Newmarket Scientific
Newmarket Scientific








Neuroscience Research


Proteins, antibodies, kits and other reagents for neuroscience


Affinity Biosciences logo   Agrisera logo     Biosensis logo   ImmunoStar logo  NS Reagents logo  

 


 

Newmarket Scientific provides Antibodies, Proteins, Kits and related reagents for neuroscience research.

 

Some products are highlighted below, but many more are available, so please use the search box above to find specific reagents or email us at tech@nktscientific.com

 

Also for more information on neuroscience research in general, including highlighted articles/papers and other resources follow our .

 



NEW NS Reagents Neuroscience Antibodies

 


 

 

PLCG2 Antibody (Cat No: AB21-10139)

Phospholipase C-gamma2 (PLCG2) is an enzyme mainly expressed in immune cells (including microglia) which are involved in innate immunity. PLCG2 has higher expression levels in pathologically affected brain regions in Alzheimer’s disease indicating that the immune system may play a key role in Alzheimer’s disease.

 


 

 

CD38 Antibody (Cat No: AB21-10136)

CD38 is a widely expressed multifunctional ectoenzyme catalysing multiple reactions and also has a role in signal transduction and calcium signaling. CD38 expression in the brain increases under neuroinflammatory conditions indicating a possible role in the regulation of neuroinflammation. In Alzheimer's disease, CD38 immunoreactivity is seen in intracellular tangles and neuropil threads.

 


 

SOD1 Western Blot Image

 

SOD1 Antibody (Cat No: AB19-10106)

Superoxide dismutase 1 (SOD1) is one of three superoxide dismutases with SOD1 being the principal cytoplasmic superoxide dismutase in humans. It binds copper and zinc ions for its activity and stability and plays a major role in redox potential regulation. SOD1 variants are a common cause of familial amyotrophic lateral sclerosis (ALS).


 

TREM2 Staining

 

TREM2 Antibody (Cat No: AB21-10133)

TREM2 (Triggering receptor expressed on myeloid cells 2) is a cell surface transmembrane glycoprotein expressed in myeloid cells including microglia. It plays a complex role in neuroinflammation with expression of TREM2 being upregulated in pathological conditions such as Parkinson's disease, Amyotrophic lateral sclerosis (ALS), stroke, traumatic brain injury and Alzheimer's Disease.

 


 

HRH3 Image

 

HRH3 Antibody (Cat No: AB21-10137)

Histamine is an important messenger molecule and neuromodulator, regulating the release of several neurotransmitters, including histamine release from histaminergic neurons. Dysregulated central histaminergic signalling has been associated with a number of psychiatric disorders including sleep disorders, ADHD, Alzheimer's disease, Parkinson's disease and schizophrenia.

 


 

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GBA Antibody (Cat No: AB19-10120)

Lysosomal acid glucosylceramidase (GBA or Glucocerebrosidase) is the lysosomal hydrolase. Mutations in the GBA gene cause Gaucher disease, a lysosomal storage disease characterised by an accumulation of glucocerebrosides. Patients with Gaucher disease are at increased risk of developing Parkinson's disease and Dementia with Lewy Bodies.

 



New microglia markers

 

Microglia are specialised macrophages found in the central nervous system (CNS).They play a key role in brain maintenance and clear cellular debris, plaques, dead neurons and synapses, and infectious agents.

 

Commonly used markers are IBA1, CD11b, CD45 as well as P2RY12; a new selective marker of microglia.

 

P2RY12 Antibody Staining image      ITGAM Antibody staining     Read more.

 


 


Fluoro-Jade C Staining Kit for identifying degenerating neurons

 

Fluoro-Jade C stains all degenerating neurons regardless of the cause of the damage or the mechanism of cell death. Due to its low background and high resolution it provides high contrast staining, making it ideal for localising degenerating nerve cell bodies as well as distal dendrites, axons and terminals. Fluoro-Jade C is resistant to fading making it compatible with most histological processing and staining protocols.

 

Fluoro-Jade C (FJC) Ready-to-Dilute Staining Kit  - 40 mL

Fluoro-Jade C (FJC) Ready-to-Dilute Staining Kit (Trial size) - 20 mL

Fluoro-Jade® C POWDER - 30 mg

(This product is equivalent to discontinued product AG325 from Merck-Millipore)

 

       Staining of cingulated rat cortex exposed to kainic acid stained with Fluoro-Jade C            Staining of degenerating neurons in the CA3 region of the hippocampus in old diabetic rats. Stained with Fluoro-Jade C            Staining of rat hippocampus exposed to kainic acid. Stained with Fluoro-Jade C

 

Fluoro-Jade® B POWDER - 30 mg

(This product is equivalent to discontinued product AG310 (FJB) from Merck-Millipore)

 

 



Tdp 43 3 cat aa17 100105

TDP43 Antibodies

 

TAR DNA-binding protein 43 (TDP43) binds DNA and RNA and has multiple functions in transcriptional repression, pre-mRNA splicing and translational regulation.

 

Characterisation of transcriptome-wide binding sites shows that thousands of RNAs are bound by TDP43 in neurons.

 

Hyperphosphorylated, fragmented and ubiquitinated forms of TDP-43 have been identified as core components of cytosolic inclusions in ALS (amyotrophic lateral sclerosis) and FTLD (frontotemporal lobar degeneration). As well as...  read more

 



Shinning bright with Biosensis Amylo-Glo!
Amylo glo

 

Beautifully stain amyloid plaques in tissues in multi-labelling and low magnification studies

 

Histologic dyes commonly used for amyloid plaque detection such as Congo Red or Thioflavin S or T come with a number of limitations, including their broad excitation frequencies which cause "bleed through" when using filters for other stains and the need for harsh chemicals during staining making them less compatible with the subsequent use of antibodies.

 

Amylo-Glo RTD (Cat. No. TR-300-AG) is a histological marker that shows clear superiority for visualising amyloid plaques over conventional markers with its... read more

 



Neuroscience - ImmunoStar
Immunostar neuroscience

 

Newmarket Scientific is the UK and Ireland Distributor of the ImmunoStar antibodies for neuroscience research. This set of antibodies was originally provided by DiaSorin (INCSTAR), before becoming ImmunoStar in 2001.

 

Having been available for many years this set of highly cited antibodies really has been tried and tested! Additionally ImmunoStar antibodies are put through extensive testing before release to ensure excellent reliability and lot-to-lot consistency.

 

Get further details of the full range of ImmunoStar antibodies for neuroscience research.

 



New antibody for Alzheimer’s research: Learn how the enzyme CYP46A1 controls brain cholesterol levels

 

Brain cholesterol is an important membrane building component of glial cells, neurons and myelin sheaths. Unable to cross the blood-brain-barrier, cholesterol is synthesised in situ, transported between the various cells and eliminated via oxidative pathways to maintain appropriate levels.

 

Key to regulating brain cholesterol homeostasis the CNS-specific cytochrome P450 enzyme, cholesterol 24-hydroxylase (CYP46A1) is mostly expressed in the brain, converting excess cholesterol to membrane-permeable 24HC (oxysterol, 24S-hydroxycholesterol). This oxidised product diffuses through the blood-brain-barrier entering the systemic circulation to reach the liver where it is degraded to bile acids. Accumulation of cholest... read more and find out about our CYP46A1 antibodies.

 



The role of retromer component VPS-35 in neurodegenerative diseases

 

Endosomes are important protein sorting stations contributing to cell homeostasis. Cargoes, originating from the plasma membrane or the biosynthesis pathways and entering the endosomal system, are either retained in endosomes for subsequent lysosomal degradation or exported from the endosomes for reuse or recycling. Deficiencies in the endosomal sorting system have been linked to neurodegenerative diseases such as Alzheimer’s and Parkinson’s.

 

Retromer is an evolutionarily conserved protein essential for the transport of transmembrane proteins from the endosomes back to the trans-Golgi network or to the plasma membrane via the recycling pathway. Retromer is a pentameric complex composed of a cargo-selective trimeric complex, with the major subunit being VPS-35 (vacuolar protein sorting 35)... read more and find out about our anti VPS35 antibodies.