Lipocalin-2 (LCN2) is a secreted glycoprotein involved in innate immunity that has roles in iron homeostasis, infection, and inflammation. It was originally identified as a major constituent of the neutrophil secondary granules, so it is also known as neutrophil gelatinase-associated lipocalin (NGAL).
It is highly expressed in the central nervous system in response to injury and inflammation and has also been identified as a potential marker for Alzheimers disease. Increased levels of Lipocalin-2 have been seen in plasma from patients with mild cognitive impairment (MCI) and in CSF from patients with multiple sclerosis. Experimental models of Vascular dementia have shown that Lipocalin-2 mediates hippocampal damage and that decreased levels are associated with less white matter damage and cognitive decline.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal Antibody
Format:
100 µg in 100 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like further information regarding the immunogen used in the productiion of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
23kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Secreted, Cytosol
Purification:
Affinity purification
References:
Franc Llorens, Peter Hermann, Anna Villar-Piqué et al - Cerebrospinal fluid lipocalin 2 as a novel biomarker for the differential diagnosis of vascular dementia. Nat Commun. 2020; 11: 619.
Lipocalin-2 (LCN2) is a secreted glycoprotein involved in innate immunity that has roles in iron homeostasis, infection, and inflammation. It was originally identified as a major constituent of the neutrophil secondary granules, so it is also known as neutrophil gelatinase-associated lipocalin (NGAL).
It is highly expressed in the central nervous system in response to injury and inflammation and has also been identified as a potential marker for Alzheimers disease. Increased levels of Lipocalin-2 have been seen in plasma from patients with mild cognitive impairment (MCI) and in CSF from patients with multiple sclerosis. Experimental models of Vascular dementia have shown that Lipocalin-2 mediates hippocampal damage and that decreased levels are associated with less white matter damage and cognitive decline.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal Antibody
Format:
50 µg in 50 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like further information regarding the immunogen used in the productiion of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
23kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Secreted, Cytosol
Purification:
Affinity purification
References:
Franc Llorens, Peter Hermann, Anna Villar-Piqué et al - Cerebrospinal fluid lipocalin 2 as a novel biomarker for the differential diagnosis of vascular dementia. Nat Commun. 2020; 11: 619.
Lipocalin-2 (LCN2) is a secreted glycoprotein involved in innate immunity that has roles in iron homeostasis, infection, and inflammation. It was originally identified as a major constituent of the neutrophil secondary granules, so it is also known as neutrophil gelatinase-associated lipocalin (NGAL).
It is highly expressed in the central nervous system in response to injury and inflammation and has also been identified as a potential marker for Alzheimers disease. Increased levels of Lipocalin-2 have been seen in plasma from patients with mild cognitive impairment (MCI) and in CSF from patients with multiple sclerosis. Experimental models of Vascular dementia have shown that Lipocalin-2 mediates hippocampal damage and that decreased levels are associated with less white matter damage and cognitive decline.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal Antibody
Format:
100 µg in 100 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like further information regarding the immunogen used in the productiion of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
23kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Secreted, Cytosol
Purification:
Affinity purification
References:
Franc Llorens, Peter Hermann, Anna Villar-Piqué et al - Cerebrospinal fluid lipocalin 2 as a novel biomarker for the differential diagnosis of vascular dementia. Nat Commun. 2020; 11: 619.
Lipocalin-2 (LCN2) is a secreted glycoprotein involved in innate immunity that has roles in iron homeostasis, infection, and inflammation. It was originally identified as a major constituent of the neutrophil secondary granules, so it is also known as neutrophil gelatinase-associated lipocalin (NGAL).
It is highly expressed in the central nervous system in response to injury and inflammation and has also been identified as a potential marker for Alzheimers disease. Increased levels of Lipocalin-2 have been seen in plasma from patients with mild cognitive impairment (MCI) and in CSF from patients with multiple sclerosis. Experimental models of Vascular dementia have shown that Lipocalin-2 mediates hippocampal damage and that decreased levels are associated with less white matter damage and cognitive decline.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal Antibody
Format:
50 µg in 50 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like further information regarding the immunogen used in the productiion of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
23kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Secreted, Cytosol
Purification:
Affinity purification
References:
Franc Llorens, Peter Hermann, Anna Villar-Piqué et al - Cerebrospinal fluid lipocalin 2 as a novel biomarker for the differential diagnosis of vascular dementia. Nat Commun. 2020; 11: 619.
Lipocalin-2 (LCN2) is a secreted glycoprotein involved in innate immunity that has roles in iron homeostasis, infection, and inflammation. It was originally identified as a major constituent of the neutrophil secondary granules, so it is also known as neutrophil gelatinase-associated lipocalin (NGAL).
It is highly expressed in the central nervous system in response to injury and inflammation and has also been identified as a potential marker for Alzheimers disease. Increased levels of Lipocalin-2 have been seen in plasma from patients with mild cognitive impairment (MCI) and in CSF from patients with multiple sclerosis. Experimental models of Vascular dementia have shown that Lipocalin-2 mediates hippocampal damage and that decreased levels are associated with less white matter damage and cognitive decline.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal Antibody
Format:
100 µg in 100 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like further information regarding the immunogen used in the productiion of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
23kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Secreted, Cytosol
Purification:
Affinity purification
References:
Franc Llorens, Peter Hermann, Anna Villar-Piqué et al - Cerebrospinal fluid lipocalin 2 as a novel biomarker for the differential diagnosis of vascular dementia. Nat Commun. 2020; 11: 619.
Lipocalin-2 (LCN2) is a secreted glycoprotein involved in innate immunity that has roles in iron homeostasis, infection, and inflammation. It was originally identified as a major constituent of the neutrophil secondary granules, so it is also known as neutrophil gelatinase-associated lipocalin (NGAL).
It is highly expressed in the central nervous system in response to injury and inflammation and has also been identified as a potential marker for Alzheimers disease. Increased levels of Lipocalin-2 have been seen in plasma from patients with mild cognitive impairment (MCI) and in CSF from patients with multiple sclerosis. Experimental models of Vascular dementia have shown that Lipocalin-2 mediates hippocampal damage and that decreased levels are associated with less white matter damage and cognitive decline.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal Antibody
Format:
50 µg in 50 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
If you would like further information regarding the immunogen used in the productiion of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
23kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Secreted, Cytosol
Purification:
Affinity purification
References:
Franc Llorens, Peter Hermann, Anna Villar-Piqué et al - Cerebrospinal fluid lipocalin 2 as a novel biomarker for the differential diagnosis of vascular dementia. Nat Commun. 2020; 11: 619.
The human Lipocalin-2 Kit is a sandwich ELISA. The capture antibody is a polyclonal human Lipocalin-2 antibody pre-coated onto the 96-well strip plates provided in the kit. Human test samples and standards of known Lipocalin-2 concentration are added to these wells and allowed to complex with the bound Lipocalin-2 antibody. A biotinylated human Lipocalin-2 polyclonal antibody is then added. This detection antibody binds to the antigen thus completing the sandwich. After washing, an enzyme Avidin-Biotin-Peroxidase complex (ABC) is added which binds to the second antibody. The peroxidase substrate TMB is added to induce a coloured reaction product. The intensity of this coloured product is directly proportional to the concentration of Lipocalin-2 present in the samples. The purpose of this kit is the in-vitro quantitative determination of human Lipocalin-2 in samples such as sera, plasma, tissue lysates and cell culture supernates. This kit has been configured for research use only and is not to be used in diagnostic or clinical procedures.
Product Type:
ELISA
Antibody Type:
Monoclonal-Polyclonal
Format:
Ready to use Assay, complete with pre-coated plates, Concentrated Buffers, Detection reagents and complete instructions.
Storage Temp:
Store at 4 °C
Species Reactivity:
Human
Immunogen:
The standard and antigen for this Lipocalin-2/NGAL ELISA is recombinant human Lipocalin-2/NGAL amino acids 21-N198 produced in an purified from a mammalian cell expression system.
The ELISA kit box contains 1 x 96-well pre-coated strip plate, protein standards, detection reagents, substrate buffer and detailed protocols.
Shelf Life:
This kit may be stored for up to 6 months at 2°C to 8°C from the date of shipment. Standards should be stored at -20°C or -80°C (recommended at 80°C) after reconstitution. Coated strips or reagents may be store for up to 1 month at 2°C to 8°C.
The human Lipocalin-2 Kit is a sandwich ELISA. The capture antibody is a polyclonal human Lipocalin-2 antibody pre-coated onto the 96-well strip plates provided in the kit. Human test samples and standards of known Lipocalin-2 concentration are added to these wells and allowed to complex with the bound Lipocalin-2 antibody. A biotinylated human Lipocalin-2 polyclonal antibody is then added. This detection antibody binds to the antigen thus completing the sandwich. After washing, an enzyme Avidin-Biotin-Peroxidase complex (ABC) is added which binds to the second antibody. The peroxidase substrate TMB is added to induce a coloured reaction product. The intensity of this coloured product is directly proportional to the concentration of Lipocalin-2 present in the samples. The purpose of this kit is the in-vitro quantitative determination of human Lipocalin-2 in samples such as sera, plasma, tissue lysates and cell culture supernates. This kit has been configured for research use only and is not to be used in diagnostic or clinical procedures.
Product Type:
ELISA
Antibody Type:
Monoclonal-Polyclonal
Format:
Ready to use Assay, complete with pre-coated plates, Concentrated Buffers, Detection reagents and complete instructions.
Storage Temp:
Store at 4 °C
Species Reactivity:
Human
Immunogen:
The standard and antigen for this Lipocalin-2/NGAL ELISA is recombinant human Lipocalin-2/NGAL amino acids 21-N198 produced in an purified from a mammalian cell expression system.
The ELISA kit box contains 2 x 96-well pre-coated strip plates, protein standards, detection reagents, substrate buffer and detailed protocols.
Shelf Life:
This kit may be stored for up to 6 months at 2°C to 8°C from the date of shipment. Standards should be stored at -20°C or -80°C (recommended at 80°C) after reconstitution. Coated strips or reagents may be store for up to 1 month at 2°C to 8°C.
Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth.
LCN2 Antibody detects endogenous levels of total LCN2
Immunogen:
A synthesized peptide derived from human LCN2
Cross Reactivity:
Human,Mouse,Rat
Conjugate:
Unconjugated
purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink(TM) Coupling Resin (Thermo Fisher Scientific).
Concentration:
1mg/ml
Fragment:
Fab fragment
Buffer:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt
Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth.
LCN2 Antibody detects endogenous levels of total LCN2
Immunogen:
A synthesized peptide derived from human LCN2
Cross Reactivity:
Human,Mouse,Rat
Conjugate:
Unconjugated
purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink(TM) Coupling Resin (Thermo Fisher Scientific).
Concentration:
1mg/ml
Fragment:
Fab fragment
Buffer:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt
Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth.
LCN2 Antibody detects endogenous levels of total LCN2
Immunogen:
A synthetic peptide of humanLCN2
Cross Reactivity:
Human,Mouse,Rat
Conjugate:
Unconjugated
purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink(TM) Coupling Resin (Thermo Fisher Scientific).
Concentration:
1mg/ml
Fragment:
Fab fragment
Buffer:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt
Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth.
LCN2 Antibody detects endogenous levels of total LCN2
Immunogen:
A synthetic peptide of humanLCN2
Cross Reactivity:
Human,Mouse,Rat
Conjugate:
Unconjugated
purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink(TM) Coupling Resin (Thermo Fisher Scientific).
Concentration:
1mg/ml
Fragment:
Fab fragment
Buffer:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt
Gene ID:
3934
Gene:
LCN2
Swiss-Prot:
P80188
Molecular Weight:
23kDa
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