Alsin (ALS2) is a 184-kDa protein of 1657 amino acids which activates the GTPases of the Ras superfamily of GTPases by acting as a guanine nucleotide exchange factor. Alsin has three guanine nucleotide exchange factor domains (RLD, DH/PH and VPS9) and eight consecutive membrane occupation and recognition nexus (MORN) motifs that are related to membrane binding in the region between the DH/PH and VPS9 domains.
Alsin functions as a modulator for endosomal dynamics by activating the small GTPase Rab5 via the C-terminal MORN/VPS9 domain, localising with RAB5 on early endosomal compartments.
Alsin is produced in a wide range of tissues, being particularly abundant in motor neurons. Many mutations in the ALS2 gene have been linked to a range of motor neurone diseases including amyotrophic lateral sclerosis (ALS).
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
Storage Temp:
Store at -20°C. Avoid freeze / thaw cycles.
Host Animal:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Expected Species:
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Alsin (ALS2) is a 184-kDa protein of 1657 amino acids which activates the GTPases of the Ras superfamily of GTPases by acting as a guanine nucleotide exchange factor. Alsin has three guanine nucleotide exchange factor domains (RLD, DH/PH and VPS9) and eight consecutive membrane occupation and recognition nexus (MORN) motifs that are related to membrane binding in the region between the DH/PH and VPS9 domains.
Alsin functions as a modulator for endosomal dynamics by activating the small GTPase Rab5 via the C-terminal MORN/VPS9 domain, localising with RAB5 on early endosomal compartments.
Alsin is produced in a wide range of tissues, being particularly abundant in motor neurons. Many mutations in the ALS2 gene have been linked to a range of motor neurone diseases including amyotrophic lateral sclerosis (ALS).
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
Storage Temp:
Store at -20°C. Avoid freeze / thaw cycles.
Host Animal:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Expected Species:
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Alsin (ALS2) is a 184-kDa protein of 1657 amino acids which activates the GTPases of the Ras superfamily of GTPases by acting as a guanine nucleotide exchange factor. Alsin has three guanine nucleotide exchange factor domains (RLD, DH/PH and VPS9) and eight consecutive membrane occupation and recognition nexus (MORN) motifs that are related to membrane binding in the region between the DH/PH and VPS9 domains.
Alsin functions as a modulator for endosomal dynamics by activating the small GTPase Rab5 via the C-terminal MORN/VPS9 domain, localising with RAB5 on early endosomal compartments.
Alsin is produced in a wide range of tissues, being particularly abundant in motor neurons. Many mutations in the ALS2 gene have been linked to a range of motor neurone diseases including amyotrophic lateral sclerosis (ALS).
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage Temp:
Store at -20°C. Avoid freeze / thaw cycles.
Host Animal:
Rabbit
Species Reactivity:
Human, Mouse
Expected Species:
Rat, Rabbit, Dog, Cat, Golden Hamster, Pig, Sheep, Bovine, Goat, Naked mole rat
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human ALS2 from the N-terminal region
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Alsin (ALS2) is a 184-kDa protein of 1657 amino acids which activates the GTPases of the Ras superfamily of GTPases by acting as a guanine nucleotide exchange factor. Alsin has three guanine nucleotide exchange factor domains (RLD, DH/PH and VPS9) and eight consecutive membrane occupation and recognition nexus (MORN) motifs that are related to membrane binding in the region between the DH/PH and VPS9 domains.
Alsin functions as a modulator for endosomal dynamics by activating the small GTPase Rab5 via the C-terminal MORN/VPS9 domain, localising with RAB5 on early endosomal compartments.
Alsin is produced in a wide range of tissues, being particularly abundant in motor neurons. Many mutations in the ALS2 gene have been linked to a range of motor neurone diseases including amyotrophic lateral sclerosis (ALS).
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage Temp:
Store at -20°C. Avoid freeze / thaw cycles.
Host Animal:
Rabbit
Species Reactivity:
Human, Mouse
Expected Species:
Rat, Rabbit, Dog, Cat, Golden Hamster, Pig, Sheep, Bovine, Goat, Naked mole rat
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human ALS2 from the N-terminal region
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
ALS2 Antibody detects endogenous levels of total ALS2
Immunogen:
A synthesized peptide derived from human ALS2
Cross Reactivity:
Human,Mouse,Rat
Conjugate:
Unconjugated
purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink(TM) Coupling Resin (Thermo Fisher Scientific).
Concentration:
1mg/ml
Buffer:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt
ALS2 Antibody detects endogenous levels of total ALS2
Immunogen:
A synthesized peptide derived from human ALS2
Cross Reactivity:
Human,Mouse,Rat
Conjugate:
Unconjugated
purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink(TM) Coupling Resin (Thermo Fisher Scientific).
Concentration:
1mg/ml
Buffer:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt
Gene ID:
57679
Gene:
ALS2
Swiss-Prot:
Q96Q42
Molecular Weight:
184 kDa
Cookies:
X
We use cookies to help personalise and improve your web experience.
By using our website you consent to our use of cookies, some of which may have already been set on your device.
View our Cookie Policy to learn more.
