Newmarket Scientific Product Search Results for BSH-7100

Product Search Results: BSH-7100
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Product Search Results: BSH-7100	Num Products Matched: 2	2

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Optibodies - Nordic BioSite

BSH-7100-100

100 µl

£210.00

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Product Detail:	Vimentin is the major subunit protein of the intermediate filaments of mesenchymal cells. It is believed to be involved with the intracellular transport of proteins between the nucleus and plasma membrane. Vimentin has been implicated to be involved in the rate of steroid synthesis via its role as a storage network for steroidogenic cholesterol containing lipid droplets. Vimentin phosphorylation by a protein kinase causes the breakdown of intermediate filaments and activation of an ATP and myosin light chain dependent contractile event. This results in cytoskeletal changes that facilitate the interaction of the lipid droplets within mitochondria, and subsequent transport of cholesterol to the organelles leading to an increase in steroid synthesis. Immunohistochemical staining for Vimentin is characteristic of sarcomas (of neural, muscle and fibroblast origin) compared to carcinomas which are generally negative. Melanomas, lymphomas and vascular tumors may all stain for Vimentin. Vimentin antibodies are thus of value in the differential diagnosis of undifferentiated neoplasms and malignant tumors. They are generally used with a panel of other antibodies including those recognising cytokeratins, lymphoid markers, S100, desmin and neurofilaments.
Product Type:	Antibodies Primary - Optibodies Antibody
Antibody Type:	monoclonal
Format:	TRIS with 0.03% sodium azide, pH7.2, Concentrate
Storage Temp:	+4 degrees C
Species Reactivity:	human,sheep/ovine,dog/canine,cat/feline
Applications:	IHC
Data Sheet:	PLEASE CLICK HERE TO DOWNLOAD
Additional Info:	Anti-Vimentin, mouse monoclonal - Optibodies
Clone number:	BS13
Application Details:	Suitable for IHC-P, IHC-Fr
Control Tissues :	Appendix, tonsil
Host:	Mouse
Uniprot ID:	P08670
Images:	https://nordicbiosite.com/uploaded/images/product_e22ffce0-8344-11e7-8cb3-4f3d7e7847e1_01.png https://nordicbiosite.com/uploaded/images/product_e22ffce0-8344-11e7-8cb3-4f3d7e7847e1_02.png https://nordicbiosite.com/uploaded/images/product_e22ffce0-8344-11e7-8cb3-4f3d7e7847e1_03.png https://nordicbiosite.com/uploaded/images/product_e22ffce0-8344-11e7-8cb3-4f3d7e7847e1_04.png https://nordicbiosite.com/uploaded/images/product_e22ffce0-8344-11e7-8cb3-4f3d7e7847e1_05.png https://nordicbiosite.com/uploaded/images/product_e22ffce0-8344-11e7-8cb3-4f3d7e7847e1_06.png https://nordicbiosite.com/uploaded/images/product_e22ffce0-8344-11e7-8cb3-4f3d7e7847e1_07.png https://nordicbiosite.com/uploaded/images/product_e22ffce0-8344-11e7-8cb3-4f3d7e7847e1_08.png https://nordicbiosite.com/uploaded/images/product_e22ffce0-8344-11e7-8cb3-4f3d7e7847e1_09.png https://nordicbiosite.com/uploaded/images/product_e22ffce0-8344-11e7-8cb3-4f3d7e7847e1_10.png https://nordicbiosite.com/uploaded/images/product_e22ffce0-8344-11e7-8cb3-4f3d7e7847e1_11.png https://nordicbiosite.com/uploaded/images/product_e22ffce0-8344-11e7-8cb3-4f3d7e7847e1_12.png https://nordicbiosite.com/uploaded/images/product_e22ffce0-8344-11e7-8cb3-4f3d7e7847e1_13.png https://nordicbiosite.com/uploaded/images/product_e22ffce0-8344-11e7-8cb3-4f3d7e7847e1_14.png
Research Area:	Histopathology

Optibodies - Nordic BioSite

BSH-7100-1

1 ml

£548.00

Please sign in or sign up to order this product online.

Product Detail:	Vimentin is the major subunit protein of the intermediate filaments of mesenchymal cells. It is believed to be involved with the intracellular transport of proteins between the nucleus and plasma membrane. Vimentin has been implicated to be involved in the rate of steroid synthesis via its role as a storage network for steroidogenic cholesterol containing lipid droplets. Vimentin phosphorylation by a protein kinase causes the breakdown of intermediate filaments and activation of an ATP and myosin light chain dependent contractile event. This results in cytoskeletal changes that facilitate the interaction of the lipid droplets within mitochondria, and subsequent transport of cholesterol to the organelles leading to an increase in steroid synthesis. Immunohistochemical staining for Vimentin is characteristic of sarcomas (of neural, muscle and fibroblast origin) compared to carcinomas which are generally negative. Melanomas, lymphomas and vascular tumors may all stain for Vimentin. Vimentin antibodies are thus of value in the differential diagnosis of undifferentiated neoplasms and malignant tumors. They are generally used with a panel of other antibodies including those recognising cytokeratins, lymphoid markers, S100, desmin and neurofilaments.
Product Type:	Antibodies Primary - Optibodies Antibody
Antibody Type:	monoclonal
Format:	TRIS with 0.03% sodium azide, pH7.2, Concentrate
Storage Temp:	+4 degrees C
Species Reactivity:	human,sheep/ovine,dog/canine,cat/feline
Applications:	IHC
Data Sheet:	PLEASE CLICK HERE TO DOWNLOAD
Additional Info:	Anti-Vimentin, mouse monoclonal - Optibodies
Clone number:	BS13
Application Details:	Suitable for IHC-P, IHC-Fr
Control Tissues :	Appendix, tonsil
Host:	Mouse
Uniprot ID:	P08670
Images:	https://nordicbiosite.com/uploaded/images/product_e2cbc7b0-8344-11e7-8cb3-4f3d7e7847e1_01.png https://nordicbiosite.com/uploaded/images/product_e2cbc7b0-8344-11e7-8cb3-4f3d7e7847e1_02.png https://nordicbiosite.com/uploaded/images/product_e2cbc7b0-8344-11e7-8cb3-4f3d7e7847e1_03.png https://nordicbiosite.com/uploaded/images/product_e2cbc7b0-8344-11e7-8cb3-4f3d7e7847e1_04.png https://nordicbiosite.com/uploaded/images/product_e2cbc7b0-8344-11e7-8cb3-4f3d7e7847e1_05.png https://nordicbiosite.com/uploaded/images/product_e2cbc7b0-8344-11e7-8cb3-4f3d7e7847e1_06.png https://nordicbiosite.com/uploaded/images/product_e2cbc7b0-8344-11e7-8cb3-4f3d7e7847e1_07.png https://nordicbiosite.com/uploaded/images/product_e2cbc7b0-8344-11e7-8cb3-4f3d7e7847e1_08.png https://nordicbiosite.com/uploaded/images/product_e2cbc7b0-8344-11e7-8cb3-4f3d7e7847e1_09.png https://nordicbiosite.com/uploaded/images/product_e2cbc7b0-8344-11e7-8cb3-4f3d7e7847e1_10.png https://nordicbiosite.com/uploaded/images/product_e2cbc7b0-8344-11e7-8cb3-4f3d7e7847e1_11.png https://nordicbiosite.com/uploaded/images/product_e2cbc7b0-8344-11e7-8cb3-4f3d7e7847e1_12.png https://nordicbiosite.com/uploaded/images/product_e2cbc7b0-8344-11e7-8cb3-4f3d7e7847e1_13.png https://nordicbiosite.com/uploaded/images/product_e2cbc7b0-8344-11e7-8cb3-4f3d7e7847e1_14.png
Research Area:	Histopathology

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