Lipocalin-2 (LCN2) is a secreted glycoprotein involved in innate immunity that has roles in iron homeostasis, infection, and inflammation. It was originally identified as a major constituent of the neutrophil secondary granules, so it is also known as neutrophil gelatinase-associated lipocalin (NGAL).
It is highly expressed in the central nervous system in response to injury and inflammation and has also been identified as a potential marker for Alzheimers disease. Increased levels of Lipocalin-2 have been seen in plasma from patients with mild cognitive impairment (MCI) and in CSF from patients with multiple sclerosis. Experimental models of Vascular dementia have shown that Lipocalin-2 mediates hippocampal damage and that decreased levels are associated with less white matter damage and cognitive decline.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal Antibody
Format:
50 µg in 50 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
23kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Secreted, Cytosol
Purification:
Affinity purification
References:
Franc Llorens, Peter Hermann, Anna Villar-Piqué et al - Cerebrospinal fluid lipocalin 2 as a novel biomarker for the differential diagnosis of vascular dementia. Nat Commun. 2020; 11: 619.
Lipocalin-2 (LCN2) is a secreted glycoprotein involved in innate immunity that has roles in iron homeostasis, infection, and inflammation. It was originally identified as a major constituent of the neutrophil secondary granules, so it is also known as neutrophil gelatinase-associated lipocalin (NGAL).
It is highly expressed in the central nervous system in response to injury and inflammation and has also been identified as a potential marker for Alzheimers disease. Increased levels of Lipocalin-2 have been seen in plasma from patients with mild cognitive impairment (MCI) and in CSF from patients with multiple sclerosis. Experimental models of Vascular dementia have shown that Lipocalin-2 mediates hippocampal damage and that decreased levels are associated with less white matter damage and cognitive decline.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal Antibody
Format:
100 µg in 100 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
23kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Secreted, Cytosol
Purification:
Affinity purification
References:
Franc Llorens, Peter Hermann, Anna Villar-Piqué et al - Cerebrospinal fluid lipocalin 2 as a novel biomarker for the differential diagnosis of vascular dementia. Nat Commun. 2020; 11: 619.
Lipocalin-2 (LCN2) is a secreted glycoprotein involved in innate immunity that has roles in iron homeostasis, infection, and inflammation. It was originally identified as a major constituent of the neutrophil secondary granules, so it is also known as neutrophil gelatinase-associated lipocalin (NGAL).
It is highly expressed in the central nervous system in response to injury and inflammation and has also been identified as a potential marker for Alzheimers disease. Increased levels of Lipocalin-2 have been seen in plasma from patients with mild cognitive impairment (MCI) and in CSF from patients with multiple sclerosis. Experimental models of Vascular dementia have shown that Lipocalin-2 mediates hippocampal damage and that decreased levels are associated with less white matter damage and cognitive decline.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal Antibody
Format:
50 µg in 50 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
23kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Secreted, Cytosol
Purification:
Affinity purification
References:
Franc Llorens, Peter Hermann, Anna Villar-Piqué et al - Cerebrospinal fluid lipocalin 2 as a novel biomarker for the differential diagnosis of vascular dementia. Nat Commun. 2020; 11: 619.
Lipocalin-2 (LCN2) is a secreted glycoprotein involved in innate immunity that has roles in iron homeostasis, infection, and inflammation. It was originally identified as a major constituent of the neutrophil secondary granules, so it is also known as neutrophil gelatinase-associated lipocalin (NGAL).
It is highly expressed in the central nervous system in response to injury and inflammation and has also been identified as a potential marker for Alzheimers disease. Increased levels of Lipocalin-2 have been seen in plasma from patients with mild cognitive impairment (MCI) and in CSF from patients with multiple sclerosis. Experimental models of Vascular dementia have shown that Lipocalin-2 mediates hippocampal damage and that decreased levels are associated with less white matter damage and cognitive decline.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal Antibody
Format:
100 µg in 100 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
23kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Secreted, Cytosol
Purification:
Affinity purification
References:
Franc Llorens, Peter Hermann, Anna Villar-Piqué et al - Cerebrospinal fluid lipocalin 2 as a novel biomarker for the differential diagnosis of vascular dementia. Nat Commun. 2020; 11: 619.
Lipocalin-2 (LCN2) is a secreted glycoprotein involved in innate immunity that has roles in iron homeostasis, infection, and inflammation. It was originally identified as a major constituent of the neutrophil secondary granules, so it is also known as neutrophil gelatinase-associated lipocalin (NGAL).
It is highly expressed in the central nervous system in response to injury and inflammation and has also been identified as a potential marker for Alzheimers disease. Increased levels of Lipocalin-2 have been seen in plasma from patients with mild cognitive impairment (MCI) and in CSF from patients with multiple sclerosis. Experimental models of Vascular dementia have shown that Lipocalin-2 mediates hippocampal damage and that decreased levels are associated with less white matter damage and cognitive decline.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal Antibody
Format:
50 µg in 50 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
23kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Secreted, Cytosol
Purification:
Affinity purification
References:
Franc Llorens, Peter Hermann, Anna Villar-Piqué et al - Cerebrospinal fluid lipocalin 2 as a novel biomarker for the differential diagnosis of vascular dementia. Nat Commun. 2020; 11: 619.
Lipocalin-2 (LCN2) is a secreted glycoprotein involved in innate immunity that has roles in iron homeostasis, infection, and inflammation. It was originally identified as a major constituent of the neutrophil secondary granules, so it is also known as neutrophil gelatinase-associated lipocalin (NGAL).
It is highly expressed in the central nervous system in response to injury and inflammation and has also been identified as a potential marker for Alzheimers disease. Increased levels of Lipocalin-2 have been seen in plasma from patients with mild cognitive impairment (MCI) and in CSF from patients with multiple sclerosis. Experimental models of Vascular dementia have shown that Lipocalin-2 mediates hippocampal damage and that decreased levels are associated with less white matter damage and cognitive decline.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal Antibody
Format:
100 µg in 100 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
23kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Secreted, Cytosol
Purification:
Affinity purification
References:
Franc Llorens, Peter Hermann, Anna Villar-Piqué et al - Cerebrospinal fluid lipocalin 2 as a novel biomarker for the differential diagnosis of vascular dementia. Nat Commun. 2020; 11: 619.
The human Lipocalin-2 Kit is a sandwich ELISA. The capture antibody is a polyclonal human Lipocalin-2 antibody pre-coated onto the 96-well strip plates provided in the kit. Human test samples and standards of known Lipocalin-2 concentration are added to these wells and allowed to complex with the bound Lipocalin-2 antibody. A biotinylated human Lipocalin-2 polyclonal antibody is then added. This detection antibody binds to the antigen thus completing the sandwich. After washing, an enzyme Avidin-Biotin-Peroxidase complex (ABC) is added which binds to the second antibody. The peroxidase substrate TMB is added to induce a coloured reaction product. The intensity of this coloured product is directly proportional to the concentration of Lipocalin-2 present in the samples. The purpose of this kit is the in-vitro quantitative determination of human Lipocalin-2 in samples such as culture supernatant, serum, plasma (Heparin), saliva and urine. This kit has been configured for research use only and is not to be used in diagnostic or clinical procedures.
Product Type:
ELISA Assay
Storage Temp:
2-8°C
Species Reactivity:
Human
Immunogen:
The standard and antigen for this Lipocalin-2/NGAL ELISA is recombinant human Lipocalin-2/NGAL amino acids 21-N198 produced in an purified from a mammalian cell expression system.
Applications:
ELISA
Additional Info:
There is no detectable cross-reactivity with other relevant proteins.
Application Details:
ELISA. For the quantification of Neutrophil gelatinase-associated lipocalin-2 (NGAL) in Culture Supernatant, Serum, Plasma (Heparin), Saliva, Urine. Please download the detailed product insert for complete instructions for the successful use of this ELISA. Use only as directed.
The ELISA kit box contains 96-well pre-coated strip plate(s), protein standards, detection reagents, substrate buffer and detailed protocols.
Storage:
Store at 2-8°C
Shelf Life:
This kit may be stored for up to 6 months at 2°C to 8°C from the date of shipment. Standards should be stored at -20°C or -80°C (recommended at 80°C) after reconstitution. Coated strips or reagents may be store for up to 1 month at 2°C to 8°C.
The human Lipocalin-2 Kit is a sandwich ELISA. The capture antibody is a polyclonal human Lipocalin-2 antibody pre-coated onto the 96-well strip plates provided in the kit. Human test samples and standards of known Lipocalin-2 concentration are added to these wells and allowed to complex with the bound Lipocalin-2 antibody. A biotinylated human Lipocalin-2 polyclonal antibody is then added. This detection antibody binds to the antigen thus completing the sandwich. After washing, an enzyme Avidin-Biotin-Peroxidase complex (ABC) is added which binds to the second antibody. The peroxidase substrate TMB is added to induce a coloured reaction product. The intensity of this coloured product is directly proportional to the concentration of Lipocalin-2 present in the samples. The purpose of this kit is the in-vitro quantitative determination of human Lipocalin-2 in samples such as culture supernatant, serum, plasma (Heparin), saliva and urine. This kit has been configured for research use only and is not to be used in diagnostic or clinical procedures.
Product Type:
ELISA Assay
Storage Temp:
2-8°C
Species Reactivity:
Human
Immunogen:
The standard and antigen for this Lipocalin-2/NGAL ELISA is recombinant human Lipocalin-2/NGAL amino acids 21-N198 produced in an purified from a mammalian cell expression system.
Applications:
ELISA
Additional Info:
There is no detectable cross-reactivity with other relevant proteins.
Application Details:
ELISA. For the quantification of Neutrophil gelatinase-associated lipocalin-2 (NGAL) in Culture Supernatant, Serum, Plasma (Heparin), Saliva, Urine. Please download the detailed product insert for complete instructions for the successful use of this ELISA. Use only as directed.
The ELISA kit box contains 96-well pre-coated strip plate(s), protein standards, detection reagents, substrate buffer and detailed protocols.
Storage:
Store at 2-8°C
Shelf Life:
This kit may be stored for up to 6 months at 2°C to 8°C from the date of shipment. Standards should be stored at -20°C or -80°C (recommended at 80°C) after reconstitution. Coated strips or reagents may be store for up to 1 month at 2°C to 8°C.
LCN2 Antibody detects endogenous levels of total LCN2.
Blocking Peptide:
A corresponding control peptide is available for this antibody (please email tech@nktscientific.com for details)
Conjugate:
Unconjugated
Uniprot:
P80188
Gene:
LCN2
Format:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
LCN2 Antibody detects endogenous levels of total LCN2.
Blocking Peptide:
A corresponding control peptide is available for this antibody (please email tech@nktscientific.com for details)
Conjugate:
Unconjugated
Uniprot:
P80188
Gene:
LCN2
Format:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
LCN2 Antibody detects endogenous levels of total LCN2.
Blocking Peptide:
A corresponding control peptide is available for this antibody (please email tech@nktscientific.com for details)
Conjugate:
Unconjugated
Uniprot:
P80188
Gene:
LCN2
Format:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
LCN2 Antibody detects endogenous levels of total LCN2.
Blocking Peptide:
A corresponding control peptide is available for this antibody (please email tech@nktscientific.com for details)
Conjugate:
Unconjugated
Uniprot:
P80188
Gene:
LCN2
Format:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Concentration:
1mg/ml
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