Glial fibrillary acidic protein (GFAP), is an intermediate filament (IF) protein belonging to the type III subclass of IF proteins. Like other IF proteins, GFAP is composed of an amino terminal head domain, central rod domain and a carboxy terminal tail domain. GFAP is specifically found in astroglia, a cell type which is highly responsive to neurologic insults. Astrogliosis is found to be a result of mechanical trauma, AIDS dementia, prion infection and inflammatory demyelinating diseases, and is accompanied by an increase in GFAP expression. GFAP is an immunohistochemical marker for localising benign astrocyte and neoplastic cells of glial origin in the central nervous system.
Product Type:
NS Reagents Antibody
Antibody Type:
Monoclonal
Format:
100 µg in 100 µl PBS containing 0.02% sodium azide.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Clone number:
Clone FD19-9
Antibody Isotype:
IgG1
Application Details:
IHC 1:100 - 1: 1000
Antibody Number:
10001
Category:
Primary Antibodies
Other names:
GFAP, ALXDRD, gfapl, Intermediate filament protein
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
50kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Cytoplasm
Purification:
Protein A Affinity Purified
References:
Yang et al. 2007. J Gastroenterol Hepatol. 22(9):1460-8. PMID: 17645461. ; Hagemann et al. 2006. J Neurosci Methods. 156(1-2):194-202. PMID: 16621008. ; Coakham et al. 1984. Lancet. 1(8386):1095-8. PMID: 6202990. ; Garson JA. The development and characterisation of monoclonal antibodies for use in neuropathology. MD thesis. University of Birmingham, 1983
Glial fibrillary acidic protein (GFAP), is an intermediate filament (IF) protein belonging to the type III subclass of IF proteins. Like other IF proteins, GFAP is composed of an amino terminal head domain, central rod domain and a carboxy terminal tail domain. GFAP is specifically found in astroglia, a cell type which is highly responsive to neurologic insults. Astrogliosis is found to be a result of mechanical trauma, AIDS dementia, prion infection and inflammatory demyelinating diseases, and is accompanied by an increase in GFAP expression. GFAP is an immunohistochemical marker for localising benign astrocyte and neoplastic cells of glial origin in the central nervous system.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Clone number:
Clone FD19-9
Antibody Isotype:
IgG1
Application Details:
IHC 1:100 - 1: 1000
Antibody Number:
10001
Category:
Primary Antibodies
Other names:
GFAP, ALXDRD, gfapl, Intermediate filament protein
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
50kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Cytoplasm
Purification:
Protein A Affinity Purified
References:
Yang et al. 2007. J Gastroenterol Hepatol. 22(9):1460-8. PMID: 17645461. ; Hagemann et al. 2006. J Neurosci Methods. 156(1-2):194-202. PMID: 16621008. ; Coakham et al. 1984. Lancet. 1(8386):1095-8. PMID: 6202990. ; Garson JA. The development and characterisation of monoclonal antibodies for use in neuropathology. MD thesis. University of Birmingham, 1983
BAG family molecular chaperone regulator 3 (BAG3) is involved in chaperone-assisted selective autophagy. Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release and has anti-apoptotic activity.
In muscle cells, BAG3 cooperates with the molecular chaperones Hsc70 and HspB8 to induce the degradation of mechanically damaged cytoskeleton components in lysosomes. This process is called chaperone-assisted selective autophagy (CASA) and is essential for maintaining muscle activity.
Defects in BAG3 are the cause of myopathy myofibrillar BAG3-related (MFM-BAG3) a neuromuscular disorder that results in early-onset, severe, progressive, diffuse muscle weakness associated with cardiomyopathy, severe respiratory insufficiency during adolescence, and a rigid spine in some patients.
Product Type:
NS Reagents Antibody
Antibody Type:
Monoclonal
Format:
100 µg in 100 µl PBS containing 0.02% sodium azide.
This antibody is specific to human BAG3 and does not bind Rat or Mouse BAG3
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the C-terminal region of Human BAG3
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Clone number:
Clone V65P1E8*D2
Antibody Isotype:
IgG1 kappa
Antibody Number:
10002
Category:
Primary Antibodies
Other names:
BAG3, Bcl-2-associated athanogene 3, Bcl-2-binding protein Bis, Docking protein CAIR-, BAG family molecular chaperone regulator 3
Research Areas:
Neuroscience, Autophagy
NS Reagents Product Area:
Neuroscience
Molecular Weight:
75kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Cytoplasm, Nucleus
Purification:
Protein A Affinity Purified
References:
[1] Sturner E. and Behl C. (2017). The role of the multifunctional BAG3 protein in cellular protein quality control and in disease. Front. Mol. Neurosci. 10, 177 10.3389/fnmol.2017.00177
BAG family molecular chaperone regulator 3 (BAG3) is involved in chaperone-assisted selective autophagy. Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release and has anti-apoptotic activity.
In muscle cells, BAG3 cooperates with the molecular chaperones Hsc70 and HspB8 to induce the degradation of mechanically damaged cytoskeleton components in lysosomes. This process is called chaperone-assisted selective autophagy (CASA) and is essential for maintaining muscle activity.
Defects in BAG3 are the cause of myopathy myofibrillar BAG3-related (MFM-BAG3) a neuromuscular disorder that results in early-onset, severe, progressive, diffuse muscle weakness associated with cardiomyopathy, severe respiratory insufficiency during adolescence, and a rigid spine in some patients.
This antibody is specific to human BAG3 and does not bind Rat or Mouse BAG3
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the C-terminal region of Human BAG3
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Clone number:
Clone V65P1E8*D2
Antibody Isotype:
IgG1 kappa
Antibody Number:
10002
Category:
Primary Antibodies
Other names:
BAG3, Bcl-2-associated athanogene 3, Bcl-2-binding protein Bis, Docking protein CAIR-1
Research Areas:
Neuroscience, Autophagy
NS Reagents Product Area:
Neuroscience
Molecular Weight:
75kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Cytoplasm, Nucleus
Purification:
Protein A Affinity Purified
References:
[1] Sturner E. and Behl C. (2017). The role of the multifunctional BAG3 protein in cellular protein quality control and in disease. Front. Mol. Neurosci. 10, 177 10.3389/fnmol.2017.00177
WNK1 is a cytoplasmic serine-threonine kinase involved in the regulation of electrolyte homeostasis, cell signalling, survival, and proliferation. It is part of the ERK5 MAP kinase pathway and acts as an activator of sodium-coupled chloride cotransporters such as SCNN1A, SCNN1B, SCNN1D and SGK1 and as an inhibitor of WNK4 by phosphorylation or through an interaction with the WNK1 autoinhibitory domain. WNK1 may also play a role in actin cytoskeletal reorganisation.
Defects in WNK1 are a cause of Gordon hyperkalemia-hypertension syndrome (pseudohypoaldosteronism type II - PHAII) an autosomal dominant disease characterised by severe hypertension and sensory and autonomic neuropathy type 2A (HSAN2A), a form of congenital sensory and autonomic neuropathy.
Homologs of this WNK1 have been found in Arabidopsis thaliana, C. elegans, Chlamydomonas reinhardtii and Vitis vinifera as well as in vertebrates including Danio rerio and Taeniopygia guttata.
This antibody was validated with HEK 293T cell lysate and HeLa cell lysate (1 in 1000 in 5% BSA)
Product Type:
NS Reagents Antibody
Antibody Type:
Monoclonal
Format:
100 µg in 100 µl PBS containing 0.02% sodium azide.
Mouse , Rat, Chicken, Duck, Hamster, Goat, Sheep, Cow, Dog, Cat, Pig and Horse.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the C-terminal region of Human WNK1 - Ovalbumin Conjugated (The selected sequence is highly conserved across many species).
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Clone number:
Clone M42-P3B10
Antibody Isotype:
IgG1 kappa
Application Details:
WB 1:1000 in 5% BSA, IHC 1:50-1:500
Antibody Number:
10003
Category:
Primary Antibodies
Other names:
WNK1, Erythrocyte 65 kDa protein, Human Accelerated Region 5, WNK Lysine Deficient Protein Kinase 1, hWNK1
Research Areas:
Cell Signalling, Neuroscience
NS Reagents Product Area:
Cell Signalling
Molecular Weight:
65kDa (Intended as a general guide and does not allow for all isoforms and species variations)
WNK1 is a cytoplasmic serine-threonine kinase involved in the regulation of electrolyte homeostasis, cell signalling, survival, and proliferation. It is part of the ERK5 MAP kinase pathway and acts as an activator of sodium-coupled chloride cotransporters such as SCNN1A, SCNN1B, SCNN1D and SGK1 and as an inhibitor of WNK4 by phosphorylation or through an interaction with the WNK1 autoinhibitory domain. WNK1 may also play a role in actin cytoskeletal reorganisation.
Defects in WNK1 are a cause of Gordon hyperkalemia-hypertension syndrome (pseudohypoaldosteronism type II - PHAII) an autosomal dominant disease characterised by severe hypertension and sensory and autonomic neuropathy type 2A (HSAN2A), a form of congenital sensory and autonomic neuropathy.
Homologs of this WNK1 have been found in Arabidopsis thaliana, C. elegans, Chlamydomonas reinhardtii and Vitis vinifera as well as in vertebrates including Danio rerio and Taeniopygia guttata.
This antibody was validated with HEK 293T cell lysate and HeLa cell lysate (1 in 1000 in 5% BSA)
Mouse , Rat, Chicken, Duck, Hamster, Goat, Sheep, Cow, Dog, Cat, Pig and Horse.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the C-terminal region of Human WNK1 - Ovalbumin Conjugated (The selected sequence is highly conserved across many species).
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Clone number:
Clone M42-P3B10
Antibody Isotype:
IgG1 kappa
Application Details:
WB 1:1000 in 5% BSA, IHC 1:50-1:500
Antibody Number:
10003
Category:
Primary Antibodies
Other names:
WNK1, Erythrocyte 65 kDa protein, Human Accelerated Region 5, WNK Lysine Deficient Protein Kinase 1, hWNK1
Research Areas:
Cell Signalling, Neuroscience
NS Reagents Product Area:
Cell Signalling
Molecular Weight:
65kDa (Intended as a general guide and does not allow for all isoforms and species variations)
The c-Myc and N-Myc oncogenes are members of the Myc family of transcription factors that regulate cell proliferation and apoptosis. c-MYC has a pivotal function in growth control, differentiation and apoptosis, being expressed in proliferating tissues, and its abnormal expression is associated with many tumors. Overexpression of c-MYC sensitises cells to apoptosis by a variety of stimuli. How the apoptotic response is regulated by c-MYC depends on the specific cell type and the physiological status of the cell.
Product Type:
NS Reagents Antibody
Antibody Type:
Monoclonal
Format:
100 µg in 100 µl PBS containing 0.02% sodium azide.
The peptide sequence selected is conserved across many species so this antibody should react with cMyc in many other species including Rat, Mouse Bovine, Dog, Cat, Sheep and Pig.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the N-terminal region of Human c-Myc Conjugated to purified protein derivative (PPD)
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Clone number:
Clone PM3E7
Antibody Isotype:
IgG2a
Antibody Number:
10004
Category:
Primary Antibodies
Other names:
MYCC, MYC Proto-oncogene, Myc proto-oncogene protein
Research Areas:
DNA & Protein Modification, Cancer
NS Reagents Product Area:
DNA & Protein Modification
Molecular Weight:
64kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Nucleoplasm, Nucleolus
Purification:
Protein A Affinity Purified
References:
Evan et al. 1988. Curr Top Microbiol Immunol. 141:189-201. PMID: 3063442.
The c-Myc and N-Myc oncogenes are members of the Myc family of transcription factors that regulate cell proliferation and apoptosis. c-MYC has a pivotal function in growth control, differentiation and apoptosis, being expressed in proliferating tissues, and its abnormal expression is associated with many tumors. Overexpression of c-MYC sensitises cells to apoptosis by a variety of stimuli. How the apoptotic response is regulated by c-MYC depends on the specific cell type and the physiological status of the cell.
The peptide sequence selected is conserved across many species so this antibody should react with cMyc in many other species including Rat, Mouse Bovine, Dog, Cat, Sheep and Pig.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the N-terminal region of Human c-Myc Conjugated to purified protein derivative (PPD)
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Clone number:
Clone PM3E7
Antibody Isotype:
IgG2a
Antibody Number:
10004
Category:
Primary Antibodies
Other names:
MYCC, MYC Proto-oncogene, Myc proto-oncogene protein
Research Areas:
DNA & Protein Modification, Cancer
NS Reagents Product Area:
DNA & Protein Modification
Molecular Weight:
64kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Nucleoplasm, Nucleolus
Purification:
Protein A Affinity Purified
References:
Evan et al. 1988. Curr Top Microbiol Immunol. 141:189-201. PMID: 3063442.
Neural cell adhesion molecule (NCAM) is a homophillic binding glycoprotein of the Immunoglobulin (Ig) superfamily. NCAM is present on a variety of neural cells including neurons, glia and skeletal muscle. However it is also found in other cells such as hematopoietic cell types including natural killer cells. NCAM has been implicated as having a role in cell-cell adhesion, neurite outgrowth, synaptic plasticity, learning and memory and in the development of the nervous system.
Anti-NCAM (Clone UJ13A) can be used in the characterisation of neuro-ectodermally derived tumours and in the identification of metastatic spread to the bone marrow. Whilst this antibody is provided as not for diagnostic use it has been used in radio immunoscintigraphy of neuroblastoma and brain tumours and in targeted radiotherapy.
Product Type:
NS Reagents Antibody
Antibody Type:
Monoclonal
Format:
100 µg in 100 µl PBS containing 0.02% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Clone number:
Clone UJ13A
Antibody Isotype:
IgG
Application Details:
IHC 1:10-1:20
Antibody Number:
10006
Category:
Primary Antibodies
Other names:
Neural Cell Adhesion Molecule, CD56 Antigen MSK39
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
120kDa, 160kDa and 180kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Cell membrane
Purification:
Protein A Affinity Purified
References:
Patel et al. 1989. Int J Cancer. 44(6):1062-8. PMID: 2558078. ; Patel et al. 1989. Br J Cancer. 60(6):861-6. PMID: 2481486. ; Moss et al. 1988. Lung Cancer. 4, 76-78. ; Allan et al. 1983. Int J Cancer. 31(5):591-8. PMID: 6852977.
Neural cell adhesion molecule (NCAM) is a homophillic binding glycoprotein of the Immunoglobulin (Ig) superfamily. NCAM is present on a variety of neural cells including neurons, glia and skeletal muscle. However it is also found in other cells such as hematopoietic cell types including natural killer cells. NCAM has been implicated as having a role in cell-cell adhesion, neurite outgrowth, synaptic plasticity, learning and memory and in the development of the nervous system.
Anti-NCAM (Clone UJ13A) can be used in the characterisation of neuro-ectodermally derived tumours and in the identification of metastatic spread to the bone marrow. Whilst this antibody is provided as not for diagnostic use it has been used in radio immunoscintigraphy of neuroblastoma and brain tumours and in targeted radiotherapy.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Clone number:
Clone UJ13A
Antibody Isotype:
IgG
Application Details:
IHC 1:10-1:20
Antibody Number:
10006
Category:
Primary Antibodies
Other names:
Neural Cell Adhesion Molecule, CD56 Antigen MSK39
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
120kDa, 160kDa and 180kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Cell membrane
Purification:
Protein A Affinity Purified
References:
Patel et al. 1989. Int J Cancer. 44(6):1062-8. PMID: 2558078. ; Patel et al. 1989. Br J Cancer. 60(6):861-6. PMID: 2481486. ; Moss et al. 1988. Lung Cancer. 4, 76-78. ; Allan et al. 1983. Int J Cancer. 31(5):591-8. PMID: 6852977.
CD90 is a 2537 kDa heavily N-glycosylated cell surface protein with a single V-like immunoglobulin domain. It was discovered as a thymocyte antigen, so it is also known as Thy-1.
CD90 expression varies between species, however cell types known to express it are thymocytes, CD34(+) prothymocytes, neurons, mesenchymal stem cells, hematopoietic stem cells, NK cells, murine T-cells, endothelium, renal glomerular mesangial cells, circulating metastatic melanoma cells, follicular dendritic cells (FDC), a fraction of fibroblasts and myofibroblasts. CD90 is a monomorphic determinant in rat but polymorphic in mice.
This antibody (Clone T11D7e) reacts with Thy1.1 mice (e.g. AKR and FVB mice), but not Thy1.2 mice (e.g. CBA and BALB/c). Clone T11D7e is also useful for removal of T lymphocytes from cell populations by complement mediated cytotoxicity.
Product Type:
NS Reagents Antibody
Antibody Type:
Monoclonal
Format:
100 µg in 100 µl PBS containing 0.02% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
CD90 is a 2537 kDa heavily N-glycosylated cell surface protein with a single V-like immunoglobulin domain. It was discovered as a thymocyte antigen, so it is also known as Thy-1.
CD90 expression varies between species, however cell types known to express it are thymocytes, CD34(+) prothymocytes, neurons, mesenchymal stem cells, hematopoietic stem cells, NK cells, murine T-cells, endothelium, renal glomerular mesangial cells, circulating metastatic melanoma cells, follicular dendritic cells (FDC), a fraction of fibroblasts and myofibroblasts. CD90 is a monomorphic determinant in rat but polymorphic in mice.
This antibody (Clone T11D7e) reacts with Thy1.1 mice (e.g. AKR and FVB mice), but not Thy1.2 mice (e.g. CBA and BALB/c). Clone T11D7e is also useful for removal of T lymphocytes from cell populations by complement mediated cytotoxicity.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Cytochrome P450 7B1 (25-hydroxycholesterol 7alpha-hydroxylase) is a member of the cytochrome P450 superfamily of enzymes involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. In the liver CYP7B1 most likely only plays a minor role in total bile acid synthesis, providing an alternate acidic pathway for the formation of bile acids through cholesterol degradation.
In the brain CYP7B1 is important in the metabolism of brain cholesterol. As there is little or no transfer of cholesterol across the blood-brain barrier, cholesterol must be produced in the brain locally, and CYP7B1 is important in maintaining the precise balance between the biosynthesis, storage, and catabolism of cholesterol metabolites.
Product Type:
NS Reagents Antibody
Antibody Type:
Monoclonal
Format:
100 µg in 100 µl PBS containing 0.02% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Ovalbumin-conjugated synthetic peptide from the C-terminal region of Human
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Cytochrome P450 7B1 (25-hydroxycholesterol 7alpha-hydroxylase) is a member of the cytochrome P450 superfamily of enzymes involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. In the liver CYP7B1 most likely only plays a minor role in total bile acid synthesis, providing an alternate acidic pathway for the formation of bile acids through cholesterol degradation.
In the brain CYP7B1 is important in the metabolism of brain cholesterol. As there is little or no transfer of cholesterol across the blood-brain barrier, cholesterol must be produced in the brain locally, and CYP7B1 is important in maintaining the precise balance between the biosynthesis, storage, and catabolism of cholesterol metabolites.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Ovalbumin-conjugated synthetic peptide from the C-terminal region of Human
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Ryk is an evolutionary-conserved Wnt receptor (lin-18 in C. elegans) that is important to neurogenesis and axon guidance and that is involved in the regulation of developmental/postdevelopmental processes such as planar cell polarity, regeneration, and hematopoietic repopulation. It has a leucine-rich extracellular domain with a WIF-type Wnt binding region, a single transmembrane domain, and an intracellular tyrosine kinase domain (a ?-secretase cleavage product that translocates in the nucleus to control neurogenesis). Evidence has shown that Ryk regulates planar cell polarity (PCP) signaling through interacting with Vangl2.
BLAST analysis shows that the immunogen peptide sequence used in the production of this antibody has 100% homology in all vertebrates, so cross reactivity in different species is expected.
Product Type:
NS Reagents Antibody
Antibody Type:
Monoclonal
Format:
100 µg in 100 µl PBS containing 0.02% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the C-terminal region of Human Receptor Like Tyrosine Kinase (RYK)
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Clone number:
Clone F35P7D7F5
Antibody Isotype:
IgG1 kappa
Antibody Number:
10009
Category:
Primary Antibodies
Other names:
receptor-like tyrosine kinase, receptor tyrosine kinase-related molecule, receptor related to tyrosine kinases, RYK
Research Areas:
Cell Signalling, Neuroscience
NS Reagents Product Area:
Cell Signalling
Molecular Weight:
67kDa (Other human Isoforms 10kDa, 16kDa, 62kDa) (Intended as a general guide and does not allow for all isoforms and species variations)
Ryk is an evolutionary-conserved Wnt receptor (lin-18 in C. elegans) that is important to neurogenesis and axon guidance and that is involved in the regulation of developmental/postdevelopmental processes such as planar cell polarity, regeneration, and hematopoietic repopulation. It has a leucine-rich extracellular domain with a WIF-type Wnt binding region, a single transmembrane domain, and an intracellular tyrosine kinase domain (a ?-secretase cleavage product that translocates in the nucleus to control neurogenesis). Evidence has shown that Ryk regulates planar cell polarity (PCP) signaling through interacting with Vangl2.
BLAST analysis shows that the immunogen peptide sequence used in the production of this antibody has 100% homology in all vertebrates, so cross reactivity in different species is expected.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the C-terminal region of Human Receptor Like Tyrosine Kinase (RYK)
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Clone number:
Clone F35P7D7F5
Antibody Isotype:
IgG1 kappa
Antibody Number:
10009
Category:
Primary Antibodies
Other names:
receptor-like tyrosine kinase, receptor tyrosine kinase-related molecule, receptor related to tyrosine kinases, RYK
Research Areas:
Cell Signalling, Neuroscience
NS Reagents Product Area:
Cell Signalling
Molecular Weight:
67kDa (Other human Isoforms 10kDa, 16kDa, 62kDa) (Intended as a general guide and does not allow for all isoforms and species variations)
TAR DNA-binding protein 43 (TDP-43) is an RNA binding protein (RBP) that has been shown to bind both DNA and RNA and have multiple functions in transcriptional repression, pre-mRNA splicing and translational regulation. It belongs to the hnRNP protein family and is highly expressed in the pancreas, placenta, lung, genital tract and spleen[1]. Characterisation of transcriptome-wide binding sites revealed that thousands of RNAs are bound by TDP-43 in neurons.
Mutations in TDP-43 have been associated with amyotrophic lateral sclerosis, frontotemporal dementia, Parkinson's disease and Alzheimer's disease.
TDP-43 is predominantly located in the nucleus under normal physiological conditions. However, hyperphosphorylated, fragmented and ubiquitinated forms of TDP-43 have been identified as core components of cytosolic inclusions in sporadic ALS and frontotemporal lobar degeneration (FTLD) [2,3,4,5,6,7,8].
TDP-43 contains a nuclear localising signal (NLS) as well as a nuclear export signal (NES)[8], which enables the shuttling of TDP-43 between the nucleus and the cytosol. Under normal conditions, TDP-43 interacts with mRNAs on which ribosomes are located separately, forming polysomes. Various stresses can induce clustering of ribosomes into a stalled state, resulting in the formation of stress granules (SG) containing TIA-1, G3BP, ataxin-2 and eIF4G1/2.
In the stalled state, transcription is inhibited in a homeostatic response. However, sustained stress and TDP-43 misfolding creates aberrant SGs and pathogenic TDP-43 aggregates [9]. Misfolding and cytosolic mislocalisation also lead directly to a loss of normal TDP-43 function, and the resultant disruption of protein and RNA homeostasis is considered another likely pathogenic mechanism in addition to the toxicity of inclusions in ALS[9].
Product Type:
NS Reagents Antibody
Antibody Type:
Monoclonal
Format:
100 µg in 100 µl PBS containing 0.02% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A His-tagged recombinant protein from the C-termnal of human TDP-43 (aa 208-414)
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Clone number:
Clone DB9
Antibody Isotype:
IgG1 kappa
Application Details:
ELISA, IHC 1:200, WB 1:1000, ICC 1:200
Antibody Number:
10010
Category:
Primary Antibodies
Other names:
TAR DNA-binding protein 43, TDP-43, transactive response DNA binding protein 43 kDa
43kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Nucleus
Purification:
Protein A Affinity Purified
References:
1. Strong MJ, Volkening K, Hammond R, et al. (2007). TDP43 is a human low molecular weight neurofilament (hNFL) mRNA-binding protein. Molecular and Cellular Neuroscience. 35 (2): 3207.
2. Kwong LK, Neumann M, Sampathu DM, et al. (2007). TDP-43 proteinopathy: The neuropathology underlying major forms of sporadic and familial frontotemporal lobar degeneration and motor neuron disease. Acta Neuropathologica. 114 (1): 6370.
3. Arai, T. et al. TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Biochem. Biophys. Res. Commun. 351, 602611 (2006). CAS
4. Neumann M, Sampathu DM, Kwong LK, Truax AC, et al. (2006). Ubiquitinated TDP-43 in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis. Science. 314 (5796): 1303.
5. Tan, C. F. et al. TDP-43 immunoreactivity in neuronal inclusions in familial amyotrophic lateral sclerosis with or without SOD1 gene mutation. Acta Neuropathol. 113, 535542 (2007).
6. Igaz, L. M. et al. Enrichment of C-terminal fragments in TAR DNA-binding protein-43 cytoplasmic inclusions in brain but not in spinal cord of frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Am. J. Pathol. 173, 182194 (2008).
7. Tremblay C, St-Amour I, Schneider J, et al. (2011). Accumulation of transactive response DNA binding protein 43 in mild cognitive impairment and Alzheimer disease. J Neuropathol Exp Neurol. 70 (9): 78898.
8. Winton, M. J. et al. Disturbance of nuclear and cytoplasmic TAR DNA-binding protein (TDP-43) induces disease-like redistribution, sequestration, and aggregate formation. J. Biol. Chem. 283, 1330213309 (2008).
9. Yoshitaka Tamaki et al. Elimination of TDP-43 inclusions linked to amyotrophic lateral sclerosis by a misfolding-specific intrabody with dual proteolytic signals. Scientific Reports: volume 8, Article number: 6030 (2018)
TAR DNA-binding protein 43 (TDP-43) is an RNA binding protein (RBP) that has been shown to bind both DNA and RNA and have multiple functions in transcriptional repression, pre-mRNA splicing and translational regulation. It belongs to the hnRNP protein family and is highly expressed in the pancreas, placenta, lung, genital tract and spleen[1]. Characterisation of transcriptome-wide binding sites revealed that thousands of RNAs are bound by TDP-43 in neurons.
Mutations in TDP-43 have been associated with amyotrophic lateral sclerosis, frontotemporal dementia, Parkinson's disease and Alzheimer's disease.
TDP-43 is predominantly located in the nucleus under normal physiological conditions. However, hyperphosphorylated, fragmented and ubiquitinated forms of TDP-43 have been identified as core components of cytosolic inclusions in sporadic ALS and frontotemporal lobar degeneration (FTLD) [2,3,4,5,6,7,8].
TDP-43 contains a nuclear localising signal (NLS) as well as a nuclear export signal (NES)[8], which enables the shuttling of TDP-43 between the nucleus and the cytosol. Under normal conditions, TDP-43 interacts with mRNAs on which ribosomes are located separately, forming polysomes. Various stresses can induce clustering of ribosomes into a stalled state, resulting in the formation of stress granules (SG) containing TIA-1, G3BP, ataxin-2 and eIF4G1/2.
In the stalled state, transcription is inhibited in a homeostatic response. However, sustained stress and TDP-43 misfolding creates aberrant SGs and pathogenic TDP-43 aggregates [9]. Misfolding and cytosolic mislocalisation also lead directly to a loss of normal TDP-43 function, and the resultant disruption of protein and RNA homeostasis is considered another likely pathogenic mechanism in addition to the toxicity of inclusions in ALS[9].
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A His-tagged recombinant protein from the C-termnal of human TDP-43 (aa 208-414)
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Clone number:
Clone DB9
Antibody Isotype:
IgG1 kappa
Application Details:
ELISA, IHC 1:200, WB 1:1000, ICC 1:200
Antibody Number:
10010
Category:
Primary Antibodies
Other names:
TAR DNA-binding protein 43, TDP-43, transactive response DNA binding protein 43 kDa. ALS10
43kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Nucleus
Purification:
Protein A Affinity Purified
References:
1. Strong MJ, Volkening K, Hammond R, et al. (2007). TDP43 is a human low molecular weight neurofilament (hNFL) mRNA-binding protein. Molecular and Cellular Neuroscience. 35 (2): 3207.
2. Kwong LK, Neumann M, Sampathu DM, et al. (2007). TDP-43 proteinopathy: The neuropathology underlying major forms of sporadic and familial frontotemporal lobar degeneration and motor neuron disease. Acta Neuropathologica. 114 (1): 6370.
3. Arai, T. et al. TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Biochem. Biophys. Res. Commun. 351, 602611 (2006). CAS
4. Neumann M, Sampathu DM, Kwong LK, Truax AC, et al. (2006). Ubiquitinated TDP-43 in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis. Science. 314 (5796): 1303.
5. Tan, C. F. et al. TDP-43 immunoreactivity in neuronal inclusions in familial amyotrophic lateral sclerosis with or without SOD1 gene mutation. Acta Neuropathol. 113, 535542 (2007).
6. Igaz, L. M. et al. Enrichment of C-terminal fragments in TAR DNA-binding protein-43 cytoplasmic inclusions in brain but not in spinal cord of frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Am. J. Pathol. 173, 182194 (2008).
7. Tremblay C, St-Amour I, Schneider J, et al. (2011). Accumulation of transactive response DNA binding protein 43 in mild cognitive impairment and Alzheimer disease. J Neuropathol Exp Neurol. 70 (9): 78898.
8. Winton, M. J. et al. Disturbance of nuclear and cytoplasmic TAR DNA-binding protein (TDP-43) induces disease-like redistribution, sequestration, and aggregate formation. J. Biol. Chem. 283, 1330213309 (2008).
9. Yoshitaka Tamaki et al. Elimination of TDP-43 inclusions linked to amyotrophic lateral sclerosis by a misfolding-specific intrabody with dual proteolytic signals. Scientific Reports: volume 8, Article number: 6030 (2018)
Neuron-specific enolase (NSE) is a glycolytic isoenzyme found in central and peripheral neurons and neuroendocrine cells. Enolase exists as a number of tissue-specific isoenzymes, consisting of homo or heterodimers of 3 different monomer-isoforms (alpha, beta, and gamma). Neuron specific enolase (NSE) is a 78 kD gamma-homodimer and represents the dominant enolase-isoenzyme found in neuronal and neuroendocrine tissues. NSE levels in other tissues, except erythrocytes, are negligible.
Concentrations of NSE in serum or cerebrospinal fluid (CSF) are generally elevated in diseases which result in neuronal destruction.
This antibody (Clone NSEP1) is not reactive with other isozyme forms of enolase.
Product Type:
NS Reagents Antibody
Antibody Type:
Monoclonal
Format:
100 µg in 100 µl PBS containing 0.02% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Ovalbumin-conjugated synthetic peptide from the C-terminal region of Human NSE
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Clone number:
Clone NSEP1
Antibody Isotype:
IgG1 kappa
Antibody Number:
10011
Category:
Primary Antibodies
Other names:
Gamma-enolase, enolase 2, ENO2, gamma-isozyme
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
47kDa or 78kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Cell membrane, Cytoplasm
Purification:
Protein A Affinity Purified
References:
Murray GI, Duncan ME, Melvin WT, Fothergill JE. Immunohistochemistry of neurone specific enolase with gamma subunit specific anti-peptide monoclonal antibodies. J. Clin. Pathol. 46:993-996, 1993.
Duncan ME, McAleese SM, Booth NA, Melvin WT, Fothergill JE. A simple enzyme-linked immunosorbent assay (ELISA) for the neuron-specific gamma isozyme of human enolase (NSE) using monoclonal antibodies raised against synthetic peptides corresponding to isozyme sequence differences. J. Immuno. Methods 151:227-236, 1992.
Neuron-specific enolase (NSE) is a glycolytic isoenzyme found in central and peripheral neurons and neuroendocrine cells. Enolase exists as a number of tissue-specific isoenzymes, consisting of homo or heterodimers of 3 different monomer-isoforms (alpha, beta, and gamma). Neuron specific enolase (NSE) is a 78 kD gamma-homodimer and represents the dominant enolase-isoenzyme found in neuronal and neuroendocrine tissues. NSE levels in other tissues, except erythrocytes, are negligible.
Concentrations of NSE in serum or cerebrospinal fluid (CSF) are generally elevated in diseases which result in neuronal destruction.
This antibody (Clone NSEP1) is not reactive with other isozyme forms of enolase.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Ovalbumin-conjugated synthetic peptide from the C-terminal region of Human NSE
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Clone number:
Clone NSEP1
Antibody Isotype:
IgG1 kappa
Antibody Number:
10011
Category:
Primary Antibodies
Other names:
Gamma-enolase, enolase 2, ENO2, gamma-isozyme
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
47kDa or 78kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Cell membrane, Cytoplasm
Purification:
Protein A Affinity Purified
References:
Murray GI, Duncan ME, Melvin WT, Fothergill JE. Immunohistochemistry of neurone specific enolase with gamma subunit specific anti-peptide monoclonal antibodies. J. Clin. Pathol. 46:993-996, 1993.
Duncan ME, McAleese SM, Booth NA, Melvin WT, Fothergill JE. A simple enzyme-linked immunosorbent assay (ELISA) for the neuron-specific gamma isozyme of human enolase (NSE) using monoclonal antibodies raised against synthetic peptides corresponding to isozyme sequence differences. J. Immuno. Methods 151:227-236, 1992.
Neuron-specific enolase (NSE) is a glycolytic isoenzyme found in central and peripheral neurons and neuroendocrine cells. Enolase exists as a number of tissue-specific isoenzymes, consisting of homo or heterodimers of 3 different monomer-isoforms (alpha, beta, and gamma). Neuron specific enolase (NSE) is a 78 kD gamma-homodimer and represents the dominant enolase-isoenzyme found in neuronal and neuroendocrine tissues. NSE levels in other tissues, except erythrocytes, are negligible.
Concentrations of NSE in serum or cerebrospinal fluid (CSF) are generally elevated in diseases which result in neuronal destruction.
This antibody (Clone NSEP2) is not reactive with other isozyme forms of enolase.
Product Type:
NS Reagents Antibody
Antibody Type:
Monoclonal
Format:
100 µg in 100 µl PBS containing 0.02% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Ovalbumin-conjugated synthetic peptide from the central region of Human NSE
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Clone number:
Clone NSEP2
Antibody Isotype:
IgG1 kappa
Application Details:
WB: 1:2000, ELISA: 1:500
Antibody Number:
10012
Category:
Primary Antibodies
Other names:
Gamma-enolase, enolase 2, ENO2, gamma-isozyme
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
47kDa or 78kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Cell membrane, Cytoplasm
Purification:
Protein A Affinity Purified
References:
Murray GI, Duncan ME, Melvin WT, Fothergill JE. Immunohistochemistry of neurone specific enolase with gamma subunit specific anti-peptide monoclonal antibodies. J. Clin. Pathol. 46:993-996, 1993.
Duncan ME, McAleese SM, Booth NA, Melvin WT, Fothergill JE. A simple enzyme-linked immunosorbent assay (ELISA) for the neuron-specific gamma isozyme of human enolase (NSE) using monoclonal antibodies raised against synthetic peptides corresponding to isozyme sequence differences. J. Immuno. Methods 151:227-236, 1992.
Neuron-specific enolase (NSE) is a glycolytic isoenzyme found in central and peripheral neurons and neuroendocrine cells. Enolase exists as a number of tissue-specific isoenzymes, consisting of homo or heterodimers of 3 different monomer-isoforms (alpha, beta, and gamma). Neuron specific enolase (NSE) is a 78 kD gamma-homodimer and represents the dominant enolase-isoenzyme found in neuronal and neuroendocrine tissues. NSE levels in other tissues, except erythrocytes, are negligible.
Concentrations of NSE in serum or cerebrospinal fluid (CSF) are generally elevated in diseases which result in neuronal destruction.
This antibody (Clone NSEP2) is not reactive with other isozyme forms of enolase.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Ovalbumin-conjugated synthetic peptide from the central region of Human NSE
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Clone number:
Clone NSEP2
Antibody Isotype:
IgG1 kappa
Application Details:
WB: 1:2000, ELISA: 1:500
Antibody Number:
10012
Category:
Primary Antibodies
Other names:
Gamma-enolase, enolase 2, ENO2, gamma-isozyme
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
47kDa or 78kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Cell membrane, Cytoplasm
Purification:
Protein A Affinity Purified
References:
Murray GI, Duncan ME, Melvin WT, Fothergill JE. Immunohistochemistry of neurone specific enolase with gamma subunit specific anti-peptide monoclonal antibodies. J. Clin. Pathol. 46:993-996, 1993.
Duncan ME, McAleese SM, Booth NA, Melvin WT, Fothergill JE. A simple enzyme-linked immunosorbent assay (ELISA) for the neuron-specific gamma isozyme of human enolase (NSE) using monoclonal antibodies raised against synthetic peptides corresponding to isozyme sequence differences. J. Immuno. Methods 151:227-236, 1992.
Anoctamin-5 (ANO5) is believed to be an integral membrane glycoprotein with a role in myogenesis and osteogenesis. It is found predominantly in the plasma membrane and intracellular membrane vesicles. In human tissues, ANO5 mRNA is detected in the brain, heart, kidney, lung and skeletal muscle, and in mice shows abundant expression in bone tissues including the calvarium, femur and mandible.
Mutations in this protein are linked to limb-girdle muscular dystrophy type 2L (LGMD2L), Miyoshi muscular dystrophy 3 (MMD3) and Gnathodiaphyseal dysplasia (GDD) and other dysferlinopathies.
ANO5 has an expected molecular mass of around 107kDa. However in western blot using lysates prepared from C2C12 cells (wt), RD and fibroblasts, 3 bands are detected at 107kDa, 55 kDa and 37 KDa.
Product Type:
NS Reagents Antibody
Antibody Type:
Monoclonal
Format:
100 µg in 100 µl PBS containing 0.02% sodium azide.
Very likely to bind to Anoctamin from other species due to 100% homology in Sheep, Goat, Dog and Cat
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the C-terminal region of Human ANO5
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Clone number:
Clone 5F7
Antibody Isotype:
IgM
Antibody Number:
10013
Category:
Primary Antibodies
Other names:
Anoctamin-5, ANO5
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
37kDa, 55kDa and 107kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Anoctamin-5 (ANO5) is believed to be an integral membrane glycoprotein with a role in myogenesis and osteogenesis. It is found predominantly in the plasma membrane and intracellular membrane vesicles. In human tissues, ANO5 mRNA is detected in the brain, heart, kidney, lung and skeletal muscle, and in mice shows abundant expression in bone tissues including the calvarium, femur and mandible.
Mutations in this protein are linked to limb-girdle muscular dystrophy type 2L (LGMD2L), Miyoshi muscular dystrophy 3 (MMD3) and Gnathodiaphyseal dysplasia (GDD) and other dysferlinopathies.
ANO5 has an expected molecular mass of around 107kDa. However in western blot using lysates prepared from C2C12 cells (wt), RD and fibroblasts, 3 bands are detected at 107kDa, 55 kDa and 37 KDa.
Very likely to bind to Anoctamin from other species due to 100% homology in Sheep, Goat, Dog and Cat
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the C-terminal region of Human ANO5
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Clone number:
Clone 5F7
Antibody Isotype:
IgM
Antibody Number:
10013
Category:
Primary Antibodies
Other names:
Anoctamin-5, ANO5
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
37kDa, 55kDa and 107kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Neuroblastoma is a disease of the sympathetic nervous system, in children under the age of 5. This tumour, derived from neuroblasts (undifferentiated embryonic nerve cells).
This antibody (Clone FMG25) can be used to differentiate between neuroblastoma and rhabdomyosarcoma. It does not bind to other small round-cell tumours of childhood. It cross reacts with normal brain and peripheral nerve.
Product Type:
NS Reagents Antibody
Antibody Type:
Monoclonal
Format:
100 µg in 100 µl PBS containing 0.02% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Human cutaneous T cell lymphoma (Cell Line - HUT 78)
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Clone number:
Clone FMG25
Antibody Isotype:
IgG1
Antibody Number:
10014
Category:
Primary Antibodies
Other names:
NB-Ab
Research Areas:
Neuroscience, Cancer
NS Reagents Product Area:
Neuroscience
Molecular Weight:
N/A
Subcellular location:
N/A
Purification:
Protein A Affinity Purified
References:
Gibson et al. 1987. Int J Cancer. 39(5):554-9. PMID: 3494688.
Neuroblastoma is a disease of the sympathetic nervous system, in children under the age of 5. This tumour, derived from neuroblasts (undifferentiated embryonic nerve cells).
This antibody (Clone FMG25) can be used to differentiate between neuroblastoma and rhabdomyosarcoma. It does not bind to other small round-cell tumours of childhood. It cross reacts with normal brain and peripheral nerve.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Human cutaneous T cell lymphoma (Cell Line - HUT 78)
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Clone number:
Clone FMG25
Antibody Isotype:
IgG1
Antibody Number:
10014
Category:
Primary Antibodies
Other names:
NB-Ab
Research Areas:
Neuroscience, Cancer
NS Reagents Product Area:
Neuroscience
Molecular Weight:
N/A
Subcellular location:
N/A
Purification:
Protein A Affinity Purified
References:
Gibson et al. 1987. Int J Cancer. 39(5):554-9. PMID: 3494688.
Autophagy-related protein 9 (ATG9) is essential component of the autophagy machinery and is found on autophagosomes. It is the only transmembrane protein in the autophagy core machinery and has been proposed to play a key role in directing membrane from donor organelles for autophagosome formation. In autophagy, the initiation of autophagosome formation requires the recruitment of ATG9 vesicles to the preautophagosomal structure. ATG9 cycles between the preautophagosomal structure/phagophore (PAS) and the cytoplasmic vesicle pool and may also participate in supplying membrane for the growing autophagosome. ATG9 is also involved in the endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress. ATG9 recruits vesicle-tethering proteins TRS85 and YPT1 to the autophagosome formation site and also recruits ATG23 and ATG8 to the PAS.
Product Type:
NS Reagents Antibody
Antibody Type:
Monoclonal
Format:
100 µg in 100 µl PBS containing 0.02% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the C-terminal region of Human ATG9
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Clone number:
Clone Atg9 14F2 8B1
Antibody Isotype:
IgG
Application Details:
ELISA 1:1000 IHC 1:50-1:100 IF 1:50-1:100 WB 1:500
Antibody Number:
10015
Category:
Primary Antibodies
Other names:
Autophagy-related protein 9 (ATG9), Cytoplasm to vacuole targeting protein 7
Research Areas:
Neuroscience, Autophagy
NS Reagents Product Area:
Neuroscience
Molecular Weight:
95kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Endosome, Endoplasmic reticulum, Golgi apparatus
Purification:
Protein A Affinity Purified
References:
Chan EY, et al. Kinase-inactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg13-independent mechanism. Mol Cell Biol.2009.29(1):157-71. PMID:18936157
Autophagy-related protein 9 (ATG9) is essential component of the autophagy machinery and is found on autophagosomes. It is the only transmembrane protein in the autophagy core machinery and has been proposed to play a key role in directing membrane from donor organelles for autophagosome formation. In autophagy, the initiation of autophagosome formation requires the recruitment of ATG9 vesicles to the preautophagosomal structure. ATG9 cycles between the preautophagosomal structure/phagophore (PAS) and the cytoplasmic vesicle pool and may also participate in supplying membrane for the growing autophagosome. ATG9 is also involved in the endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress. ATG9 recruits vesicle-tethering proteins TRS85 and YPT1 to the autophagosome formation site and also recruits ATG23 and ATG8 to the PAS.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the C-terminal region of Human ATG9
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Clone number:
Clone Atg9 14F2 8B1
Antibody Isotype:
IgG
Application Details:
ELISA 1:1000 IHC 1:50-1:100 IF 1:50-1:100 WB 1:500
Antibody Number:
10015
Category:
Primary Antibodies
Other names:
Autophagy-related protein 9 (ATG9), Cytoplasm to vacuole targeting protein 7
Research Areas:
Neuroscience, Autophagy
NS Reagents Product Area:
Neuroscience
Molecular Weight:
95kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Endosome, Endoplasmic reticulum, Golgi apparatus
Purification:
Protein A Affinity Purified
References:
Chan EY, et al. Kinase-inactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg13-independent mechanism. Mol Cell Biol.2009.29(1):157-71. PMID:18936157
Kinase D Interacting Substrate 220kDa (Kidins220) is a transmembrane protein that is preferentially expressed in brain and neuroendocrine cells. It is phosphorylated by protein Kinase (PKD) and has also been shown to function downstream of the Trk and Eph receptor tyrosine kinases.
Kidins220 controls neuronal cell survival, differentiation into exons and dendrites, and synaptic plasticity. It interacts with membrane receptors, cytosolic signaling components, and cytoskeletal proteins, serving as a scaffold that mediates crosstalk between the neurotrophin pathway and several other intracellular signaling pathways. Additionally, it has been shown to have an important role in the immune system by interacting with the B-cell and T-cell receptor.
Abnormal expression of this protein is associated with the onset of neurodegenerative diseases, including Alzheimer's disease.
Product Type:
NS Reagents Antibody
Antibody Type:
Monoclonal
Format:
100 µg in 100 µl PBS containing 0.02% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant protein from the C-terminal region of human GST-Kidins220
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Kinase D Interacting Substrate 220kDa (Kidins220) is a transmembrane protein that is preferentially expressed in brain and neuroendocrine cells. It is phosphorylated by protein Kinase (PKD) and has also been shown to function downstream of the Trk and Eph receptor tyrosine kinases.
Kidins220 controls neuronal cell survival, differentiation into exons and dendrites, and synaptic plasticity. It interacts with membrane receptors, cytosolic signaling components, and cytoskeletal proteins, serving as a scaffold that mediates crosstalk between the neurotrophin pathway and several other intracellular signaling pathways. Additionally, it has been shown to have an important role in the immune system by interacting with the B-cell and T-cell receptor.
Abnormal expression of this protein is associated with the onset of neurodegenerative diseases, including Alzheimer's disease.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant protein from the C-terminal region of human GST-Kidins220
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
L1 cell adhesion molecule (L1CAM) is a cell-surface transmembrane protein. A member of the L1 protein family of neural adhesion molecules (of the immunoglobulin superfamily) it is believed to be involved in cell migration, adhesion, neurite outgrowth, myelination and neuronal differentiation.
L1CAM is present on tumours of neuroectodermal and glial origin (e.g. neuroblastoma and schwannomas). It is also expressed in intestinal epithelial progenitor cells, cerebellum neurons such as Cerebellum granule cell and Purkinje cells.
Product Type:
NS Reagents Antibody
Antibody Type:
Monoclonal
Format:
100 µg in 100 µl PBS containing 0.02% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Homogenous suspension of 16 week human foetal brain
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
L1 cell adhesion molecule (L1CAM) is a cell-surface transmembrane protein. A member of the L1 protein family of neural adhesion molecules (of the immunoglobulin superfamily) it is believed to be involved in cell migration, adhesion, neurite outgrowth, myelination and neuronal differentiation.
L1CAM is present on tumours of neuroectodermal and glial origin (e.g. neuroblastoma and schwannomas). It is also expressed in intestinal epithelial progenitor cells, cerebellum neurons such as Cerebellum granule cell and Purkinje cells.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Homogenous suspension of 16 week human foetal brain
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
The c-Myc and N-Myc oncogenes are members of the Myc family of transcription factors that regulate cell proliferation and apoptosis. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. N-Myc is highly expressed in pre B cell and the fetal brain and is critical for normal brain development. Overexpression of N-Myc is associated with a variety of tumors, most notably neuroblastomas and small lung carcinoma.
This antibody does not react with c-Myc or L-Myc.
Product Type:
NS Reagents Antibody
Antibody Type:
Monoclonal
Format:
100 µg in 100 µl PBS containing 0.02% sodium azide.
Mouse, Rat, Gibbon, Monkey, Hamster, Porcine, Chicken
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the C-terminal region of Human N-Myc
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Clone number:
Clone NMYC-1
Antibody Isotype:
IgG2b
Antibody Number:
10018
Category:
Primary Antibodies
Other names:
N-myc proto-oncogene protein, basic helix-loop-helix protein 37 (bHLHe37), n-Myc, N-MYC
Research Areas:
DNA & Protein Modification, Cancer
NS Reagents Product Area:
DNA & Protein Modification
Molecular Weight:
50kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Nucleus
Purification:
Protein A Affinity Purified
References:
Tasseva et al. 2011. J Biol Chem. 286(2):1061-73. PMID: 21068393.
The c-Myc and N-Myc oncogenes are members of the Myc family of transcription factors that regulate cell proliferation and apoptosis. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. N-Myc is highly expressed in pre B cell and the fetal brain and is critical for normal brain development. Overexpression of N-Myc is associated with a variety of tumors, most notably neuroblastomas and small lung carcinoma.
Mouse, Rat, Gibbon, Monkey, Hamster, Porcine, Chicken
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the C-terminal region of Human N-Myc
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Clone number:
Clone NMYC-1
Antibody Isotype:
IgG2b
Antibody Number:
10018
Category:
Primary Antibodies
Other names:
N-myc proto-oncogene protein, basic helix-loop-helix protein 37 (bHLHe37), n-Myc, N-MYC
Research Areas:
DNA & Protein Modification, Cancer
NS Reagents Product Area:
DNA & Protein Modification
Molecular Weight:
50kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Nucleus
Purification:
Protein A Affinity Purified
References:
Tasseva et al. 2011. J Biol Chem. 286(2):1061-73. PMID: 21068393.
Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Integrin alpha 2b (CD41) and integrin beta3 (CD61) associate to form the heterodimer integrin a2bB3, a fibronectin receptor expressed in platelets. Activation of a2B3 leads to platelet to platelet interaction through the binding of soluble fibrinogen, which in turn leads to rapid platelet aggregation which can physically block holes in an endothelial cell surface.
M148 binds to some medulloblastoma and neuroblastoma cells and rhabdomyosarcoma and some other solid tumours. It does not bind to marrow constituents other than platelets and megakaryocytes. Abnormal integrin expression has been shown in many epithelial tumours and is important for the growth and metastatic capacity of melanoma cells. M148 prevents aggregation of platelets and therefore is expected to block the binding of Integrin alpha 2b (CD41) and integrin beta3 (CD61).
Product Type:
NS Reagents Antibody
Antibody Type:
Monoclonal
Format:
100 µg in 100 µl PBS containing 0.02% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Clone number:
Clone M148
Antibody Isotype:
IgG1
Antibody Number:
10019
Category:
Primary Antibodies
Other names:
CD41, Alpha 2 Subunit Of VLA-2 Receptor
Research Areas:
Neuroscience, Cancer
NS Reagents Product Area:
Neuroscience
Molecular Weight:
113kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Plasma membrane
Purification:
Protein A Affinity Purified
References:
Alonso-Orgaz et al. 2014. J Proteomics. 109:368-81. PMID: 25065646. ; Cloutier et al. 2013. EMBO Mol Med. 5(2):235-49. PMID: 23165896. ; Boilard et al. 2011. J Immunol. 186(7):4361-6. PMID: 21357261. ; Jones et al. 1984. Br J Haematol. 57(4):621-31. PMID: 6234927.
Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Integrin alpha 2b (CD41) and integrin beta3 (CD61) associate to form the heterodimer integrin a2bB3, a fibronectin receptor expressed in platelets. Activation of a2B3 leads to platelet to platelet interaction through the binding of soluble fibrinogen, which in turn leads to rapid platelet aggregation which can physically block holes in an endothelial cell surface.
M148 binds to some medulloblastoma and neuroblastoma cells and rhabdomyosarcoma and some other solid tumours. It does not bind to marrow constituents other than platelets and megakaryocytes. Abnormal integrin expression has been shown in many epithelial tumours and is important for the growth and metastatic capacity of melanoma cells. M148 prevents aggregation of platelets and therefore is expected to block the binding of Integrin alpha 2b (CD41) and integrin beta3 (CD61).
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Clone number:
Clone M148
Antibody Isotype:
IgG1
Antibody Number:
10019
Category:
Primary Antibodies
Other names:
CD41, Alpha 2 Subunit Of VLA-2 Receptor
Research Areas:
Neuroscience, Cancer
NS Reagents Product Area:
Neuroscience
Molecular Weight:
113kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Plasma membrane
Purification:
Protein A Affinity Purified
References:
Alonso-Orgaz et al. 2014. J Proteomics. 109:368-81. PMID: 25065646. ; Cloutier et al. 2013. EMBO Mol Med. 5(2):235-49. PMID: 23165896. ; Boilard et al. 2011. J Immunol. 186(7):4361-6. PMID: 21357261. ; Jones et al. 1984. Br J Haematol. 57(4):621-31. PMID: 6234927.
Neural cell adhesion molecule (NCAM) is a homophillic binding glycoprotein of the Immunoglobulin (Ig) superfamily. NCAM is present on a variety of neural cells including neurons, glia and skeletal muscle. However it is also found in other cells such as hematopoietic cell types including natural killer cells. NCAM has been implicated as having a role in cell-cell adhesion, neurite outgrowth, synatptic plasticity, learning and memory and in the development of the nervous system.
When used in Western Blot (WB) this antibody (ERIC-1) has been shown to detect 3 bands at 120, 140 and 180 kDa. This has been shown in both mouse and in human brain samples (weakly in Human).
Product Type:
NS Reagents Antibody
Antibody Type:
Monoclonal
Format:
100 µg in 100 µl PBS containing 0.02% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Clone number:
Clone ERIC-1
Antibody Isotype:
IgG1
Application Details:
IHC-F 1:50-1:100
Antibody Number:
10020
Category:
Primary Antibodies
Other names:
Neural Cell Adhesion Molecule, CD56 Antigen MSK39
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
95kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Plasma membrane
Purification:
Protein A Affinity Purified
References:
Markovi?-Lipkovski et al. 2015. PLoS One. 10(9):e0137028. PMID: 26327314. ; Klehr et al. 2009. J Immunother. 32(5):442-51. PMID: 19609236. ; Pruszak et al. 2007. Stem Cells. 25(9):2257-68. PMID: 17588935. ; Blaheta et al. 2004. Neoplasia. 6(4):323-31. PMID: 15256054. ; Jensen et al. 2003. Clin Exp Immunol. 134(2):253-63. PMID: 14616785. ; Gerardy-Schahn et al. 1994. Int J Cancer Suppl. 8:38-42. PMID: 7515028. ; Phimister et al. 1991. J Clin Pathol. 44(7):580-5. PMID: 1856291. ; Frost et al. 1991. Neuropathol Appl Neurobiol. 17(3):207-17. PMID: 1891065. ; Bourne et al. 1991. J Neurooncol. 10(2):111-9. PMID: 1895159.
Neural cell adhesion molecule (NCAM) is a homophillic binding glycoprotein of the Immunoglobulin (Ig) superfamily. NCAM is present on a variety of neural cells including neurons, glia and skeletal muscle. However it is also found in other cells such as hematopoietic cell types including natural killer cells. NCAM has been implicated as having a role in cell-cell adhesion, neurite outgrowth, synatptic plasticity, learning and memory and in the development of the nervous system.
When used in Western Blot (WB) this antibody (ERIC-1) has been shown to detect 3 bands at 120, 140 and 180 kDa. This has been shown in both mouse and in human brain samples (weakly in Human).
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Clone number:
Clone ERIC-1
Antibody Isotype:
IgG1
Application Details:
IHC-F 1:50-1:100
Antibody Number:
10020
Category:
Primary Antibodies
Other names:
Neural Cell Adhesion Molecule, CD56 Antigen MSK39
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
95kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Plasma membrane
Purification:
Protein A Affinity Purified
References:
Markovi?-Lipkovski et al. 2015. PLoS One. 10(9):e0137028. PMID: 26327314. ; Klehr et al. 2009. J Immunother. 32(5):442-51. PMID: 19609236. ; Pruszak et al. 2007. Stem Cells. 25(9):2257-68. PMID: 17588935. ; Blaheta et al. 2004. Neoplasia. 6(4):323-31. PMID: 15256054. ; Jensen et al. 2003. Clin Exp Immunol. 134(2):253-63. PMID: 14616785. ; Gerardy-Schahn et al. 1994. Int J Cancer Suppl. 8:38-42. PMID: 7515028. ; Phimister et al. 1991. J Clin Pathol. 44(7):580-5. PMID: 1856291. ; Frost et al. 1991. Neuropathol Appl Neurobiol. 17(3):207-17. PMID: 1891065. ; Bourne et al. 1991. J Neurooncol. 10(2):111-9. PMID: 1895159.
The c-Myc and N-Myc oncogenes are members of the Myc family of transcription factors that regulate cell proliferation and apoptosis. c-MYC has a pivotal function in growth control, differentiation and apoptosis, being expressed in proliferating tissues, and its abnormal expression is associated with many tumors. Overexpression of c-MYC sensitises cells to apoptosis by a variety of stimuli. How the apoptotic response is regulated by c-MYC depends on the specific cell type and the physiological status of the cell.
c-myc is often used as a protein tag in order to simplify the labeling and detection of proteins. This antibody can be used for detection of such proteins in western blotting.
Product Type:
NS Reagents Antibody
Antibody Type:
Monoclonal
Format:
100 µg in 100 µl PBS containing 0.02% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the C-terminal region of Human Myc proto-oncogene protein (c-Myc)
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Clone number:
Clone 9E11
Antibody Isotype:
IgG2a kappa
Application Details:
WB: 1:1,000 ELISA 1:100-1:2000 Flow Cytometry 1:200-1:400 Immunohistochemistry 1:100 ChIP 2 ug / 500 ug extract Immunoprecipitation 2ug/mg lysate
Antibody Number:
10021
Category:
Primary Antibodies
Other names:
MYCC, MYC Proto-oncogene
Research Areas:
DNA & Protein Modification, Cancer
NS Reagents Product Area:
DNA & Protein Modification
Molecular Weight:
48kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Nucleoplasm, Nucleolus
Purification:
Protein A Affinity Purified
References:
Mittal et al. 2013. PLoS One. 8(8):e70352. PMID: 23936412. ; Mirzaei et al. 2013. Proc Natl Acad Sci U S A. 110(9):3645-50. PMID: 23388641. ; Keyhanfar et al. 2007. Biochem J. 401(1):269-77. PMID: 16981855. ; Halme et al. 2004. Cell. 116(3):405-15. PMID: 15016375. ; Kari et al. 1986. J Virol. 60(2):345-52. PMID: 3021969.
The c-Myc and N-Myc oncogenes are members of the Myc family of transcription factors that regulate cell proliferation and apoptosis. c-MYC has a pivotal function in growth control, differentiation and apoptosis, being expressed in proliferating tissues, and its abnormal expression is associated with many tumors. Overexpression of c-MYC sensitises cells to apoptosis by a variety of stimuli. How the apoptotic response is regulated by c-MYC depends on the specific cell type and the physiological status of the cell.
c-myc is often used as a protein tag in order to simplify the labeling and detection of proteins. This antibody can be used for detection of such proteins in western blotting.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the C-terminal region of human Myc proto-oncogene protein
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Clone number:
Clone 9E11
Antibody Isotype:
IgG2a kappa
Application Details:
WB: 1:1,000 ELISA 1:100-1:2000 Flow Cytometry 1:200-1:400 Immunohistochemistry 1:100 ChIP 2 ug / 500 ug extract Immunoprecipitation 2ug/mg lysate
Antibody Number:
10021
Category:
Primary Antibodies
Other names:
MYCC, MYC Proto-oncogene
Research Areas:
DNA & Protein Modification, Cancer
NS Reagents Product Area:
DNA & Protein Modification
Molecular Weight:
48kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Nucleoplasm, Nucleolus
Purification:
Protein A Affinity Purified
References:
Mittal et al. 2013. PLoS One. 8(8):e70352. PMID: 23936412. ; Mirzaei et al. 2013. Proc Natl Acad Sci U S A. 110(9):3645-50. PMID: 23388641. ; Keyhanfar et al. 2007. Biochem J. 401(1):269-77. PMID: 16981855. ; Halme et al. 2004. Cell. 116(3):405-15. PMID: 15016375. ; Kari et al. 1986. J Virol. 60(2):345-52. PMID: 3021969.
Anti-Caspase-3 Antibody (Pro and Active) (Clone ABM1C12)
Background Info:
Caspases are a member of the cysteine-aspartic acid protease family. Caspase-3 (31 kDa) is an executionary caspase which directly cleaves and activates poly(ADP-ribose) polymerase (PARP), sterol regulatory element binding proteins (SREBPs) or it can also interact with other caspases like caspase-6, -7 and -9.
Caspase-3 is the principal caspase in mediating the cleavage of amyloid-beta 4A precursor protein (APP), which is related with neuronal death in Alzheimer's disease. Like other caspases, caspase-3 is also synthesized as a zymogen procaspase which is activated by specific proteolytic cleavage. High levels of caspase-3 are observed in lung, spleen, heart, liver and kidney, moderate levels in brain and skeletal muscle, and low in testis. Increased levels of caspase-3 are involved in Huntington Disease-associated cell death.
Product Type:
NS Reagents Antibody
Antibody Type:
Monoclonal
Format:
100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Anti-Caspase-3 Antibody (Pro and Active) (Clone ABM1C12)
Background Info:
Caspases are a member of the cysteine-aspartic acid protease family. Caspase-3 (31 kDa) is an executionary caspase which directly cleaves and activates poly(ADP-ribose) polymerase (PARP), sterol regulatory element binding proteins (SREBPs) or it can also interact with other caspases like caspase-6, -7 and -9.
Caspase-3 is the principal caspase in mediating the cleavage of amyloid-beta 4A precursor protein (APP), which is related with neuronal death in Alzheimer's disease. Like other caspases, caspase-3 is also synthesized as a zymogen procaspase which is activated by specific proteolytic cleavage. High levels of caspase-3 are observed in lung, spleen, heart, liver and kidney, moderate levels in brain and skeletal muscle, and low in testis. Increased levels of caspase-3 are involved in Huntington Disease-associated cell death.
Product Type:
NS Reagents Antibody
Antibody Type:
Monoclonal
Format:
50 µg in 100 µl PBS containing 0.05% BSA and 0.05% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Caspases are a member of the cysteine-aspartic acid protease family. Caspase-3 (31 kDa) is an executionary caspase which directly cleaves and activates poly(ADP-ribose) polymerase (PARP), sterol regulatory element binding proteins (SREBPs) or it can also interact with other caspases like caspase-6, -7 and -9.
Caspase-3 is the principal caspase in mediating the cleavage of amyloid-beta 4A precursor protein (APP), which is related with neuronal death in Alzheimer's disease. Like other caspases, caspase-3 is also synthesized as a zymogen procaspase which is activated by specific proteolytic cleavage. High levels of caspase-3 are observed in lung, spleen, heart, liver and kidney, moderate levels in brain and skeletal muscle, and low in testis. Increased levels of caspase-3 are involved in Huntington Disease-associated cell death.
Product Type:
NS Reagents Antibody
Antibody Type:
Monoclonal
Format:
100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Caspases are a member of the cysteine-aspartic acid protease family. Caspase-3 (31 kDa) is an executionary caspase which directly cleaves and activates poly(ADP-ribose) polymerase (PARP), sterol regulatory element binding proteins (SREBPs) or it can also interact with other caspases like caspase-6, -7 and -9.
Caspase-3 is the principal caspase in mediating the cleavage of amyloid-beta 4A precursor protein (APP), which is related with neuronal death in Alzheimer's disease. Like other caspases, caspase-3 is also synthesized as a zymogen procaspase which is activated by specific proteolytic cleavage. High levels of caspase-3 are observed in lung, spleen, heart, liver and kidney, moderate levels in brain and skeletal muscle, and low in testis. Increased levels of caspase-3 are involved in Huntington Disease-associated cell death.
Product Type:
NS Reagents Antibody
Antibody Type:
Monoclonal
Format:
50 µg in 100 µl PBS containing 0.05% BSA and 0.05% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
DNA methyltransferase 3 beta (DNMT3B), is a DNA methyltransferase believed to function in de novo methylation, rather than in maintenance methylation. DNMT3B localises to the nucleus and its expression is developmentally regulated. It has been shown to interact with CBX5, DNMT1, DNMT3A, NCAPG, SMC2, KIF4A, SUMO1 and UBE2I.
DNMT3B is has N-terminal regulatory and C-terminal catalytic domains linked by repeated GK dipeptides (Glycine-Lysine-repeats). The N-terminal domain is responsible for nucleus localisation and plays a regulatory role. It also contains a proliferating cell nuclear antigen-binding domain, a cysteine rich zinc finger DNA binding motif (ATRX), a polybromo homology domain (PHD) and a PWWP tetrapeptide chromatin-binding domain.
Product Type:
NS Reagents Antibody
Antibody Type:
Monoclonal
Format:
100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Clone number:
Clone ABM1C25
Antibody Isotype:
IgG1 kappa
Application Details:
WB: 6-8 ?g/ml
Antibody Number:
10024
Category:
Primary Antibodies
Other names:
DNMT3B, DNA (cytosine-5-)-methyltransferase 3 beta, DNA methyltransferase 3 beta, Dnmt3b
Research Areas:
Transcription and Translation, Nucleic Acid Modification, DNA methyltransferase
NS Reagents Product Area:
DNA & Protein Modification
Molecular Weight:
96kDa (Intended as a general guide and does not allow for all isoforms and species variations)
DNA methyltransferase 3 beta (DNMT3B), is a DNA methyltransferase believed to function in de novo methylation, rather than in maintenance methylation. DNMT3B localises to the nucleus and its expression is developmentally regulated. It has been shown to interact with CBX5, DNMT1, DNMT3A, NCAPG, SMC2, KIF4A, SUMO1 and UBE2I.
DNMT3B is has N-terminal regulatory and C-terminal catalytic domains linked by repeated GK dipeptides (Glycine-Lysine-repeats). The N-terminal domain is responsible for nucleus localisation and plays a regulatory role. It also contains a proliferating cell nuclear antigen-binding domain, a cysteine rich zinc finger DNA binding motif (ATRX), a polybromo homology domain (PHD) and a PWWP tetrapeptide chromatin-binding domain.
Product Type:
NS Reagents Antibody
Antibody Type:
Monoclonal
Format:
50 µg in 100 µl PBS containing 0.05% BSA and 0.05% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Clone number:
Clone ABM1C25
Antibody Isotype:
IgG1 kappa
Application Details:
WB: 6-8 ?g/ml
Antibody Number:
10024
Category:
Primary Antibodies
Other names:
DNMT3B, DNA (cytosine-5-)-methyltransferase 3 beta, DNA methyltransferase 3 beta, Dnmt3b
Research Areas:
Transcription and Translation, Nucleic Acid Modification, DNA methyltransferase
NS Reagents Product Area:
DNA & Protein Modification
Molecular Weight:
96kDa (Intended as a general guide and does not allow for all isoforms and species variations)
DNA methyltransferase 1 (DNMT1) associates with the replication machinery and restores symmetrical methylation at hemimethylated CpG sites generated by the semi-conservative DNA replication process. It maintains methylation patterns with high fidelity and is essential for embryonic development and genome integrity.
DNMT1 is one of the most abundant DNA methyltransferase in mammalian tissues. It comprises a regulatory N-terminal region and a C-terminal catalytic domain connected by a linker of seven glycine-lysine repeats. The C-terminal domains contain all ten catalytic motifs identified in bacterial DNA (cytosine-5) methyltransferases. The N-terminal part contains a PCNA binding domain (PBD), a heterochromatin targeting sequence (TS), a CXXC-type zinc finger domain and two Bromo-Adjacent Homology domains (BAH1 and BAH2).
DNMT1 interacts with RNA polymerase II, some RNA-binding proteins, and some specific Dnmt1-inhibitory RNA molecules involved in chromatin organisation, DNA repair, cell cycle regulation, and apoptosis.
Product Type:
NS Reagents Antibody
Antibody Type:
Monoclonal
Format:
100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human DNMT1 from the N-terminal region of the protein
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
DNA methyltransferase 1 (DNMT1) associates with the replication machinery and restores symmetrical methylation at hemimethylated CpG sites generated by the semi-conservative DNA replication process. It maintains methylation patterns with high fidelity and is essential for embryonic development and genome integrity.
DNMT1 is one of the most abundant DNA methyltransferase in mammalian tissues. It comprises a regulatory N-terminal region and a C-terminal catalytic domain connected by a linker of seven glycine-lysine repeats. The C-terminal domains contain all ten catalytic motifs identified in bacterial DNA (cytosine-5) methyltransferases. The N-terminal part contains a PCNA binding domain (PBD), a heterochromatin targeting sequence (TS), a CXXC-type zinc finger domain and two Bromo-Adjacent Homology domains (BAH1 and BAH2).
DNMT1 interacts with RNA polymerase II, some RNA-binding proteins, and some specific Dnmt1-inhibitory RNA molecules involved in chromatin organisation, DNA repair, cell cycle regulation, and apoptosis.
Product Type:
NS Reagents Antibody
Antibody Type:
Monoclonal
Format:
50 µg in 100 µl PBS containing 0.05% BSA and 0.05% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human DNMT1 from the N-terminal region of the protein
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
DNA methyltransferase 3A (DNMT3A) belongs to the mammalian methyltransferase gene family which is responsible for tissue-specific gene expression. DNMT3A together with other methyltransferases carries out de novo methylation of cytosine residues in CpG islands by the enzymatic addition of methyl residues from S-adenosyl-L-methionine to the 5-carbon atom of the cytosine ring.
DNMT3A also represses key genes enabling the coupling of insulin secretion to glucose levels during beta cell maturation. Loss of Dnmt3a in pancreatic beta cells prevents this developmental metabolic reprogramming, resulting in loss of GSIS (Glucose-Stimulated Insulin Secretion)). Dnmt3a overexpression has been shown in several cancers including AML (Acute Myeloid Leukemia).
Product Type:
NS Reagents Antibody
Antibody Type:
Monoclonal
Format:
100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Clone number:
Clone ABM13G4
Antibody Isotype:
IgG1 kappa
Application Details:
WB: 2-4 ug/ml, FACS: 0.5-1 ug/10^6
Antibody Number:
10026
Category:
Primary Antibodies
Other names:
DNMT3A, DNA (cytosine-5)-methyltransferase 3A, DNA methyltransferase HsaIIIA, DNA MTase HsaIIIA, M.HsaIIIA, Dnmt3a
Research Areas:
Transcription and Translation, Nucleic Acid Modification, DNA methyltransferase
NS Reagents Product Area:
DNA & Protein Modification
Molecular Weight:
102kDa (Intended as a general guide and does not allow for all isoforms and species variations)
DNA methyltransferase 3A (DNMT3A) belongs to the mammalian methyltransferase gene family which is responsible for tissue-specific gene expression. DNMT3A together with other methyltransferases carries out de novo methylation of cytosine residues in CpG islands by the enzymatic addition of methyl residues from S-adenosyl-L-methionine to the 5-carbon atom of the cytosine ring.
DNMT3A also represses key genes enabling the coupling of insulin secretion to glucose levels during beta cell maturation. Loss of Dnmt3a in pancreatic beta cells prevents this developmental metabolic reprogramming, resulting in loss of GSIS (Glucose-Stimulated Insulin Secretion)). Dnmt3a overexpression has been shown in several cancers including AML (Acute Myeloid Leukemia).
Product Type:
NS Reagents Antibody
Antibody Type:
Monoclonal
Format:
50 µg in 100 µl PBS containing 0.05% BSA and 0.05% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Clone number:
Clone ABM13G4
Antibody Isotype:
IgG1 kappa
Application Details:
WB: 2-4 ug/ml, FACS: 0.5-1 ug/10^6
Antibody Number:
10026
Category:
Primary Antibodies
Other names:
DNMT3A, DNA (cytosine-5)-methyltransferase 3A, DNA methyltransferase HsaIIIA, DNA MTase HsaIIIA, M.HsaIIIA, Dnmt3a
Research Areas:
Transcription and Translation, Nucleic Acid Modification, DNA methyltransferase
NS Reagents Product Area:
DNA & Protein Modification
Molecular Weight:
102kDa (Intended as a general guide and does not allow for all isoforms and species variations)
DNA methyltransferase 3A (DNMT3A) belongs to the mammalian methyltransferase gene family which is responsible for tissue-specific gene expression. DNMT3A together with other methyltransferases carries out de novo methylation of cytosine residues in CpG islands by the enzymatic addition of methyl residues from S-adenosyl-L-methionine to the 5-carbon atom of the cytosine ring.
DNMT3A also represses key genes enabling the coupling of insulin secretion to glucose levels during beta cell maturation. Loss of Dnmt3a in pancreatic beta cells prevents this developmental metabolic reprogramming, resulting in loss of GSIS (Glucose-Stimulated Insulin Secretion)). Dnmt3a overexpression has been shown in several cancers including AML (Acute Myeloid Leukemia).
Product Type:
NS Reagents Antibody
Antibody Type:
Monoclonal
Format:
100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
DNA methyltransferase 3A (DNMT3A) belongs to the mammalian methyltransferase gene family which is responsible for tissue-specific gene expression. DNMT3A together with other methyltransferases carries out de novo methylation of cytosine residues in CpG islands by the enzymatic addition of methyl residues from S-adenosyl-L-methionine to the 5-carbon atom of the cytosine ring.
DNMT3A also represses key genes enabling the coupling of insulin secretion to glucose levels during beta cell maturation. Loss of Dnmt3a in pancreatic beta cells prevents this developmental metabolic reprogramming, resulting in loss of GSIS (Glucose-Stimulated Insulin Secretion)). Dnmt3a overexpression has been shown in several cancers including AML (Acute Myeloid Leukemia).
Product Type:
NS Reagents Antibody
Antibody Type:
Monoclonal
Format:
50 µg in 100 µl PBS containing 0.05% BSA and 0.05% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
MBD2 and MDB3 are non-enzymatic subunits of the NuRD (nucleosome remodelling and deacetylation) complex. MBD2 and MBD3 are close relatives and probably descend via gene duplication from an ancestral MBD2/MBD3, that is present in some metazoans as for instance Caenorhabditis elegans and Drosophila. Outside the MBD domain, MBD2 and MBD3 share almost 80% homology; they both have an MBD and a coiled-coil domain (CC). Apart from this common domain, MBD2 contains an additional N-terminal glycine-arginine (GR) rich domain and a transcriptional repressor domain (TRD), whereas MBD3 has a C-terminal poly-glutamate region. Three isoforms have been described for MBD2 protein: the full length MBD2a, MBD2b lacking the N-terminal GR repeat and MBD2c that is a testis specific isoform lacking the C-terminus. Also MBD3 presents three isoforms: Mbd3b the major isoform in embryonic stem cells, Mbd3a and a smaller isoform Mbd3c. The crucial difference between MBD2 and MBD3 is that MBD3 does not bind methylated DNA, because it lacks four conserved amino acids in the MBD domain.
Product Type:
NS Reagents Antibody
Antibody Type:
Monoclonal
Format:
100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
MBD2 and MDB3 are non-enzymatic subunits of the NuRD (nucleosome remodelling and deacetylation) complex. MBD2 and MBD3 are close relatives and probably descend via gene duplication from an ancestral MBD2/MBD3, that is present in some metazoans as for instance Caenorhabditis elegans and Drosophila. Outside the MBD domain, MBD2 and MBD3 share almost 80% homology; they both have an MBD and a coiled-coil domain (CC). Apart from this common domain, MBD2 contains an additional N-terminal glycine-arginine (GR) rich domain and a transcriptional repressor domain (TRD), whereas MBD3 has a C-terminal poly-glutamate region. Three isoforms have been described for MBD2 protein: the full length MBD2a, MBD2b lacking the N-terminal GR repeat and MBD2c that is a testis specific isoform lacking the C-terminus. Also MBD3 presents three isoforms: Mbd3b the major isoform in embryonic stem cells, Mbd3a and a smaller isoform Mbd3c. The crucial difference between MBD2 and MBD3 is that MBD3 does not bind methylated DNA, because it lacks four conserved amino acids in the MBD domain.
Product Type:
NS Reagents Antibody
Antibody Type:
Monoclonal
Format:
50 µg in 100 µl PBS containing 0.05% BSA and 0.05% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Methyl-CpG-Binding Domain Protein 1 (MBD1) is a member of the MBD transcriptional repressor family and is predominantly expressed in neurons. It binds to methylated sequences in DNA, influencing transcription. It has been shown to play a role in chromatin modification through interaction with the histone H3K9 methyltransferase SETDB1. H3K9me3 is a repressive modification.
MBD1 acts as an epigenetic regulator via different mechanisms, such as the formation of the MCAF1/MBD1/SETDB1 complex or the MBD1-HDAC3 complex.
Product Type:
NS Reagents Antibody
Antibody Type:
Monoclonal
Format:
100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human MBD1 from the C-terminal region of the protein
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Methyl-CpG-Binding Domain Protein 1 (MBD1) is a member of the MBD transcriptional repressor family and is predominantly expressed in neurons. It binds to methylated sequences in DNA, influencing transcription. It has been shown to play a role in chromatin modification through interaction with the histone H3K9 methyltransferase SETDB1. H3K9me3 is a repressive modification.
MBD1 acts as an epigenetic regulator via different mechanisms, such as the formation of the MCAF1/MBD1/SETDB1 complex or the MBD1-HDAC3 complex.
Product Type:
NS Reagents Antibody
Antibody Type:
Monoclonal
Format:
50 µg in 100 µl PBS containing 0.05% BSA and 0.05% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human MBD1 from the C-terminal region of the protein
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
DNA methyltransferase 2 (DNMT2) is highly conserved cytosine-C5 methyltransferase that contains all 10 sequence motifs that are conserved among m5C MTases, including the consensus S-adenosyl-L-methionine-binding motifs and the active site ProCys dipeptide. It is a relatively small protein of 391 amino acids and lacks the large N-terminal domains present in the DNMT1 and DNMT3. DNMT2 is ubiquitously expressed with multiple mRNA species in most human and mouse adult tissues. It is variably expressed in human cancer cell lines.
Product Type:
NS Reagents Antibody
Antibody Type:
Monoclonal
Format:
100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
DNA methyltransferase 2 (DNMT2) is highly conserved cytosine-C5 methyltransferase that contains all 10 sequence motifs that are conserved among m5C MTases, including the consensus S-adenosyl-L-methionine-binding motifs and the active site ProCys dipeptide. It is a relatively small protein of 391 amino acids and lacks the large N-terminal domains present in the DNMT1 and DNMT3. DNMT2 is ubiquitously expressed with multiple mRNA species in most human and mouse adult tissues. It is variably expressed in human cancer cell lines.
Product Type:
NS Reagents Antibody
Antibody Type:
Monoclonal
Format:
50 µg in 100 µl PBS containing 0.05% BSA and 0.05% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
GPR83 is an orphan G protein-coupled receptor highly expressed in brain and thymus. It is most homologous to the tachykinin and neuropeptide Y (NPY) receptors. GPR83 is selectively up-regulated by both murine and human CD4(+)CD25(+) regulatory T cells. It was also identified as the receptor for neuroendocrine peptide PEN(1)
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human GPR83 from the central region of the protein
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB: 1-2ug/ml
Antibody Number:
10031
Category:
Primary Antibodies
Other names:
GPR83, GIR/ GPR72
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
48kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Plasma membrane
Purification:
Protein A Purified
References:
(1) Identification of GPR83 as the receptor for the neuroendocrine peptide PEN, Ivone Gomes et al. DOI:10.1126/scisignal.aad0694
GPR83 is an orphan G protein-coupled receptor highly expressed in brain and thymus. It is most homologous to the tachykinin and neuropeptide Y (NPY) receptors. GPR83 is selectively up-regulated by both murine and human CD4(+)CD25(+) regulatory T cells. It was also identified as the receptor for neuroendocrine peptide PEN(1)
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 100 µl PBS containing 0.05% BSA and 0.05% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human GPR83 from the central region of the protein
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB: 1-2ug/ml
Antibody Number:
10031
Category:
Primary Antibodies
Other names:
GPR83, GIR/ GPR72
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
48kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Plasma membrane
Purification:
Protein A Purified
References:
(1) Identification of GPR83 as the receptor for the neuroendocrine peptide PEN, Ivone Gomes et al. DOI:10.1126/scisignal.aad0694
DNA fragmentation factor subunit alpha (DFFA, ICAD, DFF45) is an inhibitor of the caspase-activated DNase (DFFB, CAD, DFF40). DNA fragmentation factor (DFF) consists of two subunits, a 40 kDa caspase-activated nuclease (DFFB, CAD, DFF40) and a 45 kDa inhibitor (DFFA, ICAD, DFF45). In proliferating cells DFFB forms a complex with DFFA. When cells undergo apoptosis, caspase 3 cleaves DFFA at two sites to dissociate the DFFA:DFFB complex (ICAD:CAD), allowing DFFB (CAD) to cleave chromosomal DNA. DFFA is expressed in brain, blood, skin, spleen, adipose tissue. It has 2 isoforms produced by alternative splicing. In addition to blocking the DNase activity of DFFB, the C-terminal region of DFFA is also important for the DFFB-specific folding chaperone activity, as demonstrated by the ability of DFFA to refold DFFB.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human DFFA from the C-terminal region of the protein
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB: 1-2 µg/ml
Antibody Number:
10032
Category:
Primary Antibodies
Other names:
DNA fragmentation factor subunit alpha, DFFA, inhibitor of caspase-activated Dnase, ICAD, DFF1, DFF-45
Research Areas:
Transcription and Translation, Nucleic Acid Modification, DNA Damage
NS Reagents Product Area:
DNA & Protein Modification
Molecular Weight:
37kDa (Intended as a general guide and does not allow for all isoforms and species variations)
DNA fragmentation factor subunit alpha (DFFA, ICAD, DFF45) is an inhibitor of the caspase-activated DNase (DFFB, CAD, DFF40). DNA fragmentation factor (DFF) consists of two subunits, a 40 kDa caspase-activated nuclease (DFFB, CAD, DFF40) and a 45 kDa inhibitor (DFFA, ICAD, DFF45). In proliferating cells DFFB forms a complex with DFFA. When cells undergo apoptosis, caspase 3 cleaves DFFA at two sites to dissociate the DFFA:DFFB complex (ICAD:CAD), allowing DFFB (CAD) to cleave chromosomal DNA. DFFA is expressed in brain, blood, skin, spleen, adipose tissue. It has 2 isoforms produced by alternative splicing. In addition to blocking the DNase activity of DFFB, the C-terminal region of DFFA is also important for the DFFB-specific folding chaperone activity, as demonstrated by the ability of DFFA to refold DFFB.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 100 µl PBS containing 0.05% BSA and 0.05% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human DFFA from the C-terminal region of the protein
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB: 1-2 µg/ml
Antibody Number:
10032
Category:
Primary Antibodies
Other names:
DNA fragmentation factor subunit alpha, DFFA, inhibitor of caspase-activated Dnase, ICAD, DFF1, DFF-45
Research Areas:
Transcription and Translation, Nucleic Acid Modification, DNA Damage
NS Reagents Product Area:
DNA & Protein Modification
Molecular Weight:
37kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Lysine-specific histone demethylase 1A (LSD1/KDM1A) regulates histone methylation and influences the epigenetic state of cells during the generation of induced pluripotent stem cells. It is a nuclear protein containing a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. It is a demethylase that acts on both Lys 4 and 9 of histone H3 (H3K4 and H3K9) and it is component of several histone deacetylase complexes. LSD1 has near ubiquitous expression and it may have roles critical in embryogenesis and tissue-specific differentiation, as well as oocyte growth and the repression of neuronal genes.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human LSD1 from the N-terminal region of the protein
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Lysine-specific histone demethylase 1A (LSD1/KDM1A) regulates histone methylation and influences the epigenetic state of cells during the generation of induced pluripotent stem cells. It is a nuclear protein containing a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. It is a demethylase that acts on both Lys 4 and 9 of histone H3 (H3K4 and H3K9) and it is component of several histone deacetylase complexes. LSD1 has near ubiquitous expression and it may have roles critical in embryogenesis and tissue-specific differentiation, as well as oocyte growth and the repression of neuronal genes.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 100 µl PBS containing 0.05% BSA and 0.05% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human LSD1 from the N-terminal region of the protein
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
DNA methyltransferase 1-associated protein 1 (DMAP1) is an enzyme consisting of 433 aminoacids. It is involved in transcription repression and activation. DMAP1 interacts with HDAC2 providing a mechanism for histone deacetylation in heterochromatin following replication of DNA at late dismissal origins. DMAP1 can also repress transcription independently of histone deacetylase activity. It participates in the nuclear localization of URI1 and increases its transcriptional co-repressor activity. It is expressed in many tissues including adipose tissue, adrenal gland, amniotic fluid, cerebellar cortex, hippocampus, liver.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human DMAP1 encompassing the Central and C-terminal regions of the protein
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB: 2-4 µg/ml
Antibody Number:
10034
Category:
Primary Antibodies
Other names:
DNA methyltransferase 1-associated protein 1, DNMAP1, DNMTAP1
Research Areas:
Transcription and Translation, Protein Modification, Transcription, Chromatin
NS Reagents Product Area:
DNA & Protein Modification
Molecular Weight:
53kDa (Intended as a general guide and does not allow for all isoforms and species variations)
DNA methyltransferase 1-associated protein 1 (DMAP1) is an enzyme consisting of 433 aminoacids. It is involved in transcription repression and activation. DMAP1 interacts with HDAC2 providing a mechanism for histone deacetylation in heterochromatin following replication of DNA at late dismissal origins. DMAP1 can also repress transcription independently of histone deacetylase activity. It participates in the nuclear localization of URI1 and increases its transcriptional co-repressor activity. It is expressed in many tissues including adipose tissue, adrenal gland, amniotic fluid, cerebellar cortex, hippocampus, liver.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 100 µl PBS containing 0.05% BSA and 0.05% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human DMAP1 encompassing the Central and C-terminal regions of the protein
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB: 2-4 µg/ml
Antibody Number:
10034
Category:
Primary Antibodies
Other names:
DNA methyltransferase 1-associated protein 1, DNMAP1, DNMTAP1
Research Areas:
Transcription and Translation, Protein Modification, Transcription, Chromatin
NS Reagents Product Area:
DNA & Protein Modification
Molecular Weight:
53kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Histone H3.3 is a replication independent variant of Histone H3 which is generally expressed in quiescent or terminally differentiated cells. It constitutes the predominant form of histone H3 in such cells and replaces conventional H3 in a wide range of nucleosomes in active genes. It is incorporated into chromatin independently of DNA synthesis. Modifications in Histone H3.3 are associated with transcriptional activation and act as an epigenetic mark of transcriptionally active chromatin. Histone H3.3 has been found to play an important role in maintaining genome integrity during mammalian development. Histone H3.3 is a 15 kDa protein which is expressed throughout the cell cycle independently of DNA synthesis in all eukaryotic genomes. H3.3 differs from the canonical replication-coupled H3 histones (H3.1/H3.2 in mammals) by only four to five amino acids, respectively, but has distinct expression patterns and chromatin incorporation mechanisms. Canonical H3 variants are expressed only during S phase.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB: 2-4 µg/ml
Antibody Number:
10035
Category:
Primary Antibodies
Other names:
H3 histone family 3A, H3 histone family member 3A
Research Areas:
Histone, Transcription and Translation, Protein Modification, Transcription, Chromatin
NS Reagents Product Area:
DNA & Protein Modification
Molecular Weight:
15kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Histone H3.3 is a replication independent variant of Histone H3 which is generally expressed in quiescent or terminally differentiated cells. It constitutes the predominant form of histone H3 in such cells and replaces conventional H3 in a wide range of nucleosomes in active genes. It is incorporated into chromatin independently of DNA synthesis. Modifications in Histone H3.3 are associated with transcriptional activation and act as an epigenetic mark of transcriptionally active chromatin. Histone H3.3 has been found to play an important role in maintaining genome integrity during mammalian development. Histone H3.3 is a 15 kDa protein which is expressed throughout the cell cycle independently of DNA synthesis in all eukaryotic genomes. H3.3 differs from the canonical replication-coupled H3 histones (H3.1/H3.2 in mammals) by only four to five amino acids, respectively, but has distinct expression patterns and chromatin incorporation mechanisms. Canonical H3 variants are expressed only during S phase.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 100 µl PBS containing 0.05% BSA and 0.05% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB: 2-4 µg/ml
Antibody Number:
10035
Category:
Primary Antibodies
Other names:
H3 histone family 3A, H3 histone family member 3A
Research Areas:
Histone, Transcription and Translation, Protein Modification, Transcription, Chromatin
NS Reagents Product Area:
DNA & Protein Modification
Molecular Weight:
15kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Furin is a member of the family of proprotein convertases involved in the activation of a large number of zymogens and proproteins. Furin catalyses proteolytic maturation of a diverse repertoire of growth factors, receptors, and enzyme precursors within multiple secretory pathway compartments. Proteolysis by furin is highly specific and occurs at C-terminal to a multibasic recognition motive.
Furin is a type I transmembrane protein composed of a signal peptide, a propeptide terminating in an endoproteolytic cleavage site comprised of a cluster of basic residues, a subtilisin-like catalytic domain, a middle domain (also called P-domain), and a cysteine-rich domain, followed by a C-terminal transmembrane anchor and a cytosolic tail. Furin is synthesized as a precursor protein of about 100 kDa that is converted into a 94 kDa protein by autoproteolytic cleavage of the propeptide. Furin is glycosylated and phosphorylated, which results in an increase of its apparent molecular mass in SDS-PAGE to Mr 100 000.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human Furin from the C-terminal region of the protein
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Furin is a member of the family of proprotein convertases involved in the activation of a large number of zymogens and proproteins. Furin catalyses proteolytic maturation of a diverse repertoire of growth factors, receptors, and enzyme precursors within multiple secretory pathway compartments. Proteolysis by furin is highly specific and occurs at C-terminal to a multibasic recognition motive.
Furin is a type I transmembrane protein composed of a signal peptide, a propeptide terminating in an endoproteolytic cleavage site comprised of a cluster of basic residues, a subtilisin-like catalytic domain, a middle domain (also called P-domain), and a cysteine-rich domain, followed by a C-terminal transmembrane anchor and a cytosolic tail. Furin is synthesized as a precursor protein of about 100 kDa that is converted into a 94 kDa protein by autoproteolytic cleavage of the propeptide. Furin is glycosylated and phosphorylated, which results in an increase of its apparent molecular mass in SDS-PAGE to Mr 100 000.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 100 µl PBS containing 0.05% BSA and 0.05% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human Furin from the C-terminal region of the protein
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Histone H2AX is expressed in all eukaryotic cells and in humans constitutes about 10% of the H2A histones in chromatin. It is a 15 kDa variant of Histone H2 required for the repair of double-stranded DNA breaks. In response to DNA double-strand break formation it is phosphorylated in the position of Ser139 producing gamma-H2AX. Histone H2AX is a substrate of several phosphoinositide 3-kinase-related protein kinases (PIKKs), such as ATM (ataxia teleangiectasia mutated), ATR (ATM and Rad3-related), or DNA-dependent protein kinase (DNA-PK).
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide.
Mouse, Rat, Zebrafish, Canine, Horse, Sheep, Goat.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB: 2-4 µg/ml
Antibody Number:
10037
Category:
Primary Antibodies
Other names:
gamma-H2AX, H2A, H2A.X
Research Areas:
Histone, Transcription and Translation, Protein Modification, Transcription, Chromatin
NS Reagents Product Area:
DNA & Protein Modification
Molecular Weight:
15kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Histone H2AX is expressed in all eukaryotic cells and in humans constitutes about 10% of the H2A histones in chromatin. It is a 15 kDa variant of Histone H2 required for the repair of double-stranded DNA breaks. In response to DNA double-strand break formation it is phosphorylated in the position of Ser139 producing gamma-H2AX. Histone H2AX is a substrate of several phosphoinositide 3-kinase-related protein kinases (PIKKs), such as ATM (ataxia teleangiectasia mutated), ATR (ATM and Rad3-related), or DNA-dependent protein kinase (DNA-PK).
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 100 µl PBS containing 0.05% BSA and 0.05% sodium azide.
Mouse, Rat, Zebrafish, Canine, Horse, Sheep, Goat.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB: 2-4 µg/ml
Antibody Number:
10037
Category:
Primary Antibodies
Other names:
gamma-H2AX, H2A, H2A.X
Research Areas:
Histone, Transcription and Translation, Protein Modification, Transcription, Chromatin
NS Reagents Product Area:
DNA & Protein Modification
Molecular Weight:
15kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Histone H2AX is expressed in all eukaryotic cells and in humans constitutes about 10% of the H2A histones in chromatin. It is a 15 kDa variant of Histone H2 required for the repair of double-stranded DNA breaks. In response to DNA double-strand break formation it is phosphorylated in the position of Ser139 producing gamma-H2AX. Histone H2AX is a substrate of several phosphoinositide 3-kinase-related protein kinases (PIKKs), such as ATM (ataxia teleangiectasia mutated), ATR (ATM and Rad3-related), or DNA-dependent protein kinase (DNA-PK).
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide.
Mouse, Rat, Zebrafish, Canine, Horse, Sheep, Goat.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB: 2-4 µg/ml
Antibody Number:
10038
Category:
Primary Antibodies
Other names:
gamma-H2AX, H2A, H2A.X
Research Areas:
Histone, Transcription and Translation, Protein Modification, Transcription, Chromatin
NS Reagents Product Area:
DNA & Protein Modification
Molecular Weight:
15kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Histone H2AX is expressed in all eukaryotic cells and in humans constitutes about 10% of the H2A histones in chromatin. It is a 15 kDa variant of Histone H2 required for the repair of double-stranded DNA breaks. In response to DNA double-strand break formation it is phosphorylated in the position of Ser139 producing gamma-H2AX. Histone H2AX is a substrate of several phosphoinositide 3-kinase-related protein kinases (PIKKs), such as ATM (ataxia teleangiectasia mutated), ATR (ATM and Rad3-related), or DNA-dependent protein kinase (DNA-PK).
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 100 µl PBS containing 0.05% BSA and 0.05% sodium azide.
Mouse, Rat, Zebrafish, Canine, Horse, Sheep, Goat.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB: 2-4 µg/ml
Antibody Number:
10038
Category:
Primary Antibodies
Other names:
gamma-H2AX, H2A, H2A.X
Research Areas:
Histone, Transcription and Translation, Protein Modification, Transcription, Chromatin
NS Reagents Product Area:
DNA & Protein Modification
Molecular Weight:
15kDa (Intended as a general guide and does not allow for all isoforms and species variations)
DNA methyltransferase 3-like (DNMT3L) as a catalytically inactive regulatory factor of DNA methyltransferases that can either promote or inhibit DNA methylation. It is not thought to function as a DNA methyltransferase itself as it does not contain the amino acid residues necessary for methyltransferase activity. However, it is essential for the function of DNMT3A and DNMT3B and it is thought to be required for the establishment of maternal genomic imprints. This protein also mediates transcriptional repression through interaction with histone deacetylase 1 and plays a key role in embryonic stem cells and germ cells.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human Dnmt3L covering the central and C-terminal regions of the protein
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB: 1-2 ug/ml
Antibody Number:
10039
Category:
Primary Antibodies
Other names:
DNA (cytosine-5-)-methyltransferase 3-like (DNMT3L), DNA methyltransferase 3-like.
Research Areas:
Transcription and Translation, Nucleic Acid Modification, Protein Modification, Transcription, Chromatin
NS Reagents Product Area:
DNA & Protein Modification
Molecular Weight:
44kDa (Intended as a general guide and does not allow for all isoforms and species variations)
DNA methyltransferase 3-like (DNMT3L) as a catalytically inactive regulatory factor of DNA methyltransferases that can either promote or inhibit DNA methylation. It is not thought to function as a DNA methyltransferase itself as it does not contain the amino acid residues necessary for methyltransferase activity. However, it is essential for the function of DNMT3A and DNMT3B and it is thought to be required for the establishment of maternal genomic imprints. This protein also mediates transcriptional repression through interaction with histone deacetylase 1 and plays a key role in embryonic stem cells and germ cells.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 100 µl PBS containing 0.05% BSA and 0.05% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human Dnmt3L covering the central and C-terminal regions of the protein
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB: 1-2 ug/ml
Antibody Number:
10039
Category:
Primary Antibodies
Other names:
DNA (cytosine-5-)-methyltransferase 3-like (DNMT3L), DNA methyltransferase 3-like.
Research Areas:
Transcription and Translation, Nucleic Acid Modification, Protein Modification, Transcription, Chromatin
NS Reagents Product Area:
DNA & Protein Modification
Molecular Weight:
44kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Non-histone chromosomal protein HMG-14 (HMG-14 - Protein: HMGN1 - Gene) binds nucleosomal DNA and is associated with transcriptionally active chromatin, potentially altering the interaction between DNA and histone and may help maintain an open chromatin configuration around transcribable genes. Its ubiquitous distribution, relative abundance and the high evolutionary conservation of its DNA-binding domain further support its likely importance in cellular function. Deletion of the 26 C-terminal amino acids of HMG-14 reduces its ability to enhance transcription from chromatin templates. In contrast, N-terminal truncation mutants have the same transcriptional enhancement activity as the full-length protein.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Full length recombinant human Non-histone chromosomal protein HMG-14
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
IHC: 20 µg/ml
Antibody Number:
10040
Category:
Primary Antibodies
Other names:
HMGN1, Non-histone chromosomal protein, high mobility group nucleosomal binding domain 1, Non-histone chromosomal protein HMG-14
Research Areas:
Transcription and Translation, Protein Modification, Transcription, Chromatin
NS Reagents Product Area:
DNA & Protein Modification
Molecular Weight:
11kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Non-histone chromosomal protein HMG-14 (HMG-14 - Protein: HMGN1 - Gene) binds nucleosomal DNA and is associated with transcriptionally active chromatin, potentially altering the interaction between DNA and histone and may help maintain an open chromatin configuration around transcribable genes. Its ubiquitous distribution, relative abundance and the high evolutionary conservation of its DNA-binding domain further support its likely importance in cellular function. Deletion of the 26 C-terminal amino acids of HMG-14 reduces its ability to enhance transcription from chromatin templates. In contrast, N-terminal truncation mutants have the same transcriptional enhancement activity as the full-length protein.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 100 µl PBS containing 0.05% BSA and 0.05% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Full length recombinant human Non-histone chromosomal protein HMG-14
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
IHC: 20 µg/ml
Antibody Number:
10040
Category:
Primary Antibodies
Other names:
HMGN1, Non-histone chromosomal protein, high mobility group nucleosomal binding domain 1, Non-histone chromosomal protein HMG-14
Research Areas:
Transcription and Translation, Protein Modification, Transcription, Chromatin
NS Reagents Product Area:
DNA & Protein Modification
Molecular Weight:
11kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Histone H2A is a core histone (along with H2B, H3 and H4). Core formation takes place through the interaction of two H2A molecules after which H2A forms a dimer with H2B; the core molecule is complete when H3-H4 also attaches to form a tetramer. H2A refers to a number of closely related proteins that vary by only a few amino acids including H2A.1, H2A.2, H2AX, and H2AZ. H2A undergoes various post-translational modifications, including acetylation, phosphorylation, methylation, and ubiquitination, which occur in response to various stimuli and directly affect the accessibility of chromatin to transcription factors. Changes in variant composition occur in differentiating cells. H2A consists of a main globular domain and a long N-terminal tail or C-terminal on one end of the molecule. The N-terminal tail or C-terminal tail is the location of post-translational modification.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB: 2-4ug/ml,Immunohistochemical analysis: 5ug/ml
Antibody Number:
10041
Category:
Primary Antibodies
Other names:
H2A
Research Areas:
Histone, Transcription and Translation, Protein Modification, Transcription, Chromatin
NS Reagents Product Area:
DNA & Protein Modification
Molecular Weight:
14kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Histone H2A is a core histone (along with H2B, H3 and H4). Core formation takes place through the interaction of two H2A molecules after which H2A forms a dimer with H2B; the core molecule is complete when H3-H4 also attaches to form a tetramer. H2A refers to a number of closely related proteins that vary by only a few amino acids including H2A.1, H2A.2, H2AX, and H2AZ. H2A undergoes various post-translational modifications, including acetylation, phosphorylation, methylation, and ubiquitination, which occur in response to various stimuli and directly affect the accessibility of chromatin to transcription factors. Changes in variant composition occur in differentiating cells. H2A consists of a main globular domain and a long N-terminal tail or C-terminal on one end of the molecule. The N-terminal tail or C-terminal tail is the location of post-translational modification.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 100 µl PBS containing 0.05% BSA and 0.05% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB: 2-4ug/ml,Immunohistochemical analysis: 5ug/ml
Antibody Number:
10041
Category:
Primary Antibodies
Other names:
H2A
Research Areas:
Histone, Transcription and Translation, Protein Modification, Transcription, Chromatin
NS Reagents Product Area:
DNA & Protein Modification
Molecular Weight:
14kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Protein arginine methyltransferase 7 (PRMT7) is a 692-amino acid member of the arginine N-methyltransferase family of proteins that transfers single methyl groups to arginine residues to generate monomethylarginines on histone proteins and other protein substrates through the transfer of methyl groups from S-adenosylmethionine (SAM). This enzyme plays a role in a wide range of biological processes, including neuronal differentiation, male germ line imprinting, small nuclear ribonucleoprotein biogenesis, and regulation of the Wnt signalling pathway. PRMT7 has predominantly cytoplasmic distribution. PRMT7 differs from the other PRMTs as it contains both N- and C-terminal putative AdoMet-binding domains. The presence of both binding domains is required for PRMT7 enzymatic activity however only the N-terminal domain actually binds AdoMet. PRMT7 is the only PRMT capable of catalysing the formation of stable MMA. PRMT7 is capable of auto-methylation, and methylates substrates (such as histone H2B) in a RXR motif. PRMT7 is unable to methylate arginine residues H2AR3 and H4R3. Previous characterisation of these arginine residues as substrates for PRMT7 was most likely due to contamination of the PRMT7 preparation with PRMT5.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human PRMT7 from the central region of the protein
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB: 4-6 µg/ml
Antibody Number:
10042
Category:
Primary Antibodies
Other names:
Protein arginine methyltransferase 7, Protein Arginine Methyltransferase 7, Myelin Basic Protein-Arginine N-Methyltransferase, Histone-Arginine N-Methyltransferase
Research Areas:
Transcription and Translation, Protein Modification, Transcription, Chromatin
NS Reagents Product Area:
DNA & Protein Modification
Molecular Weight:
79kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Protein arginine methyltransferase 7 (PRMT7) is a 692-amino acid member of the arginine N-methyltransferase family of proteins that transfers single methyl groups to arginine residues to generate monomethylarginines on histone proteins and other protein substrates through the transfer of methyl groups from S-adenosylmethionine (SAM). This enzyme plays a role in a wide range of biological processes, including neuronal differentiation, male germ line imprinting, small nuclear ribonucleoprotein biogenesis, and regulation of the Wnt signalling pathway. PRMT7 has predominantly cytoplasmic distribution. PRMT7 differs from the other PRMTs as it contains both N- and C-terminal putative AdoMet-binding domains. The presence of both binding domains is required for PRMT7 enzymatic activity however only the N-terminal domain actually binds AdoMet. PRMT7 is the only PRMT capable of catalysing the formation of stable MMA. PRMT7 is capable of auto-methylation, and methylates substrates (such as histone H2B) in a RXR motif. PRMT7 is unable to methylate arginine residues H2AR3 and H4R3. Previous characterisation of these arginine residues as substrates for PRMT7 was most likely due to contamination of the PRMT7 preparation with PRMT5.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 100 µl PBS containing 0.05% BSA and 0.05% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human PRMT7 from the central region of the protein
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB: 2-4 µg/ml
Antibody Number:
10042
Category:
Primary Antibodies
Other names:
Protein arginine methyltransferase 7, Protein Arginine Methyltransferase 7, Myelin Basic Protein-Arginine N-Methyltransferase, Histone-Arginine N-Methyltransferase
Research Areas:
Transcription and Translation, Protein Modification, Transcription, Chromatin
NS Reagents Product Area:
DNA & Protein Modification
Molecular Weight:
79kDa (Intended as a general guide and does not allow for all isoforms and species variations)
DNA damage-binding protein 1 (DDB1) is the large subunit (p127) of the heterodimeric DNA damage-binding (DDB) complex. DDB1 also functions as a core component of the cullin 4 (CUL4) ubiquitin E3 ligase complex, facilitating the binding of substrates to this complex and the ubiquitination of proteins. These factors (ubiquitin ligase substrates) regulate numerous essential processes in the cell including DNA repair (DDB2), DNA replication, chromatin remodelling (Cdt2) and more.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide.
Mouse, Rat, Bovine, Chicken, Cat, Guinea pig, Goat
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human DDB1 from the central region of the protein
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB: 2-4 µg/ml
Antibody Number:
10043
Category:
Primary Antibodies
Other names:
DNA damage-binding protein 1, DDBP1, DDB1
Research Areas:
Transcription and Translation, DNA Damage, Chromatin
NS Reagents Product Area:
DNA & Protein Modification
Molecular Weight:
127kDa (Intended as a general guide and does not allow for all isoforms and species variations)
DNA damage-binding protein 1 (DDB1) is the large subunit (p127) of the heterodimeric DNA damage-binding (DDB) complex. DDB1 also functions as a core component of the cullin 4 (CUL4) ubiquitin E3 ligase complex, facilitating the binding of substrates to this complex and the ubiquitination of proteins. These factors (ubiquitin ligase substrates) regulate numerous essential processes in the cell including DNA repair (DDB2), DNA replication, chromatin remodelling (Cdt2) and more.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 100 µl PBS containing 0.05% BSA and 0.05% sodium azide.
Mouse, Rat, Bovine, Chicken, Cat, Guinea pig, Goat
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human DDB1 from the central region of the protein
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB: 2-4 µg/ml
Antibody Number:
10043
Category:
Primary Antibodies
Other names:
DNA damage-binding protein 1, DDBP1, DDB1
Research Areas:
Transcription and Translation, DNA Damage, Chromatin
NS Reagents Product Area:
DNA & Protein Modification
Molecular Weight:
127kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Neurotensin receptor type 2 (NTSR2) is a G protein-coupled receptor for tridecapeptide neurotensin that activates a phosphatidylinositol-calcium second messenger system. Binding and pharmacological studies demonstrate this receptor binds neurotensin as well as other ligands already described for neurotensin NTSR1 receptor, but also binds levocabastine (a histamine H1 receptor antagonist) that competes with neurotensin for low-affinity binding sites in brain).
Interaction of NTSR2 with the oncogenic tyrosine kinase receptor TrkB may play an important role in B-cell chronic lymphocytic leukaemia (B-CLL), protecting these cells from apoptosis by activating survival signalling pathways, including the Src and AKT kinase pathways, as well as expression of the anti-apoptotic proteins Bcl-2 and Bcl-xL.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human Neurotensin receptor 2 (aa 100-390)
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB: 0.5-1.0 µg/ml
Antibody Number:
10044
Category:
Primary Antibodies
Other names:
NTSR2, NT2, Neurotensin receptor type 2
Research Areas:
Cell Signalling, Neuroscience
NS Reagents Product Area:
Cell Signalling
Molecular Weight:
45kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Neurotensin receptor type 2 (NTSR2) is a G protein-coupled receptor for tridecapeptide neurotensin that activates a phosphatidylinositol-calcium second messenger system. Binding and pharmacological studies demonstrate this receptor binds neurotensin as well as other ligands already described for neurotensin NTSR1 receptor, but also binds levocabastine (a histamine H1 receptor antagonist) that competes with neurotensin for low-affinity binding sites in brain).
Interaction of NTSR2 with the oncogenic tyrosine kinase receptor TrkB may play an important role in B-cell chronic lymphocytic leukaemia (B-CLL), protecting these cells from apoptosis by activating survival signalling pathways, including the Src and AKT kinase pathways, as well as expression of the anti-apoptotic proteins Bcl-2 and Bcl-xL.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 100 µl PBS containing 0.05% BSA and 0.05% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human Neurotensin receptor 2 (aa 100-390)
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB: 0.5-1.0 µg/ml
Antibody Number:
10044
Category:
Primary Antibodies
Other names:
NTSR2, NT2, Neurotensin receptor type 2
Research Areas:
Cell Signalling, Neuroscience
NS Reagents Product Area:
Cell Signalling
Molecular Weight:
45kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCHL1) is a neuronal biomarker that is expressed in neurons and neuroendocrine cells in vertebrates where it comprises about 5-10% of soluble cytoplasmic proteins. It is involved in the processing of both ubiquitin precursors and ubiquitinated proteins, as a thiol protease that recognises and hydrolyses a peptide bond at the C-terminal glycine of ubiquitin. A minor proportion of UCHL1 in brain is tightly bound to the membrane. UCHL1 Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCHL1) is a neuronal biomarker that is expressed in neurons and neuroendocrine cells in vertebrates where it comprises about 5-10% of soluble cytoplasmic proteins. It is involved in the processing of both ubiquitin precursors and ubiquitinated proteins, as a thiol protease that recognises and hydrolyses a peptide bond at the C-terminal glycine of ubiquitin. A minor proportion of UCHL1 in brain is tightly bound to the membrane. UCHL1 Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 100 µl PBS containing 0.05% BSA and 0.05% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Microtubules are major components of the cytoskeleton found in all eukaryotic cells. They are involved in mitosis, cell motility, intracellular transport, and maintenance of cell shape. Tubulin, the protein subunit of microtubules (MTs), is an alpha/beta heterodimer. Because beta-tubulin is ubiquitously expressed in all eukaryotic cells, it can be used as a loading control for Western blotting.
Alpha- and beta-tubulin subunits are encoded by 19 genes in humans (10 alpha and 9 beta) with each tubulin showing over 90% amino acid homology with other tubulins of the same type. Tubulin isotype expression and distribution varies across different cells and tissues, indicating that all tubulins, whilst important for the basic structural functions they perform, are most likely important for other functions in specific cell types.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human beta Tubulin from the C-terminal region of the protein
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB: 4-6 µg/ml
Antibody Number:
10046
Category:
Primary Antibodies
Other names:
TUBB, ?-tubulin
Research Areas:
Transcription and Translation, DNA Damage and Methylation, Protein and Nucleic Acid Modification
NS Reagents Product Area:
DNA & Protein Modification
Molecular Weight:
50kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Microtubules are major components of the cytoskeleton found in all eukaryotic cells. They are involved in mitosis, cell motility, intracellular transport, and maintenance of cell shape. Tubulin, the protein subunit of microtubules (MTs), is an alpha/beta heterodimer. Because beta-tubulin is ubiquitously expressed in all eukaryotic cells, it can be used as a loading control for Western blotting.
Alpha- and beta-tubulin subunits are encoded by 19 genes in humans (10 alpha and 9 beta) with each tubulin showing over 90% amino acid homology with other tubulins of the same type. Tubulin isotype expression and distribution varies across different cells and tissues, indicating that all tubulins, whilst important for the basic structural functions they perform, are most likely important for other functions in specific cell types.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 100 µl PBS containing 0.05% BSA and 0.05% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human beta Tubulin from the C-terminal region of the protein
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB: 4-6 µg/ml
Antibody Number:
10046
Category:
Primary Antibodies
Other names:
TUBB, ?-tubulin
Research Areas:
Transcription and Translation, DNA Damage and Methylation, Protein and Nucleic Acid Modification
NS Reagents Product Area:
DNA & Protein Modification
Molecular Weight:
50kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Bifunctional apoptosis regulator (BFAR/BAR) is a multidomain protein originally identified as an inhibitor of Bax-induced apoptosis. It is predominantly found in the endoplasmic reticulum (ER) and is thought to be a scaffold protein that may bridge components of both extrinsic and intrinsic apoptosis pathways.
BFAR contains a DED (death effector domain) like domain that suppresses death receptor apoptosis signalling pathways. It is highly expressed in the brain and is believed to be involved in regulating neuronal survival, helping neurons to survive for the entire lifetime of the organism by playing a central role in inhibiting ER initiated apoptosis.
This antibody is not expected to bind to Bifunctional apoptosis regulator from other species. The immunogens was epcifically selected for this purpose.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the N-terminal region of Human BFAR (BAR)
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Death-domain-associated protein (DAXX) is a transcription regulator, that interacts with proteins involved in transcriptional silencing, such as histone deacetylases (HDAC1 and HDAC2) and DNA methyltransferase DNMT1. It represses the activity of several transcriptional factors, including C/EBP beta, c-Met, Pax3, Ets1, p53, p73, p63, glucocorticoid receptor, androgen receptor, and SMAD4.
DAXX is a nuclear protein associated with the promyelocytic leukaemia nuclear body (PML-NB) and other subnuclear domains. It can be either a pro-apoptotic or an anti-apoptotic factor, depending on the cell type and context. Daxx is thought to play a role in the pathology of human diseases including cancer and neurodegenerative disorders.
Mouse (single amino acid difference with the immunogen/human peptide sequence).
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the central region of Human Daxx
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
TAR DNA-binding protein 43 (TDP-43) is an RNA binding protein (RBP) that has been shown to bind both DNA and RNA and have multiple functions in transcriptional repression, pre-mRNA splicing and translational regulation. It belongs to the hnRNP protein family and is highly expressed in the pancreas, placenta, lung, genital tract and spleen[1]. Characterisation of transcriptome-wide binding sites revealed that thousands of RNAs are bound by TDP-43 in neurons.
Mutations in TDP-43 have been associated with amyotrophic lateral sclerosis, frontotemporal dementia, Parkinson's disease and Alzheimer's disease.
TDP-43 is predominantly located in the nucleus under normal physiological conditions. However, hyperphosphorylated, fragmented and ubiquitinated forms of TDP-43 have been identified as core components of cytosolic inclusions in sporadic ALS and frontotemporal lobar degeneration (FTLD) [2,3,4,5,6,7,8].
TDP-43 contains a nuclear localising signal (NLS) as well as a nuclear export signal (NES)[8], which enables the shuttling of TDP-43 between the nucleus and the cytosol. Under normal conditions, TDP-43 interacts with mRNAs on which ribosomes are located separately, forming polysomes. Various stresses can induce clustering of ribosomes into a stalled state, resulting in the formation of stress granules (SG) containing TIA-1, G3BP, ataxin-2 and eIF4G1/2.
In the stalled state, transcription is inhibited in a homeostatic response. However, sustained stress and TDP-43 misfolding creates aberrant SGs and pathogenic TDP-43 aggregates [9]. Misfolding and cytosolic mislocalisation also lead directly to a loss of normal TDP-43 function, and the resultant disruption of protein and RNA homeostasis is considered another likely pathogenic mechanism in addition to the toxicity of inclusions in ALS[9].
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS containing 0.02% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human TDP-43 from the N-terminal region of the protein
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000. IHC 1:50-100. IF 1:20-100. IP 1:50-100. RIP 1:20-50.
Antibody Number:
10049
Category:
Primary Antibodies
Other names:
TAR DNA-binding protein 43, TARDBP, transactive response DNA binding protein 43 kDa, ALS10
43kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Nucleus
Purification:
Affinity purification
References:
1. Strong MJ, Volkening K, Hammond R, et al. (2007). TDP43 is a human low molecular weight neurofilament (hNFL) mRNA-binding protein. Molecular and Cellular Neuroscience. 35 (2): 3207.
2. Kwong LK, Neumann M, Sampathu DM, et al. (2007). TDP-43 proteinopathy: The neuropathology underlying major forms of sporadic and familial frontotemporal lobar degeneration and motor neuron disease. Acta Neuropathologica. 114 (1): 6370.
3. Arai, T. et al. TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Biochem. Biophys. Res. Commun. 351, 602611 (2006). CAS
4. Neumann M, Sampathu DM, Kwong LK, Truax AC, et al. (2006). Ubiquitinated TDP-43 in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis. Science. 314 (5796): 1303.
5. Tan, C. F. et al. TDP-43 immunoreactivity in neuronal inclusions in familial amyotrophic lateral sclerosis with or without SOD1 gene mutation. Acta Neuropathol. 113, 535542 (2007).
6. Igaz, L. M. et al. Enrichment of C-terminal fragments in TAR DNA-binding protein-43 cytoplasmic inclusions in brain but not in spinal cord of frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Am. J. Pathol. 173, 182194 (2008).
7. Tremblay C, St-Amour I, Schneider J, et al. (2011). Accumulation of transactive response DNA binding protein 43 in mild cognitive impairment and Alzheimer disease. J Neuropathol Exp Neurol. 70 (9): 78898.
8. Winton, M. J. et al. Disturbance of nuclear and cytoplasmic TAR DNA-binding protein (TDP-43) induces disease-like redistribution, sequestration, and aggregate formation. J. Biol. Chem. 283, 1330213309 (2008).
9. Yoshitaka Tamaki et al. Elimination of TDP-43 inclusions linked to amyotrophic lateral sclerosis by a misfolding-specific intrabody with dual proteolytic signals. Scientific Reports: volume 8, Article number: 6030 (2018)
TAR DNA-binding protein 43 (TDP-43) is an RNA binding protein (RBP) that has been shown to bind both DNA and RNA and have multiple functions in transcriptional repression, pre-mRNA splicing and translational regulation. It belongs to the hnRNP protein family and is highly expressed in the pancreas, placenta, lung, genital tract and spleen[1]. Characterisation of transcriptome-wide binding sites revealed that thousands of RNAs are bound by TDP-43 in neurons.
Mutations in TDP-43 have been associated with amyotrophic lateral sclerosis, frontotemporal dementia, Parkinson's disease and Alzheimer's disease.
TDP-43 is predominantly located in the nucleus under normal physiological conditions. However, hyperphosphorylated, fragmented and ubiquitinated forms of TDP-43 have been identified as core components of cytosolic inclusions in sporadic ALS and frontotemporal lobar degeneration (FTLD) [2,3,4,5,6,7,8].
TDP-43 contains a nuclear localising signal (NLS) as well as a nuclear export signal (NES)[8], which enables the shuttling of TDP-43 between the nucleus and the cytosol. Under normal conditions, TDP-43 interacts with mRNAs on which ribosomes are located separately, forming polysomes. Various stresses can induce clustering of ribosomes into a stalled state, resulting in the formation of stress granules (SG) containing TIA-1, G3BP, ataxin-2 and eIF4G1/2.
In the stalled state, transcription is inhibited in a homeostatic response. However, sustained stress and TDP-43 misfolding creates aberrant SGs and pathogenic TDP-43 aggregates [9]. Misfolding and cytosolic mislocalisation also lead directly to a loss of normal TDP-43 function, and the resultant disruption of protein and RNA homeostasis is considered another likely pathogenic mechanism in addition to the toxicity of inclusions in ALS[9].
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human TDP-43 from the N-terminal region of the protein
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000. IHC 1:50-100. IF 1:20-100. IP 1:50-100. RIP 1:20-50.
Antibody Number:
10049
Category:
Primary Antibodies
Other names:
TAR DNA-binding protein 43, TARDBP, transactive response DNA binding protein 43 kDa, ALS10
43kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Nucleus
Purification:
Affinity purification
References:
1. Strong MJ, Volkening K, Hammond R, et al. (2007). TDP43 is a human low molecular weight neurofilament (hNFL) mRNA-binding protein. Molecular and Cellular Neuroscience. 35 (2): 3207.
2. Kwong LK, Neumann M, Sampathu DM, et al. (2007). TDP-43 proteinopathy: The neuropathology underlying major forms of sporadic and familial frontotemporal lobar degeneration and motor neuron disease. Acta Neuropathologica. 114 (1): 6370.
3. Arai, T. et al. TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Biochem. Biophys. Res. Commun. 351, 602611 (2006). CAS
4. Neumann M, Sampathu DM, Kwong LK, Truax AC, et al. (2006). Ubiquitinated TDP-43 in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis. Science. 314 (5796): 1303.
5. Tan, C. F. et al. TDP-43 immunoreactivity in neuronal inclusions in familial amyotrophic lateral sclerosis with or without SOD1 gene mutation. Acta Neuropathol. 113, 535542 (2007).
6. Igaz, L. M. et al. Enrichment of C-terminal fragments in TAR DNA-binding protein-43 cytoplasmic inclusions in brain but not in spinal cord of frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Am. J. Pathol. 173, 182194 (2008).
7. Tremblay C, St-Amour I, Schneider J, et al. (2011). Accumulation of transactive response DNA binding protein 43 in mild cognitive impairment and Alzheimer disease. J Neuropathol Exp Neurol. 70 (9): 78898.
8. Winton, M. J. et al. Disturbance of nuclear and cytoplasmic TAR DNA-binding protein (TDP-43) induces disease-like redistribution, sequestration, and aggregate formation. J. Biol. Chem. 283, 1330213309 (2008).
9. Yoshitaka Tamaki et al. Elimination of TDP-43 inclusions linked to amyotrophic lateral sclerosis by a misfolding-specific intrabody with dual proteolytic signals. Scientific Reports: volume 8, Article number: 6030 (2018)
Glucagon-like peptide-1 receptor (GLP1R) is a 7-transmembrane receptor protein found on beta cells of the pancreas. It functions as a receptor for glucagon-like peptide 1 (GLP-1) hormone, which stimulates glucose-induced insulin secretion. GLP1R functions at the cell surface and becomes internalised in response to GLP-1 and GLP-1 analogs, playing an important role in the signalling cascades leading to insulin secretion. It is a member of the glucagon receptor family of G protein-coupled receptors [1]. GLP1R is composed of two domains, an extracellular domain that binds the C-terminal helix of GLP-1 [2], and a transmembrane domain [3] that binds the N-terminal region of GLP-1 [4][5][6].
GLP1R also displays neuroprotective effects in animal models. Polymorphisms in this gene are associated with diabetes, making it an important drug target for the treatment of type 2 diabetes. Alternative splicing of the GLP1R gene results in multiple transcript variants.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS containing 0.02% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the N-terminal region of Human GLP1R
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
53kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Cell membrane, Multi-pass membrane protein
Purification:
Affinity purification
References:
1. Brubaker PL, Drucker DJ (2002). "Structure-function of the glucagon receptor family of the G protein-coupled receptors: the glucagon, GIP, GLP-1, and GLP-2 receptors". Recept. Channels. 8 (34): 17988.
2. Underwood CR, Garibay P, Knudsen LB, Hastrup S, Peters GH, Rudolph R, Reedtz-Runge S (June 2010). "Crystal structure of glucagon-like peptide-1 in complex with the extracellular domain of the glucagon-like peptide-1 receptor". Journal of Biological Chemistry. 285 (1): 723730.
3. Song G, Yang D, Wang Y, de Graaf C, Zhou Q, Jiang S, Liu K, Cai X, Dai A, Lin G, Liu D, Wu F, Wu Y, Zhao S, Ye L, Han GW, Lau J, Wu B, Hanson MA, Liu ZJ, Wang MW, Stevens RC (2017). "Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators)". Nature. 546: 312315.
4. Wooten D, Reynolds CA, Koole C, Smith KJ, Mobarec JC, Simms J, Quon T, Coudrat T, Furness SG, Miller LJ, Christopolous A, Sexton PM (March 2016). "A Hydrogen-Bonded Polar Network in the Core of the Glucagon-Like Peptide-1 Receptor Is a Fulcrum for Biased Agonism: Lessons from Class B Crystal Structures". Molecular Pharmacology. 89 (3): 335347.
5. Wooten D, Reynolds CA, Smith KJ, Mobarec JC, Koole C, Savage EE, Pabreja K, Simms J, Sridhar R, Furness SG, Liu M, Thompson PE, Miller LJ, Christopolous A, Sexton PM (June 2016). "The extracellular surface of the GLP-1 receptor is a molecular trigger for biased agonism". Cell. 165 (7): 16321643.
6. Yang D, de Graaf C, Yang L, Song G, Dai A, Cai X, Feng Y, Reedtz-Runge S, Hanson MA, Yang H, Jiang H, Stevens RC, Wang MW (June 2016). "Structural Determinants of Binding the Seven-transmembrane Domain of the Glucagon-like Peptide-1 Receptor (GLP-1R)". Journal of Biological Chemistry. 291 (25): 129913004.
7. Wooten D, Reynolds CA, Smith KJ, Mobarec JC, Furness SG, Miller LJ, Christopolous A, Sexton PM (August 2016). "Key interactions by conserved polar amino acids located at the transmembrane helical boundaries in Class B GPCRs modulate activation, effector specificity and biased signalling in the glucagon-like peptide-1 receptor". Biochemical Pharmacology. 118: 6887.
Glucagon-like peptide-1 receptor (GLP1R) is a 7-transmembrane receptor protein found on beta cells of the pancreas. It functions as a receptor for glucagon-like peptide 1 (GLP-1) hormone, which stimulates glucose-induced insulin secretion. GLP1R functions at the cell surface and becomes internalised in response to GLP-1 and GLP-1 analogs, playing an important role in the signalling cascades leading to insulin secretion. It is a member of the glucagon receptor family of G protein-coupled receptors [1]. GLP1R is composed of two domains, an extracellular domain that binds the C-terminal helix of GLP-1 [2], and a transmembrane domain [3] that binds the N-terminal region of GLP-1 [4][5][6].
GLP1R also displays neuroprotective effects in animal models. Polymorphisms in this gene are associated with diabetes, making it an important drug target for the treatment of type 2 diabetes. Alternative splicing of the GLP1R gene results in multiple transcript variants.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the N-terminal region of Human GLP1R
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
53kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Cell membrane, Multi-pass membrane protein
Purification:
Affinity purification
References:
1. Brubaker PL, Drucker DJ (2002). "Structure-function of the glucagon receptor family of the G protein-coupled receptors: the glucagon, GIP, GLP-1, and GLP-2 receptors". Recept. Channels. 8 (34): 17988.
2. Underwood CR, Garibay P, Knudsen LB, Hastrup S, Peters GH, Rudolph R, Reedtz-Runge S (June 2010). "Crystal structure of glucagon-like peptide-1 in complex with the extracellular domain of the glucagon-like peptide-1 receptor". Journal of Biological Chemistry. 285 (1): 723730.
3. Song G, Yang D, Wang Y, de Graaf C, Zhou Q, Jiang S, Liu K, Cai X, Dai A, Lin G, Liu D, Wu F, Wu Y, Zhao S, Ye L, Han GW, Lau J, Wu B, Hanson MA, Liu ZJ, Wang MW, Stevens RC (2017). "Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators)". Nature. 546: 312315.
4. Wooten D, Reynolds CA, Koole C, Smith KJ, Mobarec JC, Simms J, Quon T, Coudrat T, Furness SG, Miller LJ, Christopolous A, Sexton PM (March 2016). "A Hydrogen-Bonded Polar Network in the Core of the Glucagon-Like Peptide-1 Receptor Is a Fulcrum for Biased Agonism: Lessons from Class B Crystal Structures". Molecular Pharmacology. 89 (3): 335347.
5. Wooten D, Reynolds CA, Smith KJ, Mobarec JC, Koole C, Savage EE, Pabreja K, Simms J, Sridhar R, Furness SG, Liu M, Thompson PE, Miller LJ, Christopolous A, Sexton PM (June 2016). "The extracellular surface of the GLP-1 receptor is a molecular trigger for biased agonism". Cell. 165 (7): 16321643.
6. Yang D, de Graaf C, Yang L, Song G, Dai A, Cai X, Feng Y, Reedtz-Runge S, Hanson MA, Yang H, Jiang H, Stevens RC, Wang MW (June 2016). "Structural Determinants of Binding the Seven-transmembrane Domain of the Glucagon-like Peptide-1 Receptor (GLP-1R)". Journal of Biological Chemistry. 291 (25): 129913004.
7. Wooten D, Reynolds CA, Smith KJ, Mobarec JC, Furness SG, Miller LJ, Christopolous A, Sexton PM (August 2016). "Key interactions by conserved polar amino acids located at the transmembrane helical boundaries in Class B GPCRs modulate activation, effector specificity and biased signalling in the glucagon-like peptide-1 receptor". Biochemical Pharmacology. 118: 6887.
Fragile X Mental Retardation 1 (FRM1) is an RNA binding protein that plays a central role in neuronal development and synaptic plasticity through the regulation of alternative mRNA splicing, mRNA stability, mRNA dendritic transport and postsynaptic local protein synthesis of a subset of mRNAs.
A trinucleotide repeat (CGG) in the gene encoding this protein is normally found at 6-53 copies, but an expansion to 55-230 repeats is the cause of fragile X syndrome. Expansion of the trinucleotide repeat may also cause one form of premature ovarian failure (POF1). Multiple alternatively spliced transcript variants that encode different protein isoforms and which are located in different cellular locations have also been described for this gene.
FRM1 has been shown to play a translation-independent role in the modulation of presynaptic action potential (AP) duration and neurotransmitter release via large-conductance calcium-activated potassium (BK) channels in hippocampal and cortical excitatory neurons [1]. FMR1 may be involved in the control of DNA damage response (DDR) mechanisms through the regulation of ATR-dependent signaling pathways such as histone H2AFX/H2A.x and BRCA1 phosphorylations [2].
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS containing 0.02% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human FMR1 from the N-terminal region of the protein
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Fragile X Mental Retardation 1 (FRM1) is an RNA binding protein that plays a central role in neuronal development and synaptic plasticity through the regulation of alternative mRNA splicing, mRNA stability, mRNA dendritic transport and postsynaptic local protein synthesis of a subset of mRNAs.
A trinucleotide repeat (CGG) in the gene encoding this protein is normally found at 6-53 copies, but an expansion to 55-230 repeats is the cause of fragile X syndrome. Expansion of the trinucleotide repeat may also cause one form of premature ovarian failure (POF1). Multiple alternatively spliced transcript variants that encode different protein isoforms and which are located in different cellular locations have also been described for this gene.
FRM1 has been shown to play a translation-independent role in the modulation of presynaptic action potential (AP) duration and neurotransmitter release via large-conductance calcium-activated potassium (BK) channels in hippocampal and cortical excitatory neurons [1]. FMR1 may be involved in the control of DNA damage response (DDR) mechanisms through the regulation of ATR-dependent signaling pathways such as histone H2AFX/H2A.x and BRCA1 phosphorylations [2].
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human FMR1 from the N-terminal region of the protein
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Proteasome subunit beta type-4 (PSMB4) is an essential subunit that contributes to the assembly of the 20S proteasome complex. The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. PSMB4 is a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit.
Among proteasome family members, proteasome beta-4 subunit (PSMB4) is well established because it functions predominantly as regulating the assembly of the proteasome [1, 2]. PSMB4 was identified as the first proteasomal subunit with oncogenic properties promoting cancer cell survival and tumor growthin vivo [3]. PSMB4 is significantly associated with neuronal apoptosis in neuroinflammation [4].
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS containing 0.02% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000. IF 1:50-200.
Antibody Number:
10052
Category:
Primary Antibodies
Other names:
HN3, HsN3, PROS-26, PROS26
Research Areas:
Neuroscience, Transcription and Translation, Protein Modification, Transcription, Chromatin, Cancer
NS Reagents Product Area:
Neuroscience
Molecular Weight:
29kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Cytoplasm, Nucleus
Purification:
Affinity purification
References:
[1] Hirano Y, Kaneko T, Okamoto K, Bai M, Yashiroda H, Furuyama K, Kato K, Tanaka K, Murata S (2008) Dissecting beta-ring assembly pathway of the mammalian 20 S proteasome. EMBO J 27(16):22042213. doi:10.1038/emboj.2008.148 [2] Murata S, Yashiroda H, Tanaka K (2009) Molecular mechanisms of proteasome assembly. Nat Rev Mol Cell Biol 10(2):104115. doi:10.1038/nrm2630 [3]. Lee GY, Haverty PM, Li L, Kljavin NM, Bourgon R, Lee J, Stern H, Modrusan Z, Seshagiri S, Zhang Z, Davis D, Stokoe D, Settleman J, de Sauvage FJ, Neve RM (2014) Comparative oncogenomics identifies PSMB4 and SHMT2 as potential cancer driver genes. Cancer Res 74(11):31143126. doi:10.1158/0008-5472. CAN-13-2683 [4]. Shi, J., Liu, X., Xu, C. et al. J Mol Hist (2015) 46: 457. Up-regulation of PSMB4 is associated with neuronal apoptosis after neuroinflammation induced by lipopolysaccharide.
Proteasome subunit beta type-4 (PSMB4) is an essential subunit that contributes to the assembly of the 20S proteasome complex. The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. PSMB4 is a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit.
Among proteasome family members, proteasome beta-4 subunit (PSMB4) is well established because it functions predominantly as regulating the assembly of the proteasome [1, 2]. PSMB4 was identified as the first proteasomal subunit with oncogenic properties promoting cancer cell survival and tumor growthin vivo [3]. PSMB4 is significantly associated with neuronal apoptosis in neuroinflammation [4].
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000. IF 1:50-200.
Antibody Number:
10052
Category:
Primary Antibodies
Other names:
HN3, HsN3, PROS-26, PROS26
Research Areas:
Neuroscience, Transcription and Translation, Protein Modification, Transcription, Chromatin, Cancer
NS Reagents Product Area:
Neuroscience
Molecular Weight:
29kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Cytoplasm, Nucleus
Purification:
Affinity purification
References:
[1] Hirano Y, Kaneko T, Okamoto K, Bai M, Yashiroda H, Furuyama K, Kato K, Tanaka K, Murata S (2008) Dissecting beta-ring assembly pathway of the mammalian 20 S proteasome. EMBO J 27(16):22042213. doi:10.1038/emboj.2008.148 [2] Murata S, Yashiroda H, Tanaka K (2009) Molecular mechanisms of proteasome assembly. Nat Rev Mol Cell Biol 10(2):104115. doi:10.1038/nrm2630 [3]. Lee GY, Haverty PM, Li L, Kljavin NM, Bourgon R, Lee J, Stern H, Modrusan Z, Seshagiri S, Zhang Z, Davis D, Stokoe D, Settleman J, de Sauvage FJ, Neve RM (2014) Comparative oncogenomics identifies PSMB4 and SHMT2 as potential cancer driver genes. Cancer Res 74(11):31143126. doi:10.1158/0008-5472. CAN-13-2683 [4]. Shi, J., Liu, X., Xu, C. et al. J Mol Hist (2015) 46: 457. Up-regulation of PSMB4 is associated with neuronal apoptosis after neuroinflammation induced by lipopolysaccharide.
Mitofusin-2 (MFN2) is a mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion and contributes to the maintenance and operation of the mitochondrial network. MFN2 is involved in the regulation of vascular smooth muscle cell proliferation, and it may play a role in the pathophysiology of obesity. Mutations in this gene cause Charcot-Marie-Tooth disease type 2A2, and hereditary motor and sensory neuropathy VI, which are both disorders of the peripheral nervous system. Defects in this gene have also been associated with early-onset stroke.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
Mouse, Rat, Rabbit, Chicken, Guinea Pig, Chinese Hamster, Cat, Rainbow Trout, Turbot, Naked Mole Rat, Cuckoo and many other species
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide of 13 aa taken from human MFN2 between aa 100 and 300
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Mitofusin-2 (MFN2) is a mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion and contributes to the maintenance and operation of the mitochondrial network. MFN2 is involved in the regulation of vascular smooth muscle cell proliferation, and it may play a role in the pathophysiology of obesity. Mutations in this gene cause Charcot-Marie-Tooth disease type 2A2, and hereditary motor and sensory neuropathy VI, which are both disorders of the peripheral nervous system. Defects in this gene have also been associated with early-onset stroke.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
Mouse, Rat, Rabbit, Chicken, Guinea Pig, Chinese Hamster, Cat, Rainbow Trout, Turbot, Naked Mole Rat, Cuckoo and many other species
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide of 13 aa taken from human MFN2 between aa 100 and 300
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Ephrin type-B receptor 2 (EPHB2) is a member of the Eph receptor family of receptor tyrosine kinase transmembrane glycoproteins. These receptors are composed of an N-terminal glycosylated ligand-binding domain, a transmembrane region and an intracellular kinase domain. They bind ligands called ephrins on adjacent cells, leading to contact-dependent bidirectional signalling into neighbouring cells because both receptors and ligands are able to transduce a signalling cascade. Eph receptors are involved in many cellular processes including motility, division, and differentiation. Proteins of the EphB subgroup are distinguished from other members of the Eph receptor family by sequence homology and a preferential binding affinity for membrane-bound ephrin-B ligands. Allelic variants are associated with prostate and brain cancer susceptibility.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS containing 0.02% sodium azide.
Rat, Chicken, Guinea Pig, Japanese quail, Bovine, Goat Rabbit, Sheep, Pig, Horse, Zebrafish, Cat, Dog
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human EPHB2 from the N-terminal half of the protein
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Ephrin type-B receptor 2 (EPHB2) is a member of the Eph receptor family of receptor tyrosine kinase transmembrane glycoproteins. These receptors are composed of an N-terminal glycosylated ligand-binding domain, a transmembrane region and an intracellular kinase domain. They bind ligands called ephrins on adjacent cells, leading to contact-dependent bidirectional signalling into neighbouring cells because both receptors and ligands are able to transduce a signalling cascade. Eph receptors are involved in many cellular processes including motility, division, and differentiation. Proteins of the EphB subgroup are distinguished from other members of the Eph receptor family by sequence homology and a preferential binding affinity for membrane-bound ephrin-B ligands. Allelic variants are associated with prostate and brain cancer susceptibility.
Rat, Chicken, Guinea Pig, Japanese quail, Bovine, Goat Rabbit, Sheep, Pig, Horse, Zebrafish, Cat, Dog
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human EPHB2 from the N-terminal half of the protein
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Ubiquilin-2 (UBQLN2) is a 624-amino acid multi-domain adaptor protein and a member of the ubiquilin family of proteins that regulate the degradation of ubiquitinated proteins by the ubiquitin-proteasome system (UPS), autophagy and the endoplasmic reticulum-associated protein degradation (ERAD) pathway. Ubiquilins are characterised by the presence of an N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. The central portion is highly variable.
UBQLN2 Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding to their polyubiquitin chains, through the ubiquitin-associated domain (UBA) and by interacting with the subunits of the proteasome through the ubiquitin-like domain (ULD).
Mutations in UBQLN2 are associated with Amyotrophic Lateral Sclerosis with most ALS-linked mutations localised to the proline-rich repeat (Pxx) region that is unique to ubiquilin-2 and not present in the other members of the ubiquilin protein family. UBQLN2 has also been shown to bind the ATPase domain of the Hsp70-like Stch protein. Mutations in UBQLN2 are also observed in familial ALS (FALS) cases associated with aberrant TDP-43 inclusions.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS containing 0.02% sodium azide.
Rat, Golden hamster, Guinea Pig, Pig, Horse, Ord's kangaroo rat, Cat, Dog
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human UBQLN2 from the N-terminal region
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Ubiquilin-2 (UBQLN2) is a 624-amino acid multi-domain adaptor protein and a member of the ubiquilin family of proteins that regulate the degradation of ubiquitinated proteins by the ubiquitin-proteasome system (UPS), autophagy and the endoplasmic reticulum-associated protein degradation (ERAD) pathway. Ubiquilins are characterised by the presence of an N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. The central portion is highly variable.
UBQLN2 Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding to their polyubiquitin chains, through the ubiquitin-associated domain (UBA) and by interacting with the subunits of the proteasome through the ubiquitin-like domain (ULD).
Mutations in UBQLN2 are associated with Amyotrophic Lateral Sclerosis with most ALS-linked mutations localised to the proline-rich repeat (Pxx) region that is unique to ubiquilin-2 and not present in the other members of the ubiquilin protein family. UBQLN2 has also been shown to bind the ATPase domain of the Hsp70-like Stch protein. Mutations in UBQLN2 are also observed in familial ALS (FALS) cases associated with aberrant TDP-43 inclusions.
Rat, Golden hamster, Guinea Pig, Pig, Horse, Ord's kangaroo rat, Cat, Dog
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human UBQLN2 from the N-terminal region
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Sequestosome-1 (SQSTM1) is an autophagy receptor that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. SQSTM1 functions as a scaffolding/adaptor protein with TNF receptor-associated factor 6 (TRAF6). Mutations in SQSTM1 are also observed in familial ALS cases associated with aberrant TDP-43 inclusions and additionally mutations in SQSTM1 may result in Paget disease of bone. SQSTM1 may also be involved in cell differentiation, apoptosis, immune response and regulation of K+ channels.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS containing 0.02% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000. IHC 1:50-200. IF 1:50-200. IP 1:50-100.
Antibody Number:
10056
Category:
Primary Antibodies
Other names:
Sequestosome-1, A170, DMRV, FTDALS3, NADGP, OSIL, p60, p62, p62B, PDB3, ZIP3, A170, FTDALS3, OSIL, p60, p62, p62B, PDB3, ZIP3, EBI3-associated protein of 60 kDa, EBIAP, Ubiquitin-binding protein p62
Sequestosome-1 (SQSTM1) is an autophagy receptor that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. SQSTM1 functions as a scaffolding/adaptor protein with TNF receptor-associated factor 6 (TRAF6). Mutations in SQSTM1 are also observed in familial ALS cases associated with aberrant TDP-43 inclusions and additionally mutations in SQSTM1 may result in Paget disease of bone. SQSTM1 may also be involved in cell differentiation, apoptosis, immune response and regulation of K+ channels.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000. IHC 1:50-200. IF 1:50-200. IP 1:50-100.
Antibody Number:
10056
Category:
Primary Antibodies
Other names:
Sequestosome-1, A170, DMRV, FTDALS3, NADGP, OSIL, p60, p62, p62B, PDB3, ZIP3, A170, FTDALS3, OSIL, p60, p62, p62B, PDB3, ZIP3, EBI3-associated protein of 60 kDa, EBIAP, Ubiquitin-binding protein p62
Sequestosome-1 (SQSTM1) is an autophagy receptor that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. SQSTM1 functions as a scaffolding/adaptor protein with TNF receptor-associated factor 6 (TRAF6). Mutations in SQSTM1 are also observed in familial ALS cases associated with aberrant TDP-43 inclusions and additionally mutations in SQSTM1 may result in Paget disease of bone. SQSTM1 may also be involved in cell differentiation, apoptosis, immune response and regulation of K+ channels.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the C-terminal region of Human Sequestosome-1 (SQSTM1)
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:3000.
Antibody Number:
10057
Category:
Primary Antibodies
Other names:
Sequestosome-1, A170, DMRV, FTDALS3, NADGP, OSIL, p60, p62, p62B, PDB3, ZIP3, A170, FTDALS3, OSIL, p60, p62, p62B, PDB3, ZIP3, EBI3-associated protein of 60 kDa, EBIAP, Ubiquitin-binding protein p62
Sequestosome-1 (SQSTM1) is an autophagy receptor that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. SQSTM1 functions as a scaffolding/adaptor protein with TNF receptor-associated factor 6 (TRAF6). Mutations in SQSTM1 are also observed in familial ALS cases associated with aberrant TDP-43 inclusions and additionally mutations in SQSTM1 may result in Paget disease of bone. SQSTM1 may also be involved in cell differentiation, apoptosis, immune response and regulation of K+ channels.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the C-terminal region of Human Sequestosome-1 (SQSTM1)
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:3000.
Antibody Number:
10057
Category:
Primary Antibodies
Other names:
Sequestosome-1, A170, DMRV, FTDALS3, NADGP, OSIL, p60, p62, p62B, PDB3, ZIP3, A170, FTDALS3, OSIL, p60, p62, p62B, PDB3, ZIP3, EBI3-associated protein of 60 kDa, EBIAP, Ubiquitin-binding protein p62
Optineurin (OPTN) is an autophagy receptor that interacts with numerous proteins. It is involved in regulating many cellular functions, including vesicular trafficking from the Golgi to plasma membrane, endocytic trafficking, and signaling leading to NF-kappa-B (see 164011) activation [1]
Optineurin has been shown to interact with huntingtin [2], transcription factor IIIA [3], and RAB8 [4] and may therefore function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation. Alternative splicing of the gene results in multiple transcript variants encoding the same protein.
Optineurin mutations are associated with Glaucoma and Amyotrophic lateral sclerosis (ALS).
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS containing 0.02% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
[1] Vaibhava, V., Nagabhushana, A., Chalasani, M. L. S., Sudhakar, C., Kumari, A., Swarup, G. Optineurin mediates a negative regulation of Rab8 by the GTPase-activating protein TBC1D17. J. Cell Sci. 125: 5026-5039, 2012. [2]Faber, P. W., Barnes, G. T., Srinidhi, J., Chen, J., Gusella, J. F., MacDonald, M. E. Huntingtin interacts with a family of WW domain proteins. Hum. Molec. Genet. 7: 1463-1474, 1998. [3] Moreland, R. J., Dresser, M. E., Rodgers, J. S., Roe, B. A., Conaway, J. W., Conaway, R. C., Hanas, J. S. Identification of a transcription factor IIIA-interacting protein. Nucleic Acids Res. 28: 1986-1993, 2000. [4] Hattula, K., Peranen, J. FIP-2, a coiled-coil protein, links huntingtin to Rab8 and modulates cellular morphogenesis. Curr. Biol. 10: 1603-1606, 2000.
Optineurin (OPTN) is an autophagy receptor that interacts with numerous proteins. It is involved in regulating many cellular functions, including vesicular trafficking from the Golgi to plasma membrane, endocytic trafficking, and signaling leading to NF-kappa-B (see 164011) activation [1]
Optineurin has been shown to interact with huntingtin [2], transcription factor IIIA [3], and RAB8 [4] and may therefore function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation. Alternative splicing of the gene results in multiple transcript variants encoding the same protein.
Optineurin mutations are associated with Glaucoma and Amyotrophic lateral sclerosis (ALS).
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
[1] Vaibhava, V., Nagabhushana, A., Chalasani, M. L. S., Sudhakar, C., Kumari, A., Swarup, G. Optineurin mediates a negative regulation of Rab8 by the GTPase-activating protein TBC1D17. J. Cell Sci. 125: 5026-5039, 2012. [2]Faber, P. W., Barnes, G. T., Srinidhi, J., Chen, J., Gusella, J. F., MacDonald, M. E. Huntingtin interacts with a family of WW domain proteins. Hum. Molec. Genet. 7: 1463-1474, 1998. [3] Moreland, R. J., Dresser, M. E., Rodgers, J. S., Roe, B. A., Conaway, J. W., Conaway, R. C., Hanas, J. S. Identification of a transcription factor IIIA-interacting protein. Nucleic Acids Res. 28: 1986-1993, 2000. [4] Hattula, K., Peranen, J. FIP-2, a coiled-coil protein, links huntingtin to Rab8 and modulates cellular morphogenesis. Curr. Biol. 10: 1603-1606, 2000.
Protein arginine N-methyltransferase 6 (PRMT6) like other arginine N-methyltransferases, catalyses the sequential transfer of a methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins to form methylated arginine derivatives and S-adenosyl-L-homocysteine.
PRMT6 catalyses both, the formation of omega-N monomethylarginine and asymmetrical dimethylarginine, with a strong preference for the latter. It specifically mediates the asymmetric dimethylation of histone H3 arginine 2 (H3R2me2a) and the methylated form represents a specific tag for epigenetic transcriptional repression. This protein also forms a complex with, and methylates DNA polymerase beta, resulting in stimulation of polymerase activity by enhancing DNA binding and processivity.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS containing 0.02% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000. IF 1:50-200.
Antibody Number:
10059
Category:
Primary Antibodies
Other names:
HRMT1L6, PROTEIN ARGININE N-METHYLTRANSFERASE 6, Heterogeneous Nuclear Ribonucleoprotein Methyltransferase-Like Protein 6 , HMT1 HnRNP Methyltransferase-Like 6, HMT1 HnRNP
Research Areas:
Transcription and Translation, Protein Modification, Transcription, Chromatin
NS Reagents Product Area:
DNA & Protein Modification
Molecular Weight:
42kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Protein arginine N-methyltransferase 6 (PRMT6) like other arginine N-methyltransferases, catalyses the sequential transfer of a methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins to form methylated arginine derivatives and S-adenosyl-L-homocysteine.
PRMT6 catalyses both, the formation of omega-N monomethylarginine and asymmetrical dimethylarginine, with a strong preference for the latter. It specifically mediates the asymmetric dimethylation of histone H3 arginine 2 (H3R2me2a) and the methylated form represents a specific tag for epigenetic transcriptional repression. This protein also forms a complex with, and methylates DNA polymerase beta, resulting in stimulation of polymerase activity by enhancing DNA binding and processivity.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000. IF 1:50-200.
Antibody Number:
10059
Category:
Primary Antibodies
Other names:
HRMT1L6, PROTEIN ARGININE N-METHYLTRANSFERASE 6, Heterogeneous Nuclear Ribonucleoprotein Methyltransferase-Like Protein 6 , HMT1 HnRNP Methyltransferase-Like 6, HMT1 HnRNP
Research Areas:
Transcription and Translation, Protein Modification, Transcription, Chromatin
NS Reagents Product Area:
DNA & Protein Modification
Molecular Weight:
42kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Receptor Activity Modifying Protein 1 (RAMP1) is a member of the RAMP family of single-transmembrane-domain proteins, which are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus.
RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP1) protein, CRLR functions as a CGRP receptor.
RAMP1 forms a complex with calcitonin receptor-like receptor (CLR) to produce the receptor for calcitonin gene-related peptide (CGRP). It facilitates the cell-surface expression of CLR and is also essential for the binding of CGRP to the receptor. The RAMP1 protein can also interact with the calcitonin receptor (CT) protein, where heteromerisation of RAMP1 with CT converts CT from a calcitonin receptor to the amylin receptor AMY1.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:200-1000. IHC 1:10-50.
Antibody Number:
10060
Category:
Primary Antibodies
Other names:
RAMP1, Receptor Activity Modifying Protein 1, Calcitonin Receptor-Like Receptor Activity Modifying Protein 1
Research Areas:
Cell Signalling and Transport, calcitonin-receptor-like receptor
NS Reagents Product Area:
Cell Signalling
Molecular Weight:
17kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Receptor Activity Modifying Protein 1 (RAMP1) is a member of the RAMP family of single-transmembrane-domain proteins, which are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus.
RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP1) protein, CRLR functions as a CGRP receptor.
RAMP1 forms a complex with calcitonin receptor-like receptor (CLR) to produce the receptor for calcitonin gene-related peptide (CGRP). It facilitates the cell-surface expression of CLR and is also essential for the binding of CGRP to the receptor. The RAMP1 protein can also interact with the calcitonin receptor (CT) protein, where heteromerisation of RAMP1 with CT converts CT from a calcitonin receptor to the amylin receptor AMY1.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:200-1000. IHC 1:10-50.
Antibody Number:
10060
Category:
Primary Antibodies
Other names:
RAMP1, Receptor Activity Modifying Protein 1, Calcitonin Receptor-Like Receptor Activity Modifying Protein 1
Research Areas:
Cell Signalling and Transport, calcitonin-receptor-like receptor
NS Reagents Product Area:
Cell Signalling
Molecular Weight:
17kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Receptor Activity Modifying Protein 2 (RAMP2) is a member of the RAMP family of single-transmembrane-domain proteins, which are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus.
RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP2) protein, CRLR functions as an adrenomedullin receptor.
The RAMP2 protein is involved in core glycosylation and transportation of adrenomedullin receptor to the cell surface.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS containing 0.02% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human RAMP2 from the N-terminal region
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000.
Antibody Number:
10061
Category:
Primary Antibodies
Other names:
RAMP2, Receptor Activity Modifying Protein 2, Calcitonin Receptor-Like Receptor Activity Modifying Protein 2
Research Areas:
Cell Signalling and Transport, calcitonin-receptor-like receptor
NS Reagents Product Area:
Cell Signalling
Molecular Weight:
20kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Receptor Activity Modifying Protein 2 (RAMP2) is a member of the RAMP family of single-transmembrane-domain proteins, which are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus.
RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP2) protein, CRLR functions as an adrenomedullin receptor.
The RAMP2 protein is involved in core glycosylation and transportation of adrenomedullin receptor to the cell surface.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human RAMP2 from the N-terminal region
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000.
Antibody Number:
10061
Category:
Primary Antibodies
Other names:
RAMP2, Receptor Activity Modifying Protein 2, Calcitonin Receptor-Like Receptor Activity Modifying Protein 2
Research Areas:
Cell Signalling and Transport, calcitonin-receptor-like receptor
NS Reagents Product Area:
Cell Signalling
Molecular Weight:
20kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Receptor Activity Modifying Protein 3 (RAMP3) is a member of the RAMP family of single-transmembrane-domain proteins, which are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus.
RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed.
In the presence of this (RAMP3) protein, CRLR functions as an adrenomedullin receptor.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS containing 0.02% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human RAMP3 from the N-terminal region
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000. IF 1:10-100.
Antibody Number:
10062
Category:
Primary Antibodies
Other names:
RAMP3, Receptor Activity Modifying Protein 3, Calcitonin Receptor-Like Receptor Activity Modifying Protein 3
Research Areas:
Cell Signalling and Transport, calcitonin-receptor-like receptor
NS Reagents Product Area:
Cell Signalling
Molecular Weight:
17kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Cell membrane, Membrane, Single-pass type I membrane protein
Receptor Activity Modifying Protein 3 (RAMP3) is a member of the RAMP family of single-transmembrane-domain proteins, which are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus.
RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed.
In the presence of this (RAMP3) protein, CRLR functions as an adrenomedullin receptor.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human RAMP3 from the N-terminal region
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000. IF 1:10-100.
Antibody Number:
10062
Category:
Primary Antibodies
Other names:
RAMP3, Receptor Activity Modifying Protein 3, Calcitonin Receptor-Like Receptor Activity Modifying Protein 3
Research Areas:
Cell Signalling and Transport, calcitonin-receptor-like receptor
NS Reagents Product Area:
Cell Signalling
Molecular Weight:
17kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Cell membrane, Membrane, Single-pass type I membrane protein
Carnitine palmitoyltransferase I (CPT1) is a liver enzyme involved in fatty acid oxidation. Three isoforms of CPT1 are currently known: CPT1A, CPT1B, and CPT1C. This antibody recognises CPT1A.
The carnitine palmitoyltransferase (CPT) enzyme system, with acyl-CoA synthetase and carnitine/acylcarnitine translocas, provide the mechanism for long-chain fatty acids to be transferred from the cytosol to the mitochondrial matrix to undergo beta-oxidation for energy production.
The mitochondrial oxidation of long-chain fatty acids is initiated by the sequential action of carnitine palmitoyltransferase I (which is located in the outer membrane and is detergent-labile) and carnitine palmitoyltransferase II (which is located in the inner membrane and is detergent-stable), together with a carnitine-acylcarnitine translocase.
Carnitine palmitoyltransferase I is responsible for the formation of acyl carnitines, catalysing the transfer of the acyl group of a long-chain fatty acyl-CoA from coenzyme A to l-carnitine, allowing movement of the acyl carnitine from the cytosol into the intermembrane space of mitochondria. CPT I is key for carnitine-dependent transport across the mitochondrial inner membrane and its deficiency results in a decreased rate of fatty acid beta-oxidation.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS containing 0.02% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human CPT1A from the C-terminal region
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000. IF 1:50-200. IP 1:50-100.
Antibody Number:
10063
Category:
Primary Antibodies
Other names:
CPT1, CPT1-L, L-CPT1, Carnitine palmitoyltransferase IA
Research Areas:
Cell Signalling and Transport, Transcription and Translation, Protein Modification, Transcription, Chromatin
NS Reagents Product Area:
Cell Signalling
Molecular Weight:
88kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Mitochondrion outer membrane, Multi-pass membrane protein
Carnitine palmitoyltransferase I (CPT1) is a liver enzyme involved in fatty acid oxidation. Three isoforms of CPT1 are currently known: CPT1A, CPT1B, and CPT1C. This antibody recognises CPT1A.
The carnitine palmitoyltransferase (CPT) enzyme system, with acyl-CoA synthetase and carnitine/acylcarnitine translocas, provide the mechanism for long-chain fatty acids to be transferred from the cytosol to the mitochondrial matrix to undergo beta-oxidation for energy production.
The mitochondrial oxidation of long-chain fatty acids is initiated by the sequential action of carnitine palmitoyltransferase I (which is located in the outer membrane and is detergent-labile) and carnitine palmitoyltransferase II (which is located in the inner membrane and is detergent-stable), together with a carnitine-acylcarnitine translocase.
Carnitine palmitoyltransferase I is responsible for the formation of acyl carnitines, catalysing the transfer of the acyl group of a long-chain fatty acyl-CoA from coenzyme A to l-carnitine, allowing movement of the acyl carnitine from the cytosol into the intermembrane space of mitochondria. CPT I is key for carnitine-dependent transport across the mitochondrial inner membrane and its deficiency results in a decreased rate of fatty acid beta-oxidation.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human CPT1A from the C-terminal region
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000. IF 1:50-200. IP 1:50-100.
Antibody Number:
10063
Category:
Primary Antibodies
Other names:
CPT1, CPT1-L, L-CPT1, Carnitine palmitoyltransferase IA
Research Areas:
Cell Signalling and Transport, Transcription and Translation, Protein Modification, Transcription, Chromatin
NS Reagents Product Area:
Cell Signalling
Molecular Weight:
88kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Mitochondrion outer membrane, Multi-pass membrane protein
Anti-G protein-coupled estrogen receptor 1 (GPER1/GPR30) is a novel estrogenic receptor that binds to 17-beta-estradiol (E2) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. Different from traditional estrogen nuclear receptors, GPR30 exerts its biological effects through rapid non-genomic mechanisms [1].
GPR30 is involved in several physiopathological disorders and especially in estrogen-dependent diseases such as breast cancer and also has a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a RAMP3-dependent manner. It is highly expressed in the brain [2,3] and activation of GPR30 has neuroprotective effects on ischemic brain injury [4]. In Humans GPR30 is 375 amino acids in length, contains an N-terminal extracellular region (1?62), a series of seven TM domains (63?327), and a C-terminal cytoplasmic tail (328?375).
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the C-terminal region of human GPER1
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
1. Prossnitz E.R., Barton M. The G-protein-coupled estrogen receptor GPER in health and disease. Nat Rev Endocrinol. 2011;7:715726
2. Brailoiu E, Dun SL, Brailoiu GC, Mizuo K, Sklar LA, Oprea TI, et al. Distribution and characterization of estrogen receptor G protein-coupled receptor 30 in the rat central nervous system. J Endocrinol. 2007;193:311321. doi: 10.1677/JOE-07-0017. [PubMed] [CrossRef]
3. Tang H, Zhang Q, Yang L, Dong Y, Khan M, Yang F, et al. GPR30 mediates estrogen rapid signaling and neuroprotection. Mol Cell Endocrinol. 2014;387:528. doi: 10.1016/j.mce.2014.01.024.
4. Kosaka Y., Quillinan N., Bond C. GPER1/GPR30 activation improves neuronal survival following global cerebral ischemia induced by cardiac arrest in mice. Transl Stroke Res. 2012;3:500507.
Anti-G protein-coupled estrogen receptor 1 (GPER1/GPR30) is a novel estrogenic receptor that binds to 17-beta-estradiol (E2) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. Different from traditional estrogen nuclear receptors, GPR30 exerts its biological effects through rapid non-genomic mechanisms [1].
GPR30 is involved in several physiopathological disorders and especially in estrogen-dependent diseases such as breast cancer and also has a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a RAMP3-dependent manner. It is highly expressed in the brain [2,3] and activation of GPR30 has neuroprotective effects on ischemic brain injury [4]. In Humans GPR30 is 375 amino acids in length, contains an N-terminal extracellular region (1?62), a series of seven TM domains (63?327), and a C-terminal cytoplasmic tail (328?375).
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the C-terminal region of human GPER1
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
1. Prossnitz E.R., Barton M. The G-protein-coupled estrogen receptor GPER in health and disease. Nat Rev Endocrinol. 2011;7:715726
2. Brailoiu E, Dun SL, Brailoiu GC, Mizuo K, Sklar LA, Oprea TI, et al. Distribution and characterization of estrogen receptor G protein-coupled receptor 30 in the rat central nervous system. J Endocrinol. 2007;193:311321. doi: 10.1677/JOE-07-0017. [PubMed] [CrossRef]
3. Tang H, Zhang Q, Yang L, Dong Y, Khan M, Yang F, et al. GPR30 mediates estrogen rapid signaling and neuroprotection. Mol Cell Endocrinol. 2014;387:528. doi: 10.1016/j.mce.2014.01.024.
4. Kosaka Y., Quillinan N., Bond C. GPER1/GPR30 activation improves neuronal survival following global cerebral ischemia induced by cardiac arrest in mice. Transl Stroke Res. 2012;3:500507.
G protein-coupled receptor class C group 6 member A (GPRC6A) is a widely expressed G-protein coupled receptor, believed to be a master regulator of complex endocrine networks and metabolic processes. GPRC6A is activated by multiple ligands, including osteocalcin (Ocn), testosterone (T), basic amino acids, and various cations. [1]
Members of family C of the G protein-coupled receptor (GPCR) superfamily, such as GPRC6A, are characterised by an evolutionarily conserved amino acid-sensing motif linked to an intramembranous 7-transmembrane loop region. Several members of GPCR family C, including GPRC6A, also have a long N-terminal domain.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS containing 0.02% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human GPRC6A from the central region of the protein
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000. IHC 1:50-200.
Antibody Number:
10065
Category:
Primary Antibodies
Other names:
G-protein coupled receptor family C group 6 member A, hGPRC6A, GPRC6A, GPCR, bA86F4.3, GPCR33, hGPCR33
Research Areas:
Cell Signalling and Transport, calcitonin-receptor-like receptor
NS Reagents Product Area:
Cell Signalling
Molecular Weight:
105kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Cell membrane, Multi-pass membrane protein
Purification:
Affinity purification
References:
1. Min Pi, Satoru Kenneth Nishimoto, L. Darryl Quarles. Mol Metab. 2017 Feb; 6(2): 185193.
G protein-coupled receptor class C group 6 member A (GPRC6A) is a widely expressed G-protein coupled receptor, believed to be a master regulator of complex endocrine networks and metabolic processes. GPRC6A is activated by multiple ligands, including osteocalcin (Ocn), testosterone (T), basic amino acids, and various cations. [1]
Members of family C of the G protein-coupled receptor (GPCR) superfamily, such as GPRC6A, are characterised by an evolutionarily conserved amino acid-sensing motif linked to an intramembranous 7-transmembrane loop region. Several members of GPCR family C, including GPRC6A, also have a long N-terminal domain.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human GPRC6A from the central region of the protein
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000. IHC 1:50-200.
Antibody Number:
10065
Category:
Primary Antibodies
Other names:
G-protein coupled receptor family C group 6 member A, hGPRC6A, GPRC6A, GPCR, bA86F4.3, GPCR33, hGPCR33
Research Areas:
Cell Signalling and Transport, calcitonin-receptor-like receptor
NS Reagents Product Area:
Cell Signalling
Molecular Weight:
105kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Cell membrane, Multi-pass membrane protein
Purification:
Affinity purification
References:
1. Min Pi, Satoru Kenneth Nishimoto, L. Darryl Quarles. Mol Metab. 2017 Feb; 6(2): 185193.
LGR5 (leucine-rich repeat-containing G protein-coupled receptor 5) is a member of the G-protein-coupled receptor family of proteins and a target of Wnt signalling [1]. It plays a role in the formation and maintenance of adult intestinal stem cells during postembryonic development, but is expressed by a wide range of adult tissues and organs acting as a biomarker for adult stem cells in certain tissues. Functionally, LGR5 is a part of Wnt signalling complex on the cell membrane, where it seems to enhance the activity of the Wnt/ß-catenin signalling.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS containing 0.02% sodium azide.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the C-terminal region of human LGR5
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:1000-2000. IF 1:50-200.
Antibody Number:
10066
Category:
Primary Antibodies
Other names:
FEX, GPR49, GPR67, GRP49, HG38
Research Areas:
Cell Signalling, Cancer, Neuroscience
NS Reagents Product Area:
Cell Signalling
Molecular Weight:
100kDa (Intended as a general guide and does not allow for all isoforms and species variations)
1. de LW, Barker N, Low TY, Koo B, Li VSW, Teunissen H, et al. Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling. Nature. 2011;476:293297.
LGR5 (leucine-rich repeat-containing G protein-coupled receptor 5) is a member of the G-protein-coupled receptor family of proteins and a target of Wnt signalling [1]. It plays a role in the formation and maintenance of adult intestinal stem cells during postembryonic development, but is expressed by a wide range of adult tissues and organs acting as a biomarker for adult stem cells in certain tissues. Functionally, LGR5 is a part of Wnt signalling complex on the cell membrane, where it seems to enhance the activity of the Wnt/ß-catenin signalling.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the C-terminal region of human LGR5
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
