Histone deacetylase 6 (HDAC6) is a member of the HDAC family of enzymes that remove acetyl groups from lysines of histones thereby acting as gene transcription regulators. HDAC6 is more specifically a member of the class IIB HDAC family and contains two catalytic domains and a C-terminal zinc finger domain that binds free ubiquitin as well as ubiquitinated proteins with high affinity. As a cytoplasmic deacetylase, HDAC6 can deacetylate substrates such as tubulin, heat shock protein 90 (HSP90).
HDAC6 plays an important role in protein degradation, alongside roles in cell morphology, adhesion, migration, and tumor cell invasion/metastasis.
Inhibition of Histone deacetylases (HDACs) has been shown to be neuroprotective in animal models of neurodegenerative diseases and HDAC6 is one possible target, however theoretically HDAC6 should actually contribute to the degradation of protein aggregates seen in neurodegenerative disorders such as Alzheimers, Parkinsons and Hutingtons diseases, So HDAC6 as a target for neurodegenerative disorders remains controversial.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Histone deacetylase 6 (HDAC6) is a member of the HDAC family of enzymes that remove acetyl groups from lysines of histones thereby acting as gene transcription regulators. HDAC6 is more specifically a member of the class IIB HDAC family and contains two catalytic domains and a C-terminal zinc finger domain that binds free ubiquitin as well as ubiquitinated proteins with high affinity. As a cytoplasmic deacetylase, HDAC6 can deacetylate substrates such as tubulin, heat shock protein 90 (HSP90).
HDAC6 plays an important role in protein degradation, alongside roles in cell morphology, adhesion, migration, and tumor cell invasion/metastasis.
Inhibition of Histone deacetylases (HDACs) has been shown to be neuroprotective in animal models of neurodegenerative diseases and HDAC6 is one possible target, however theoretically HDAC6 should actually contribute to the degradation of protein aggregates seen in neurodegenerative disorders such as Alzheimers, Parkinsons and Hutingtons diseases, So HDAC6 as a target for neurodegenerative disorders remains controversial.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
HDAC6 Antibody detects endogenous levels of total HDAC6.
Blocking Peptide:
A corresponding control peptide is available for this antibody (please email tech@nktscientific.com for details)
Conjugate:
Unconjugated
Uniprot:
Q9UBN7
Gene:
HDAC6
Format:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
HDAC6 Antibody detects endogenous levels of total HDAC6.
Blocking Peptide:
A corresponding control peptide is available for this antibody (please email tech@nktscientific.com for details)
Conjugate:
Unconjugated
Uniprot:
Q9UBN7
Gene:
HDAC6
Format:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
HDAC6 Antibody detects endogenous levels of total HDAC6.
Blocking Peptide:
A corresponding control peptide is available for this antibody (please email tech@nktscientific.com for details)
Conjugate:
Unconjugated
Uniprot:
Q9UBN7
Gene:
HDAC6
Format:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
HDAC6 Antibody detects endogenous levels of total HDAC6.
Blocking Peptide:
A corresponding control peptide is available for this antibody (please email tech@nktscientific.com for details)
Conjugate:
Unconjugated
Uniprot:
Q9UBN7
Gene:
HDAC6
Format:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
HDAC6 Antibody detects endogenous levels of total HDAC6.
Blocking Peptide:
A corresponding control peptide is available for this antibody (please email tech@nktscientific.com for details)
Conjugate:
Unconjugated
Uniprot:
Q9UBN7
Gene:
HDAC6
Format:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
HDAC6 Antibody detects endogenous levels of total HDAC6.
Blocking Peptide:
A corresponding control peptide is available for this antibody (please email tech@nktscientific.com for details)
Conjugate:
Unconjugated
Uniprot:
Q9UBN7
Gene:
HDAC6
Format:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Phospho-HDAC6 (Ser22) Antibody detects endogenous levels of HDAC6 only when phosphorylated at Serine 22.
Blocking Peptide:
A corresponding control peptide is available for this antibody (please email tech@nktscientific.com for details)
Conjugate:
Unconjugated
Uniprot:
Q9UBN7
Gene:
HDAC6
Format:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Phospho-HDAC6 (Ser22) Antibody detects endogenous levels of HDAC6 only when phosphorylated at Serine 22.
Blocking Peptide:
A corresponding control peptide is available for this antibody (please email tech@nktscientific.com for details)
Conjugate:
Unconjugated
Uniprot:
Q9UBN7
Gene:
HDAC6
Format:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
HDAC6 Antibody detects endogenous levels of total HDAC6.
Blocking Peptide:
A corresponding control peptide is available for this antibody (please email tech@nktscientific.com for details)
Conjugate:
Unconjugated
Uniprot:
Q9UBN7
Gene:
HDAC6
Format:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
HDAC6 Antibody detects endogenous levels of total HDAC6.
Blocking Peptide:
A corresponding control peptide is available for this antibody (please email tech@nktscientific.com for details)
Conjugate:
Unconjugated
Uniprot:
Q9UBN7
Gene:
HDAC6
Format:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
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