Newmarket Scientific Product Search Results for antibody to vimentin

Product Search Results: antibody to vimentin
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Product Search Results: antibody to vimentin	Num Products Matched: 2	2

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Nordic BioSite

AMB-RRWX7W-100

100µl

£542.00

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Product Detail:	Vimentin, also know as VIM. It is the major subunit protein of the intermediate filaments of mesenchymal cells. It is believed to be involved with the intracellular transport of proteins between the nucleus and plasma membrane. Vimentin has been implicated to be involved in the rate of steroid synthesis via its role as a storage network for steroidogenic cholesterol containing lipid droplets. Vimentin phosphorylation by a protein kinase causes the breakdown of intermediate filaments and activation of an ATP and myosin light chain dependent contractile event. This results in cytoskeletal changes that facilitate the interaction of the lipid droplets within mitochondria, and subsequent transport of cholesterol to the organelles leading to an increase in steroid synthesis. Immunohistochemical staining for Vimentin is characteristic of sarcomas (of neural, muscle and fibroblast origin) compared to carcinomas which are generally negative. Melanomas, lymphomas and vascular tumors may all stain for Vimentin. Vimentin antibodies are thus of value in the differential diagnosis of undifferentiated neoplasms and malignant tumors. They are generally used with a panel of other antibodies including those recognising cytokeratins, lymphoid markers, S100, desmin and neurofilaments.
Product Type:	Antibodies Primary
Antibody Type:	monoclonal
Storage Temp:	4°C -20°C for long term storage
Host Animal:	mouse
Immunogen:	Purified recombinant fragment of Vimentin (aa2-466) expressed in E. Coli.
Applications:	ELISA,WB,IHC
Clone number:	4F2E9;
Antibody Isotype:	IgG1
Application Details:	ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000
Biosite Brand:	BioSite mAb
Species Reactivity:	human,monkey
EntrezGene ID:	7431

Nordic BioSite

AMB-V9JIUU-100

100µl

£470.00

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Product Detail:	Vimentin is the major subunit protein of the intermediate filaments of mesenchymal cells. It is believed to be involved with the intracellular transport of proteins between the nucleus and plasma membrane. Vimentin has been implicated to be involved in the rate of steroid synthesis via its role as a storage network for steroidogenic cholesterol containing lipid droplets. Vimentin phosphorylation by a protein kinase causes the breakdown of intermediate filaments and activation of an ATP and myosin light chain dependent contractile event. This results in cytoskeletal changes that facilitate the interaction of the lipid droplets within mitochondria, and subsequent transport of cholesterol to the organelles leading to an increase in steroid synthesis. Immunohistochemical staining for Vimentin is characteristic of sarcomas (of neural, muscle and fibroblast origin) compared to carcinomas which are generally negative. Melanomas, lymphomas and vascular tumors may all stain for Vimentin. Vimentin antibodies are thus of value in the differential diagnosis of undifferentiated neoplasms and malignant tumors. They are generally used with a panel of other antibodies including those recognising cytokeratins, lymphoid markers, S100, desmin and neurofilaments.
Product Type:	Antibodies Primary
Antibody Type:	monoclonal
Storage Temp:	4°C -20°C for long term storage
Host Animal:	mouse
Immunogen:	Purified recombinant fragment of Vimentin expressed in E. Coli.
Applications:	ELISA,WB,IHC
Clone number:	9E7E7;
Antibody Isotype:	IgG1
Application Details:	ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000
Biosite Brand:	BioSite mAb
Species Reactivity:	human
EntrezGene ID:	7431

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