Newmarket Scientific Product Search Results for P49768

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Product Detail:	Rabbit anti-Presenilin 1 loop region Polyclonal Antibody (Unconjugated), suitable for WB.
Background Info:	Presenilin-1 (PSEN1) is a multi-pass membrane protein and component of the gamma-secretase complex. PSEN1 is thought to play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. It may also play a role in hematopoiesis. Defects in PSEN1 are a cause of Alzheimer disease type 3 (AD3), a familial early-onset form of Alzheimer disease (Ref:SWISS-Prot).
Product Type:	Antibody
Antibody Type:	Polyclonal
Format:	Lyophilized from PBS, pH 7.4. Contains no preservative.
Host Animal:	Rabbit
Species Reactivity:	Human,Mouse
Immunogen:	A synthetic peptide (GDPEAQRRVSKNSKYNA-C) corresponding to human PS1 [301-317] in the loop region conjugated via additional C-terminal Cys to Diphtheria toxoid.
Applications:	WB
Antibody Isotype:	IgG
Application Details:	Western Blot. Suggested dilution of 1:1,000 is recommended for WB. Full length presenilin 1 (467 aa) has relative MW of about 45 kDa, with this antibody most commonly detected as cleaved CTF of 19 kDa. Human or mouse brain samples commonly prepared with reducing agent (50mM DTT), urea (2.3 M), SDS (1.5%) in 62.5 mM Tris-HCL pH 6.8 sample buffer (without boiling) heating to 50 C for 15 min. Biosensis recommends that the optimal working dilution should be determined by the end user.
Alternative Names:	Presenilin 1; PS-1; Protein S182; PS1-CTF12; PSEN1; AD3; PS1; PSNL1
Biosensis Brand:	Biosensis®
Conjugate:	Unconjugated
Shelf Life:	12 months after date of receipt (unopened vial).
Use:	For research use only.
Specificity:	Confirmed by Western blotting using transfected cells, presenilin 1 knock-out mouse cells and mouse and human brain.
Storage:	Short term storage at 2-8°C for one week. At -20°C as an undiluted liquid for up to 12 months.
Purification:	Protein G purified IgG
Target:	Presenilin 1 loop region
Uniprot Number:	P49768

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Product Detail:	Rabbit anti-Presenilin 1 (PS-1) Polyclonal Antibody (Unconjugated), suitable for WB.
Background Info:	Presenilin-1 (PSEN1) is a multi-pass membrane protein and component of the gamma-secretase complex. PSEN1 is thought to play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. It may also play a role in hematopoiesis. Defects in PSEN1 are a cause of Alzheimer disease type 3 (AD3), a familial early-onset form of Alzheimer disease (Ref:SWISS-Prot).
Product Type:	Antibody
Antibody Type:	Polyclonal
Format:	Lyophilized from PBS, pH 7.4. Contains no preservative.
Host Animal:	Rabbit
Species Reactivity:	Human,Mouse
Immunogen:	A synthetic peptide corresponding to a region (1-20 aa) from the N-terminus of human Presenilin 1 conjugated to Diptheria toxoid.
Applications:	WB
Antibody Isotype:	IgG
Application Details:	IF and WB. Suggested dilution of 1:2,000 is recommended for WB. On SDS-PAGE, the predominant form detected by this antibody is the N-terminal Presenilin 1 fragment of approx 29 kDa. The uncleaved form of Presenilin 1 migrates to approx 45 kDa. Human and mouse brain samples commonly prepared with reducing agent (50mM DTT), urea (2.3M), SDS (1%) in 62.5 mM Tris-HCl pH 6.8 sample buffer heated to 50C for 15 min. The suggested dilution for IF is 1:100 for acetone or paraformaldehyde fixed cells or tissue. Biosensis recommends that the optimal working dilution should be determined by the end user.
Alternative Names:	Presenilin 1; PS-1; Protein S182; PS1-CTF12; PSEN1; AD3; PS1; PSNL1;
Biosensis Brand:	Biosensis®
Conjugate:	Unconjugated
Shelf Life:	12 months after date of receipt (unopened vial).
Use:	For research use only.
Specificity:	Specificity confirmed by WB and IF using transfected cells, Presenilin 1 knock-out mouse cells, mouse and human brain.
Storage:	Short term storage at 2-8°C for one week. At -20°C as an undiluted liquid for up to 12 months.
Purification:	Protein G purified IgG
Target:	Presenilin 1 (PS-1)
Uniprot Number:	P49768

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Product Detail:	Chicken anti-Presenilin-1 (PS-1) Polyclonal Antibody (Unconjugated), suitable for WB, ELISA.
Background Info:	Presenilin-1 (PSEN1) is a multi-pass membrane protein and component of the gamma-secretase complex. PSEN1 is thought to play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. It may also play a role in hematopoiesis. Defects in PSEN1 are a cause of Alzheimer disease type 3 (AD3), a familial early-onset form of Alzheimer disease (Ref:SWISS-Prot).
Product Type:	Antibody
Antibody Type:	Polyclonal
Format:	Liquid. PBS with 0.02% Sodium Azide
Host Animal:	Chicken
Species Reactivity:	Human,Mouse,Rat
Immunogen:	Mixture of two human Presenilin 1 peptides (311-322 and 341-352 aa). Both sequences are highly conserved in human, mouse and rat.
Applications:	ELISA,WB
Antibody Isotype:	IgY
Application Details:	WB and ELISA. Suggested dilution of 1:1,000 to 1:4,000. To minimise background staining, a higher concentration of detergent (such as Tween-20) is suggested in the dilution and washing steps. Biosensis recommends that the optimal working dilution should be determined by the end user.
Alternative Names:	Presenilin 1; PS-1; Protein S182; PS1-CTF12; PSEN1; AD3; PS1; PSNL1;
Biosensis Brand:	Biosensis®
Conjugate:	Unconjugated
Shelf Life:	12 months after date of receipt (unopened vial).
Use:	For research use only.
Specificity:	Human Presenilin 1
Storage:	Short term storage at 2-8°C for one week. At -20°C as an undiluted liquid for up to 12 months.
Purification:	Affinity-purified
Target:	Presenilin-1 (PS-1)
Uniprot Number:	P49768

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Product Detail:	Human Presenilin-1 ELISA Kit
Product Type:	Assay & Detection
Storage Temp:	4°C
Applications:	ELISA
Biosite Brand:	BioSite ELISA
Species Reactivity:	human
UniProt No:	P49768

Product Search Results: P49768
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Product Search Results: P49768	Num Products Matched: 4	4

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Product Search Results: P49768

Product Search Results: P49768

Presenilin 1 loop region, Rabbit Polyclonal Antibody-500 µg

Presenilin 1 (PS-1), Rabbit Polyclonal Antibody-500 µg

Presenilin-1 (PS-1), Chicken Polyclonal Antibody-500 µL

Human Presenilin-1 ELISA Kit