Cytoplasmic activation/proliferation?associated protein-1 (Caprin?1) is a ubiquitously expressed and highly conserved cytoplasmic phosphoprotein. It is an RNA?binding protein involved in the regulation of cell cycle control?associated genes, having the characteristic arginine-glycine-glycine (RGG) motif and RG enrichment region associated with RNA binding proteins, as well as two highly conserved regions, homologous region-1 and homologous region-2.
Caprin-1 levels (other than in the brain), are tightly correlated with cellular proliferation. In neurons it may specifically regulate the transport and translation of mRNAs for proteins involved in synaptic plasticity. . Mutations in Caprin-1 have been linked to conditions such as amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD) and autism spectrum disorder (ASD).
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
Storage Temp:
Store at -20?. Avoid freeze / thaw cycles.
Host Animal:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Expected Species:
Bovine, Chicken, Dog, Sheep, Goat
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the productiion of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Cytoplasmic activation/proliferation?associated protein-1 (Caprin?1) is a ubiquitously expressed and highly conserved cytoplasmic phosphoprotein. It is an RNA?binding protein involved in the regulation of cell cycle control?associated genes, having the characteristic arginine-glycine-glycine (RGG) motif and RG enrichment region associated with RNA binding proteins, as well as two highly conserved regions, homologous region-1 and homologous region-2.
Caprin-1 levels (other than in the brain), are tightly correlated with cellular proliferation. In neurons it may specifically regulate the transport and translation of mRNAs for proteins involved in synaptic plasticity. . Mutations in Caprin-1 have been linked to conditions such as amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD) and autism spectrum disorder (ASD).
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
Storage Temp:
Store at -20?. Avoid freeze / thaw cycles.
Host Animal:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Expected Species:
Bovine, Chicken, Dog, Sheep, Goat
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the productiion of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
May regulate the transport and translation of mRNAs of proteins involved in synaptic plasticity in neurons and cell proliferation and migration in multiple cell types. Binds directly and selectively to MYC and CCND2 RNAs. In neuronal cells, directly binds to several mRNAs associated with RNA granules, including BDNF, CAMK2A, CREB1, MAP2, NTRK2 mRNAs, as well as to GRIN1 and KPNB1 mRNAs, but not to rRNAs.
CAPRIN1 antibody detects endogenous levels of CAPRIN1.
Immunogen:
A synthesized peptide derived from human CAPRIN1.
Cross Reactivity:
Human,Mouse,Rat
Conjugate:
Unconjugated
purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink(TM) Coupling Resin (Thermo Fisher Scientific).
Concentration:
1mg/ml
Fragment:
Fab fragment
Buffer:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt
May regulate the transport and translation of mRNAs of proteins involved in synaptic plasticity in neurons and cell proliferation and migration in multiple cell types. Binds directly and selectively to MYC and CCND2 RNAs. In neuronal cells, directly binds to several mRNAs associated with RNA granules, including BDNF, CAMK2A, CREB1, MAP2, NTRK2 mRNAs, as well as to GRIN1 and KPNB1 mRNAs, but not to rRNAs.
CAPRIN1 antibody detects endogenous levels of CAPRIN1.
Immunogen:
A synthesized peptide derived from human CAPRIN1.
Cross Reactivity:
Human,Mouse,Rat
Conjugate:
Unconjugated
purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink(TM) Coupling Resin (Thermo Fisher Scientific).
Concentration:
1mg/ml
Fragment:
Fab fragment
Buffer:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt
Gene ID:
4076
Gene:
CAPRIN1
Swiss-Prot:
Q14444
Molecular Weight:
116kd
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