximity with the E2 ubiquitin-conjugating enzyme recruited by the E3ubiquitin ligase.
The F-box only protein 7 (Fbxo7) is one of the many FBPs identified in humans and mutations in Fbxo7 have been associated with early-onset parkinsons and cancer.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human FBXO7 from the C-terminal region
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000. IHC 1:50-200. IF 1:50-200.
Category:
Primary Antibodies
Other names:
FBX, FBX07, FBX7, PARK15, PKPS, F-Box Protein 7, F-box only protein 7
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
59kDa (Intended as a general guide and does not allow for all isoforms and species variations)
The F-box protein family are the substrate-recognition components of the Skp1-Cullin-F-box protein E3 ubiquitin ligase complex (SCF) which catalyses the phosphorylation-dependent ubiquitination of proteins destined for proteasomal degradation.
F-box proteins make up one of the four subunits of the SCF complex, contributing to its specificity by aggregating to target proteins independently of the complex and then binding to the Skp1 component, thereby allowing the target protein to be brought into proximity with the E2 ubiquitin-conjugating enzyme recruited by the E3ubiquitin ligase.
The F-box only protein 7 (Fbxo7) is one of the many FBPs identified in humans and mutations in Fbxo7 have been associated with early-onset parkinsons and cancer.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human FBXO7 from the C-terminal region
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000. IHC 1:50-200. IF 1:50-200.
Category:
Primary Antibodies
Other names:
FBX, FBX07, FBX7, PARK15, PKPS, F-Box Protein 7, F-box only protein 7
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
59kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Mitochondrial serine protease HtrA2 is expressed as a 49-kDa proenzyme that is targeted to the mitochondrial intermembrane space. Full-length HtrA2 consists of five functional regions: an N-terminal mitochondrial localisation signal, a transmembrane segment, an inhibitor of apoptosis protein binding motif, a serine protease domain and a C-terminal PDZ domain. It is believed that the transmembrane anchor attaches the precursor protein to the mitochondrial inner membrane, where it undergoes maturation. The fully processed protein loses 133 amino acids from the N-terminal (the localisation signal and the transmembrane anchor), exposing an N-terminal inhibitor of apoptosis protein binding motif.
The protease activity of the HtrA2 is required for mitochondrial homeostasis and mutations inactivating HtrA2 have been linked to neurodegenerative disorders such as Parkinson's disease. Additionally HtrA2 released into the cytosol is involved in apoptosis.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the C-terminal region of human HTRA2
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:2000-5000. IHC 1:50-200.
Category:
Primary Antibodies
Other names:
HTRA2, MGCA8, OMI, PARK13, PRSS25, HtrA Serine Peptidase 2, High Temperature Requirement Protein A2, Serine Protease HTRA2 Mitochondrial, Omi Stress-Regulated Endoprotease, Serine Proteinase OMI, Protease Serine 25, EC 3.4.21.108, Epididymis Secretory Sperm Binding Protein, HtrA-Like Serine Protease 3
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
49kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Mitochondrial serine protease HtrA2 is expressed as a 49-kDa proenzyme that is targeted to the mitochondrial intermembrane space. Full-length HtrA2 consists of five functional regions: an N-terminal mitochondrial localisation signal, a transmembrane segment, an inhibitor of apoptosis protein binding motif, a serine protease domain and a C-terminal PDZ domain. It is believed that the transmembrane anchor attaches the precursor protein to the mitochondrial inner membrane, where it undergoes maturation. The fully processed protein loses 133 amino acids from the N-terminal (the localisation signal and the transmembrane anchor), exposing an N-terminal inhibitor of apoptosis protein binding motif.
The protease activity of the HtrA2 is required for mitochondrial homeostasis and mutations inactivating HtrA2 have been linked to neurodegenerative disorders such as Parkinson's disease. Additionally HtrA2 released into the cytosol is involved in apoptosis.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the C-terminal region of human HTRA2
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:2000-5000. IHC 1:50-200.
Category:
Primary Antibodies
Other names:
HTRA2, MGCA8, OMI, PARK13, PRSS25, HtrA Serine Peptidase 2, High Temperature Requirement Protein A2, Serine Protease HTRA2 Mitochondrial, Omi Stress-Regulated Endoprotease, Serine Proteinase OMI, Protease Serine 25, EC 3.4.21.108, Epididymis Secretory Sperm Binding Protein, HtrA-Like Serine Protease 3
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
49kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Eukaryotic Translation Initiation Factor 4 Gamma 1 (EIF4G1) serves as a scaffold for the assembly of cap-dependent translation components in the formation of the EIF4F complex, which recruits ribosomes to mRNA such that the 5? untranslated region (5? UTR) can be scanned by ribosomes in search of an initiation codon.
A domain at the N-terminal of EIF4G1 can also interact with the poly(A)-binding protein, which may mediate the circularisation of mRNA during translation. Mutations in EIF4G1 have been linked to Parkinson's disease, however reports are conflicting
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Eukaryotic Translation Initiation Factor 4 Gamma 1 (EIF4G1) serves as a scaffold for the assembly of cap-dependent translation components in the formation of the EIF4F complex, which recruits ribosomes to mRNA such that the 5? untranslated region (5? UTR) can be scanned by ribosomes in search of an initiation codon.
A domain at the N-terminal of EIF4G1 can also interact with the poly(A)-binding protein, which may mediate the circularisation of mRNA during translation. Mutations in EIF4G1 have been linked to Parkinson's disease, however reports are conflicting
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Eukaryotic Translation Initiation Factor 4A-III (EIF4A3) belongs to the Asp-Glu-Ala-Asp (DEAD) box superfamily of proteins that have ATP-dependent RNA helicase activity and are involved in a number of areas of RNA biology, from transcription and translation to mRNA decay. EIF4A3 is named as such because it has homology at the amino-acid level to the translation initiation factors, EIF4A1 and EIF4A2, however it is actually a core component of the exon junction complex (EJC), which is associated with splicing and does not play an essential role in translation initiation (in contrast to EIF4A1 and EIF4A2).
EIF4A3 may have a role in parkinsons disease in relation to the deregulation of mRNA translation.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Eukaryotic Translation Initiation Factor 4A-III (EIF4A3) belongs to the Asp-Glu-Ala-Asp (DEAD) box superfamily of proteins that have ATP-dependent RNA helicase activity and are involved in a number of areas of RNA biology, from transcription and translation to mRNA decay. EIF4A3 is named as such because it has homology at the amino-acid level to the translation initiation factors, EIF4A1 and EIF4A2, however it is actually a core component of the exon junction complex (EJC), which is associated with splicing and does not play an essential role in translation initiation (in contrast to EIF4A1 and EIF4A2).
EIF4A3 may have a role in parkinsons disease in relation to the deregulation of mRNA translation.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Ubiquitin-specific protease 10 (USP10) is a deubiquitinase that is ubiquitously expressed in many cell types. Substrates of USP10 deubiquitinase include stress regulators, tumor suppressor p53, sirtuin6 and adenosine monophosphate-activated protein kinase. USP10 also has deubiquitinase-independent functions, inhibiting apoptosis by reducing reactive oxygen species (ROS) production induced by an oxidative stress inducer, suggesting that USP10 is a critical stress-protective factor under various stress conditions.
USP10 promotes the formation of both stress granules (SGs) and aggresomes and localises in SGs in cultured cells treated with SG stimulators by directly interacting with the SG-initiation protein G3BP. Depletion of USP10 partially reduces the formation of SGs and also reduces aggresome formation in cells treated with a proteasome inhibitor. Additionally through inducing aggresome formation, USP10 increases the aggregation of several pathogenic proteins such as ?-synuclein and Tau suggesting that USP10 may play a key role in the initiation of pathogenic Tau aggregation in Alzheimers disease (AD), through SG formation.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human USP10 from the C-terminal region
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Ubiquitin-specific protease 10 (USP10) is a deubiquitinase that is ubiquitously expressed in many cell types. Substrates of USP10 deubiquitinase include stress regulators, tumor suppressor p53, sirtuin6 and adenosine monophosphate-activated protein kinase. USP10 also has deubiquitinase-independent functions, inhibiting apoptosis by reducing reactive oxygen species (ROS) production induced by an oxidative stress inducer, suggesting that USP10 is a critical stress-protective factor under various stress conditions.
USP10 promotes the formation of both stress granules (SGs) and aggresomes and localises in SGs in cultured cells treated with SG stimulators by directly interacting with the SG-initiation protein G3BP. Depletion of USP10 partially reduces the formation of SGs and also reduces aggresome formation in cells treated with a proteasome inhibitor. Additionally through inducing aggresome formation, USP10 increases the aggregation of several pathogenic proteins such as ?-synuclein and Tau suggesting that USP10 may play a key role in the initiation of pathogenic Tau aggregation in Alzheimers disease (AD), through SG formation.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human USP10 from the C-terminal region
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Histone deacetylase 6 (HDAC6) is a member of the HDAC family of enzymes that remove acetyl groups from lysines of histones thereby acting as gene transcription regulators. HDAC6 is more specifically a member of the class IIB HDAC family and contains two catalytic domains and a C-terminal zinc finger domain that binds free ubiquitin as well as ubiquitinated proteins with high affinity. As a cytoplasmic deacetylase, HDAC6 can deacetylate substrates such as tubulin, heat shock protein 90 (HSP90).
HDAC6 plays an important role in protein degradation, alongside roles in cell morphology, adhesion, migration, and tumor cell invasion/metastasis.
Inhibition of Histone deacetylases (HDACs) has been shown to be neuroprotective in animal models of neurodegenerative diseases and HDAC6 is one possible target, however theoretically HDAC6 should actually contribute to the degradation of protein aggregates seen in neurodegenerative disorders such as Alzheimers, Parkinsons and Hutingtons diseases, So HDAC6 as a target for neurodegenerative disorders remains controversial.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Histone deacetylase 6 (HDAC6) is a member of the HDAC family of enzymes that remove acetyl groups from lysines of histones thereby acting as gene transcription regulators. HDAC6 is more specifically a member of the class IIB HDAC family and contains two catalytic domains and a C-terminal zinc finger domain that binds free ubiquitin as well as ubiquitinated proteins with high affinity. As a cytoplasmic deacetylase, HDAC6 can deacetylate substrates such as tubulin, heat shock protein 90 (HSP90).
HDAC6 plays an important role in protein degradation, alongside roles in cell morphology, adhesion, migration, and tumor cell invasion/metastasis.
Inhibition of Histone deacetylases (HDACs) has been shown to be neuroprotective in animal models of neurodegenerative diseases and HDAC6 is one possible target, however theoretically HDAC6 should actually contribute to the degradation of protein aggregates seen in neurodegenerative disorders such as Alzheimers, Parkinsons and Hutingtons diseases, So HDAC6 as a target for neurodegenerative disorders remains controversial.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Ras GTPase-activating protein-binding protein 1 (G3BP1) is a RNA-binding protein which along with G3BP2 regulates stress granule (SG) formation. Both G3BP1 & 2 contain disordered regions and an ordered nuclear transport factor 2 (NTF2)-like dimerisation domain at the N-terminal that is that is required for SG formation.
G3BP1 has endoribonuclease and helicase activity and is part of the Ras signal transduction pathway, binding specifically to Ras-GTPase-activating protein via its SH3 domain. G3BP1 has multiple phosphorylation sites which may be involved in its function in regulating stress granules. SG-like structures have been reported in neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), so it is believed that G3BP1 may play a role in such neurodegenerative diseases.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Rat, Cow, Chicken, Guinea Pig, Zebra finch, Goat, Dog, Cat
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human G3BP1 from the C-terminal region
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000. IHC 1:50-200. IF 1:50-200.
Category:
Primary Antibodies
Other names:
G3BP, HDH-VIII, ATP-dependent DNA helicase VIII, GAP SH3 domain-binding protein 1, G3BP-1
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
52kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Ras GTPase-activating protein-binding protein 1 (G3BP1) is a RNA-binding protein which along with G3BP2 regulates stress granule (SG) formation. Both G3BP1 & 2 contain disordered regions and an ordered nuclear transport factor 2 (NTF2)-like dimerisation domain at the N-terminal that is that is required for SG formation.
G3BP1 has endoribonuclease and helicase activity and is part of the Ras signal transduction pathway, binding specifically to Ras-GTPase-activating protein via its SH3 domain. G3BP1 has multiple phosphorylation sites which may be involved in its function in regulating stress granules. SG-like structures have been reported in neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), so it is believed that G3BP1 may play a role in such neurodegenerative diseases.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Rat, Cow, Chicken, Guinea Pig, Zebra finch, Goat, Dog, Cat
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human G3BP1 from the C-terminal region
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000. IHC 1:50-200. IF 1:50-200.
Category:
Primary Antibodies
Other names:
G3BP, HDH-VIII, ATP-dependent DNA helicase VIII, GAP SH3 domain-binding protein 1, G3BP-1
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
52kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Cytoplasmic activation/proliferation?associated protein-1 (Caprin?1) is a ubiquitously expressed and highly conserved cytoplasmic phosphoprotein. It is an RNA?binding protein involved in the regulation of cell cycle control?associated genes, having the characteristic arginine-glycine-glycine (RGG) motif and RG enrichment region associated with RNA binding proteins, as well as two highly conserved regions, homologous region-1 and homologous region-2.
Caprin-1 levels (other than in the brain), are tightly correlated with cellular proliferation. In neurons it may specifically regulate the transport and translation of mRNAs for proteins involved in synaptic plasticity. . Mutations in Caprin-1 have been linked to conditions such as amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD) and autism spectrum disorder (ASD).
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Cytoplasmic activation/proliferation?associated protein-1 (Caprin?1) is a ubiquitously expressed and highly conserved cytoplasmic phosphoprotein. It is an RNA?binding protein involved in the regulation of cell cycle control?associated genes, having the characteristic arginine-glycine-glycine (RGG) motif and RG enrichment region associated with RNA binding proteins, as well as two highly conserved regions, homologous region-1 and homologous region-2.
Caprin-1 levels (other than in the brain), are tightly correlated with cellular proliferation. In neurons it may specifically regulate the transport and translation of mRNAs for proteins involved in synaptic plasticity. . Mutations in Caprin-1 have been linked to conditions such as amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD) and autism spectrum disorder (ASD).
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
GTP cyclohydrolase 1 (GCH1) is an essential enzyme for dopamine production in nigrostriatal cells. It is required for BH4 synthesis (6(R)-l-erythro-5,6,7,8-tetrahydrobiopterin), a cofactor required for the production of aromatic amino acids, neurotransmitters, and nitric oxide. Through this requirement, GCH1 is implicated in neurological disorders such as DOPA-responsive dystonia and Parkinsons disease.
GCH1 is also relevant in pain sensitivity, cardiovascular risk, some cancers and chronic diseases such as hypertension, diabetes and atherosclerosis.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
GTP cyclohydrolase 1 (GCH1) is an essential enzyme for dopamine production in nigrostriatal cells. It is required for BH4 synthesis (6(R)-l-erythro-5,6,7,8-tetrahydrobiopterin), a cofactor required for the production of aromatic amino acids, neurotransmitters, and nitric oxide. Through this requirement, GCH1 is implicated in neurological disorders such as DOPA-responsive dystonia and Parkinsons disease.
GCH1 is also relevant in pain sensitivity, cardiovascular risk, some cancers and chronic diseases such as hypertension, diabetes and atherosclerosis.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
The vacuolar protein sorting 35 (VPS35) is a major component of the retromer recognition core complex which regulates intracellular protein sorting and trafficking.
Mutations in the VPS35 gene are linked to late-onset, autosomal dominant familial Parkinsons disease (PD) , which may involve a link with tau pathology with VPS35 shown to be significantly reduced in two distinct primary tauopathies (Progressive Supra-nuclear Palsy and Picks disease, two distinct primary tauopathies) [1]. There may also be a link between VPS35 and ?-synuclein accumulation, but more work is required to establish the details of the pathiogenic/neuroprotective role of VPS35.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000.
Category:
Primary Antibodies
Other names:
MEM3, PARK17, Vacuolar protein sorting-associated protein 35, hVPS35, Maternal-embryonic 3, Vesicle protein sorting 35
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
92kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Cytoplasm, Endosome
Purification:
Affinity purification
References:
[1] Vagnozzi, A.N., Li, J., Chiu, J. et al. VPS35 regulates tau phosphorylation and neuropathology in tauopathy. Mol Psychiatry (2019) doi:10.1038/s41380-019-0453-x
The vacuolar protein sorting 35 (VPS35) is a major component of the retromer recognition core complex which regulates intracellular protein sorting and trafficking.
Mutations in the VPS35 gene are linked to late-onset, autosomal dominant familial Parkinsons disease (PD) , which may involve a link with tau pathology with VPS35 shown to be significantly reduced in two distinct primary tauopathies (Progressive Supra-nuclear Palsy and Picks disease, two distinct primary tauopathies) [1]. There may also be a link between VPS35 and ?-synuclein accumulation, but more work is required to establish the details of the pathiogenic/neuroprotective role of VPS35.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000.
Category:
Primary Antibodies
Other names:
MEM3, PARK17, Vacuolar protein sorting-associated protein 35, hVPS35, Maternal-embryonic 3, Vesicle protein sorting 35
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
92kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Cytoplasm, Endosome
Purification:
Affinity purification
References:
[1] Vagnozzi, A.N., Li, J., Chiu, J. et al. VPS35 regulates tau phosphorylation and neuropathology in tauopathy. Mol Psychiatry (2019) doi:10.1038/s41380-019-0453-x
The vacuolar protein sorting 35 (VPS35) is a major component of the retromer recognition core complex which regulates intracellular protein sorting and trafficking.
Mutations in the VPS35 gene are linked to late-onset, autosomal dominant familial Parkinsons disease (PD) , which may involve a link with tau pathology with VPS35 shown to be significantly reduced in two distinct primary tauopathies (Progressive Supra-nuclear Palsy and Picks disease, two distinct primary tauopathies) [1]. There may also be a link between VPS35 and ?-synuclein accumulation, but more work is required to establish the details of the pathiogenic/neuroprotective role of VPS35.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000. IHC 1:25-100.
Category:
Primary Antibodies
Other names:
MEM3, PARK17, Vacuolar protein sorting-associated protein 35, hVPS35, Maternal-embryonic 3, Vesicle protein sorting 35
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
92 kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Cytoplasm, Endosome
Purification:
Affinity purification
References:
[1] Vagnozzi, A.N., Li, J., Chiu, J. et al. VPS35 regulates tau phosphorylation and neuropathology in tauopathy. Mol Psychiatry (2019) doi:10.1038/s41380-019-0453-x
Glial fibrillary acidic protein (GFAP), is an intermediate filament (IF) protein belonging to the type III subclass of IF proteins. Like other IF proteins, GFAP is composed of an amino terminal head domain, central rod domain and a carboxy terminal tail domain. GFAP is specifically found in astroglia, a cell type which is highly responsive to neurologic insults. Astrogliosis is found to be a result of mechanical trauma, AIDS dementia, prion infection and inflammatory demyelinating diseases, and is accompanied by an increase in GFAP expression. GFAP is an immunohistochemical marker for localising benign astrocyte and neoplastic cells of glial origin in the central nervous system.
Product Type:
NS Reagents Antibody
Antibody Type:
Monoclonal
Format:
100 µg in 100 µl PBS containing 0.02% sodium azide.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Clone number:
Clone FD19-9
Antibody Isotype:
IgG1
Application Details:
IHC 1:100 - 1: 1000
Category:
Primary Antibodies
Other names:
GFAP, ALXDRD, gfapl, Intermediate filament protein
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
50kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Cytoplasm
Purification:
Protein A Affinity Purified
References:
Yang et al. 2007. J Gastroenterol Hepatol. 22(9):1460-8. PMID: 17645461. ; Hagemann et al. 2006. J Neurosci Methods. 156(1-2):194-202. PMID: 16621008. ; Coakham et al. 1984. Lancet. 1(8386):1095-8. PMID: 6202990. ; Garson JA. The development and characterisation of monoclonal antibodies for use in neuropathology. MD thesis. University of Birmingham, 1983
The vacuolar protein sorting 35 (VPS35) is a major component of the retromer recognition core complex which regulates intracellular protein sorting and trafficking.
Mutations in the VPS35 gene are linked to late-onset, autosomal dominant familial Parkinsons disease (PD) , which may involve a link with tau pathology with VPS35 shown to be significantly reduced in two distinct primary tauopathies (Progressive Supra-nuclear Palsy and Picks disease, two distinct primary tauopathies) [1]. There may also be a link between VPS35 and ?-synuclein accumulation, but more work is required to establish the details of the pathiogenic/neuroprotective role of VPS35.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000. IHC 1:25-100.
Category:
Primary Antibodies
Other names:
MEM3, PARK17, Vacuolar protein sorting-associated protein 35, hVPS35, Maternal-embryonic 3, Vesicle protein sorting 35
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
92 kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Cytoplasm, Endosome
Purification:
Affinity purification
References:
[1] Vagnozzi, A.N., Li, J., Chiu, J. et al. VPS35 regulates tau phosphorylation and neuropathology in tauopathy. Mol Psychiatry (2019) doi:10.1038/s41380-019-0453-x
TATA-binding protein-associated factor 2N (TAF15) is a member of the FET/TET (FUS/TLS, EWS, TAF15) family of RNA-binding proteins (RBPs) that have roles in transcription, pre-mRNA splicing, DNA repair, and mRNA transport in neurons.
TAF15 (like all FET family members) is highly conserved and ubiquitously expressed, with several conserved domains: a serine-tyrosine-glycine-glutamine (SYGQ) domain embedded in the DNA activation domain (AD), 3 glycine-arginine (RGG) rich regions that affect RNA binding, one conserved RNA-binding domain (RBD, formed by a RNA-recognition motif, RRM), and a zinc finger domain that is also involved in nucleic acid binding [1].
Mutations in the TAF15 gene may have a role in the pathogenesis of Amyotrophic lateral sclerosis (ALS) with TAF15 accumulating as cytoplasmic aggregates in neuronal cells. It has also been shown that parkin directly binds to TAF15 and may suppress the defective TAF15 genotype in ALS. TAF15 is also implicated in a number of other neurodegenerative disorders.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
62kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Cytoplasm, Nucleus
Purification:
Affinity purification
References:
[1] Role of FET proteins in neurodegenerative disorders Francesca Svetoni, Paola Frisone, Maria Paola Paronetto RNA Biol. 2016; 13(11): 10891102. Published online 2016 Jul 14. doi: 10.1080/15476286.2016.1211225
TATA-binding protein-associated factor 2N (TAF15) is a member of the FET/TET (FUS/TLS, EWS, TAF15) family of RNA-binding proteins (RBPs) that have roles in transcription, pre-mRNA splicing, DNA repair, and mRNA transport in neurons.
TAF15 (like all FET family members) is highly conserved and ubiquitously expressed, with several conserved domains: a serine-tyrosine-glycine-glutamine (SYGQ) domain embedded in the DNA activation domain (AD), 3 glycine-arginine (RGG) rich regions that affect RNA binding, one conserved RNA-binding domain (RBD, formed by a RNA-recognition motif, RRM), and a zinc finger domain that is also involved in nucleic acid binding [1].
Mutations in the TAF15 gene may have a role in the pathogenesis of Amyotrophic lateral sclerosis (ALS) with TAF15 accumulating as cytoplasmic aggregates in neuronal cells. It has also been shown that parkin directly binds to TAF15 and may suppress the defective TAF15 genotype in ALS. TAF15 is also implicated in a number of other neurodegenerative disorders.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
62kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Cytoplasm, Nucleus
Purification:
Affinity purification
References:
[1] Role of FET proteins in neurodegenerative disorders Francesca Svetoni, Paola Frisone, Maria Paola Paronetto RNA Biol. 2016; 13(11): 10891102. Published online 2016 Jul 14. doi: 10.1080/15476286.2016.1211225
Vesicle-associated membrane protein-associated protein B (VAPB) interacts with lipid-binding proteins that have a FFAT motif (a short motif containing two phenylalanines in an acidic tract). This targets it to the cytosolic surface of the endoplasmic reticulum. It is found as a homodimer and as a heterodimer with VAPA and is believed to be involved in vesicle trafficking. VAPB is abundant in motor neurons and a mutation in the conserved major sperm protein homology domain of VAPB has been linked to motor-neuron degeneration in amyotrophic lateral sclerosis (ALS) through aggregation of mutant VAPB in tubular ER clusters, which interferes with its FFAT-motif binding, and traps VAP in mutant aggregates.
VAPB is also linked to the mitochondrial membrane protein, protein tyrosine phosphatase interacting protein-51 (PTPIP51) with both proteins with the pair acting as a tether between regions of ER to the mitochondrial surface. Disruption of the interaction of VAPB and PTPIP51 is linked to the pathogenic process in Parkinsons disease, fronto-temporal dementia (FTD) and related amyotrophic lateral sclerosis (ALS).
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000. IHC 1:50-200. IF 1:20-50.
Category:
Primary Antibodies
Other names:
ALS8, VAMP-B, VAP-B, Vesicle-associated membrane protein-associated protein B/C
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
27kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Endoplasmic reticulum membrane Single-pass type IV membrane protein
Purification:
Affinity purification
References:
[1] Gómez-Suaga, P., Pérez-Nievas, B.G., Glennon, E.B. et al. The VAPB-PTPIP51 endoplasmic reticulum-mitochondria tethering proteins are present in neuronal synapses and regulate synaptic activity. acta neuropathol commun 7, 35 (2019) doi:10.1186/s40478-019-0688-4
Intraflagellar transport protein 74 homolog (IFT74) is an intraflagellar transport (IFT) protein being part of the core of a multi-protein complex involved in the transport of ciliary proteins along axonemal microtubules. IFT74 directly interacts with IFT81 (Intraflagellar transport protein 81 homolog) and both proteins together bind and transport tubulin within cilia and are required for ciliogenesis.
IFT74 has been shown to be required for assembly and stability of the multi-protein complex, both proteins having extended central and C-terminal coiled-coil domains that seem to be necessary for their interaction. Mutations in IFT74 are associated with amyotrophic lateral sclerosis--frontotemporal dementia and Bardet-Biedl Syndrome.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human IFT74 from the N-terminal region
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:1000-3000.
Category:
Primary Antibodies
Other names:
BBS20, CCDC2, CMG-1, CMG1, Capillary morphogenesis gene 1 protein, Intraflagellar transport protein 74 homolog, Coiled-coil domain-containing protein 2
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
69kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Vesicle-associated membrane protein-associated protein B (VAPB) interacts with lipid-binding proteins that have a FFAT motif (a short motif containing two phenylalanines in an acidic tract). This targets it to the cytosolic surface of the endoplasmic reticulum. It is found as a homodimer and as a heterodimer with VAPA and is believed to be involved in vesicle trafficking. VAPB is abundant in motor neurons and a mutation in the conserved major sperm protein homology domain of VAPB has been linked to motor-neuron degeneration in amyotrophic lateral sclerosis (ALS) through aggregation of mutant VAPB in tubular ER clusters, which interferes with its FFAT-motif binding, and traps VAP in mutant aggregates.
VAPB is also linked to the mitochondrial membrane protein, protein tyrosine phosphatase interacting protein-51 (PTPIP51) with both proteins with the pair acting as a tether between regions of ER to the mitochondrial surface. Disruption of the interaction of VAPB and PTPIP51 is linked to the pathogenic process in Parkinsons disease, fronto-temporal dementia (FTD) and related amyotrophic lateral sclerosis (ALS).
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000. IHC 1:50-200. IF 1:20-50.
Category:
Primary Antibodies
Other names:
ALS8, VAMP-B, VAP-B, Vesicle-associated membrane protein-associated protein B/C
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
27kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Endoplasmic reticulum membrane, Single-pass type IV membrane protein
Purification:
Affinity purification
References:
[1] Gómez-Suaga, P., Pérez-Nievas, B.G., Glennon, E.B. et al. The VAPB-PTPIP51 endoplasmic reticulum-mitochondria tethering proteins are present in neuronal synapses and regulate synaptic activity. acta neuropathol commun 7, 35 (2019) doi:10.1186/s40478-019-0688-4
Superoxide dismutase 1 (SOD1) is one of three superoxide dismutases with SOD1 being the principal cytoplasmic superoxide dismutase in humans. It binds copper and zinc ions for its activity and stability and plays a major role in redox potential regulation. It catalyses the transformation of the superoxide anion (O2?) into hydrogen peroxide. SOD1 variants are a common cause of familial amyotrophic lateral sclerosis (ALS).
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000. IHC 1:50-200.
Category:
Primary Antibodies
Other names:
ALS, ALS1, HEL-S-44, IPOA, SOD, hSod1, homodimer
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
16kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Superoxide dismutase 1 (SOD1) is one of three superoxide dismutases with SOD1 being the principal cytoplasmic superoxide dismutase in humans. It binds copper and zinc ions for its activity and stability and plays a major role in redox potential regulation. It catalyses the transformation of the superoxide anion (O2?) into hydrogen peroxide. SOD1 variants are a common cause of familial amyotrophic lateral sclerosis (ALS).
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000. IHC 1:50-200.
Category:
Primary Antibodies
Other names:
ALS, ALS1, HEL-S-44, IPOA, SOD, hSod1, homodimer
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
16kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Intraflagellar transport protein 74 homolog (IFT74) is an intraflagellar transport (IFT) protein being part of the core of a multi-protein complex involved in the transport of ciliary proteins along axonemal microtubules. IFT74 directly interacts with IFT81 (Intraflagellar transport protein 81 homolog) and both proteins together bind and transport tubulin within cilia and are required for ciliogenesis.
IFT74 has been shown to be required for assembly and stability of the multi-protein complex, both proteins having extended central and C-terminal coiled-coil domains that seem to be necessary for their interaction. Mutations in IFT74 are associated with amyotrophic lateral sclerosis--frontotemporal dementia and Bardet-Biedl Syndrome.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human IFT74 from the N-terminal region
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:1000-3000.
Category:
Primary Antibodies
Other names:
BBS20, CCDC2, CMG-1, CMG1, Capillary morphogenesis gene 1 protein, Intraflagellar transport protein 74 homolog, Coiled-coil domain-containing protein 2
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
69kDa (Intended as a general guide and does not allow for all isoforms and species variations)
FUS (fused in sarcoma) is a member of the FET/TET (FUS/TLS, EWS, TAF15) family of RNA-binding proteins (RBPs) that have roles in transcription, pre-mRNA splicing, DNA repair, and mRNA transport in neurons.
FUS (like all FET family members) is highly conserved and ubiquitously expressed, with several conserved domains: a serine-tyrosine-glycine-glutamine (SYGQ) domain embedded in the DNA activation domain (AD), 3 glycine-arginine (RGG) rich regions that affect RNA binding, one conserved RNA-binding domain (RBD, formed by a RNA-recognition motif, RRM), and a zinc finger domain that is also involved in nucleic acid binding [1].
FUS binds to single and double stranded DNA as well as RNA and participates in multiple cellular functions. Alternative splicing results in multiple transcript variants. Defects in the FUS gene are associated with amyotrophic lateral sclerosis (ALS). FUS is also implicated in a number of other neurodegenerative disorders.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
IHC 1:30-150.
Category:
Primary Antibodies
Other names:
ALS6, ETM4, HNRNPP2, POMP75, TLS, fused in sarcoma, translocated in liposarcoma
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
53kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Nucleus
Purification:
Affinity purification
References:
[1] Role of FET proteins in neurodegenerative disorders Francesca Svetoni, Paola Frisone, Maria Paola Paronetto RNA Biol. 2016; 13(11): 10891102. Published online 2016 Jul 14. doi: 10.1080/15476286.2016.1211225
[2] Functions of FUS/TLS From DNA Repair to Stress Response: Implications for ALS Reddy Ranjith Kumar Sama, Catherine L. Ward, Daryl A. Bosco ASN Neuro. 2014 May-Jun; 6(4): 1759091414544472. doi: 10.1177/1759091414544472
FUS (fused in sarcoma) is a member of the FET/TET (FUS/TLS, EWS, TAF15) family of RNA-binding proteins (RBPs) that have roles in transcription, pre-mRNA splicing, DNA repair, and mRNA transport in neurons.
FUS (like all FET family members) is highly conserved and ubiquitously expressed, with several conserved domains: a serine-tyrosine-glycine-glutamine (SYGQ) domain embedded in the DNA activation domain (AD), 3 glycine-arginine (RGG) rich regions that affect RNA binding, one conserved RNA-binding domain (RBD, formed by a RNA-recognition motif, RRM), and a zinc finger domain that is also involved in nucleic acid binding [1].
FUS binds to single and double stranded DNA as well as RNA and participates in multiple cellular functions. Alternative splicing results in multiple transcript variants. Defects in the FUS gene are associated with amyotrophic lateral sclerosis (ALS). FUS is also implicated in a number of other neurodegenerative disorders.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
IHC 1:30-150.
Category:
Primary Antibodies
Other names:
ALS6, ETM4, HNRNPP2, POMP75, TLS, fused in sarcoma, translocated in liposarcoma
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
53kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Nucleus
Purification:
Affinity purification
References:
[1] Role of FET proteins in neurodegenerative disorders Francesca Svetoni, Paola Frisone, Maria Paola Paronetto RNA Biol. 2016; 13(11): 10891102. Published online 2016 Jul 14. doi: 10.1080/15476286.2016.1211225
[2] Functions of FUS/TLS From DNA Repair to Stress Response: Implications for ALS Reddy Ranjith Kumar Sama, Catherine L. Ward, Daryl A. Bosco ASN Neuro. 2014 May-Jun; 6(4): 1759091414544472. doi: 10.1177/1759091414544472
Excitatory amino acid transporter 2 (EAAT2/SLC1A2) is a membrane-bound protein expressed primarily on astrocytes that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors.
Impaired glutamate uptake by dysfunction or reduced expression of EAAT2 can lead to excitotoxicity, which has been implicated in the pathogenesis of neurodegenerative diseases, including Alzheimers disease, Huntingtons disease and amyotrophic lateral sclerosis. Increased astrocytic EAAT2 expression appears to afford greater neuroprotection under excitotoxic conditions.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the C-terminal region of human SLC1A2
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
IHC 1:25-100.
Category:
Primary Antibodies
Other names:
EAAT2, GLT-1, SLC1A2, Glutamate/aspartate transporter II, Sodium-dependent glutamate/aspartate transporter 2, Solute carrier family 1 member 2, Excitatory amino acid transporter 2
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
62kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Excitatory amino acid transporter 2 (EAAT2/SLC1A2) is a membrane-bound protein expressed primarily on astrocytes that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors.
Impaired glutamate uptake by dysfunction or reduced expression of EAAT2 can lead to excitotoxicity, which has been implicated in the pathogenesis of neurodegenerative diseases, including Alzheimers disease, Huntingtons disease and amyotrophic lateral sclerosis. Increased astrocytic EAAT2 expression appears to afford greater neuroprotection under excitotoxic conditions.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the C-terminal region of human SLC1A2
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
IHC 1:25-100.
Category:
Primary Antibodies
Other names:
EAAT2, GLT-1, SLC1A2, Glutamate/aspartate transporter II, Sodium-dependent glutamate/aspartate transporter 2, Solute carrier family 1 member 2, Excitatory amino acid transporter 2
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
62kDa (Intended as a general guide and does not allow for all isoforms and species variations)
14-3-3 protein theta (YWHAQ) mediates signal transduction by binding to phosphoserine-containing proteins. It is found in both plants and mammals and is highly conserved across different species. 14-3-3 protein theta contains in its 5' UTR a 6 bp tandem repeat sequence which is polymorphic.
Another 14-3-3 protein family member (zeta/delta - YWHAZ) has been shown to interact with TDP-43 and SOD1 in ALS to modulate neurofilament light chain mRNA stability and 14-3-3 protein was also found in lewy bodies in sALS and also interacts with FUS in ALS. YWHAQ was reported to have significantly elevated mRNA level in sALS patients, so it may have a role in ALS pathology, however its specific role remains unknown.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
Rabbit, Bovine, Chicken, Dog, Golden Hamster, Naked Mole Rat
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:1000-5000. IHC 1:25-100.
Category:
Primary Antibodies
Other names:
1C5, HS1, 14-3-3, 14-3-3 protein theta, YWHAQ, 14-3-3 protein T-cell, 14-3-3 protein tau, Protein HS1
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
28kDa (Intended as a general guide and does not allow for all isoforms and species variations)
14-3-3 protein theta (YWHAQ) mediates signal transduction by binding to phosphoserine-containing proteins. It is found in both plants and mammals and is highly conserved across different species. 14-3-3 protein theta contains in its 5' UTR a 6 bp tandem repeat sequence which is polymorphic.
Another 14-3-3 protein family member (zeta/delta - YWHAZ) has been shown to interact with TDP-43 and SOD1 in ALS to modulate neurofilament light chain mRNA stability and 14-3-3 protein was also found in lewy bodies in sALS and also interacts with FUS in ALS. YWHAQ was reported to have significantly elevated mRNA level in sALS patients, so it may have a role in ALS pathology, however its specific role remains unknown.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
Rabbit, Bovine, Chicken, Dog, Golden Hamster, Naked Mole Rat
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:1000-5000. IHC 1:25-100.
Category:
Primary Antibodies
Other names:
1C5, HS1, 14-3-3, 14-3-3 protein theta, YWHAQ, 14-3-3 protein T-cell, 14-3-3 protein tau, Protein HS1
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
28kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Dickkopf WNT signaling pathway inhibitor 1 (DKK1) is a secreted glycoprotein that inhibits Wnt/Beta-signaling by interaction with low-density lipoprotein receptor-related protein 5/6 (LRP5/6). It is involved in embryonic development and may be important in boone formation in adults. DKK1 has two cysteine rich regions that mediate protein-protein interactions.
Wnt signaling has a vital role in both the development of the nervous system and higher functions including synaptic plasticity and memory. DKK1 may have a role in the development of Alzheimers disease (AD) due to reduced Wnt/Beta-signaling, which leads to synapse vulnerability through reduced regulation of the Wnt signaling pathway.
Elevated DKK1 has also been observed in numerous human cancers with elevated levels in bone marrow plasma and peripheral blood associated with the presence of osteolytic bone lesions in patients with multiple myeloma.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:200-1000.
Category:
Primary Antibodies
Other names:
SK, DKK-1
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
29kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Dickkopf WNT signaling pathway inhibitor 1 (DKK1) is a secreted glycoprotein that inhibits Wnt/Beta-signaling by interaction with low-density lipoprotein receptor-related protein 5/6 (LRP5/6). It is involved in embryonic development and may be important in boone formation in adults. DKK1 has two cysteine rich regions that mediate protein-protein interactions.
Wnt signaling has a vital role in both the development of the nervous system and higher functions including synaptic plasticity and memory. DKK1 may have a role in the development of Alzheimers disease (AD) due to reduced Wnt/Beta-signaling, which leads to synapse vulnerability through reduced regulation of the Wnt signaling pathway.
Elevated DKK1 has also been observed in numerous human cancers with elevated levels in bone marrow plasma and peripheral blood associated with the presence of osteolytic bone lesions in patients with multiple myeloma.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:200-1000.
Category:
Primary Antibodies
Other names:
SK, DKK-1
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
29kDa (Intended as a general guide and does not allow for all isoforms and species variations)
CD2-associated protein (CD2AP) is an adaptor protein, that regulates membrane trafficking. It has three N-terminal SH3 domains and a C-terminal proline-rich actin binding domain and coiled-coil. CD2AP is active in a range of tissues including the nervous system. Its role in the nervous system is however not fully understood, but it is known to play a role in amyloid precursor protein trafficking and processing [1] making it a relevant protein in Alzheimer's disease research. It is also involved in axonal growth [2] and maintenance of blood-brain barrier integrity [3]
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the central region of human CD2AP
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:5000-8000.
Category:
Primary Antibodies
Other names:
CD2AP, CD2-associated protein, Adapter protein CMS, CMS,
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
71kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Cytoplasm
Purification:
Affinity purification
References:
[1] F. Ubelmann, T. Burrinha, L. Salavessa, R. Gomes, C. Ferreira, N. Moreno, C. Guimas Almeida. Bin1 and CD2AP polarise the endocytic generation of beta-amyloid. EMBO Rep., 18 (2017), pp. 102-122
[2] B.J. Harrison, G. Venkat, J.L. Lamb, T.H. Hutson, C. Drury, K.K. Rau, M.B. Bunge, L.M. Mendell, F.H. Gage, R.D. Johnson, et al. The Adaptor Protein CD2AP Is a Coordinator of Neurotrophin Signaling-Mediated Axon Arbor Plasticity. J. Neurosci., 36 (2016), pp. 4259-4275.
[3] J.N. Cochran, T. Rush, S.C. Buckingham, E.D. Roberson. The Alzheimers disease risk factor CD2AP maintains blood-brain barrier integrity. Hum. Mol. Genet., 24 (2015), pp. 6667-6674.
CD2-associated protein (CD2AP) is an adaptor protein, that regulates membrane trafficking. It has three N-terminal SH3 domains and a C-terminal proline-rich actin binding domain and coiled-coil. CD2AP is active in a range of tissues including the nervous system. Its role in the nervous system is however not fully understood, but it is known to play a role in amyloid precursor protein trafficking and processing [1] making it a relevant protein in Alzheimer's disease research. It is also involved in axonal growth [2] and maintenance of blood-brain barrier integrity [3]
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the central region of human CD2AP
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:5000-8000.
Category:
Primary Antibodies
Other names:
CD2AP, CD2-associated protein, Adapter protein CMS, CMS,
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
71kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Cytoplasm
Purification:
Affinity purification
References:
[1] F. Ubelmann, T. Burrinha, L. Salavessa, R. Gomes, C. Ferreira, N. Moreno, C. Guimas Almeida. Bin1 and CD2AP polarise the endocytic generation of beta-amyloid. EMBO Rep., 18 (2017), pp. 102-122
[2] B.J. Harrison, G. Venkat, J.L. Lamb, T.H. Hutson, C. Drury, K.K. Rau, M.B. Bunge, L.M. Mendell, F.H. Gage, R.D. Johnson, et al. The Adaptor Protein CD2AP Is a Coordinator of Neurotrophin Signaling-Mediated Axon Arbor Plasticity. J. Neurosci., 36 (2016), pp. 4259-4275.
[3] J.N. Cochran, T. Rush, S.C. Buckingham, E.D. Roberson. The Alzheimers disease risk factor CD2AP maintains blood-brain barrier integrity. Hum. Mol. Genet., 24 (2015), pp. 6667-6674.
Gephyrin is a 93-kDa protein that was initially identified as a tubulin-binding molecule that co-purifies with GlyRs (Glycine Receptors). It is highly expressed in brain tissues, localising to neuronal postsynaptic membranes and is essential for postsynaptic localisation of inhibitory GlyRs and GABA-ARs (GABA-A Receptors). It is thought to anchor the receptors to subsynaptic microtubules.
In vertebrates gephyrin has an N-terminal G-domain and a C-terminal E-domain connected by a central linker region or C-domain. At least five splice variants of Gephyrin have been identified in rat and human brain tissue covering a range of molecular weights.
An accumulation of gephyrin within Beta-amyloid plaques due to a shift in its solubility, has been seen in Alzheimer's disease with an accumulation of a lower molecular weight isoform (a product of gephyrin cleavage), and a reduced amount of the full length gephyrin.
Gephyrin is also required for molybdenum cofactor biosynthesis (in all tissues) and mutations in the Gephyrin gene may be associated with the neurological condition hyperplexia and molybdenum cofactor deficiency.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Gephyrin is a 93-kDa protein that was initially identified as a tubulin-binding molecule that co-purifies with GlyRs (Glycine Receptors). It is highly expressed in brain tissues, localising to neuronal postsynaptic membranes and is essential for postsynaptic localisation of inhibitory GlyRs and GABA-ARs (GABA-A Receptors). It is thought to anchor the receptors to subsynaptic microtubules.
In vertebrates gephyrin has an N-terminal G-domain and a C-terminal E-domain connected by a central linker region or C-domain. At least five splice variants of Gephyrin have been identified in rat and human brain tissue covering a range of molecular weights.
An accumulation of gephyrin within Beta-amyloid plaques due to a shift in its solubility, has been seen in Alzheimer's disease with an accumulation of a lower molecular weight isoform (a product of gephyrin cleavage), and a reduced amount of the full length gephyrin.
Gephyrin is also required for molybdenum cofactor biosynthesis (in all tissues) and mutations in the Gephyrin gene may be associated with the neurological condition hyperplexia and molybdenum cofactor deficiency.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Gephyrin is a 93-kDa protein that was initially identified as a tubulin-binding molecule that co-purifies with GlyRs (Glycine Receptors). It is highly expressed in brain tissues, localising to neuronal postsynaptic membranes and is essential for postsynaptic localisation of inhibitory GlyRs and GABA-ARs (GABA-A Receptors). It is thought to anchor the receptors to subsynaptic microtubules.
In vertebrates gephyrin has an N-terminal G-domain and a C-terminal E-domain connected by a central linker region or C-domain. At least five splice variants of Gephyrin have been identified in rat and human brain tissue covering a range of molecular weights.
An accumulation of gephyrin within Beta-amyloid plaques due to a shift in its solubility, has been seen in Alzheimer's disease with an accumulation of a lower molecular weight isoform (a product of gephyrin cleavage), and a reduced amount of the full length gephyrin.
Gephyrin is also required for molybdenum cofactor biosynthesis (in all tissues) and mutations in the Gephyrin gene may be associated with the neurological condition hyperplexia and molybdenum cofactor deficiency.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human Gephyrin from the C-terminal region
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Gephyrin is a 93-kDa protein that was initially identified as a tubulin-binding molecule that co-purifies with GlyRs (Glycine Receptors). It is highly expressed in brain tissues, localising to neuronal postsynaptic membranes and is essential for postsynaptic localisation of inhibitory GlyRs and GABA-ARs (GABA-A Receptors). It is thought to anchor the receptors to subsynaptic microtubules.
In vertebrates gephyrin has an N-terminal G-domain and a C-terminal E-domain connected by a central linker region or C-domain. At least five splice variants of Gephyrin have been identified in rat and human brain tissue covering a range of molecular weights.
An accumulation of gephyrin within Beta-amyloid plaques due to a shift in its solubility, has been seen in Alzheimer's disease with an accumulation of a lower molecular weight isoform (a product of gephyrin cleavage), and a reduced amount of the full length gephyrin.
Gephyrin is also required for molybdenum cofactor biosynthesis (in all tissues) and mutations in the Gephyrin gene may be associated with the neurological condition hyperplexia and molybdenum cofactor deficiency.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human Gephyrin from the C-terminal region
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Cholesterol 24-hydroxylase (CYP46A1) is a cytochrome P450 enzyme and endoplasmic reticulum protein expressed in brain tissues, It is important in brain cholesterol homeostasis being responsible for cholesterol elimination by its hydroxylation into 24S-hydroxycholesterol. Cholesterol cannot cross the blood-brain barrier, but 24S-hydroxycholesterol can, allowing it to travel via the circulatory system to the liver for catabolism. Increasing evidence suggests that CYP46A1 has a role in the pathogenesis and progression of neurodegenerative disorders with there being significant CYP46A1 expression in astrocytes and around amyloid plaques in Alzheimers disease, and increases in the level of CYP46A1 in the brain having a possible neuroprotective role in Huntingtons disease.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human CYP46A1 from the N-terminal region
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Cholesterol 24-hydroxylase (CYP46A1) is a cytochrome P450 enzyme and endoplasmic reticulum protein expressed in brain tissues, It is important in brain cholesterol homeostasis being responsible for cholesterol elimination by its hydroxylation into 24S-hydroxycholesterol. Cholesterol cannot cross the blood-brain barrier, but 24S-hydroxycholesterol can, allowing it to travel via the circulatory system to the liver for catabolism. Increasing evidence suggests that CYP46A1 has a role in the pathogenesis and progression of neurodegenerative disorders with there being significant CYP46A1 expression in astrocytes and around amyloid plaques in Alzheimers disease, and increases in the level of CYP46A1 in the brain having a possible neuroprotective role in Huntingtons disease.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human CYP46A1 from the N-terminal region
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Angiotensin converting enzyme (ACE) is a central component of the reninangiotensin system (RAS), which converts the hormone angiotensin I to the angiotensin II and active vasoconstrictor thereby controling blood pressure. ACE inhibitors are widely used as pharmaceutical drugs for treatment of cardiovascular diseases.
ACE in brain tissues appears to have a role in converting amyloid beta 42 to amyloid beta 40 with data in some studies indicatiing that Alzheimers disease (AD) patients taking ACE inhibitors declined more rapidly, however other studies have shown a reduced risk of Alzheimer's disease under certain conditions with AD patients taking ACE inhibitors. Additionally studies have indicated that ACE inhibitors may reduce the risk for developing ALS.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A long synthetic peptide from the middle of human ACE
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000, IHC 1:50-100
Category:
Primary Antibodies
Other names:
ACE1, CD143, DCP, DCP1, Dipeptidyl carboxypeptidase I, Angiotensin converting enzyme
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
79/83/132/150kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Cell membrane Cytoplasm Secreted Single-pass type I membrane protein
Angiotensin converting enzyme (ACE) is a central component of the reninangiotensin system (RAS), which converts the hormone angiotensin I to the angiotensin II and active vasoconstrictor thereby controling blood pressure. ACE inhibitors are widely used as pharmaceutical drugs for treatment of cardiovascular diseases.
ACE in brain tissues appears to have a role in converting amyloid beta 42 to amyloid beta 40 with data in some studies indicatiing that Alzheimers disease (AD) patients taking ACE inhibitors declined more rapidly, however other studies have shown a reduced risk of Alzheimer's disease under certain conditions with AD patients taking ACE inhibitors. Additionally studies have indicated that ACE inhibitors may reduce the risk for developing ALS.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A long synthetic peptide from the middle of human ACE
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000, IHC 1:50-100
Category:
Primary Antibodies
Other names:
ACE1, CD143, DCP, DCP1, Dipeptidyl carboxypeptidase I, Angiotensin converting enzyme
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
79/83/132/150kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Cell membrane Cytoplasm Secreted Single-pass type I membrane protein
Bridging INtegrator 1 (BIN1) is a member of the Bin/Amphiphysin/Rvs (BAR) family of adaptor proteins that regulates lipid membrane dynamics. It is ubiquitously expressed throughout the body with high expression in brain tissues. In the brain, BIN1 is expressed in multiple isoforms, the ubiquitously expressed isoforms 9 and 10, along with brain-specific isoforms 1 to 7. BIN1 is involved in a wide range of cellular functions associated with membrane curvature, including phagocytosis and clathrin-mediated endocytosis and is believed to interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms expressed in the central nervous system are involved in synaptic vesicle endocytosis. BIN1 has N-terminal Bin-Amphiphysin-Rvs and C-terminal Src homology 3 domains. BIN1 is believed to be involved in the pathogenesis of Alzheimers disease (AD) as a modulator of Tau pathology, rather than as a promoter of A? deposition. Depletion of BIN1 increases cellular BACE1 levels through impaired endosomal trafficking, resulting in increased amyloid-beta production. In neuronal circuits, endocytosis regulation may influence the internalisation of paired helical filaments (PHF) tau aggregates.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human BIN1 from the C-terminal region of the protein
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000. IHC 1:50-200. IF 1:20-50.
Category:
Primary Antibodies
Other names:
AMPH2, AMPHL, SH3P9, amphiphysin II, amphiphysin-like protein, AMPHL, BIN1_HUMAN, box-dependent myc-interacting protein 1, myc box-dependent-interacting protein 1
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
65kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Bridging INtegrator 1 (BIN1) is a member of the Bin/Amphiphysin/Rvs (BAR) family of adaptor proteins that regulates lipid membrane dynamics. It is ubiquitously expressed throughout the body with high expression in brain tissues. In the brain, BIN1 is expressed in multiple isoforms, the ubiquitously expressed isoforms 9 and 10, along with brain-specific isoforms 1 to 7. BIN1 is involved in a wide range of cellular functions associated with membrane curvature, including phagocytosis and clathrin-mediated endocytosis and is believed to interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms expressed in the central nervous system are involved in synaptic vesicle endocytosis. BIN1 has N-terminal Bin-Amphiphysin-Rvs and C-terminal Src homology 3 domains. BIN1 is believed to be involved in the pathogenesis of Alzheimers disease (AD) as a modulator of Tau pathology, rather than as a promoter of A? deposition. Depletion of BIN1 increases cellular BACE1 levels through impaired endosomal trafficking, resulting in increased amyloid-beta production. In neuronal circuits, endocytosis regulation may influence the internalisation of paired helical filaments (PHF) tau aggregates.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human BIN1 from the C-terminal region of the protein
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000. IHC 1:50-200. IF 1:20-50.
Category:
Primary Antibodies
Other names:
AMPH2, AMPHL, SH3P9, amphiphysin II, amphiphysin-like protein, AMPHL, BIN1_HUMAN, box-dependent myc-interacting protein 1, myc box-dependent-interacting protein 1
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
65kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Tubulin alpha-4A chain (TUBA4A) is a component of microtubules, which are an essential part of the eukaryotic cytoskeleton, performing a wide range of functions. Tubulin is a heterodimer of alpha and beta tubulin and fundamental to neuronal morphogenesis and function.
TUBA4A mutations have been associated with familial ALS.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Tubulin alpha-4A chain (TUBA4A) is a component of microtubules, which are an essential part of the eukaryotic cytoskeleton, performing a wide range of functions. Tubulin is a heterodimer of alpha and beta tubulin and fundamental to neuronal morphogenesis and function.
TUBA4A mutations have been associated with familial ALS.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Dynactin subunit 1 (DCTN1) is the largest (approximately 150 kD) subunit of dynactin, a macromolecular complex consisting of multiple subunits ranging in from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein and is involved in a diverse range of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis.
DCTN1 contains N-terminal CAP-Gly and basic domains, followed by the coiled-coil (CC) 1 and 2 domains [1]. The CAP-Gly and basic domains form the microtubule binding domain (MTBD) [2] and the CC1 and CC2 domains mediate the interactions with dynein intermediate chain (DIC) and the other dynactin subunits [1]. The MTBDs of DCTN1 allow microtubule binding during spindle formation and chromosome movement making them essential for cell division[3],
Mutations in the DCTN1 gene are associated with amyotrophic lateral sclerosis (ALS) and distal hereditary motor neuronopathy type VIIB (HMN7B/spinal and bulbar muscular atrophy/dSBMA).
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
142kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Cytoplasm
Purification:
Affinity purification
References:
1: Schroer TA. Dynactin. Annu Rev Cell Dev Biol. 2004;20:75979. 2: Culver-Hanlon TL, Lex SA, Stephens AD, Quintyne NJ, King SJ. A microtubule-binding domain in dynactin increases dynein processivity by skating along microtubules. Nat Cell Biol. 2006;8(3):26470. 3: Robinson RW, Snyder JA. Colocalization studies of Arp1 and p150Glued to spindle microtubules during mitosis: the effect of cytochalasin on the organization of microtubules and motor proteins in PtK1 cells. Cell Biol Int. 2006;30(7):6319.
Dynactin subunit 1 (DCTN1) is the largest (approximately 150 kD) subunit of dynactin, a macromolecular complex consisting of multiple subunits ranging in from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein and is involved in a diverse range of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis.
DCTN1 contains N-terminal CAP-Gly and basic domains, followed by the coiled-coil (CC) 1 and 2 domains [1]. The CAP-Gly and basic domains form the microtubule binding domain (MTBD) [2] and the CC1 and CC2 domains mediate the interactions with dynein intermediate chain (DIC) and the other dynactin subunits [1]. The MTBDs of DCTN1 allow microtubule binding during spindle formation and chromosome movement making them essential for cell division[3],
Mutations in the DCTN1 gene are associated with amyotrophic lateral sclerosis (ALS) and distal hereditary motor neuronopathy type VIIB (HMN7B/spinal and bulbar muscular atrophy/dSBMA).
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
142kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Cytoplasm
Purification:
Affinity purification
References:
1: Schroer TA. Dynactin. Annu Rev Cell Dev Biol. 2004;20:75979. 2: Culver-Hanlon TL, Lex SA, Stephens AD, Quintyne NJ, King SJ. A microtubule-binding domain in dynactin increases dynein processivity by skating along microtubules. Nat Cell Biol. 2006;8(3):26470. 3: Robinson RW, Snyder JA. Colocalization studies of Arp1 and p150Glued to spindle microtubules during mitosis: the effect of cytochalasin on the organization of microtubules and motor proteins in PtK1 cells. Cell Biol Int. 2006;30(7):6319.
Dynactin subunit 1 (DCTN1) is the largest (approximately 150 kD) subunit of dynactin, a macromolecular complex consisting of multiple subunits ranging in from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein and is involved in a diverse range of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis.
DCTN1 contains N-terminal CAP-Gly and basic domains, followed by the coiled-coil (CC) 1 and 2 domains [1]. The CAP-Gly and basic domains form the microtubule binding domain (MTBD) [2] and the CC1 and CC2 domains mediate the interactions with dynein intermediate chain (DIC) and the other dynactin subunits [1]. The MTBDs of DCTN1 allow microtubule binding during spindle formation and chromosome movement making them essential for cell division[3],
Mutations in the DCTN1 gene are associated with amyotrophic lateral sclerosis (ALS) and distal hereditary motor neuronopathy type VIIB (HMN7B/spinal and bulbar muscular atrophy/dSBMA).
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human DCTN1 from the C-terminal region
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
142kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Cytoplasm cytoskeleton
Purification:
Affinity purification
References:
1: Schroer TA. Dynactin. Annu Rev Cell Dev Biol. 2004;20:75979. 2: Culver-Hanlon TL, Lex SA, Stephens AD, Quintyne NJ, King SJ. A microtubule-binding domain in dynactin increases dynein processivity by skating along microtubules. Nat Cell Biol. 2006;8(3):26470. 3: Robinson RW, Snyder JA. Colocalization studies of Arp1 and p150Glued to spindle microtubules during mitosis: the effect of cytochalasin on the organization of microtubules and motor proteins in PtK1 cells. Cell Biol Int. 2006;30(7):6319.
Dynactin subunit 1 (DCTN1) is the largest (approximately 150 kD) subunit of dynactin, a macromolecular complex consisting of multiple subunits ranging in from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein and is involved in a diverse range of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis.
DCTN1 contains N-terminal CAP-Gly and basic domains, followed by the coiled-coil (CC) 1 and 2 domains [1]. The CAP-Gly and basic domains form the microtubule binding domain (MTBD) [2] and the CC1 and CC2 domains mediate the interactions with dynein intermediate chain (DIC) and the other dynactin subunits [1]. The MTBDs of DCTN1 allow microtubule binding during spindle formation and chromosome movement making them essential for cell division[3],
Mutations in the DCTN1 gene are associated with amyotrophic lateral sclerosis (ALS) and distal hereditary motor neuronopathy type VIIB (HMN7B/spinal and bulbar muscular atrophy/dSBMA).
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human DCTN1 from the C-terminal region
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
142kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Cytoplasm cytoskeleton
Purification:
Affinity purification
References:
1: Schroer TA. Dynactin. Annu Rev Cell Dev Biol. 2004;20:75979. 2: Culver-Hanlon TL, Lex SA, Stephens AD, Quintyne NJ, King SJ. A microtubule-binding domain in dynactin increases dynein processivity by skating along microtubules. Nat Cell Biol. 2006;8(3):26470. 3: Robinson RW, Snyder JA. Colocalization studies of Arp1 and p150Glued to spindle microtubules during mitosis: the effect of cytochalasin on the organization of microtubules and motor proteins in PtK1 cells. Cell Biol Int. 2006;30(7):6319.
Profilin 1 (PFN1) is a member of the profilin family of small actin-binding proteins. This 140-amino-acid protein acts as a major regulator of actin polymerisation through its binding of actin-ADP monomers, promoting the conversion of actin-ADP to actin-ATP. PFN1 also binds to phosphoinositides and a large network of proteins with poly-L-proline stretches. Through these binding interactions, PFN1 regulates a number of cellular functions including actin dynamics, membrane trafficking, neuronal synaptic structure and activity and small GTPase signaling.
Mutations in the PFN1 gene are associated with amyotrophic lateral sclerosis (ALS).
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000.
Category:
Primary Antibodies
Other names:
Amyotrophic lateral sclerosis 18, ALS18, PFN1, Epididymis Tissue Protein Li 184a, Profilin-1
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
15kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Profilin 1 (PFN1) is a member of the profilin family of small actin-binding proteins. This 140-amino-acid protein acts as a major regulator of actin polymerisation through its binding of actin-ADP monomers, promoting the conversion of actin-ADP to actin-ATP. PFN1 also binds to phosphoinositides and a large network of proteins with poly-L-proline stretches. Through these binding interactions, PFN1 regulates a number of cellular functions including actin dynamics, membrane trafficking, neuronal synaptic structure and activity and small GTPase signaling.
Mutations in the PFN1 gene are associated with amyotrophic lateral sclerosis (ALS).
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000.
Category:
Primary Antibodies
Other names:
Amyotrophic lateral sclerosis 18, ALS18, PFN1, Epididymis Tissue Protein Li 184a, Profilin-1
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
15kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Charged Multivesicular Body Protein 2B (CHMP2B) forms part of one of the endosomal sorting complexes required for transport (ESCRT), specifically ESCRT-III. (ESCRT)-III proteins catalyse a number of membrane remodeling processes essential for many cellular functions with CHMP2B mediating the endosomal sorting of ubiquitinated transmembrane proteins into the multivesicular bodies (MVBs) for transport to lysosomes.
ESCRT-III comprises IST1, two isoforms of CHMP1, two isoforms of CHMP2, CHMP3, three isoforms of CHMP4, CHMP5, CHMP6 and CHMP7. The ESCRT-III proteins are expressed ubiquitously with CHMP2B having a specialised role in neurons during the formation and maintenance of synapses. Mutations in the CHMP2B gene results in two C-terminally truncated variants of the protein leading to an autosomal dominant form of frontotemporal dementia (FTD).
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000. IHC 1:50-200.
Category:
Primary Antibodies
Other names:
ALS17, CHMP2.5, DMT1, VPS2-2, VPS2B, VPS2 Homolog B, Vacuolar Protein Sorting-Associated Protein 2-2,Charged Multivesicular Body Protein 2b
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
24kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Cytoplasm Late endosome membrane Peripheral membrane protein cytosol
Charged Multivesicular Body Protein 2B (CHMP2B) forms part of one of the endosomal sorting complexes required for transport (ESCRT), specifically ESCRT-III. (ESCRT)-III proteins catalyse a number of membrane remodeling processes essential for many cellular functions with CHMP2B mediating the endosomal sorting of ubiquitinated transmembrane proteins into the multivesicular bodies (MVBs) for transport to lysosomes.
ESCRT-III comprises IST1, two isoforms of CHMP1, two isoforms of CHMP2, CHMP3, three isoforms of CHMP4, CHMP5, CHMP6 and CHMP7. The ESCRT-III proteins are expressed ubiquitously with CHMP2B having a specialised role in neurons during the formation and maintenance of synapses. Mutations in the CHMP2B gene results in two C-terminally truncated variants of the protein leading to an autosomal dominant form of frontotemporal dementia (FTD).
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000. IHC 1:50-200.
Category:
Primary Antibodies
Other names:
ALS17, CHMP2.5, DMT1, VPS2-2, VPS2B, VPS2 Homolog B, Vacuolar Protein Sorting-Associated Protein 2-2,Charged Multivesicular Body Protein 2b
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
24kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Cytoplasm Late endosome membrane Peripheral membrane protein cytosol
Matrin 3 (MATR3) is a DNA and RNA binding protein with a range of functions in nucleic acid metabolism including gene transcription, splicing, RNA degradation and the DNA damage response.
Mutations of the MATR3 gene are associated with distal myopathy, vocal cord and pharyngeal weakness, amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). However even without the presence of MATR3 mutations, patients with ALS due to C9orf72 hexanucleotide expansions and FUS mutations may also have cytoplasmic Matrin 3 accumulation as well as strong nuclear Matrin 3 immunostaining indicating that Matrin 3 may more generally be a common mediator in ALS.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000.
Category:
Primary Antibodies
Other names:
MPD2, ALS21, VCPDM, Matrin-3, Vocal Cord And Pharyngeal Weakness With Distal Myopathy, Myopathy Distal 2, KIAA0723
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
95kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Matrin 3 (MATR3) is a DNA and RNA binding protein with a range of functions in nucleic acid metabolism including gene transcription, splicing, RNA degradation and the DNA damage response.
Mutations of the MATR3 gene are associated with distal myopathy, vocal cord and pharyngeal weakness, amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). However even without the presence of MATR3 mutations, patients with ALS due to C9orf72 hexanucleotide expansions and FUS mutations may also have cytoplasmic Matrin 3 accumulation as well as strong nuclear Matrin 3 immunostaining indicating that Matrin 3 may more generally be a common mediator in ALS.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000.
Category:
Primary Antibodies
Other names:
MPD2, ALS21, VCPDM, Matrin-3, Vocal Cord And Pharyngeal Weakness With Distal Myopathy, Myopathy Distal 2, KIAA0723
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
95kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Heterogeneous Nuclear Ribonucleoprotein A2B1 (hnRNPA2B1) is one of a family of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). These RNA-binding proteins associate with pre-mRNAs in the nucleus and influence pre-mRNA processing and transport. hnRNPA2B1, regulates alternative splicing, nuclear export, translation, and other RNA processing events and also plays a crucial role in mRNA trafficking in neurons and oligodendrocytes.
HnRNP A2B1 is 37 kDa protein with a modular domain structure consisting of two RNA recognition motifs (RRMs) referred to as unwinding protein 1 (UP1) an intrinsically disordered RGG-rich C terminus and a prion-like domain (PrLD). UP1 is the primary RNA binding domain and the C terminus mediates protein-protein interactions.
Mutations in the HnRNP A2B1 gene have been linked to amyotrophic lateral sclerosis (ALS), multisystem proteinopathy (MSP) and other neurodegenerative diseases.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Bovine, Cat, Dog, Chicken, Guinea Pig, Pig, Goat, Western European hedgehog
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human HNRNPA2B1 from the N-terminal region
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Heterogeneous Nuclear Ribonucleoprotein A2B1 (hnRNPA2B1) is one of a family of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). These RNA-binding proteins associate with pre-mRNAs in the nucleus and influence pre-mRNA processing and transport. hnRNPA2B1, regulates alternative splicing, nuclear export, translation, and other RNA processing events and also plays a crucial role in mRNA trafficking in neurons and oligodendrocytes.
HnRNP A2B1 is 37 kDa protein with a modular domain structure consisting of two RNA recognition motifs (RRMs) referred to as unwinding protein 1 (UP1) an intrinsically disordered RGG-rich C terminus and a prion-like domain (PrLD). UP1 is the primary RNA binding domain and the C terminus mediates protein-protein interactions.
Mutations in the HnRNP A2B1 gene have been linked to amyotrophic lateral sclerosis (ALS), multisystem proteinopathy (MSP) and other neurodegenerative diseases.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Bovine, Cat, Dog, Chicken, Guinea Pig, Pig, Goat, Western European hedgehog
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human HNRNPA2B1 from the N-terminal region
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Heterogeneous Nuclear Ribonucleoprotein A1 (hnRNPA1) is one of a family of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). These RNA-binding proteins associate with pre-mRNAs in the nucleus and influence pre-mRNA processing and transport. hnRNPA1, regulates alternative splicing, nuclear export, translation, and other RNA processing events
HnRNP A1 is a 34 kDa protein with a modular domain structure consisting of two RNA recognition motifs (RRMs) referred to as unwinding protein 1 (UP1) an intrinsically disordered RGG-rich C terminus and a prion-like domain (PrLD). UP1 is the primary RNA binding domain and the C terminus mediates protein-protein interactions.
Mutations in the HnRNP A1 gene have been linked to amyotrophic lateral sclerosis (ALS), multisystem proteinopathy (MSP) and other neurodegenerative diseases.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Bovine, Pig, Sheep, Dog, Cat, Chicken, Golden Hamster, Rabbit
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human HNRNPA1 from the N-terminal region
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000. IF 1:50-100.
Category:
Primary Antibodies
Other names:
ALS19, ALS20, HNRPA1, HNRPA1L3, IBMPFD3, UP 1, hnRNP A1, hnRNP-A1
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
39kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Heterogeneous Nuclear Ribonucleoprotein A1 (hnRNPA1) is one of a family of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). These RNA-binding proteins associate with pre-mRNAs in the nucleus and influence pre-mRNA processing and transport. hnRNPA1, regulates alternative splicing, nuclear export, translation, and other RNA processing events
HnRNP A1 is a 34 kDa protein with a modular domain structure consisting of two RNA recognition motifs (RRMs) referred to as unwinding protein 1 (UP1) an intrinsically disordered RGG-rich C terminus and a prion-like domain (PrLD). UP1 is the primary RNA binding domain and the C terminus mediates protein-protein interactions.
Mutations in the HnRNP A1 gene have been linked to amyotrophic lateral sclerosis (ALS), multisystem proteinopathy (MSP) and other neurodegenerative diseases.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Bovine, Pig, Sheep, Dog, Cat, Chicken, Golden Hamster, Rabbit
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human HNRNPA1 from the N-terminal region
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000. IF 1:50-100.
Category:
Primary Antibodies
Other names:
ALS19, ALS20, HNRPA1, HNRPA1L3, IBMPFD3, UP 1, hnRNP A1, hnRNP-A1
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
39kDa (Intended as a general guide and does not allow for all isoforms and species variations)
T-cell intracellular antigen 1 (TIA1) is an RNA binding protein that binds to the 5'TOP sequence of 5'TOP mRNAs. Under stress conditions, TIA1 localises to cellular RNA-protein conglomerations (stress granules). The major granule-associated species is a 15-kDa protein that is likely derived from the carboxyl terminus of the 40-kDa product by proteolytic processing.
TIA1 has been shown to co-localise with hyperphosphorylated tau and progressively accumulate with aggregated tau in tau-mediated neurodegeneration. Additionally mutations in the TIA1 gene have been associated with amyotrophic lateral sclerosis, frontotemporal dementia and Welander distal myopathy.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
T-cell intracellular antigen 1 (TIA1) is an RNA binding protein that binds to the 5'TOP sequence of 5'TOP mRNAs. Under stress conditions, TIA1 localises to cellular RNA-protein conglomerations (stress granules). The major granule-associated species is a 15-kDa protein that is likely derived from the carboxyl terminus of the 40-kDa product by proteolytic processing.
TIA1 has been shown to co-localise with hyperphosphorylated tau and progressively accumulate with aggregated tau in tau-mediated neurodegeneration. Additionally mutations in the TIA1 gene have been associated with amyotrophic lateral sclerosis, frontotemporal dementia and Welander distal myopathy.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
T-cell intracellular antigen 1 (TIA1) is an RNA binding protein that binds to the 5'TOP sequence of 5'TOP mRNAs. Under stress conditions, TIA1 localises to cellular RNA-protein conglomerations (stress granules). The major granule-associated species is a 15-kDa protein that is likely derived from the carboxyl terminus of the 40-kDa product by proteolytic processing.
TIA1 has been shown to co-localise with hyperphosphorylated tau and progressively accumulate with aggregated tau in tau-mediated neurodegeneration. Additionally mutations in the TIA1 gene have been associated with amyotrophic lateral sclerosis, frontotemporal dementia and Welander distal myopathy.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the C-terminal region of human TIA1
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
T-cell intracellular antigen 1 (TIA1) is an RNA binding protein that binds to the 5'TOP sequence of 5'TOP mRNAs. Under stress conditions, TIA1 localises to cellular RNA-protein conglomerations (stress granules). The major granule-associated species is a 15-kDa protein that is likely derived from the carboxyl terminus of the 40-kDa product by proteolytic processing.
TIA1 has been shown to co-localise with hyperphosphorylated tau and progressively accumulate with aggregated tau in tau-mediated neurodegeneration. Additionally mutations in the TIA1 gene have been associated with amyotrophic lateral sclerosis, frontotemporal dementia and Welander distal myopathy.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the C-terminal region of human TIA1
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Alsin (ALS2) is a 184-kDa protein of 1657 amino acids which activates the GTPases of the Ras superfamily of GTPases by acting as a guanine nucleotide exchange factor. Alsin has three guanine nucleotide exchange factor domains (RLD, DH/PH and VPS9) and eight consecutive membrane occupation and recognition nexus (MORN) motifs that are related to membrane binding in the region between the DH/PH and VPS9 domains.
Alsin functions as a modulator for endosomal dynamics by activating the small GTPase Rab5 via the C-terminal MORN/VPS9 domain, localising with RAB5 on early endosomal compartments.
Alsin is produced in a wide range of tissues, being particularly abundant in motor neurons. Many mutations in the ALS2 gene have been linked to a range of motor neurone diseases including amyotrophic lateral sclerosis (ALS).
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Rat, Rabbit, Dog, Cat, Golden Hamster, Pig, Sheep, Bovine, Goat, Naked mole rat
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human ALS2 from the N-terminal region
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Alsin (ALS2) is a 184-kDa protein of 1657 amino acids which activates the GTPases of the Ras superfamily of GTPases by acting as a guanine nucleotide exchange factor. Alsin has three guanine nucleotide exchange factor domains (RLD, DH/PH and VPS9) and eight consecutive membrane occupation and recognition nexus (MORN) motifs that are related to membrane binding in the region between the DH/PH and VPS9 domains.
Alsin functions as a modulator for endosomal dynamics by activating the small GTPase Rab5 via the C-terminal MORN/VPS9 domain, localising with RAB5 on early endosomal compartments.
Alsin is produced in a wide range of tissues, being particularly abundant in motor neurons. Many mutations in the ALS2 gene have been linked to a range of motor neurone diseases including amyotrophic lateral sclerosis (ALS).
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Rat, Rabbit, Dog, Cat, Golden Hamster, Pig, Sheep, Bovine, Goat, Naked mole rat
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human ALS2 from the N-terminal region
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Alsin (ALS2) is a 184-kDa protein of 1657 amino acids which activates the GTPases of the Ras superfamily of GTPases by acting as a guanine nucleotide exchange factor. Alsin has three guanine nucleotide exchange factor domains (RLD, DH/PH and VPS9) and eight consecutive membrane occupation and recognition nexus (MORN) motifs that are related to membrane binding in the region between the DH/PH and VPS9 domains.
Alsin functions as a modulator for endosomal dynamics by activating the small GTPase Rab5 via the C-terminal MORN/VPS9 domain, localising with RAB5 on early endosomal compartments.
Alsin is produced in a wide range of tissues, being particularly abundant in motor neurons. Many mutations in the ALS2 gene have been linked to a range of motor neurone diseases including amyotrophic lateral sclerosis (ALS).
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Alsin (ALS2) is a 184-kDa protein of 1657 amino acids which activates the GTPases of the Ras superfamily of GTPases by acting as a guanine nucleotide exchange factor. Alsin has three guanine nucleotide exchange factor domains (RLD, DH/PH and VPS9) and eight consecutive membrane occupation and recognition nexus (MORN) motifs that are related to membrane binding in the region between the DH/PH and VPS9 domains.
Alsin functions as a modulator for endosomal dynamics by activating the small GTPase Rab5 via the C-terminal MORN/VPS9 domain, localising with RAB5 on early endosomal compartments.
Alsin is produced in a wide range of tissues, being particularly abundant in motor neurons. Many mutations in the ALS2 gene have been linked to a range of motor neurone diseases including amyotrophic lateral sclerosis (ALS).
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Kinesin heavy chain isoform 5A (KIF5A) is an ATPase-active molecular motor protein expressed in neurons that is the heavy chain A of kinesin, A motor protein involved in motility functions within neuron. KIF5A is involved in microtubule-dependent axonal transport of neurofilament proteins (NFH, NFM and NFL). It also contributes to the transport of other proteins in neurons including proteins essential for axon elongation. KIF5A consists of an N-terminal motor domain, a stalk domain and a C-terminal binding domain. The KIF5A gene has been identified as a causative gene in hereditary spastic paraplegia (HSP), Charcot-Marie-Tooth (CMT) type 2 (CMT2) and amyotrophic lateral sclerosis (ALS).
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the C-terminal region of human KIF5A
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
IHC 1:50-100.
Category:
Primary Antibodies
Other names:
NKHC, ALS25, MY050, NEIMY, SPG10, D12S1889
Research Areas:
Neuroscience, Amyotrophic lateral sclerosis
NS Reagents Product Area:
Neuroscience
Molecular Weight:
117kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Kinesin heavy chain isoform 5A (KIF5A) is an ATPase-active molecular motor protein expressed in neurons that is the heavy chain A of kinesin, A motor protein involved in motility functions within neuron. KIF5A is involved in microtubule-dependent axonal transport of neurofilament proteins (NFH, NFM and NFL). It also contributes to the transport of other proteins in neurons including proteins essential for axon elongation. KIF5A consists of an N-terminal motor domain, a stalk domain and a C-terminal binding domain. The KIF5A gene has been identified as a causative gene in hereditary spastic paraplegia (HSP), Charcot-Marie-Tooth (CMT) type 2 (CMT2) and amyotrophic lateral sclerosis (ALS).
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the C-terminal region of human KIF5A
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
IHC 1:50-100.
Category:
Primary Antibodies
Other names:
NKHC, ALS25, MY050, NEIMY, SPG10, D12S1889
Research Areas:
Neuroscience, Amyotrophic lateral sclerosis
NS Reagents Product Area:
Neuroscience
Molecular Weight:
117kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Kinesin heavy chain isoform 5A (KIF5A) is an ATPase-active molecular motor protein expressed in neurons that is the heavy chain A of kinesin, A motor protein involved in motility functions within neuron. KIF5A is involved in microtubule-dependent axonal transport of neurofilament proteins (NFH, NFM and NFL). It also contributes to the transport of other proteins in neurons including proteins essential for axon elongation. KIF5A consists of an N-terminal motor domain, a stalk domain and a C-terminal binding domain. The KIF5A gene has been identified as a causative gene in hereditary spastic paraplegia (HSP), Charcot-Marie-Tooth (CMT) type 2 (CMT2) and amyotrophic lateral sclerosis (ALS).
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human KIF5A from the C-terminal region
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:1000-3000. IHC 1:50-200.
Category:
Primary Antibodies
Other names:
NKHC, ALS25, MY050, NEIMY, SPG10, D12S1889
Research Areas:
Neuroscience, Amyotrophic lateral sclerosis
NS Reagents Product Area:
Neuroscience
Molecular Weight:
117kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Kinesin heavy chain isoform 5A (KIF5A) is an ATPase-active molecular motor protein expressed in neurons that is the heavy chain A of kinesin, A motor protein involved in motility functions within neuron. KIF5A is involved in microtubule-dependent axonal transport of neurofilament proteins (NFH, NFM and NFL). It also contributes to the transport of other proteins in neurons including proteins essential for axon elongation. KIF5A consists of an N-terminal motor domain, a stalk domain and a C-terminal binding domain. The KIF5A gene has been identified as a causative gene in hereditary spastic paraplegia (HSP), Charcot-Marie-Tooth (CMT) type 2 (CMT2) and amyotrophic lateral sclerosis (ALS).
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human KIF5A from the C-terminal region
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:1000-3000. IHC 1:50-200.
Category:
Primary Antibodies
Other names:
NKHC, ALS25, MY050, NEIMY, SPG10, D12S1889
Research Areas:
Neuroscience, Amyotrophic lateral sclerosis
NS Reagents Product Area:
Neuroscience
Molecular Weight:
117kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Oligodendrocyte transcription factor (OLIG2) is a 32kDa bHLH (basic helix-loop-helix) transcription factor that is 329 amino acids long. It is one of the three members of the bHLH family. Expression of OLIG2 is largely restricted to the tissues of the central nervous system, where it plays an important role in motor neuron and oligodendrocyte differentiation and sustaining replication in early development.
The OLIG2 gene is located within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome. OLIG2 has also been associated with neurodegenerative disorders such as Alzheimers disease.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
Rat, Chicken, Pig, Gunea Pig, Golden Hamster, Goat, Bovine, Horse
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the N-terminal region of human OLIG2
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
IHC 1:25-100.
Category:
Primary Antibodies
Other names:
BHLHB1, OLIGO2, PRKCBP2, RACK17, bHLHe19, oligodendrocyte transcription factor 2, Class B basic helix-loop-helix protein 1, Class E basic helix-loop-helix protein 19, Protein kinase C-binding protein 2
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
32kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Oligodendrocyte transcription factor (OLIG2) is a 32kDa bHLH (basic helix-loop-helix) transcription factor that is 329 amino acids long. It is one of the three members of the bHLH family. Expression of OLIG2 is largely restricted to the tissues of the central nervous system, where it plays an important role in motor neuron and oligodendrocyte differentiation and sustaining replication in early development.
The OLIG2 gene is located within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome. OLIG2 has also been associated with neurodegenerative disorders such as Alzheimers disease.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
Rat, Chicken, Pig, Gunea Pig, Golden Hamster, Goat, Bovine, Horse
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the N-terminal region of human OLIG2
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
IHC 1:25-100.
Category:
Primary Antibodies
Other names:
BHLHB1, OLIGO2, PRKCBP2, RACK17, bHLHe19, oligodendrocyte transcription factor 2, Class B basic helix-loop-helix protein 1, Class E basic helix-loop-helix protein 19, Protein kinase C-binding protein 2
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
32kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Amine oxidase copper-containing 1 (AOC1) is an enzyme that catalyses the degradation of compounds such as neurotransmitters, putrescine, histamine and related substances involved in a wide range of funtions including allergic and immune responses, cell proliferation, tissue differentiation, tumor formation and apoptosis.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human AOC1 from the N-terminal region
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Amine oxidase copper-containing 1 (AOC1) is an enzyme that catalyses the degradation of compounds such as neurotransmitters, putrescine, histamine and related substances involved in a wide range of funtions including allergic and immune responses, cell proliferation, tissue differentiation, tumor formation and apoptosis.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS containing 0.02% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human AOC1 from the N-terminal region
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Solute carrier family 2, facilitated glucose transporter member 4 (SLC2A4, GLUT4) is an insulin-regulated glucose transporter found primarily in adipose tissues and striated muscle (skeletal and cardiac). It facilitates the diffusion of circulating glucose down its concentration gradient into muscle and fat cells, playing a key role in removal of glucose from circulation with the response to insulin being regulated by its intracellular localisation. In the absence of insulin, it is retained intracellularly within storage compartments in muscle and fat cells and following insulin stimulation it translocates to the cell surface. SLC2A4 has a phenylalanine on the N-terminus and two Leucine residues and acidic motifs on the C-terminus which are believed to play a key role in its glucose transport function.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human GTR4 (SLC2A4) from the C-terminal region
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000. IHC 1:50-200.
Category:
Primary Antibodies
Other names:
GLUT4, SLC2A4, GEF, HDBP 1, SLC2A4RG, glucose transporter type 4, insulin-responsive glucose transporter type 4, solute carrier family 2, facilitated glucose transporter member 4
Research Areas:
Neuroscience, Diabetes
NS Reagents Product Area:
Neuroscience
Molecular Weight:
55kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Cell membrane, Cytoplasm, Endomembrane system, Multi-pass membrane protein, perinuclear region
Solute carrier family 2, facilitated glucose transporter member 4 (SLC2A4, GLUT4) is an insulin-regulated glucose transporter found primarily in adipose tissues and striated muscle (skeletal and cardiac). It facilitates the diffusion of circulating glucose down its concentration gradient into muscle and fat cells, playing a key role in removal of glucose from circulation with the response to insulin being regulated by its intracellular localisation. In the absence of insulin, it is retained intracellularly within storage compartments in muscle and fat cells and following insulin stimulation it translocates to the cell surface. SLC2A4 has a phenylalanine on the N-terminus and two Leucine residues and acidic motifs on the C-terminus which are believed to play a key role in its glucose transport function.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human GTR4 (SLC2A4) from the C-terminal region
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000. IHC 1:50-200.
Category:
Primary Antibodies
Other names:
GLUT4, SLC2A4, GEF, HDBP 1, SLC2A4RG, glucose transporter type 4, insulin-responsive glucose transporter type 4, solute carrier family 2, facilitated glucose transporter member 4
Research Areas:
Neuroscience, Diabetes
NS Reagents Product Area:
Neuroscience
Molecular Weight:
55kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Cell membrane, Cytoplasm, Endomembrane system, Multi-pass membrane protein, perinuclear region
PARK7 consists of 189 amino acids in humans with three cysteine residues at 46, 53 and 106. It acts as an antioxidant, transcriptional co-activator, and molecular chaperone with oxidation and nitrosylation of the cysteine residues determining its function. PARK7 acts as a neuroprotective protein via modulation of multiple cellular survival signaling pathways
PARK7 is a ubiquitous protein being expressed in most cells and tissues. In the brain it is expressed in both neurons and glial cells. The expression level of PARK7 is increased under oxidative stress conditions both in PD and other neurodegenerative diseases. Defects in the PARK7 gene are the cause of autosomal recessive early-onset Parkinson disease 7.
Bovine, Zebrafish, Golden Hamster, Pig, Guinea Pig, Cat, Chicken
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
PARK7 consists of 189 amino acids in humans with three cysteine residues at 46, 53 and 106. It acts as an antioxidant, transcriptional co-activator, and molecular chaperone with oxidation and nitrosylation of the cysteine residues determining its function. PARK7 acts as a neuroprotective protein via modulation of multiple cellular survival signaling pathways
PARK7 is a ubiquitous protein being expressed in most cells and tissues. In the brain it is expressed in both neurons and glial cells. The expression level of PARK7 is increased under oxidative stress conditions both in PD and other neurodegenerative diseases. Defects in the PARK7 gene are the cause of autosomal recessive early-onset Parkinson disease 7.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS containing 0.02% sodium azide.
Bovine, Zebrafish, Golden Hamster, Pig, Guinea Pig, Cat, Chicken
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Tumor suppressor candidate 2 (TUSC2) is known to act as a tumor-suppressor and reduced expression of TUSC2 is seen in specific cancers across a number of different tissues. TUSC2 is a target for many microRNAs (miRNAs) that act as modulators of tumorigenesis and tumor progression. In glioblastoma (and possibly in other cancers) TUSC2 acts by up-regulating the level of miR-197 [1]. In Triple Negative Breast Cancer (TNBC) the TUSC2 gene is silenced by miR-138 binding to a unique 5?-UTR target-site, which overlaps with the translation start-site of the transcript. In ovarian cancer miR-663 acts as a potential tumor-promoting miRN through targeting TUSC2.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
12kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Mitochondrion
Purification:
Affinity purification
References:
1. Xin J, Zhang XK, Xin DY, Li XF, Sun DK, Ma YY, Tian LQ. FUS1 acts as a tumor-suppressor gene by upregulating miR-197 in human glioblastoma. Oncol Rep. 2015;34(2):86876.
Tumor suppressor candidate 2 (TUSC2) is known to act as a tumor-suppressor and reduced expression of TUSC2 is seen in specific cancers across a number of different tissues. TUSC2 is a target for many microRNAs (miRNAs) that act as modulators of tumorigenesis and tumor progression. In glioblastoma (and possibly in other cancers) TUSC2 acts by up-regulating the level of miR-197 [1]. In Triple Negative Breast Cancer (TNBC) the TUSC2 gene is silenced by miR-138 binding to a unique 5?-UTR target-site, which overlaps with the translation start-site of the transcript. In ovarian cancer miR-663 acts as a potential tumor-promoting miRN through targeting TUSC2.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS containing 0.02% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
12kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Mitochondrion
Purification:
Affinity purification
References:
1. Xin J, Zhang XK, Xin DY, Li XF, Sun DK, Ma YY, Tian LQ. FUS1 acts as a tumor-suppressor gene by upregulating miR-197 in human glioblastoma. Oncol Rep. 2015;34(2):86876.
FUS (fused in sarcoma) is a member of the FET/TET (FUS/TLS, EWS, TAF15) family of RNA-binding proteins (RBPs) that have roles in transcription, pre-mRNA splicing, DNA repair, and mRNA transport in neurons.
FUS (like all FET family members) is highly conserved and ubiquitously expressed, with several conserved domains: a serine-tyrosine-glycine-glutamine (SYGQ) domain embedded in the DNA activation domain (AD), 3 glycine-arginine (RGG) rich regions that affect RNA binding, one conserved RNA-binding domain (RBD, formed by a RNA-recognition motif, RRM), and a zinc finger domain that is also involved in nucleic acid binding [1].
FUS binds to single and double stranded DNA as well as RNA and participates in multiple cellular functions. Alternative splicing results in multiple transcript variants. Defects in the FUS gene are associated with amyotrophic lateral sclerosis (ALS). FUS is also implicated in a number of other neurodegenerative disorders.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant protein from the C-terminal region of human FUS
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000.
Category:
Primary Antibodies
Other names:
ALS6, ETM4, HNRNPP2, POMP75, TLS, fused in sarcoma, translocated in liposarcoma
Research Areas:
Neuroscience, Amyotrophic lateral sclerosis
NS Reagents Product Area:
Neuroscience
Molecular Weight:
53kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Nucleus
Purification:
Affinity purification
References:
[1] Role of FET proteins in neurodegenerative disorders Francesca Svetoni, Paola Frisone, Maria Paola Paronetto RNA Biol. 2016; 13(11): 10891102. Published online 2016 Jul 14. doi: 10.1080/15476286.2016.1211225
[2] Functions of FUS/TLS From DNA Repair to Stress Response: Implications for ALS Reddy Ranjith Kumar Sama, Catherine L. Ward, Daryl A. Bosco ASN Neuro. 2014 May-Jun; 6(4): 1759091414544472. doi: 10.1177/1759091414544472
