Newmarket Scientific Product Search Results for BEK-2216

Product Search Results: BEK-2216
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Product Search Results: BEK-2216	Num Products Matched: 2	2

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Biosensis

BEK-2216-1P

1 plate

£363.00

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Product Detail:	The Biosensis Alpha-Synuclein RapidTM enzyme-linked immunosorbent assay (ELISA) Kit is a sandwich ELISA that allows the quantification of human alpha-synuclein in less than 4 hours in human citrate-plasma, serum and CSF only if used as directed. Please refer to the kit protocol for specific use instructions for blood and CSF application. This ELISA kit consists of a pre-coated sheep polyclonal anti-alpha-synuclein (aa: 116-131) capture antibody, a biotinylated mouse monoclonal anti-alpha-synuclein detection antibody (aa: 61-95) and horseradish peroxidase (HRP)-conjugated streptavidin. The addition of a substrate (3,3',5,5'-tetramethylbenzidine, TMB) yields a colored reaction product which is directly proportional to the concentration of alpha-synuclein present in samples and protein standards. A human alpha-synuclein positive control (QC sample) is provided to assure consistent assay performance. This ELISA kit has not been tested for other applications. It has been configured for research use only and is not to be used for diagnostic or clinical procedures.
Background Info:	Alpha synuclein is an abundant 140 amino acid neuronal protein, expressed primarily at presynaptic terminals in the central nervous system. Alpha synuclein has been associated with several neurodegenerative diseases. A point mutation in the gene coding for the alpha-synuclein protein was the first discovery linking this protein to a rare familial form of Parkinson's disease (PD). Subsequently, other mutations in the alpha-synuclein gene have been identified in familial PD. The aggregated proteinaceous inclusions called Lewy bodies found in PD and cortical Lewy body dementia (LBD) were discovered to be predominantly alpha-synuclein. Aberrant aggregation of alpha-synuclein has been detected in an increasing number of neurodegenerative diseases, collectively known as synucleopathies. Alpha-synuclein exists physiologically in both soluble and membrane-bound states, in unstructured and alpha-helical conformations, respectively. The physiological function of alpha-synuclein appears to require its translocation between these subcellular compartments and interconversion between the 2 conformations. Abnormal processing of alpha-synuclein is predicted to lead to pathological changes in its binding properties and function.
Product Type:	ELISA
Antibody Type:	Monoclonal-Polyclonal
Storage Temp:	Store at 2-8 °C.
Species Reactivity:	Human
Immunogen:	The standard for this kit is recombinant alpha-synuclein protein produced in and purified from E.coli.
Applications:	ELISA
Data Sheet:	PLEASE CLICK HERE TO DOWNLOAD
Additional Info:	While not directly tested in the ELISA, mouse and rat alpha-synuclein are expected to cross-react due to species cross-reactivity of both capture and detection antibody.
Application Details:	Please download the detailed product insert for complete instructions for the successful use of this ELISA; Use only as directed.
Alternative Names:	Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; NACP
Accession Number:	P37840 SYUA_HUMAN
Kit Components:	The ELISA kit box contains 1 x 96-well pre-coated strip plates, protein standards, QC sample, detection reagents, wash and sample buffers, substrate buffer and detailed protocols.
Shelf Life:	12 months from purchase.
Specificity:	Human alpha-synuclein. While not directly tested in the ELISA, beta- and gamma-synuclein is not expected to cross-react due to the specificity of both capture and detection antibody for alpha-synuclein. Individual alpha-synuclein isoforms have not yet been tested, but it is expected that this ELISA kit detects monomeric, oligomeric and phosphorylated alpha-synuclein isoforms.
Assay Range:	0.16 - 10 ng/mL
Sensitivity:	Typical limit of detection (LOD) for alpha-synuclein is < 100 pg/mL, determined as alpha-synuclein concentration at blank OD plus 3x standard deviation of blank OD (n=10).
Related Products:	BL-004-500, Heterophilic antibody blocker: Sample diluent additive for accurate quantification of proBDNF in human serum and citrate-plasma. BEK-2240: Mature BDNF/proBDNF Combo Rapid ELISA Kit

Biosensis

BEK-2216-2P

2 plates

£698.00

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Product Detail:	The Biosensis Alpha-Synuclein RapidTM enzyme-linked immunosorbent assay (ELISA) Kit is a sandwich ELISA that allows the quantification of human alpha-synuclein in less than 4 hours in human citrate-plasma, serum and CSF only if used as directed. Please refer to the kit protocol for specific use instructions for blood and CSF application. This ELISA kit consists of a pre-coated sheep polyclonal anti-alpha-synuclein (aa: 116-131) capture antibody, a biotinylated mouse monoclonal anti-alpha-synuclein detection antibody (aa: 61-95) and horseradish peroxidase (HRP)-conjugated streptavidin. The addition of a substrate (3,3',5,5'-tetramethylbenzidine, TMB) yields a colored reaction product which is directly proportional to the concentration of alpha-synuclein present in samples and protein standards. A human alpha-synuclein positive control (QC sample) is provided to assure consistent assay performance. This ELISA kit has not been tested for other applications. It has been configured for research use only and is not to be used for diagnostic or clinical procedures.
Background Info:	Alpha synuclein is an abundant 140 amino acid neuronal protein, expressed primarily at presynaptic terminals in the central nervous system. Alpha synuclein has been associated with several neurodegenerative diseases. A point mutation in the gene coding for the alpha-synuclein protein was the first discovery linking this protein to a rare familial form of Parkinson's disease (PD). Subsequently, other mutations in the alpha-synuclein gene have been identified in familial PD. The aggregated proteinaceous inclusions called Lewy bodies found in PD and cortical Lewy body dementia (LBD) were discovered to be predominantly alpha-synuclein. Aberrant aggregation of alpha-synuclein has been detected in an increasing number of neurodegenerative diseases, collectively known as synucleopathies. Alpha-synuclein exists physiologically in both soluble and membrane-bound states, in unstructured and alpha-helical conformations, respectively. The physiological function of alpha-synuclein appears to require its translocation between these subcellular compartments and interconversion between the 2 conformations. Abnormal processing of alpha-synuclein is predicted to lead to pathological changes in its binding properties and function.
Product Type:	ELISA
Antibody Type:	Monoclonal-Polyclonal
Storage Temp:	Store at 2-8 °C.
Species Reactivity:	Human
Immunogen:	The standard for this kit is recombinant alpha-synuclein protein produced in and purified from E.coli.
Applications:	ELISA
Data Sheet:	PLEASE CLICK HERE TO DOWNLOAD
Additional Info:	While not directly tested in the ELISA, mouse and rat alpha-synuclein are expected to cross-react due to species cross-reactivity of both capture and detection antibody.
Application Details:	Please download the detailed product insert for complete instructions for the successful use of this ELISA; Use only as directed.
Alternative Names:	Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; NACP
Accession Number:	P37840 SYUA_HUMAN
Kit Components:	The ELISA kit box contains 2 x 96-well pre-coated strip plates, protein standards, QC sample, detection reagents, wash and sample buffers, substrate buffer and detailed protocols.
Shelf Life:	12 months from purchase.
Specificity:	Human alpha-synuclein. While not directly tested in the ELISA, beta- and gamma-synuclein is not expected to cross-react due to the specificity of both capture and detection antibody for alpha-synuclein. Individual alpha-synuclein isoforms have not yet been tested, but it is expected that this ELISA kit detects monomeric, oligomeric and phosphorylated alpha-synuclein isoforms.
Assay Range:	0.16 - 10 ng/mL
Sensitivity:	Typical limit of detection (LOD) for alpha-synuclein is < 100 pg/mL, determined as alpha-synuclein concentration at blank OD plus 3x standard deviation of blank OD (n=10).
Related Products:	BL-004-500, Heterophilic antibody blocker: Sample diluent additive for accurate quantification of proBDNF in human serum and citrate-plasma. BEK-2240: Mature BDNF/proBDNF Combo Rapid ELISA Kit

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