CD11b is a membranous protein with a role in adhesive interactions of many leukocytes, especially macrophages, and subsets of lymphocytes. The expression of CD11b increases during maturation and expression levels vary depending on the type of cell. CD11b can be used as common myeloid and NK cell marker. Useful marker for acute promyelocytic leukemia, hair cell leukemia and AML differentiations. Systemic lupus erythematosus is also shown to be associated with CD11b dysfunction.
CD11b is a membranous protein with a role in adhesive interactions of many leukocytes, especially macrophages, and subsets of lymphocytes. The expression of CD11b increases during maturation and expression levels vary depending on the type of cell. CD11b can be used as common myeloid and NK cell marker. Useful marker for acute promyelocytic leukemia, hair cell leukemia and AML differentiations. Systemic lupus erythematosus is also shown to be associated with CD11b dysfunction.
Rat anti-CD11b Recombinant Antibody (Unconjugated), suitable for ICC, IHC-Frozen.
Background Info:
This constant region of this antibody has been modified to bind to Protein A, allowing highly-specific purification of this antibody by Protein A-affinity column.
Product Type:
Antibody
Antibody Type:
Recombinant
Format:
Liquid. PBS with 0.02% Proclin 300.
Host Animal:
Rat
Species Reactivity:
Human,Mouse
Immunogen:
Fusion of spleen cells from AO rats immunised with Thioglycollate-elicted muine peritoneal macrophages (TPM) and the Y3 rat myeloma line.
Applications:
ICC,IHC-Frozen
Clone number:
5C6 (recombinant version)
Antibody Isotype:
IgG2b, kappa
Alternative Names:
integrin alpha M; CD11 antigen-like family member B; CR-3 alpha chain; Cell surface glycoprotein MAC-1 subunit alpha; Leukocyte adhesion receptor MO1; Neutrophil adherence receptor
Accession Number:
P11215 (ITAM_HUMAN)
Storage:
Store at 2-8°C for up to 1 month. For longer storage, aliquot and store at -20_C. Avoid mulitiple freeze thaw cycles.
Shelf Life:
Store at 2-8°C for up to 3 months. For longer storage, aliquot and store at -20°C for up to 12 months.
Specificity:
This antibody specifically recognize CD11b, also known as the integrin alpha M chain (MAC-1), which is a differentiation antigen expressed by granulocytes, monocytes, NK cells and tissue macrophages.
Mouse anti-Integrin alpha-M Recombinant Antibody (Unconjugated), suitable for ELISA, FC.
Background Info:
The antibody binds specifically to integrin ?-M, a protein subunit of the ?-M- ?-2 molecule, which is expressed on the surface of leukocytes. Integrin ?-M is involved in the adhesive interaction between molecules of the innate immune system, and plays a role in the uptake of complement-coated particles. The monoclonal antibody 107 has a blocking activity by binding to the metal-ion-dependent-adhesion site, favouring a low affinity conformation of the antigen.
Product Type:
Antibody
Antibody Type:
Recombinant
Format:
Liquid. PBS with 0.02% Proclin 300.
Host Animal:
Mouse
Species Reactivity:
Human
Immunogen:
Wild type (WT) recombinant CD11b.
Applications:
ELISA,FC
Clone number:
107
Antibody Isotype:
IgG1, kappa
Application Details:
The antibody binds specifically to integrin ?-M, a protein subunit of the ?-M- ?-2 molecule, which is expressed on the surface of leukocytes. Integrin ?-M is involved in the adhesive interaction between molecules of the innate immune system, and plays a role in the uptake of complement-coated particles. The monoclonal antibody 107 has a blocking activity by binding to the metal-ion-dependent-adhesion site, favouring a low affinity conformation of the antigen.
Rabbit anti-CD11b Recombinant Antibody (Unconjugated), suitable for ICC, IHC-Frozen.
Background Info:
This chimeric rabbit antibody was made using the variable domain sequences of the original Rat IgG2b format, for improved compatibility with existing reagents, assays and techniques.
Product Type:
Antibody
Antibody Type:
Recombinant
Format:
Liquid. PBS with 0.02% Proclin 300.
Host Animal:
Rabbit
Species Reactivity:
Human,Mouse
Immunogen:
Fusion of spleen cells from AO rats immunised with Thioglycollate-elicted muine peritoneal macrophages (TPM) and the Y3 rat myeloma line.
Applications:
ICC,IHC-Frozen
Clone number:
5C6 (recombinant version)
Antibody Isotype:
IgG, kappa
Alternative Names:
integrin alpha M; CD11 antigen-like family member B; CR-3 alpha chain; Cell surface glycoprotein MAC-1 subunit alpha; Leukocyte adhesion receptor MO1; Neutrophil adherence receptor
Accession Number:
P11215 (ITAM_HUMAN)
Storage:
Store at 2-8°C for up to 1 month. For longer storage, aliquot and store at -20_C. Avoid mulitiple freeze thaw cycles.
Shelf Life:
Store at 2-8°C for up to 3 months. For longer storage, aliquot and store at -20°C for up to 12 months.
Specificity:
This antibody specifically recognize CD11b, also known as the integrin alpha M chain (MAC-1), which is a differentiation antigen expressed by granulocytes, monocytes, NK cells and tissue macrophages.
ITGAM Antibody detects endogenous levels of total ITGAM.
Blocking Peptide:
A corresponding control peptide is available for this antibody (please email tech@nktscientific.com for details)
Conjugate:
Unconjugated
Uniprot:
P11215
Gene:
ITGAM
Format:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
ITGAM Antibody detects endogenous levels of total ITGAM.
Blocking Peptide:
A corresponding control peptide is available for this antibody (please email tech@nktscientific.com for details)
Conjugate:
Unconjugated
Uniprot:
P11215
Gene:
ITGAM
Format:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
ITGAM Antibody detects endogenous levels of total ITGAM.
Blocking Peptide:
A corresponding control peptide is available for this antibody (please email tech@nktscientific.com for details)
Conjugate:
Unconjugated
Uniprot:
P11215
Gene:
ITGAM
Format:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
ITGAM Antibody detects endogenous levels of total ITGAM.
Blocking Peptide:
A corresponding control peptide is available for this antibody (please email tech@nktscientific.com for details)
Conjugate:
Unconjugated
Uniprot:
P11215
Gene:
ITGAM
Format:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
ITGAM Antibody detects endogenous levels of total ITGAM.
Blocking Peptide:
A corresponding control peptide is available for this antibody (please email tech@nktscientific.com for details)
Conjugate:
Unconjugated
Uniprot:
P11215
Gene:
ITGAM
Format:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
ITGAM Antibody detects endogenous levels of total ITGAM.
Blocking Peptide:
A corresponding control peptide is available for this antibody (please email tech@nktscientific.com for details)
Conjugate:
Unconjugated
Uniprot:
P11215
Gene:
ITGAM
Format:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Concentration:
1mg/ml
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