Newmarket Scientific Product Search Results for AX17-10008

Product Search Results: AX17-10008
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Product Search Results: AX17-10008	Num Products Matched: 2	2

Newmarket Scientific - NS Reagents

AX17-10008-100ug

100 µg

275

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Product Detail:	Anti-Cytochrome P450 7B1 (Clone M17-P3F2)
Background Info:	Cytochrome P450 7B1 (25-hydroxycholesterol 7alpha-hydroxylase) is a member of the cytochrome P450 superfamily of enzymes involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. In the liver CYP7B1 most likely only plays a minor role in total bile acid synthesis, providing an alternate acidic pathway for the formation of bile acids through cholesterol degradation. In the brain CYP7B1 is important in the metabolism of brain cholesterol. As there is little or no transfer of cholesterol across the blood-brain barrier, cholesterol must be produced in the brain locally, and CYP7B1 is important in maintaining the precise balance between the biosynthesis, storage, and catabolism of cholesterol metabolites.
Product Type:	NS Reagents Antibody
Antibody Type:	Monoclonal
Format:	100 µg in 100 µl PBS containing 0.02% sodium azide.
Storage Temp:	6 months: 4°C. Long-term storage: -20°C. Avoid multiple freeze and thaw cycles.
Host Animal:	Mouse
Species Reactivity:	Human
Expected Species:	If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:	Ovalbumin-conjugated synthetic peptide from the C-terminal region of Human
Applications:	ELISA ¦ IHC ¦ WB
Data Sheet:	PLEASE CLICK HERE TO DOWNLOAD
Additional Info:	If you would like further information regarding the immunogen used in the productiion of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Clone number:	Clone M17-P3F2
Antibody Isotype:	IgG1 lambda
Category:	Primary Antibodies
Other names:	25-hydroxycholesterol 7-alpha-hydroxylase, CP7B, CP7B1, oxysterol 7-alpha-hydroxylase, CYP450 7B1
Research Areas:	Neuroscience, cholesterol
NS Reagents Product Area:	Neuroscience
Peptide Sequence (Internal Use only):	Peptide sequence (IQYPDSDVL) aa 491-499 Full length protein is 506 aa in length 10 20 30 40 50 MAGEVSAATG RFSLERLGLP GLALAAALLL LALCLLVRRT RRPGEPPLIK 60 70 80 90 100 GWLPYLGVVL NLRKDPLRFM KTLQKQHGDT FTVLLGGKYI TFILDPFQYQ 110 120 130 140 150 LVIKNHKQLS FRVFSNKLLE KAFSISQLQK NHDMNDELHL CYQFLQGKSL 160 170 180 190 200 DILLESMMQN LKQVFEPQLL KTTSWDTAEL YPFCSSIIFE ITFTTIYGKV 210 220 230 240 250 IVCDNNKFIS ELRDDFLKFD DKFAYLVSNI PIELLGNVKS IREKIIKCFS 260 270 280 290 300 SEKLAKMQGW SEVFQSRQDV LEKYYVHEDL EIGAHHLGFL WASVANTIPT 310 320 330 340 350 MFWAMYYLLR HPEAMAAVRD EIDRLLQSTG QKKGSGFPIH LTREQLDSLI 360 370 380 390 400 CLESSIFEAL RLSSYSTTIR FVEEDLTLSS ETGDYCVRKG DLVAIFPPVL 410 420 430 440 450 HGDPEIFEAP EEFRYDRFIE DGKKKTTFFK RGKKLKCYLM PFGTGTSKCP 460 470 480 490 500 GRFFALMEIK QLLVILLTYF DLEIIDDKPI GLNYSRLLFG IQYPDSDVLF RYKVKS
Molecular Weight:	59kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:	Endoplasmic reticulum
Purification:	Protein A Affinity Purified
References:	Swan et al. 2016. Oncotarget. :. PMID: 27341022.
Uniprot ID:	O75881
Gene ID:	9420
Gene symbol:	CYP7B1
Release Date:	Oct-17

Newmarket Scientific - NS Reagents

AX17-10008-50ug

50 µg

220

Please sign in or sign up to order this product online.

Product Detail:	Anti-Cytochrome P450 7B1 (Clone M17-P3F2)
Background Info:	Cytochrome P450 7B1 (25-hydroxycholesterol 7alpha-hydroxylase) is a member of the cytochrome P450 superfamily of enzymes involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. In the liver CYP7B1 most likely only plays a minor role in total bile acid synthesis, providing an alternate acidic pathway for the formation of bile acids through cholesterol degradation. In the brain CYP7B1 is important in the metabolism of brain cholesterol. As there is little or no transfer of cholesterol across the blood-brain barrier, cholesterol must be produced in the brain locally, and CYP7B1 is important in maintaining the precise balance between the biosynthesis, storage, and catabolism of cholesterol metabolites.
Product Type:	NS Reagents Antibody
Antibody Type:	Monoclonal
Format:	50 µg in 50 µl PBS containing 0.02% sodium azide.
Storage Temp:	6 months: 4°C. Long-term storage: -20°C. Avoid multiple freeze and thaw cycles.
Host Animal:	Mouse
Species Reactivity:	Human
Expected Species:	If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:	Ovalbumin-conjugated synthetic peptide from the C-terminal region of Human
Applications:	ELISA ¦ IHC ¦ WB
Data Sheet:	PLEASE CLICK HERE TO DOWNLOAD
Additional Info:	If you would like further information regarding the immunogen used in the productiion of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Clone number:	Clone M17-P3F2
Antibody Isotype:	IgG1 lambda
Category:	Primary Antibodies
Other names:	25-hydroxycholesterol 7-alpha-hydroxylase, CP7B, CP7B1, oxysterol 7-alpha-hydroxylase, CYP450 7B1
Research Areas:	Neuroscience, cholesterol
NS Reagents Product Area:	Neuroscience
Peptide Sequence (Internal Use only):	Peptide sequence (IQYPDSDVL) aa 491-499 Full length protein is 506 aa in length 10 20 30 40 50 MAGEVSAATG RFSLERLGLP GLALAAALLL LALCLLVRRT RRPGEPPLIK 60 70 80 90 100 GWLPYLGVVL NLRKDPLRFM KTLQKQHGDT FTVLLGGKYI TFILDPFQYQ 110 120 130 140 150 LVIKNHKQLS FRVFSNKLLE KAFSISQLQK NHDMNDELHL CYQFLQGKSL 160 170 180 190 200 DILLESMMQN LKQVFEPQLL KTTSWDTAEL YPFCSSIIFE ITFTTIYGKV 210 220 230 240 250 IVCDNNKFIS ELRDDFLKFD DKFAYLVSNI PIELLGNVKS IREKIIKCFS 260 270 280 290 300 SEKLAKMQGW SEVFQSRQDV LEKYYVHEDL EIGAHHLGFL WASVANTIPT 310 320 330 340 350 MFWAMYYLLR HPEAMAAVRD EIDRLLQSTG QKKGSGFPIH LTREQLDSLI 360 370 380 390 400 CLESSIFEAL RLSSYSTTIR FVEEDLTLSS ETGDYCVRKG DLVAIFPPVL 410 420 430 440 450 HGDPEIFEAP EEFRYDRFIE DGKKKTTFFK RGKKLKCYLM PFGTGTSKCP 460 470 480 490 500 GRFFALMEIK QLLVILLTYF DLEIIDDKPI GLNYSRLLFG IQYPDSDVLF RYKVKS
Molecular Weight:	59kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:	Endoplasmic reticulum
Purification:	Protein A Affinity Purified
References:	Swan et al. 2016. Oncotarget. :. PMID: 27341022.
Uniprot ID:	O75881
Gene ID:	9420
Gene symbol:	CYP7B1
Release Date:	Oct-17

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Product Search Results: AX17-10008

Product Search Results: AX17-10008

Anti-Cytochrome P450 7B1 Antibody

Anti-Cytochrome P450 7B1 Antibody