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Product Search Results: smc602d

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Product Search Results: smc602d

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StressMarq SMC-602D 100 µg £308.00
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Product Detail: This antibody is available conjugated to the following 23 tags: AP (Alkaline Phosphatase), HRP (Horseradish peroxidase), Biotin, Streptavidin, Dylights 350, 405, 488, 594, 633, APC/Cy7; ATTO 390, ATTO 488, ATTO 565, ATTO 594, PE/ATTO594, ATTO633, ATTO 655, ATTO 680, ATTO700, FITC, R-PE, APC, PerCP. Please call for pricing.
Background Info: Vacuolar Protein Sorter-35 (VPS35) is a component of the retromer complex, which is essential for endosome-to-Golgi retrieval of membrane proteins. VPS35 mutations such as D620N have been linked to Parkinson’s Disease (PD) (1,2) and affect retromer function, protein homeostasis, and mitochondria (3).
Product Type: Antibodies
Format: PBS pH 7.4, 50% glycerol, 0.09% Sodium Azide
Storage Temp: -20ºC
Host Animal: Mouse
Species Reactivity: Hu | Ms
Immunogen: Full length recombinant human VSP35
Applications: WB | ICC/IF | IP
Clone number: 7 E4
Antibody Isotype: IgG2a
Application Details: WB (1:200); ICC/IF (1:200); IP (1:200); optimal dilutions for assays should be determined by the user.
Research Area(s): Cell Signaling | Neuroscience |Neurodegeneration | Parkinson's Disease | Membrane Trafficking Proteins | Golgi Proteins | Protein Trafficking | Alzheimer's Disease
Target: VPS35
Conjugate: Unconjugated
Alternative Name(s): Vacuolar protein sorting-associated protein 35, MEM3, PARK17, VPS35 retromer complex component, maternal-embryonic 3, vesicle protein sortin 35, TCCCTA00141, FLJ10752
Category: Monoclonal
Immunogen Species: Human
Accession Number: NP_060676.2
Gene ID: 55737
Swiss-Prot: Q96QK1
Species Reactivity Full Name: Human | Mouse
Purification: Protein G Purified
Concentration: 1 mg/ml
Specificity: Detects ~92 kDa.
Certificate of Analysis: A 1:5 (tissue culture supernatant) dilution of SMC-602 was sufficient for detection of VPS35 in 10 µg of A549 and MEF by ECL immunoblot analysis using Goat Anti-Mouse IgG:HRP as the secondary antibody.
Cellular Localization: Endosome | Lysosome | Vesicles | Cytoplasm | Membrane
Tissue Specificity: Ubiquitous. Highly expressed in brain, colon, heart, kidney, ovary, placenta, skeletal muscle, small intestine, testis, thymus.
References: 1. Vilarino-Guell, C. et al. (2011) Am J Hum Genet 89:162–167
2. Zimprich, A. et al. (2011) Am J Hum Genet 89:168–175
3. Rahman, A.A., Morrison, B.E. (2019) Neurosci 401:1-10.
Tarriff Code: 3002.15.0000
ADR Code: Non-hazardous
UN Code for transport: Non-hazardous
Country of Origin: Canada
Cite this Product: Mouse Anti-Human VPS35 Monoclonal (StressMarq Biosciences, Victoria BC, Cat# SMC-602D)