Heterogeneous Nuclear Ribonucleoprotein A2B1 (hnRNPA2B1) is one of a family of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). These RNA-binding proteins associate with pre-mRNAs in the nucleus and influence pre-mRNA processing and transport. hnRNPA2B1, regulates alternative splicing, nuclear export, translation, and other RNA processing events and also plays a crucial role in mRNA trafficking in neurons and oligodendrocytes.
HnRNP A2B1 is 37 kDa protein with a modular domain structure consisting of two RNA recognition motifs (RRMs) referred to as unwinding protein 1 (UP1) an intrinsically disordered RGG-rich C terminus and a prion-like domain (PrLD). UP1 is the primary RNA binding domain and the C terminus mediates protein-protein interactions.
Mutations in the HnRNP A2B1 gene have been linked to amyotrophic lateral sclerosis (ALS), multisystem proteinopathy (MSP) and other neurodegenerative diseases.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Bovine, Cat, Dog, Chicken, Guinea Pig, Pig, Goat, Western European hedgehog
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human HNRNPA2B1 from the N-terminal region
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Heterogeneous Nuclear Ribonucleoprotein A2B1 (hnRNPA2B1) is one of a family of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). These RNA-binding proteins associate with pre-mRNAs in the nucleus and influence pre-mRNA processing and transport. hnRNPA2B1, regulates alternative splicing, nuclear export, translation, and other RNA processing events and also plays a crucial role in mRNA trafficking in neurons and oligodendrocytes.
HnRNP A2B1 is 37 kDa protein with a modular domain structure consisting of two RNA recognition motifs (RRMs) referred to as unwinding protein 1 (UP1) an intrinsically disordered RGG-rich C terminus and a prion-like domain (PrLD). UP1 is the primary RNA binding domain and the C terminus mediates protein-protein interactions.
Mutations in the HnRNP A2B1 gene have been linked to amyotrophic lateral sclerosis (ALS), multisystem proteinopathy (MSP) and other neurodegenerative diseases.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Bovine, Cat, Dog, Chicken, Guinea Pig, Pig, Goat, Western European hedgehog
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
Partial length recombinant human HNRNPA2B1 from the N-terminal region
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
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