ABCG2 (BCRP1/ABCP/MXR) is a member of the ATP-binding cassette transporter family that functions as ATP-dependent transporters for a wide variety of chemical compounds and are associated with drug-resistance in cancer cells. ABCG2 is a heavily glycosylated transmembrane protein with six transmembrane spanning regions consistent with it functioning as a half-transporter. The ABC family can exist as either full-length transporters or as half-transporters that form functional transporters through homo- or heterodimerization. Originally thought to play a role in drug resistance due to its resistance to a number of chemotherapeutic drugs, ABCG2 has also been found in the kidney, and stem cell populations. Studies also suggest that it can be used as a cell surface marker to identify hematopoietic stem cells within the bone marrow fraction of lineage negative cells. The expression of ABCG2 appears greatest on CD34- cells and is downregulated with the acquisition of CD34 on the cell surface.
WB (1:2000), IHC (1:200); optimal dilutions for assays should be determined by the user.
Target:
ABCG2
Conjugate:
Unconjugated
Research Area(s):
Tags and Cell Markers | Cell Signaling | Metabolism | Stem Cells | Hematopoietic Progenitors | HP Surface Molecules | Stem Cells | Neural Stem Cells | Cell Signaling | Metabolism | Cancer | Cancer Metabolism | Cell Signaling | Metabolism | Drug Metabolism
Alternative Name(s):
ABC transporter antibody ABC15 antibody ABCG 2 antibody ABCG2 antibody ABCG2_HUMAN antibody ABCP antibody ATP binding cassette sub family G (WHITE) member 2 antibody ATP binding cassette transporter G2 antibody ATP-binding cassette sub-family G member 2 antibody BCRP antibody BCRP1 antibody BMDP antibody Breast cancer resistance protein antibody CD338 antibody CDw338 antibody CDw338 antigen antibody EST157481 antibody GOUT1 antibody MGC102821 antibody Mitoxantrone resistance associated protein antibody Mitoxantrone resistance-associated protein antibody MRX antibody Multi drug resistance efflux transport ATP binding cassette sub family G (WHITE) member 2 antibody MXR antibody MXR1 antibody Placenta specific ATP binding cassette transporter antibody Placenta specific MDR protein antibody Placenta-specific ATP-binding cassette transporter antibody UAQTL1 antibody
Category:
Polyclonal
Immunogen Species:
Human
Accession Number:
NP_004818.2
Gene ID:
9429
Swiss-Prot:
Q9UNQ0
Species Reactivity Full Name:
Human
Purification:
Peptide Affinity Purified
Specificity:
Detects endogenous levels of total ABCG2
Certificate of Analysis:
A 1:1000 dilution of SPC-1317 was sufficient for detection of ABCG2 in 10 µg of mouse kidney cell lyates by ECL immunoblot analysis using Goat Anti-Rabbit IgG:HRP as the secondary antibody.
Cellular Localization:
Cell Membrane | Mitochondrion Membrane
References:
1. Zhou S., et al. (2001) Nat. Medicine. 7: 1028. 2. Doyle L.A. and Ross D.D. (2003) Oncogene. 22: 7340-58. 3. Allen J.D. et al. (1999) Cancer Res. 59: 4237-41. 4. Doyle L.A., et al. (1998) Proc Natl Acad Sci USA. 95: 15665-70. 5. Allikmets R., et al. (1998) Cancer Res. 58: 5337-9. 6. Miyake K., et al. (1999) Cancer Res. 59: 8-13. 7. Robey R.W., et al. (2001) Clin Cancer Res. 7: 145-52. Zhou S., et al. (2001) Nat. Medicine. 7: 1028.
ABCG2 (BCRP1/ABCP/MXR) is a member of the ATP-binding cassette transporter family that functions as ATP-dependent transporters for a wide variety of chemical compounds and are associated with drug-resistance in cancer cells. ABCG2 is a heavily glycosylated transmembrane protein with six transmembrane spanning regions consistent with it functioning as a half-transporter. The ABC family can exist as either full-length transporters or as half-transporters that form functional transporters through homo- or heterodimerization. Originally thought to play a role in drug resistance due to its resistance to a number of chemotherapeutic drugs, ABCG2 has also been found in the kidney, and stem cell populations. Studies also suggest that it can be used as a cell surface marker to identify hematopoietic stem cells within the bone marrow fraction of lineage negative cells. The expression of ABCG2 appears greatest on CD34- cells and is downregulated with the acquisition of CD34 on the cell surface.
WB (1:2000), IHC (1:200); optimal dilutions for assays should be determined by the user.
Target:
ABCG2
Conjugate:
ATTO 390
Research Area(s):
Tags and Cell Markers | Cell Signaling | Metabolism | Stem Cells | Hematopoietic Progenitors | HP Surface Molecules | Stem Cells | Neural Stem Cells | Cell Signaling | Metabolism | Cancer | Cancer Metabolism | Cell Signaling | Metabolism | Drug Metabolism
Alternative Name(s):
ABC transporter antibody ABC15 antibody ABCG 2 antibody ABCG2 antibody ABCG2_HUMAN antibody ABCP antibody ATP binding cassette sub family G (WHITE) member 2 antibody ATP binding cassette transporter G2 antibody ATP-binding cassette sub-family G member 2 antibody BCRP antibody BCRP1 antibody BMDP antibody Breast cancer resistance protein antibody CD338 antibody CDw338 antibody CDw338 antigen antibody EST157481 antibody GOUT1 antibody MGC102821 antibody Mitoxantrone resistance associated protein antibody Mitoxantrone resistance-associated protein antibody MRX antibody Multi drug resistance efflux transport ATP binding cassette sub family G (WHITE) member 2 antibody MXR antibody MXR1 antibody Placenta specific ATP binding cassette transporter antibody Placenta specific MDR protein antibody Placenta-specific ATP-binding cassette transporter antibody UAQTL1 antibody
Category:
Polyclonal
Immunogen Species:
Human
Accession Number:
NP_004818.2
Gene ID:
9429
Swiss-Prot:
Q9UNQ0
Species Reactivity Full Name:
Human
Purification:
Peptide Affinity Purified
Specificity:
Detects endogenous levels of total ABCG2
Certificate of Analysis:
A 1:1000 dilution of SPC-1317 was sufficient for detection of ABCG2 in 10 µg of mouse kidney cell lyates by ECL immunoblot analysis using Goat Anti-Rabbit IgG:HRP as the secondary antibody.
Cellular Localization:
Cell Membrane | Mitochondrion Membrane
References:
1. Zhou S., et al. (2001) Nat. Medicine. 7: 1028. 2. Doyle L.A. and Ross D.D. (2003) Oncogene. 22: 7340-58. 3. Allen J.D. et al. (1999) Cancer Res. 59: 4237-41. 4. Doyle L.A., et al. (1998) Proc Natl Acad Sci USA. 95: 15665-70. 5. Allikmets R., et al. (1998) Cancer Res. 58: 5337-9. 6. Miyake K., et al. (1999) Cancer Res. 59: 8-13. 7. Robey R.W., et al. (2001) Clin Cancer Res. 7: 145-52. Zhou S., et al. (2001) Nat. Medicine. 7: 1028.
ABCG2 (BCRP1/ABCP/MXR) is a member of the ATP-binding cassette transporter family that functions as ATP-dependent transporters for a wide variety of chemical compounds and are associated with drug-resistance in cancer cells. ABCG2 is a heavily glycosylated transmembrane protein with six transmembrane spanning regions consistent with it functioning as a half-transporter. The ABC family can exist as either full-length transporters or as half-transporters that form functional transporters through homo- or heterodimerization. Originally thought to play a role in drug resistance due to its resistance to a number of chemotherapeutic drugs, ABCG2 has also been found in the kidney, and stem cell populations. Studies also suggest that it can be used as a cell surface marker to identify hematopoietic stem cells within the bone marrow fraction of lineage negative cells. The expression of ABCG2 appears greatest on CD34- cells and is downregulated with the acquisition of CD34 on the cell surface.
WB (1:2000), IHC (1:200); optimal dilutions for assays should be determined by the user.
Target:
ABCG2
Conjugate:
ATTO 488
Research Area(s):
Tags and Cell Markers | Cell Signaling | Metabolism | Stem Cells | Hematopoietic Progenitors | HP Surface Molecules | Stem Cells | Neural Stem Cells | Cell Signaling | Metabolism | Cancer | Cancer Metabolism | Cell Signaling | Metabolism | Drug Metabolism
Alternative Name(s):
ABC transporter antibody ABC15 antibody ABCG 2 antibody ABCG2 antibody ABCG2_HUMAN antibody ABCP antibody ATP binding cassette sub family G (WHITE) member 2 antibody ATP binding cassette transporter G2 antibody ATP-binding cassette sub-family G member 2 antibody BCRP antibody BCRP1 antibody BMDP antibody Breast cancer resistance protein antibody CD338 antibody CDw338 antibody CDw338 antigen antibody EST157481 antibody GOUT1 antibody MGC102821 antibody Mitoxantrone resistance associated protein antibody Mitoxantrone resistance-associated protein antibody MRX antibody Multi drug resistance efflux transport ATP binding cassette sub family G (WHITE) member 2 antibody MXR antibody MXR1 antibody Placenta specific ATP binding cassette transporter antibody Placenta specific MDR protein antibody Placenta-specific ATP-binding cassette transporter antibody UAQTL1 antibody
Category:
Polyclonal
Immunogen Species:
Human
Accession Number:
NP_004818.2
Gene ID:
9429
Swiss-Prot:
Q9UNQ0
Species Reactivity Full Name:
Human
Purification:
Peptide Affinity Purified
Specificity:
Detects endogenous levels of total ABCG2
Certificate of Analysis:
A 1:1000 dilution of SPC-1317 was sufficient for detection of ABCG2 in 10 µg of mouse kidney cell lyates by ECL immunoblot analysis using Goat Anti-Rabbit IgG:HRP as the secondary antibody.
Cellular Localization:
Cell Membrane | Mitochondrion Membrane
References:
1. Zhou S., et al. (2001) Nat. Medicine. 7: 1028. 2. Doyle L.A. and Ross D.D. (2003) Oncogene. 22: 7340-58. 3. Allen J.D. et al. (1999) Cancer Res. 59: 4237-41. 4. Doyle L.A., et al. (1998) Proc Natl Acad Sci USA. 95: 15665-70. 5. Allikmets R., et al. (1998) Cancer Res. 58: 5337-9. 6. Miyake K., et al. (1999) Cancer Res. 59: 8-13. 7. Robey R.W., et al. (2001) Clin Cancer Res. 7: 145-52. Zhou S., et al. (2001) Nat. Medicine. 7: 1028.
ABCG2 (BCRP1/ABCP/MXR) is a member of the ATP-binding cassette transporter family that functions as ATP-dependent transporters for a wide variety of chemical compounds and are associated with drug-resistance in cancer cells. ABCG2 is a heavily glycosylated transmembrane protein with six transmembrane spanning regions consistent with it functioning as a half-transporter. The ABC family can exist as either full-length transporters or as half-transporters that form functional transporters through homo- or heterodimerization. Originally thought to play a role in drug resistance due to its resistance to a number of chemotherapeutic drugs, ABCG2 has also been found in the kidney, and stem cell populations. Studies also suggest that it can be used as a cell surface marker to identify hematopoietic stem cells within the bone marrow fraction of lineage negative cells. The expression of ABCG2 appears greatest on CD34- cells and is downregulated with the acquisition of CD34 on the cell surface.
WB (1:2000), IHC (1:200); optimal dilutions for assays should be determined by the user.
Target:
ABCG2
Conjugate:
ATTO 565
Research Area(s):
Tags and Cell Markers | Cell Signaling | Metabolism | Stem Cells | Hematopoietic Progenitors | HP Surface Molecules | Stem Cells | Neural Stem Cells | Cell Signaling | Metabolism | Cancer | Cancer Metabolism | Cell Signaling | Metabolism | Drug Metabolism
Alternative Name(s):
ABC transporter antibody ABC15 antibody ABCG 2 antibody ABCG2 antibody ABCG2_HUMAN antibody ABCP antibody ATP binding cassette sub family G (WHITE) member 2 antibody ATP binding cassette transporter G2 antibody ATP-binding cassette sub-family G member 2 antibody BCRP antibody BCRP1 antibody BMDP antibody Breast cancer resistance protein antibody CD338 antibody CDw338 antibody CDw338 antigen antibody EST157481 antibody GOUT1 antibody MGC102821 antibody Mitoxantrone resistance associated protein antibody Mitoxantrone resistance-associated protein antibody MRX antibody Multi drug resistance efflux transport ATP binding cassette sub family G (WHITE) member 2 antibody MXR antibody MXR1 antibody Placenta specific ATP binding cassette transporter antibody Placenta specific MDR protein antibody Placenta-specific ATP-binding cassette transporter antibody UAQTL1 antibody
Category:
Polyclonal
Immunogen Species:
Human
Accession Number:
NP_004818.2
Gene ID:
9429
Swiss-Prot:
Q9UNQ0
Species Reactivity Full Name:
Human
Purification:
Peptide Affinity Purified
Specificity:
Detects endogenous levels of total ABCG2
Certificate of Analysis:
A 1:1000 dilution of SPC-1317 was sufficient for detection of ABCG2 in 10 µg of mouse kidney cell lyates by ECL immunoblot analysis using Goat Anti-Rabbit IgG:HRP as the secondary antibody.
Cellular Localization:
Cell Membrane | Mitochondrion Membrane
References:
1. Zhou S., et al. (2001) Nat. Medicine. 7: 1028. 2. Doyle L.A. and Ross D.D. (2003) Oncogene. 22: 7340-58. 3. Allen J.D. et al. (1999) Cancer Res. 59: 4237-41. 4. Doyle L.A., et al. (1998) Proc Natl Acad Sci USA. 95: 15665-70. 5. Allikmets R., et al. (1998) Cancer Res. 58: 5337-9. 6. Miyake K., et al. (1999) Cancer Res. 59: 8-13. 7. Robey R.W., et al. (2001) Clin Cancer Res. 7: 145-52. Zhou S., et al. (2001) Nat. Medicine. 7: 1028.
ABCG2 (BCRP1/ABCP/MXR) is a member of the ATP-binding cassette transporter family that functions as ATP-dependent transporters for a wide variety of chemical compounds and are associated with drug-resistance in cancer cells. ABCG2 is a heavily glycosylated transmembrane protein with six transmembrane spanning regions consistent with it functioning as a half-transporter. The ABC family can exist as either full-length transporters or as half-transporters that form functional transporters through homo- or heterodimerization. Originally thought to play a role in drug resistance due to its resistance to a number of chemotherapeutic drugs, ABCG2 has also been found in the kidney, and stem cell populations. Studies also suggest that it can be used as a cell surface marker to identify hematopoietic stem cells within the bone marrow fraction of lineage negative cells. The expression of ABCG2 appears greatest on CD34- cells and is downregulated with the acquisition of CD34 on the cell surface.
WB (1:2000), IHC (1:200); optimal dilutions for assays should be determined by the user.
Target:
ABCG2
Conjugate:
ATTO 594
Research Area(s):
Tags and Cell Markers | Cell Signaling | Metabolism | Stem Cells | Hematopoietic Progenitors | HP Surface Molecules | Stem Cells | Neural Stem Cells | Cell Signaling | Metabolism | Cancer | Cancer Metabolism | Cell Signaling | Metabolism | Drug Metabolism
Alternative Name(s):
ABC transporter antibody ABC15 antibody ABCG 2 antibody ABCG2 antibody ABCG2_HUMAN antibody ABCP antibody ATP binding cassette sub family G (WHITE) member 2 antibody ATP binding cassette transporter G2 antibody ATP-binding cassette sub-family G member 2 antibody BCRP antibody BCRP1 antibody BMDP antibody Breast cancer resistance protein antibody CD338 antibody CDw338 antibody CDw338 antigen antibody EST157481 antibody GOUT1 antibody MGC102821 antibody Mitoxantrone resistance associated protein antibody Mitoxantrone resistance-associated protein antibody MRX antibody Multi drug resistance efflux transport ATP binding cassette sub family G (WHITE) member 2 antibody MXR antibody MXR1 antibody Placenta specific ATP binding cassette transporter antibody Placenta specific MDR protein antibody Placenta-specific ATP-binding cassette transporter antibody UAQTL1 antibody
Category:
Polyclonal
Immunogen Species:
Human
Accession Number:
NP_004818.2
Gene ID:
9429
Swiss-Prot:
Q9UNQ0
Species Reactivity Full Name:
Human
Purification:
Peptide Affinity Purified
Specificity:
Detects endogenous levels of total ABCG2
Certificate of Analysis:
A 1:1000 dilution of SPC-1317 was sufficient for detection of ABCG2 in 10 µg of mouse kidney cell lyates by ECL immunoblot analysis using Goat Anti-Rabbit IgG:HRP as the secondary antibody.
Cellular Localization:
Cell Membrane | Mitochondrion Membrane
References:
1. Zhou S., et al. (2001) Nat. Medicine. 7: 1028. 2. Doyle L.A. and Ross D.D. (2003) Oncogene. 22: 7340-58. 3. Allen J.D. et al. (1999) Cancer Res. 59: 4237-41. 4. Doyle L.A., et al. (1998) Proc Natl Acad Sci USA. 95: 15665-70. 5. Allikmets R., et al. (1998) Cancer Res. 58: 5337-9. 6. Miyake K., et al. (1999) Cancer Res. 59: 8-13. 7. Robey R.W., et al. (2001) Clin Cancer Res. 7: 145-52. Zhou S., et al. (2001) Nat. Medicine. 7: 1028.
ABCG2 (BCRP1/ABCP/MXR) is a member of the ATP-binding cassette transporter family that functions as ATP-dependent transporters for a wide variety of chemical compounds and are associated with drug-resistance in cancer cells. ABCG2 is a heavily glycosylated transmembrane protein with six transmembrane spanning regions consistent with it functioning as a half-transporter. The ABC family can exist as either full-length transporters or as half-transporters that form functional transporters through homo- or heterodimerization. Originally thought to play a role in drug resistance due to its resistance to a number of chemotherapeutic drugs, ABCG2 has also been found in the kidney, and stem cell populations. Studies also suggest that it can be used as a cell surface marker to identify hematopoietic stem cells within the bone marrow fraction of lineage negative cells. The expression of ABCG2 appears greatest on CD34- cells and is downregulated with the acquisition of CD34 on the cell surface.
WB (1:2000), IHC (1:200); optimal dilutions for assays should be determined by the user.
Target:
ABCG2
Conjugate:
ATTO 633
Research Area(s):
Tags and Cell Markers | Cell Signaling | Metabolism | Stem Cells | Hematopoietic Progenitors | HP Surface Molecules | Stem Cells | Neural Stem Cells | Cell Signaling | Metabolism | Cancer | Cancer Metabolism | Cell Signaling | Metabolism | Drug Metabolism
Alternative Name(s):
ABC transporter antibody ABC15 antibody ABCG 2 antibody ABCG2 antibody ABCG2_HUMAN antibody ABCP antibody ATP binding cassette sub family G (WHITE) member 2 antibody ATP binding cassette transporter G2 antibody ATP-binding cassette sub-family G member 2 antibody BCRP antibody BCRP1 antibody BMDP antibody Breast cancer resistance protein antibody CD338 antibody CDw338 antibody CDw338 antigen antibody EST157481 antibody GOUT1 antibody MGC102821 antibody Mitoxantrone resistance associated protein antibody Mitoxantrone resistance-associated protein antibody MRX antibody Multi drug resistance efflux transport ATP binding cassette sub family G (WHITE) member 2 antibody MXR antibody MXR1 antibody Placenta specific ATP binding cassette transporter antibody Placenta specific MDR protein antibody Placenta-specific ATP-binding cassette transporter antibody UAQTL1 antibody
Category:
Polyclonal
Immunogen Species:
Human
Accession Number:
NP_004818.2
Gene ID:
9429
Swiss-Prot:
Q9UNQ0
Species Reactivity Full Name:
Human
Purification:
Peptide Affinity Purified
Specificity:
Detects endogenous levels of total ABCG2
Certificate of Analysis:
A 1:1000 dilution of SPC-1317 was sufficient for detection of ABCG2 in 10 µg of mouse kidney cell lyates by ECL immunoblot analysis using Goat Anti-Rabbit IgG:HRP as the secondary antibody.
Cellular Localization:
Cell Membrane | Mitochondrion Membrane
References:
1. Zhou S., et al. (2001) Nat. Medicine. 7: 1028. 2. Doyle L.A. and Ross D.D. (2003) Oncogene. 22: 7340-58. 3. Allen J.D. et al. (1999) Cancer Res. 59: 4237-41. 4. Doyle L.A., et al. (1998) Proc Natl Acad Sci USA. 95: 15665-70. 5. Allikmets R., et al. (1998) Cancer Res. 58: 5337-9. 6. Miyake K., et al. (1999) Cancer Res. 59: 8-13. 7. Robey R.W., et al. (2001) Clin Cancer Res. 7: 145-52. Zhou S., et al. (2001) Nat. Medicine. 7: 1028.
ABCG2 (BCRP1/ABCP/MXR) is a member of the ATP-binding cassette transporter family that functions as ATP-dependent transporters for a wide variety of chemical compounds and are associated with drug-resistance in cancer cells. ABCG2 is a heavily glycosylated transmembrane protein with six transmembrane spanning regions consistent with it functioning as a half-transporter. The ABC family can exist as either full-length transporters or as half-transporters that form functional transporters through homo- or heterodimerization. Originally thought to play a role in drug resistance due to its resistance to a number of chemotherapeutic drugs, ABCG2 has also been found in the kidney, and stem cell populations. Studies also suggest that it can be used as a cell surface marker to identify hematopoietic stem cells within the bone marrow fraction of lineage negative cells. The expression of ABCG2 appears greatest on CD34- cells and is downregulated with the acquisition of CD34 on the cell surface.
WB (1:2000), IHC (1:200); optimal dilutions for assays should be determined by the user.
Target:
ABCG2
Conjugate:
ATTO 655
Research Area(s):
Tags and Cell Markers | Cell Signaling | Metabolism | Stem Cells | Hematopoietic Progenitors | HP Surface Molecules | Stem Cells | Neural Stem Cells | Cell Signaling | Metabolism | Cancer | Cancer Metabolism | Cell Signaling | Metabolism | Drug Metabolism
Alternative Name(s):
ABC transporter antibody ABC15 antibody ABCG 2 antibody ABCG2 antibody ABCG2_HUMAN antibody ABCP antibody ATP binding cassette sub family G (WHITE) member 2 antibody ATP binding cassette transporter G2 antibody ATP-binding cassette sub-family G member 2 antibody BCRP antibody BCRP1 antibody BMDP antibody Breast cancer resistance protein antibody CD338 antibody CDw338 antibody CDw338 antigen antibody EST157481 antibody GOUT1 antibody MGC102821 antibody Mitoxantrone resistance associated protein antibody Mitoxantrone resistance-associated protein antibody MRX antibody Multi drug resistance efflux transport ATP binding cassette sub family G (WHITE) member 2 antibody MXR antibody MXR1 antibody Placenta specific ATP binding cassette transporter antibody Placenta specific MDR protein antibody Placenta-specific ATP-binding cassette transporter antibody UAQTL1 antibody
Category:
Polyclonal
Immunogen Species:
Human
Accession Number:
NP_004818.2
Gene ID:
9429
Swiss-Prot:
Q9UNQ0
Species Reactivity Full Name:
Human
Purification:
Peptide Affinity Purified
Specificity:
Detects endogenous levels of total ABCG2
Certificate of Analysis:
A 1:1000 dilution of SPC-1317 was sufficient for detection of ABCG2 in 10 µg of mouse kidney cell lyates by ECL immunoblot analysis using Goat Anti-Rabbit IgG:HRP as the secondary antibody.
Cellular Localization:
Cell Membrane | Mitochondrion Membrane
References:
1. Zhou S., et al. (2001) Nat. Medicine. 7: 1028. 2. Doyle L.A. and Ross D.D. (2003) Oncogene. 22: 7340-58. 3. Allen J.D. et al. (1999) Cancer Res. 59: 4237-41. 4. Doyle L.A., et al. (1998) Proc Natl Acad Sci USA. 95: 15665-70. 5. Allikmets R., et al. (1998) Cancer Res. 58: 5337-9. 6. Miyake K., et al. (1999) Cancer Res. 59: 8-13. 7. Robey R.W., et al. (2001) Clin Cancer Res. 7: 145-52. Zhou S., et al. (2001) Nat. Medicine. 7: 1028.
ABCG2 (BCRP1/ABCP/MXR) is a member of the ATP-binding cassette transporter family that functions as ATP-dependent transporters for a wide variety of chemical compounds and are associated with drug-resistance in cancer cells. ABCG2 is a heavily glycosylated transmembrane protein with six transmembrane spanning regions consistent with it functioning as a half-transporter. The ABC family can exist as either full-length transporters or as half-transporters that form functional transporters through homo- or heterodimerization. Originally thought to play a role in drug resistance due to its resistance to a number of chemotherapeutic drugs, ABCG2 has also been found in the kidney, and stem cell populations. Studies also suggest that it can be used as a cell surface marker to identify hematopoietic stem cells within the bone marrow fraction of lineage negative cells. The expression of ABCG2 appears greatest on CD34- cells and is downregulated with the acquisition of CD34 on the cell surface.
WB (1:2000), IHC (1:200); optimal dilutions for assays should be determined by the user.
Target:
ABCG2
Conjugate:
ATTO 680
Research Area(s):
Tags and Cell Markers | Cell Signaling | Metabolism | Stem Cells | Hematopoietic Progenitors | HP Surface Molecules | Stem Cells | Neural Stem Cells | Cell Signaling | Metabolism | Cancer | Cancer Metabolism | Cell Signaling | Metabolism | Drug Metabolism
Alternative Name(s):
ABC transporter antibody ABC15 antibody ABCG 2 antibody ABCG2 antibody ABCG2_HUMAN antibody ABCP antibody ATP binding cassette sub family G (WHITE) member 2 antibody ATP binding cassette transporter G2 antibody ATP-binding cassette sub-family G member 2 antibody BCRP antibody BCRP1 antibody BMDP antibody Breast cancer resistance protein antibody CD338 antibody CDw338 antibody CDw338 antigen antibody EST157481 antibody GOUT1 antibody MGC102821 antibody Mitoxantrone resistance associated protein antibody Mitoxantrone resistance-associated protein antibody MRX antibody Multi drug resistance efflux transport ATP binding cassette sub family G (WHITE) member 2 antibody MXR antibody MXR1 antibody Placenta specific ATP binding cassette transporter antibody Placenta specific MDR protein antibody Placenta-specific ATP-binding cassette transporter antibody UAQTL1 antibody
Category:
Polyclonal
Immunogen Species:
Human
Accession Number:
NP_004818.2
Gene ID:
9429
Swiss-Prot:
Q9UNQ0
Species Reactivity Full Name:
Human
Purification:
Peptide Affinity Purified
Specificity:
Detects endogenous levels of total ABCG2
Certificate of Analysis:
A 1:1000 dilution of SPC-1317 was sufficient for detection of ABCG2 in 10 µg of mouse kidney cell lyates by ECL immunoblot analysis using Goat Anti-Rabbit IgG:HRP as the secondary antibody.
Cellular Localization:
Cell Membrane | Mitochondrion Membrane
References:
1. Zhou S., et al. (2001) Nat. Medicine. 7: 1028. 2. Doyle L.A. and Ross D.D. (2003) Oncogene. 22: 7340-58. 3. Allen J.D. et al. (1999) Cancer Res. 59: 4237-41. 4. Doyle L.A., et al. (1998) Proc Natl Acad Sci USA. 95: 15665-70. 5. Allikmets R., et al. (1998) Cancer Res. 58: 5337-9. 6. Miyake K., et al. (1999) Cancer Res. 59: 8-13. 7. Robey R.W., et al. (2001) Clin Cancer Res. 7: 145-52. Zhou S., et al. (2001) Nat. Medicine. 7: 1028.
ABCG2 (BCRP1/ABCP/MXR) is a member of the ATP-binding cassette transporter family that functions as ATP-dependent transporters for a wide variety of chemical compounds and are associated with drug-resistance in cancer cells. ABCG2 is a heavily glycosylated transmembrane protein with six transmembrane spanning regions consistent with it functioning as a half-transporter. The ABC family can exist as either full-length transporters or as half-transporters that form functional transporters through homo- or heterodimerization. Originally thought to play a role in drug resistance due to its resistance to a number of chemotherapeutic drugs, ABCG2 has also been found in the kidney, and stem cell populations. Studies also suggest that it can be used as a cell surface marker to identify hematopoietic stem cells within the bone marrow fraction of lineage negative cells. The expression of ABCG2 appears greatest on CD34- cells and is downregulated with the acquisition of CD34 on the cell surface.
WB (1:2000), IHC (1:200); optimal dilutions for assays should be determined by the user.
Target:
ABCG2
Conjugate:
ATTO 700
Research Area(s):
Tags and Cell Markers | Cell Signaling | Metabolism | Stem Cells | Hematopoietic Progenitors | HP Surface Molecules | Stem Cells | Neural Stem Cells | Cell Signaling | Metabolism | Cancer | Cancer Metabolism | Cell Signaling | Metabolism | Drug Metabolism
Alternative Name(s):
ABC transporter antibody ABC15 antibody ABCG 2 antibody ABCG2 antibody ABCG2_HUMAN antibody ABCP antibody ATP binding cassette sub family G (WHITE) member 2 antibody ATP binding cassette transporter G2 antibody ATP-binding cassette sub-family G member 2 antibody BCRP antibody BCRP1 antibody BMDP antibody Breast cancer resistance protein antibody CD338 antibody CDw338 antibody CDw338 antigen antibody EST157481 antibody GOUT1 antibody MGC102821 antibody Mitoxantrone resistance associated protein antibody Mitoxantrone resistance-associated protein antibody MRX antibody Multi drug resistance efflux transport ATP binding cassette sub family G (WHITE) member 2 antibody MXR antibody MXR1 antibody Placenta specific ATP binding cassette transporter antibody Placenta specific MDR protein antibody Placenta-specific ATP-binding cassette transporter antibody UAQTL1 antibody
Category:
Polyclonal
Immunogen Species:
Human
Accession Number:
NP_004818.2
Gene ID:
9429
Swiss-Prot:
Q9UNQ0
Species Reactivity Full Name:
Human
Purification:
Peptide Affinity Purified
Specificity:
Detects endogenous levels of total ABCG2
Certificate of Analysis:
A 1:1000 dilution of SPC-1317 was sufficient for detection of ABCG2 in 10 µg of mouse kidney cell lyates by ECL immunoblot analysis using Goat Anti-Rabbit IgG:HRP as the secondary antibody.
Cellular Localization:
Cell Membrane | Mitochondrion Membrane
References:
1. Zhou S., et al. (2001) Nat. Medicine. 7: 1028. 2. Doyle L.A. and Ross D.D. (2003) Oncogene. 22: 7340-58. 3. Allen J.D. et al. (1999) Cancer Res. 59: 4237-41. 4. Doyle L.A., et al. (1998) Proc Natl Acad Sci USA. 95: 15665-70. 5. Allikmets R., et al. (1998) Cancer Res. 58: 5337-9. 6. Miyake K., et al. (1999) Cancer Res. 59: 8-13. 7. Robey R.W., et al. (2001) Clin Cancer Res. 7: 145-52. Zhou S., et al. (2001) Nat. Medicine. 7: 1028.
ABCG2 (BCRP1/ABCP/MXR) is a member of the ATP-binding cassette transporter family that functions as ATP-dependent transporters for a wide variety of chemical compounds and are associated with drug-resistance in cancer cells. ABCG2 is a heavily glycosylated transmembrane protein with six transmembrane spanning regions consistent with it functioning as a half-transporter. The ABC family can exist as either full-length transporters or as half-transporters that form functional transporters through homo- or heterodimerization. Originally thought to play a role in drug resistance due to its resistance to a number of chemotherapeutic drugs, ABCG2 has also been found in the kidney, and stem cell populations. Studies also suggest that it can be used as a cell surface marker to identify hematopoietic stem cells within the bone marrow fraction of lineage negative cells. The expression of ABCG2 appears greatest on CD34- cells and is downregulated with the acquisition of CD34 on the cell surface.
WB (1:2000), IHC (1:200); optimal dilutions for assays should be determined by the user.
Target:
ABCG2
Conjugate:
Alkaline Phosphatase
Research Area(s):
Tags and Cell Markers | Cell Signaling | Metabolism | Stem Cells | Hematopoietic Progenitors | HP Surface Molecules | Stem Cells | Neural Stem Cells | Cell Signaling | Metabolism | Cancer | Cancer Metabolism | Cell Signaling | Metabolism | Drug Metabolism
Alternative Name(s):
ABC transporter antibody ABC15 antibody ABCG 2 antibody ABCG2 antibody ABCG2_HUMAN antibody ABCP antibody ATP binding cassette sub family G (WHITE) member 2 antibody ATP binding cassette transporter G2 antibody ATP-binding cassette sub-family G member 2 antibody BCRP antibody BCRP1 antibody BMDP antibody Breast cancer resistance protein antibody CD338 antibody CDw338 antibody CDw338 antigen antibody EST157481 antibody GOUT1 antibody MGC102821 antibody Mitoxantrone resistance associated protein antibody Mitoxantrone resistance-associated protein antibody MRX antibody Multi drug resistance efflux transport ATP binding cassette sub family G (WHITE) member 2 antibody MXR antibody MXR1 antibody Placenta specific ATP binding cassette transporter antibody Placenta specific MDR protein antibody Placenta-specific ATP-binding cassette transporter antibody UAQTL1 antibody
Category:
Polyclonal
Immunogen Species:
Human
Accession Number:
NP_004818.2
Gene ID:
9429
Swiss-Prot:
Q9UNQ0
Species Reactivity Full Name:
Human
Purification:
Peptide Affinity Purified
Specificity:
Detects endogenous levels of total ABCG2
Certificate of Analysis:
A 1:1000 dilution of SPC-1317 was sufficient for detection of ABCG2 in 10 µg of mouse kidney cell lyates by ECL immunoblot analysis using Goat Anti-Rabbit IgG:HRP as the secondary antibody.
Cellular Localization:
Cell Membrane | Mitochondrion Membrane
References:
1. Zhou S., et al. (2001) Nat. Medicine. 7: 1028. 2. Doyle L.A. and Ross D.D. (2003) Oncogene. 22: 7340-58. 3. Allen J.D. et al. (1999) Cancer Res. 59: 4237-41. 4. Doyle L.A., et al. (1998) Proc Natl Acad Sci USA. 95: 15665-70. 5. Allikmets R., et al. (1998) Cancer Res. 58: 5337-9. 6. Miyake K., et al. (1999) Cancer Res. 59: 8-13. 7. Robey R.W., et al. (2001) Clin Cancer Res. 7: 145-52. Zhou S., et al. (2001) Nat. Medicine. 7: 1028.
ABCG2 (BCRP1/ABCP/MXR) is a member of the ATP-binding cassette transporter family that functions as ATP-dependent transporters for a wide variety of chemical compounds and are associated with drug-resistance in cancer cells. ABCG2 is a heavily glycosylated transmembrane protein with six transmembrane spanning regions consistent with it functioning as a half-transporter. The ABC family can exist as either full-length transporters or as half-transporters that form functional transporters through homo- or heterodimerization. Originally thought to play a role in drug resistance due to its resistance to a number of chemotherapeutic drugs, ABCG2 has also been found in the kidney, and stem cell populations. Studies also suggest that it can be used as a cell surface marker to identify hematopoietic stem cells within the bone marrow fraction of lineage negative cells. The expression of ABCG2 appears greatest on CD34- cells and is downregulated with the acquisition of CD34 on the cell surface.
WB (1:2000), IHC (1:200); optimal dilutions for assays should be determined by the user.
Target:
ABCG2
Conjugate:
APC
Research Area(s):
Tags and Cell Markers | Cell Signaling | Metabolism | Stem Cells | Hematopoietic Progenitors | HP Surface Molecules | Stem Cells | Neural Stem Cells | Cell Signaling | Metabolism | Cancer | Cancer Metabolism | Cell Signaling | Metabolism | Drug Metabolism
Alternative Name(s):
ABC transporter antibody ABC15 antibody ABCG 2 antibody ABCG2 antibody ABCG2_HUMAN antibody ABCP antibody ATP binding cassette sub family G (WHITE) member 2 antibody ATP binding cassette transporter G2 antibody ATP-binding cassette sub-family G member 2 antibody BCRP antibody BCRP1 antibody BMDP antibody Breast cancer resistance protein antibody CD338 antibody CDw338 antibody CDw338 antigen antibody EST157481 antibody GOUT1 antibody MGC102821 antibody Mitoxantrone resistance associated protein antibody Mitoxantrone resistance-associated protein antibody MRX antibody Multi drug resistance efflux transport ATP binding cassette sub family G (WHITE) member 2 antibody MXR antibody MXR1 antibody Placenta specific ATP binding cassette transporter antibody Placenta specific MDR protein antibody Placenta-specific ATP-binding cassette transporter antibody UAQTL1 antibody
Category:
Polyclonal
Immunogen Species:
Human
Accession Number:
NP_004818.2
Gene ID:
9429
Swiss-Prot:
Q9UNQ0
Species Reactivity Full Name:
Human
Purification:
Peptide Affinity Purified
Specificity:
Detects endogenous levels of total ABCG2
Certificate of Analysis:
A 1:1000 dilution of SPC-1317 was sufficient for detection of ABCG2 in 10 µg of mouse kidney cell lyates by ECL immunoblot analysis using Goat Anti-Rabbit IgG:HRP as the secondary antibody.
Cellular Localization:
Cell Membrane | Mitochondrion Membrane
References:
1. Zhou S., et al. (2001) Nat. Medicine. 7: 1028. 2. Doyle L.A. and Ross D.D. (2003) Oncogene. 22: 7340-58. 3. Allen J.D. et al. (1999) Cancer Res. 59: 4237-41. 4. Doyle L.A., et al. (1998) Proc Natl Acad Sci USA. 95: 15665-70. 5. Allikmets R., et al. (1998) Cancer Res. 58: 5337-9. 6. Miyake K., et al. (1999) Cancer Res. 59: 8-13. 7. Robey R.W., et al. (2001) Clin Cancer Res. 7: 145-52. Zhou S., et al. (2001) Nat. Medicine. 7: 1028.
ABCG2 (BCRP1/ABCP/MXR) is a member of the ATP-binding cassette transporter family that functions as ATP-dependent transporters for a wide variety of chemical compounds and are associated with drug-resistance in cancer cells. ABCG2 is a heavily glycosylated transmembrane protein with six transmembrane spanning regions consistent with it functioning as a half-transporter. The ABC family can exist as either full-length transporters or as half-transporters that form functional transporters through homo- or heterodimerization. Originally thought to play a role in drug resistance due to its resistance to a number of chemotherapeutic drugs, ABCG2 has also been found in the kidney, and stem cell populations. Studies also suggest that it can be used as a cell surface marker to identify hematopoietic stem cells within the bone marrow fraction of lineage negative cells. The expression of ABCG2 appears greatest on CD34- cells and is downregulated with the acquisition of CD34 on the cell surface.
WB (1:2000), IHC (1:200); optimal dilutions for assays should be determined by the user.
Target:
ABCG2
Conjugate:
Biotin
Research Area(s):
Tags and Cell Markers | Cell Signaling | Metabolism | Stem Cells | Hematopoietic Progenitors | HP Surface Molecules | Stem Cells | Neural Stem Cells | Cell Signaling | Metabolism | Cancer | Cancer Metabolism | Cell Signaling | Metabolism | Drug Metabolism
Alternative Name(s):
ABC transporter antibody ABC15 antibody ABCG 2 antibody ABCG2 antibody ABCG2_HUMAN antibody ABCP antibody ATP binding cassette sub family G (WHITE) member 2 antibody ATP binding cassette transporter G2 antibody ATP-binding cassette sub-family G member 2 antibody BCRP antibody BCRP1 antibody BMDP antibody Breast cancer resistance protein antibody CD338 antibody CDw338 antibody CDw338 antigen antibody EST157481 antibody GOUT1 antibody MGC102821 antibody Mitoxantrone resistance associated protein antibody Mitoxantrone resistance-associated protein antibody MRX antibody Multi drug resistance efflux transport ATP binding cassette sub family G (WHITE) member 2 antibody MXR antibody MXR1 antibody Placenta specific ATP binding cassette transporter antibody Placenta specific MDR protein antibody Placenta-specific ATP-binding cassette transporter antibody UAQTL1 antibody
Category:
Polyclonal
Immunogen Species:
Human
Accession Number:
NP_004818.2
Gene ID:
9429
Swiss-Prot:
Q9UNQ0
Species Reactivity Full Name:
Human
Purification:
Peptide Affinity Purified
Specificity:
Detects endogenous levels of total ABCG2
Certificate of Analysis:
A 1:1000 dilution of SPC-1317 was sufficient for detection of ABCG2 in 10 µg of mouse kidney cell lyates by ECL immunoblot analysis using Goat Anti-Rabbit IgG:HRP as the secondary antibody.
Cellular Localization:
Cell Membrane | Mitochondrion Membrane
References:
1. Zhou S., et al. (2001) Nat. Medicine. 7: 1028. 2. Doyle L.A. and Ross D.D. (2003) Oncogene. 22: 7340-58. 3. Allen J.D. et al. (1999) Cancer Res. 59: 4237-41. 4. Doyle L.A., et al. (1998) Proc Natl Acad Sci USA. 95: 15665-70. 5. Allikmets R., et al. (1998) Cancer Res. 58: 5337-9. 6. Miyake K., et al. (1999) Cancer Res. 59: 8-13. 7. Robey R.W., et al. (2001) Clin Cancer Res. 7: 145-52. Zhou S., et al. (2001) Nat. Medicine. 7: 1028.
ABCG2 (BCRP1/ABCP/MXR) is a member of the ATP-binding cassette transporter family that functions as ATP-dependent transporters for a wide variety of chemical compounds and are associated with drug-resistance in cancer cells. ABCG2 is a heavily glycosylated transmembrane protein with six transmembrane spanning regions consistent with it functioning as a half-transporter. The ABC family can exist as either full-length transporters or as half-transporters that form functional transporters through homo- or heterodimerization. Originally thought to play a role in drug resistance due to its resistance to a number of chemotherapeutic drugs, ABCG2 has also been found in the kidney, and stem cell populations. Studies also suggest that it can be used as a cell surface marker to identify hematopoietic stem cells within the bone marrow fraction of lineage negative cells. The expression of ABCG2 appears greatest on CD34- cells and is downregulated with the acquisition of CD34 on the cell surface.
WB (1:2000), IHC (1:200); optimal dilutions for assays should be determined by the user.
Target:
ABCG2
Conjugate:
FITC
Research Area(s):
Tags and Cell Markers | Cell Signaling | Metabolism | Stem Cells | Hematopoietic Progenitors | HP Surface Molecules | Stem Cells | Neural Stem Cells | Cell Signaling | Metabolism | Cancer | Cancer Metabolism | Cell Signaling | Metabolism | Drug Metabolism
Alternative Name(s):
ABC transporter antibody ABC15 antibody ABCG 2 antibody ABCG2 antibody ABCG2_HUMAN antibody ABCP antibody ATP binding cassette sub family G (WHITE) member 2 antibody ATP binding cassette transporter G2 antibody ATP-binding cassette sub-family G member 2 antibody BCRP antibody BCRP1 antibody BMDP antibody Breast cancer resistance protein antibody CD338 antibody CDw338 antibody CDw338 antigen antibody EST157481 antibody GOUT1 antibody MGC102821 antibody Mitoxantrone resistance associated protein antibody Mitoxantrone resistance-associated protein antibody MRX antibody Multi drug resistance efflux transport ATP binding cassette sub family G (WHITE) member 2 antibody MXR antibody MXR1 antibody Placenta specific ATP binding cassette transporter antibody Placenta specific MDR protein antibody Placenta-specific ATP-binding cassette transporter antibody UAQTL1 antibody
Category:
Polyclonal
Immunogen Species:
Human
Accession Number:
NP_004818.2
Gene ID:
9429
Swiss-Prot:
Q9UNQ0
Species Reactivity Full Name:
Human
Purification:
Peptide Affinity Purified
Specificity:
Detects endogenous levels of total ABCG2
Certificate of Analysis:
A 1:1000 dilution of SPC-1317 was sufficient for detection of ABCG2 in 10 µg of mouse kidney cell lyates by ECL immunoblot analysis using Goat Anti-Rabbit IgG:HRP as the secondary antibody.
Cellular Localization:
Cell Membrane | Mitochondrion Membrane
References:
1. Zhou S., et al. (2001) Nat. Medicine. 7: 1028. 2. Doyle L.A. and Ross D.D. (2003) Oncogene. 22: 7340-58. 3. Allen J.D. et al. (1999) Cancer Res. 59: 4237-41. 4. Doyle L.A., et al. (1998) Proc Natl Acad Sci USA. 95: 15665-70. 5. Allikmets R., et al. (1998) Cancer Res. 58: 5337-9. 6. Miyake K., et al. (1999) Cancer Res. 59: 8-13. 7. Robey R.W., et al. (2001) Clin Cancer Res. 7: 145-52. Zhou S., et al. (2001) Nat. Medicine. 7: 1028.
ABCG2 (BCRP1/ABCP/MXR) is a member of the ATP-binding cassette transporter family that functions as ATP-dependent transporters for a wide variety of chemical compounds and are associated with drug-resistance in cancer cells. ABCG2 is a heavily glycosylated transmembrane protein with six transmembrane spanning regions consistent with it functioning as a half-transporter. The ABC family can exist as either full-length transporters or as half-transporters that form functional transporters through homo- or heterodimerization. Originally thought to play a role in drug resistance due to its resistance to a number of chemotherapeutic drugs, ABCG2 has also been found in the kidney, and stem cell populations. Studies also suggest that it can be used as a cell surface marker to identify hematopoietic stem cells within the bone marrow fraction of lineage negative cells. The expression of ABCG2 appears greatest on CD34- cells and is downregulated with the acquisition of CD34 on the cell surface.
WB (1:2000), IHC (1:200); optimal dilutions for assays should be determined by the user.
Target:
ABCG2
Conjugate:
HRP
Research Area(s):
Tags and Cell Markers | Cell Signaling | Metabolism | Stem Cells | Hematopoietic Progenitors | HP Surface Molecules | Stem Cells | Neural Stem Cells | Cell Signaling | Metabolism | Cancer | Cancer Metabolism | Cell Signaling | Metabolism | Drug Metabolism
Alternative Name(s):
ABC transporter antibody ABC15 antibody ABCG 2 antibody ABCG2 antibody ABCG2_HUMAN antibody ABCP antibody ATP binding cassette sub family G (WHITE) member 2 antibody ATP binding cassette transporter G2 antibody ATP-binding cassette sub-family G member 2 antibody BCRP antibody BCRP1 antibody BMDP antibody Breast cancer resistance protein antibody CD338 antibody CDw338 antibody CDw338 antigen antibody EST157481 antibody GOUT1 antibody MGC102821 antibody Mitoxantrone resistance associated protein antibody Mitoxantrone resistance-associated protein antibody MRX antibody Multi drug resistance efflux transport ATP binding cassette sub family G (WHITE) member 2 antibody MXR antibody MXR1 antibody Placenta specific ATP binding cassette transporter antibody Placenta specific MDR protein antibody Placenta-specific ATP-binding cassette transporter antibody UAQTL1 antibody
Category:
Polyclonal
Immunogen Species:
Human
Accession Number:
NP_004818.2
Gene ID:
9429
Swiss-Prot:
Q9UNQ0
Species Reactivity Full Name:
Human
Purification:
Peptide Affinity Purified
Specificity:
Detects endogenous levels of total ABCG2
Certificate of Analysis:
A 1:1000 dilution of SPC-1317 was sufficient for detection of ABCG2 in 10 µg of mouse kidney cell lyates by ECL immunoblot analysis using Goat Anti-Rabbit IgG:HRP as the secondary antibody.
Cellular Localization:
Cell Membrane | Mitochondrion Membrane
References:
1. Zhou S., et al. (2001) Nat. Medicine. 7: 1028. 2. Doyle L.A. and Ross D.D. (2003) Oncogene. 22: 7340-58. 3. Allen J.D. et al. (1999) Cancer Res. 59: 4237-41. 4. Doyle L.A., et al. (1998) Proc Natl Acad Sci USA. 95: 15665-70. 5. Allikmets R., et al. (1998) Cancer Res. 58: 5337-9. 6. Miyake K., et al. (1999) Cancer Res. 59: 8-13. 7. Robey R.W., et al. (2001) Clin Cancer Res. 7: 145-52. Zhou S., et al. (2001) Nat. Medicine. 7: 1028.
ABCG2 (BCRP1/ABCP/MXR) is a member of the ATP-binding cassette transporter family that functions as ATP-dependent transporters for a wide variety of chemical compounds and are associated with drug-resistance in cancer cells. ABCG2 is a heavily glycosylated transmembrane protein with six transmembrane spanning regions consistent with it functioning as a half-transporter. The ABC family can exist as either full-length transporters or as half-transporters that form functional transporters through homo- or heterodimerization. Originally thought to play a role in drug resistance due to its resistance to a number of chemotherapeutic drugs, ABCG2 has also been found in the kidney, and stem cell populations. Studies also suggest that it can be used as a cell surface marker to identify hematopoietic stem cells within the bone marrow fraction of lineage negative cells. The expression of ABCG2 appears greatest on CD34- cells and is downregulated with the acquisition of CD34 on the cell surface.
WB (1:2000), IHC (1:200); optimal dilutions for assays should be determined by the user.
Target:
ABCG2
Conjugate:
PE/ATTO 594
Research Area(s):
Tags and Cell Markers | Cell Signaling | Metabolism | Stem Cells | Hematopoietic Progenitors | HP Surface Molecules | Stem Cells | Neural Stem Cells | Cell Signaling | Metabolism | Cancer | Cancer Metabolism | Cell Signaling | Metabolism | Drug Metabolism
Alternative Name(s):
ABC transporter antibody ABC15 antibody ABCG 2 antibody ABCG2 antibody ABCG2_HUMAN antibody ABCP antibody ATP binding cassette sub family G (WHITE) member 2 antibody ATP binding cassette transporter G2 antibody ATP-binding cassette sub-family G member 2 antibody BCRP antibody BCRP1 antibody BMDP antibody Breast cancer resistance protein antibody CD338 antibody CDw338 antibody CDw338 antigen antibody EST157481 antibody GOUT1 antibody MGC102821 antibody Mitoxantrone resistance associated protein antibody Mitoxantrone resistance-associated protein antibody MRX antibody Multi drug resistance efflux transport ATP binding cassette sub family G (WHITE) member 2 antibody MXR antibody MXR1 antibody Placenta specific ATP binding cassette transporter antibody Placenta specific MDR protein antibody Placenta-specific ATP-binding cassette transporter antibody UAQTL1 antibody
Category:
Polyclonal
Immunogen Species:
Human
Accession Number:
NP_004818.2
Gene ID:
9429
Swiss-Prot:
Q9UNQ0
Species Reactivity Full Name:
Human
Purification:
Peptide Affinity Purified
Specificity:
Detects endogenous levels of total ABCG2
Certificate of Analysis:
A 1:1000 dilution of SPC-1317 was sufficient for detection of ABCG2 in 10 µg of mouse kidney cell lyates by ECL immunoblot analysis using Goat Anti-Rabbit IgG:HRP as the secondary antibody.
Cellular Localization:
Cell Membrane | Mitochondrion Membrane
References:
1. Zhou S., et al. (2001) Nat. Medicine. 7: 1028. 2. Doyle L.A. and Ross D.D. (2003) Oncogene. 22: 7340-58. 3. Allen J.D. et al. (1999) Cancer Res. 59: 4237-41. 4. Doyle L.A., et al. (1998) Proc Natl Acad Sci USA. 95: 15665-70. 5. Allikmets R., et al. (1998) Cancer Res. 58: 5337-9. 6. Miyake K., et al. (1999) Cancer Res. 59: 8-13. 7. Robey R.W., et al. (2001) Clin Cancer Res. 7: 145-52. Zhou S., et al. (2001) Nat. Medicine. 7: 1028.
ABCG2 (BCRP1/ABCP/MXR) is a member of the ATP-binding cassette transporter family that functions as ATP-dependent transporters for a wide variety of chemical compounds and are associated with drug-resistance in cancer cells. ABCG2 is a heavily glycosylated transmembrane protein with six transmembrane spanning regions consistent with it functioning as a half-transporter. The ABC family can exist as either full-length transporters or as half-transporters that form functional transporters through homo- or heterodimerization. Originally thought to play a role in drug resistance due to its resistance to a number of chemotherapeutic drugs, ABCG2 has also been found in the kidney, and stem cell populations. Studies also suggest that it can be used as a cell surface marker to identify hematopoietic stem cells within the bone marrow fraction of lineage negative cells. The expression of ABCG2 appears greatest on CD34- cells and is downregulated with the acquisition of CD34 on the cell surface.
WB (1:2000), IHC (1:200); optimal dilutions for assays should be determined by the user.
Target:
ABCG2
Conjugate:
PerCP
Research Area(s):
Tags and Cell Markers | Cell Signaling | Metabolism | Stem Cells | Hematopoietic Progenitors | HP Surface Molecules | Stem Cells | Neural Stem Cells | Cell Signaling | Metabolism | Cancer | Cancer Metabolism | Cell Signaling | Metabolism | Drug Metabolism
Alternative Name(s):
ABC transporter antibody ABC15 antibody ABCG 2 antibody ABCG2 antibody ABCG2_HUMAN antibody ABCP antibody ATP binding cassette sub family G (WHITE) member 2 antibody ATP binding cassette transporter G2 antibody ATP-binding cassette sub-family G member 2 antibody BCRP antibody BCRP1 antibody BMDP antibody Breast cancer resistance protein antibody CD338 antibody CDw338 antibody CDw338 antigen antibody EST157481 antibody GOUT1 antibody MGC102821 antibody Mitoxantrone resistance associated protein antibody Mitoxantrone resistance-associated protein antibody MRX antibody Multi drug resistance efflux transport ATP binding cassette sub family G (WHITE) member 2 antibody MXR antibody MXR1 antibody Placenta specific ATP binding cassette transporter antibody Placenta specific MDR protein antibody Placenta-specific ATP-binding cassette transporter antibody UAQTL1 antibody
Category:
Polyclonal
Immunogen Species:
Human
Accession Number:
NP_004818.2
Gene ID:
9429
Swiss-Prot:
Q9UNQ0
Species Reactivity Full Name:
Human
Purification:
Peptide Affinity Purified
Specificity:
Detects endogenous levels of total ABCG2
Certificate of Analysis:
A 1:1000 dilution of SPC-1317 was sufficient for detection of ABCG2 in 10 µg of mouse kidney cell lyates by ECL immunoblot analysis using Goat Anti-Rabbit IgG:HRP as the secondary antibody.
Cellular Localization:
Cell Membrane | Mitochondrion Membrane
References:
1. Zhou S., et al. (2001) Nat. Medicine. 7: 1028. 2. Doyle L.A. and Ross D.D. (2003) Oncogene. 22: 7340-58. 3. Allen J.D. et al. (1999) Cancer Res. 59: 4237-41. 4. Doyle L.A., et al. (1998) Proc Natl Acad Sci USA. 95: 15665-70. 5. Allikmets R., et al. (1998) Cancer Res. 58: 5337-9. 6. Miyake K., et al. (1999) Cancer Res. 59: 8-13. 7. Robey R.W., et al. (2001) Clin Cancer Res. 7: 145-52. Zhou S., et al. (2001) Nat. Medicine. 7: 1028.
ABCG2 (BCRP1/ABCP/MXR) is a member of the ATP-binding cassette transporter family that functions as ATP-dependent transporters for a wide variety of chemical compounds and are associated with drug-resistance in cancer cells. ABCG2 is a heavily glycosylated transmembrane protein with six transmembrane spanning regions consistent with it functioning as a half-transporter. The ABC family can exist as either full-length transporters or as half-transporters that form functional transporters through homo- or heterodimerization. Originally thought to play a role in drug resistance due to its resistance to a number of chemotherapeutic drugs, ABCG2 has also been found in the kidney, and stem cell populations. Studies also suggest that it can be used as a cell surface marker to identify hematopoietic stem cells within the bone marrow fraction of lineage negative cells. The expression of ABCG2 appears greatest on CD34- cells and is downregulated with the acquisition of CD34 on the cell surface.
WB (1:2000), IHC (1:200); optimal dilutions for assays should be determined by the user.
Target:
ABCG2
Conjugate:
RPE
Research Area(s):
Tags and Cell Markers | Cell Signaling | Metabolism | Stem Cells | Hematopoietic Progenitors | HP Surface Molecules | Stem Cells | Neural Stem Cells | Cell Signaling | Metabolism | Cancer | Cancer Metabolism | Cell Signaling | Metabolism | Drug Metabolism
Alternative Name(s):
ABC transporter antibody ABC15 antibody ABCG 2 antibody ABCG2 antibody ABCG2_HUMAN antibody ABCP antibody ATP binding cassette sub family G (WHITE) member 2 antibody ATP binding cassette transporter G2 antibody ATP-binding cassette sub-family G member 2 antibody BCRP antibody BCRP1 antibody BMDP antibody Breast cancer resistance protein antibody CD338 antibody CDw338 antibody CDw338 antigen antibody EST157481 antibody GOUT1 antibody MGC102821 antibody Mitoxantrone resistance associated protein antibody Mitoxantrone resistance-associated protein antibody MRX antibody Multi drug resistance efflux transport ATP binding cassette sub family G (WHITE) member 2 antibody MXR antibody MXR1 antibody Placenta specific ATP binding cassette transporter antibody Placenta specific MDR protein antibody Placenta-specific ATP-binding cassette transporter antibody UAQTL1 antibody
Category:
Polyclonal
Immunogen Species:
Human
Accession Number:
NP_004818.2
Gene ID:
9429
Swiss-Prot:
Q9UNQ0
Species Reactivity Full Name:
Human
Purification:
Peptide Affinity Purified
Specificity:
Detects endogenous levels of total ABCG2
Certificate of Analysis:
A 1:1000 dilution of SPC-1317 was sufficient for detection of ABCG2 in 10 µg of mouse kidney cell lyates by ECL immunoblot analysis using Goat Anti-Rabbit IgG:HRP as the secondary antibody.
Cellular Localization:
Cell Membrane | Mitochondrion Membrane
References:
1. Zhou S., et al. (2001) Nat. Medicine. 7: 1028. 2. Doyle L.A. and Ross D.D. (2003) Oncogene. 22: 7340-58. 3. Allen J.D. et al. (1999) Cancer Res. 59: 4237-41. 4. Doyle L.A., et al. (1998) Proc Natl Acad Sci USA. 95: 15665-70. 5. Allikmets R., et al. (1998) Cancer Res. 58: 5337-9. 6. Miyake K., et al. (1999) Cancer Res. 59: 8-13. 7. Robey R.W., et al. (2001) Clin Cancer Res. 7: 145-52. Zhou S., et al. (2001) Nat. Medicine. 7: 1028.
ABCG2 (BCRP1/ABCP/MXR) is a member of the ATP-binding cassette transporter family that functions as ATP-dependent transporters for a wide variety of chemical compounds and are associated with drug-resistance in cancer cells. ABCG2 is a heavily glycosylated transmembrane protein with six transmembrane spanning regions consistent with it functioning as a half-transporter. The ABC family can exist as either full-length transporters or as half-transporters that form functional transporters through homo- or heterodimerization. Originally thought to play a role in drug resistance due to its resistance to a number of chemotherapeutic drugs, ABCG2 has also been found in the kidney, and stem cell populations. Studies also suggest that it can be used as a cell surface marker to identify hematopoietic stem cells within the bone marrow fraction of lineage negative cells. The expression of ABCG2 appears greatest on CD34- cells and is downregulated with the acquisition of CD34 on the cell surface.
WB (1:2000), IHC (1:200); optimal dilutions for assays should be determined by the user.
Target:
ABCG2
Conjugate:
Streptavidin
Research Area(s):
Tags and Cell Markers | Cell Signaling | Metabolism | Stem Cells | Hematopoietic Progenitors | HP Surface Molecules | Stem Cells | Neural Stem Cells | Cell Signaling | Metabolism | Cancer | Cancer Metabolism | Cell Signaling | Metabolism | Drug Metabolism
Alternative Name(s):
ABC transporter antibody ABC15 antibody ABCG 2 antibody ABCG2 antibody ABCG2_HUMAN antibody ABCP antibody ATP binding cassette sub family G (WHITE) member 2 antibody ATP binding cassette transporter G2 antibody ATP-binding cassette sub-family G member 2 antibody BCRP antibody BCRP1 antibody BMDP antibody Breast cancer resistance protein antibody CD338 antibody CDw338 antibody CDw338 antigen antibody EST157481 antibody GOUT1 antibody MGC102821 antibody Mitoxantrone resistance associated protein antibody Mitoxantrone resistance-associated protein antibody MRX antibody Multi drug resistance efflux transport ATP binding cassette sub family G (WHITE) member 2 antibody MXR antibody MXR1 antibody Placenta specific ATP binding cassette transporter antibody Placenta specific MDR protein antibody Placenta-specific ATP-binding cassette transporter antibody UAQTL1 antibody
Category:
Polyclonal
Immunogen Species:
Human
Accession Number:
NP_004818.2
Gene ID:
9429
Swiss-Prot:
Q9UNQ0
Species Reactivity Full Name:
Human
Purification:
Peptide Affinity Purified
Specificity:
Detects endogenous levels of total ABCG2
Certificate of Analysis:
A 1:1000 dilution of SPC-1317 was sufficient for detection of ABCG2 in 10 µg of mouse kidney cell lyates by ECL immunoblot analysis using Goat Anti-Rabbit IgG:HRP as the secondary antibody.
Cellular Localization:
Cell Membrane | Mitochondrion Membrane
References:
1. Zhou S., et al. (2001) Nat. Medicine. 7: 1028. 2. Doyle L.A. and Ross D.D. (2003) Oncogene. 22: 7340-58. 3. Allen J.D. et al. (1999) Cancer Res. 59: 4237-41. 4. Doyle L.A., et al. (1998) Proc Natl Acad Sci USA. 95: 15665-70. 5. Allikmets R., et al. (1998) Cancer Res. 58: 5337-9. 6. Miyake K., et al. (1999) Cancer Res. 59: 8-13. 7. Robey R.W., et al. (2001) Clin Cancer Res. 7: 145-52. Zhou S., et al. (2001) Nat. Medicine. 7: 1028.
High-capacity urate exporter functioning in both renal and extrarenal urate excretion. Plays a role in porphyrin homeostasis as it is able to mediates the export of protoporhyrin IX (PPIX) both from mitochondria to cytosol and from cytosol to extracellular space, and cellular export of hemin, and heme. Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. Implicated in the efflux of numerous drugs and xenobiotics: mitoxantrone, the photosensitizer pheophorbide, camptothecin, methotrexate, azidothymidine (AZT), and the anthracyclines daunorubicin and doxorubicin.
High-capacity urate exporter functioning in both renal and extrarenal urate excretion. Plays a role in porphyrin homeostasis as it is able to mediates the export of protoporhyrin IX (PPIX) both from mitochondria to cytosol and from cytosol to extracellular space, and cellular export of hemin, and heme. Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. Implicated in the efflux of numerous drugs and xenobiotics: mitoxantrone, the photosensitizer pheophorbide, camptothecin, methotrexate, azidothymidine (AZT), and the anthracyclines daunorubicin and doxorubicin.
High-capacity urate exporter functioning in both renal and extrarenal urate excretion. Plays a role in porphyrin homeostasis as it is able to mediates the export of protoporhyrin IX (PPIX) both from mitochondria to cytosol and from cytosol to extracellular space, and cellular export of hemin, and heme. Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. Implicated in the efflux of numerous drugs and xenobiotics: mitoxantrone, the photosensitizer pheophorbide, camptothecin, methotrexate, azidothymidine (AZT), and the anthracyclines daunorubicin and doxorubicin.
High-capacity urate exporter functioning in both renal and extrarenal urate excretion. Plays a role in porphyrin homeostasis as it is able to mediates the export of protoporhyrin IX (PPIX) both from mitochondria to cytosol and from cytosol to extracellular space, and cellular export of hemin, and heme. Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. Implicated in the efflux of numerous drugs and xenobiotics: mitoxantrone, the photosensitizer pheophorbide, camptothecin, methotrexate, azidothymidine (AZT), and the anthracyclines daunorubicin and doxorubicin.
ABCG2 Antibody detects endogenous levels of total ABCG2
Immunogen:
A synthesized peptide derived from human ABCG2
Cross Reactivity:
Human
Conjugate:
Unconjugated
purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink(TM) Coupling Resin (Thermo Fisher Scientific).
Concentration:
1mg/ml
Fragment:
Fab fragment
Buffer:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt
Gene ID:
9429
Gene:
ABCG2
Swiss-Prot:
Q9UNQ0
Molecular Weight:
72 kDa
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