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Product Search Results: AB18-10060 (100ug)

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Product Search Results: AB18-10060 (100ug)

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Newmarket Scientific - NS Reagents AB18-10060-100ug 100 µg £275.00
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Product Detail: Anti-RAMP1 Antibody (Polyclonal)
Background Info: Receptor Activity Modifying Protein 1 (RAMP1) is a member of the RAMP family of single-transmembrane-domain proteins, which are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus.

RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP1) protein, CRLR functions as a CGRP receptor.

RAMP1 forms a complex with calcitonin receptor-like receptor (CLR) to produce the receptor for calcitonin gene-related peptide (CGRP). It facilitates the cell-surface expression of CLR and is also essential for the binding of CGRP to the receptor. The RAMP1 protein can also interact with the calcitonin receptor (CT) protein, where heteromerisation of RAMP1 with CT converts CT from a calcitonin receptor to the amylin receptor AMY1.
Product Type: NS Reagents Antibody
Antibody Type: Polyclonal
Format: 100 µg in 100 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
Storage Temp: 6 months: 4°C. Long-term storage: -20°C. Avoid multiple freeze and thaw cycles.
Host Animal: Rabbit
Species Reactivity: Human, Mouse
Expected Species: If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen: Full length recombinant human RAMP1
Applications: WB IHC
Additional Info: If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype: IgG
Application Details: WB 1:200-1000. IHC 1:10-50.
Antibody Number: 10060
Category: Primary Antibodies
Other names: RAMP1, Receptor Activity Modifying Protein 1, Calcitonin Receptor-Like Receptor Activity Modifying Protein 1
Research Areas: Cell Signalling and Transport, calcitonin-receptor-like receptor
NS Reagents Product Area: Cell Signalling
Molecular Weight: 17kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location: Membrane, Cytoplasm
Purification: Affinity purification
Uniprot ID: O60894
Gene ID: 10267
Gene symbol: RAMP1
Release Date: Nov-18