Newmarket Scientific
Newmarket Scientific








Biosensis


Antibodies, kits and reagents for neuroscience research



Biosensis - fine bioscience tools

 

 

 

Biosensis specialises in antibodies and reagents for Neuroscience, with particular emphasis on neurotrophins and neurotrophin receptors. In addition to neurotrophins, the Biosensis neuroscience portfolio includes products for research in neurodegenerative diseases, neurodevelopment, and neuro-metabolism.

 

Areas of focus include Alzheimer's, Parkinson's and ALS diseases, as well as autophagy and metabolic and stress disorders including metabolic syndrome research, obesity, and neuroimmunology and inflammation.

 

The Biosensis’ range includes neuroscience research antibodies, more than 200 quantitative ELISA kits, tissue staining and cell visualization reagents, and purified proteins targeted for neuroscience and cellular disease research, many having been used in peer reviewed research publications.

 

Find your product using the search box above or if you have any questions please contact us as detailed on our contact and ordering page.

 


 


Biosensis MOAB-2 antibody to Amyloid beta peptide (40/42)

The presence of aggregated amyloid-β peptides (Aβ) is one of the hallmarks of Alzheimer's Disease (AD). However, the form(s) of Aβ-peptides that are associated with this pathology remains unclear. In particular, the neurotoxicity of intraneuronal Aβ accumulation is an area of considerable research and controversy principally because antibodies thought to be specific for Aβ have been shown to actually detect intraneuronal amyloid precursor protein (APP) and not Aβ exclusively.

 

Our Biosensis MOAB-2 antibody (M-1586-100) is a new pan-specific monoclonal antibody to Amyloid beta residues 1-4 and provides unparalleled staining clarity, stronger reactivity and greater sensitivity than any other Abeta monoclonal antibodies previously available for research. Also, unlike other monoclonals such as 6E10 and 4G8, MOAB-2 does not cross react with APP or APP C-terminal fragments.

 

The Biosensis formulation of MOAB-2 is also the only one endorsed by the original developers.

 

Biosensis MOAB-2 antibody to Amyloid beta peptide (A beta 40/42)

 

Related products:

Biosensis APP antibodies, Oligomeric Amyloid-beta ELISA Kits,

Amylo-Glo - Amyloid beta plaque staining solution

 



BDNF Rapid ELISA Kit

BDNF belongs to the neurotrophin family and regulate the survival and differentiation of neurons during development. The alterations in BDNF expression induced by various kinds of brain insult including stress, ischemia, seizure activity and hypoglycaemia may contribute to some pathologies such as depression, epilepsy, Alzheimer’s Disease and Parkinson’s Disease. BDNF promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it. BDNF is also a major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.

 

Biosensis BDNF Rapid™ ELISA kit BEK-2211:

- Now measure BDNF in serum, cell culture supernatants and brain extracts in less than 3 hours.

- Quantify BDNF in Human and Rodent samples against a WHO approved BDNF standard

- High sensitivities gives you the advantage of using small sample volumes

- Our kits contain pre-coated 96 well strip plates – use only what you need

- Also available CE marked (BEK-2211-1P-CE/BEK-2211-2P-CE

 

Below: Analysis of two human serum samples: Our kit gives reliable results in a wide dilution range (A) and with high confidence (B)

 

Analysis of two human serum samples with our BDNF ELISA Kit

 

Related products: BDNF, proBDNF and mature BDNF ELISA kits, BDNF antibodies.

 



Nerve Growth Factor Receptor (p75NTR)

The nerve growth factor (NGF) receptor, also known as p75 neurotrophin receptor (p75NTR), is a low affinity NGF receptor. The other members of the neurotrophin family, including brain-derived neurotrophic factor (BDNF), neurotrophin (NT)-3 and NT-4/5 bind to p75NTR with equal affinity. This receptor also binds pro-neurotrophins. p75NTR mediates signalling of neurotrophins for neuronal survival, apoptosis, neurite outgrowth and synaptic plasticity. Altered neurotrophin levels and p75NTR expression are implicated in degeneration of spinal motor neurons in human and mouse models of amyotrophic lateral sclerosis (ALS).

 

Our new p75NTR antibody (clone 8J2) to the extracellular domain of p75NTR is ideal for:

 

- In vivo targeting: retrograde tracing and receptor trafficking

- Flow cytometry, immunopanning, western blot, immunohistochemistry and more.

- Most mammalian species, including human, mouse and rat

- Replacing clone MLR2 (A comparative study can be viewed here).

 

p75NTR antibody (clone 8J2)

 

Related products:

NGFR/p75ECD Rapid ELISA Kits (Human or Mouse),

Antibodies to p75NTR

NT3 Kits and Antibodies

NT4/5 Kits and Antibodies

 



Neurofilaments

Neurofilaments (NF) are the major constituent of the neuronal cytoskeleton. They are composed of a mixture of subunits which principally include the neurofilament triplet proteins NF-L (light), NF-M (medium) and NF-H (heavy). Neurofilaments may also include peripherin, alpha-internexin, nestin and in some cases vimentin. A role of neurofilaments in a variety of neurodegenerative diseases has been increasingly appreciated in recent years. The aggregation and hyper-phosphorylation of NFs, for instance, has been associated with the progression of some forms of multiple sclerosis and amyotrophic lateral sclerosis. Neurofilaments are incorporated in the structure of intracellular Lewis bodies which are a histopathological hallmark of Parkinson’s Disease.

 

Details of our neurofilament antibodies

 

rat cerebral cortex stained with rabbit polyclonal antibody to Neurofilament

Above: Section of rat cerebral cortex stained with rabbit polyclonal antibody to Neurofilament Medium Cat No R-1395-50 (red).

 

Rat CNS cells stained with mouse monoclonal antibody to alpha-Internexin [1D2]

Above: Mixed cultures of rat CNS cells stained with mouse monoclonal antibody to alpha-Internexin [1D2] Cat No M-1378-250 (red) and Chicken polyclonal antibody to MAP2 Cat No C-1382-50 (green).

 



Fluorescent dyes for for imaging sub-cellular structures

Biosensis’ new range of fluorescence imaging reagents are superb tools to image polar lipids, endoplasmic reticulum, mitochondria, lipid-rich compartment imaging reagents.

 

These unique dyes are characterised by compatibility with other fluorescent dyes and antibodies, usability on live and fixed samples, excellent photo-stability, low cytotoxicity, large Stokes Shift, and rapid cellular uptake.

 

A complete product comparison is available here.

 

Comparison of Biosensis ER-O™  and ER-Tracker™

 

Above: Comparison of Biosensis ER-O™ Endoplasmic Reticulum Tracing Reagent (TR-601-ER1) with a competitor product (ER-Tracker™, a registered trademark of Invitrogen, upper panel). Merged image demonstrates identical staining patterns, but unlike ER-Tracker™, ER-O™ can be used to stain the endoplasmic reticulum in live and fixed tissues without any loss of signal (lower panel).