Newmarket Scientific
Newmarket Scientific

Product Search Results: AB18-10060 (100ug)

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Product Search Results: AB18-10060 (100ug)

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Newmarket Scientific - NS Reagents AB18-10060-100ug 100ug £275.00
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Product Detail: Anti-RAMP1 Polyclonal Antibody
Background Info: Receptor Activity Modifying Protein 1 (RAMP1) is a member of the RAMP family of single-transmembrane-domain proteins, which are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus.

RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP1) protein, CRLR functions as a CGRP receptor.

RAMP1 forms a complex with calcitonin receptor-like receptor (CLR) to produce the receptor for calcitonin gene-related peptide (CGRP). It facilitates the cell-surface expression of CLR and is also essential for the binding of CGRP to the receptor. The RAMP1 protein can also interact with the calcitonin receptor (CT) protein, where heteromerisation of RAMP1 with CT converts CT from a calcitonin receptor to the amylin receptor AMY1.
Product Type: NS Reagents Antibody
Antibody Type: Polyclonal
Format: 100 µg in 100 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
Storage Temp: 6 months: 4°C. Long-term storage: -20°C. Avoid multiple freeze and thaw cycles.
Host Animal: Rabbit
Species Reactivity: Human Mouse
Immunogen: Recombinant human RAMP1
Applications: WB IHC
Alternative Name: RAMP1, Receptor Activity Modifying Protein 1, Calcitonin Receptor-Like Receptor Activity Modifying Protein 1
Antibody Isotype: IgG
Application Details: WB 1:200-1000. IHC 1:10-50.
Category: Primary Antibodies
Research Areas: Cell Signalling and Transport, calcitonin-receptor-like receptor
NS Reagents Product Area: Cell Signalling
Molecular Weight: 17kDa
Subcellular location: Membrane, Cytoplasm
Purification: Affinity purification
Uniprot ID: O60894
Gene ID: 10267
Release Date: Nov-18