| Product Detail: |
Anti-HNRNPA2B1 Antibody (Polyclonal) |
| Background Info: |
Heterogeneous Nuclear Ribonucleoprotein A2B1 (hnRNPA2B1) is one of a family of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). These RNA-binding proteins associate with pre-mRNAs in the nucleus and influence pre-mRNA processing and transport. hnRNPA2B1, regulates alternative splicing, nuclear export, translation, and other RNA processing events and also plays a crucial role in mRNA trafficking in neurons and oligodendrocytes.
HnRNP A2B1 is 37 kDa protein with a modular domain structure consisting of two RNA recognition motifs (RRMs) referred to as unwinding protein 1 (UP1) an intrinsically disordered RGG-rich C terminus and a prion-like domain (PrLD). UP1 is the primary RNA binding domain and the C terminus mediates protein-protein interactions.
Mutations in the HnRNP A2B1 gene have been linked to amyotrophic lateral sclerosis (ALS), multisystem proteinopathy (MSP) and other neurodegenerative diseases. |
| Product Type: |
NS Reagents Antibody |
| Antibody Type: |
Polyclonal |
| Format: |
100 µg in 100 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Storage Temp: |
Store at -20°C. Avoid freeze / thaw cycles. |
| Host Animal: |
Rabbit |
| Species Reactivity: |
Human, Mouse, Rat |
| Expected Species: |
Bovine, Cat, Dog, Chicken, Guinea Pig, Pig, Goat, Western European hedgehog
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you. |
| Immunogen: |
Partial length recombinant human HNRNPA2B1 from the N-terminal region |
| Applications: |
WB IHC IF |
| Data Sheet: |
PLEASE CLICK HERE TO DOWNLOAD |
| Additional Info: |
If you would like further information regarding the immunogen used in the productiion of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you. |
| Antibody Isotype: |
IgG |
| Application Details: |
WB 1:500-2000. IHC 1:50-200. IF 1:50-200. |
| Category: |
Primary Antibodies |
| Other names: |
HNRNPA2, HNRNPB1, HNRPA2, HNRPA2B1, HNRPB1, IBMPFD2, RNPA2, SNRPB1 |
| Research Areas: |
Neuroscience |
| NS Reagents Product Area: |
Neuroscience |
| Peptide Sequence (Internal Use only): |
MEREKEQFRKLFIGGLSFETTEESLRNYYEQWGKLTDCVVMRDPASKRSRGFGFVTFSSMAEVDAAMAARPHSIDGRVVEPKRAVAREESGKPGAHVTVKKLFVGGIKEDTEEHHLRDYFEEYGKIDTIEIITDRQSGKKRGFGFVTFDDHDPVDKIVLQKYHTINGHNAEVRKALSRQE
Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human HNRNPA2B1
Full Protein is 353 aa in length |
| Molecular Weight: |
37kDa (Intended as a general guide and does not allow for all isoforms and species variations) |
| Subcellular location: |
Cytoplasm Nucleus nucleoplasm |
| Purification: |
Affinity purification |
| Uniprot ID: |
P22626 |
| Gene ID: |
3181 |
| Gene symbol: |
HNRNPA2B1 |
| Release Date: |
May-19 |
