Heterogeneous Nuclear Ribonucleoprotein A1 (hnRNPA1) is one of a family of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). These RNA-binding proteins associate with pre-mRNAs in the nucleus and influence pre-mRNA processing and transport. hnRNPA1, regulates alternative splicing, nuclear export, translation, and other RNA processing events
HnRNP A1 is a 34 kDa protein with a modular domain structure consisting of two RNA recognition motifs (RRMs) referred to as unwinding protein 1 (UP1) an intrinsically disordered RGG-rich C terminus and a prion-like domain (PrLD). UP1 is the primary RNA binding domain and the C terminus mediates protein-protein interactions.
Mutations in the HnRNP A1 gene have been linked to amyotrophic lateral sclerosis (ALS), multisystem proteinopathy (MSP) and other neurodegenerative diseases.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage Temp:
Store at -20°C. Avoid freeze / thaw cycles.
Host Animal:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Expected Species:
Bovine, Pig, Sheep, Dog, Cat, Chicken, Golden Hamster, Rabbit
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human HNRNPA1 from the N-terminal region
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000. IF 1:50-100.
Antibody Number:
10087
Category:
Primary Antibodies
Other names:
ALS19, ALS20, HNRPA1, HNRPA1L3, IBMPFD3, UP 1, hnRNP A1, hnRNP-A1
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
39kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Heterogeneous Nuclear Ribonucleoprotein A1 (hnRNPA1) is one of a family of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). These RNA-binding proteins associate with pre-mRNAs in the nucleus and influence pre-mRNA processing and transport. hnRNPA1, regulates alternative splicing, nuclear export, translation, and other RNA processing events
HnRNP A1 is a 34 kDa protein with a modular domain structure consisting of two RNA recognition motifs (RRMs) referred to as unwinding protein 1 (UP1) an intrinsically disordered RGG-rich C terminus and a prion-like domain (PrLD). UP1 is the primary RNA binding domain and the C terminus mediates protein-protein interactions.
Mutations in the HnRNP A1 gene have been linked to amyotrophic lateral sclerosis (ALS), multisystem proteinopathy (MSP) and other neurodegenerative diseases.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage Temp:
Store at -20°C. Avoid freeze / thaw cycles.
Host Animal:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Expected Species:
Bovine, Pig, Sheep, Dog, Cat, Chicken, Golden Hamster, Rabbit
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human HNRNPA1 from the N-terminal region
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000. IF 1:50-100.
Antibody Number:
10087
Category:
Primary Antibodies
Other names:
ALS19, ALS20, HNRPA1, HNRPA1L3, IBMPFD3, UP 1, hnRNP A1, hnRNP-A1
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
39kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection (PubMed:17371836). May bind to specific miRNA hairpins (PubMed:28431233).
hnRNP A1 Antibody detects endogenous levels of total hnRNP A1
Immunogen:
A synthesized peptide derived from human hnRNP A1
Cross Reactivity:
Human,Mouse,Rat
Conjugate:
Unconjugated
purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink(TM) Coupling Resin (Thermo Fisher Scientific).
Concentration:
1mg/ml
Buffer:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt
Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection (PubMed:17371836). May bind to specific miRNA hairpins (PubMed:28431233).
hnRNP A1 Antibody detects endogenous levels of total hnRNP A1
Immunogen:
A synthesized peptide derived from human hnRNP A1
Cross Reactivity:
Human,Mouse,Rat
Conjugate:
Unconjugated
purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink(TM) Coupling Resin (Thermo Fisher Scientific).
Concentration:
1mg/ml
Buffer:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt
Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection (PubMed:17371836). May bind to specific miRNA hairpins (PubMed:28431233).
hnRNP A1 Antibody detects endogenous levels of total hnRNP A1
Immunogen:
A synthesized peptide
Cross Reactivity:
Human,Mouse,Rat
Conjugate:
Unconjugated
purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink(TM) Coupling Resin (Thermo Fisher Scientific).
Concentration:
1mg/ml
Buffer:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt
Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection (PubMed:17371836). May bind to specific miRNA hairpins (PubMed:28431233).
hnRNP A1 Antibody detects endogenous levels of total hnRNP A1
Immunogen:
A synthesized peptide
Cross Reactivity:
Human,Mouse,Rat
Conjugate:
Unconjugated
purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink(TM) Coupling Resin (Thermo Fisher Scientific).
Concentration:
1mg/ml
Buffer:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt
Gene ID:
3178
Gene:
HNRNPA1
Swiss-Prot:
P09651
Molecular Weight:
33 KD
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