Exosome and Microvesicle Research
Exosome isolation and quantification, exosome standards, antibodies and RNA extraction
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Our Extracellular Vesicle Research range includes exosome standards, exosome isolation and purification tools and also antibodies to microvesicles that have actually been tested with exosomes in each application.
Some products are highlighted below, followed by a more in depth list but please use the search box above if you are looking for a specific product or email us.
More information on exosome research including highlighted papers and other resources is available on our Exosome Twitter feed: Tweets by NKTSciExosome.
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PURE-EVs size exclusion chromatography columns have been designed specifically for isolating and purifying extracellular vesicles from small volume samples (100 ul - 20 ml). The unique composition of the matrix gives you better purity and recovery yields of your EVs compared to commonly used Semaphore CL-2B SEC columns.
The simple and quick protocol (just 15 minutes) is perfect for isolating Extracellular Vesicles (EVs) from biofluids and cell media and purifying pre-isolated EVs from contaminants, because it preserves the original shape and functionality of the vesicles.
We have 3 columns for EV purification: PURE-EVs, miniPURE-EVs & maxi-PURE-EVs for use with a range of starting volumes. Plus our PURE-EVs PLUS system, provides Pure-EV columns with our TFF-Easy concentrator for concentrating EVs from larger volumes of dilute fluids and preparations, before purifying them using the columns.
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HansaBioMed's TFF-Easy concentrator can be used to concentrate extracellular vesicles (EVs) and remove small proteins from diluted matrices such as cell conditioned media, urine or blood samples prior to EV purification or dialysis.
The TFF-Easy concentrator is a filter cartridge made from polysulfone hollow fibres with 20 nm pores that uses constant agitation parallel to the porous membrane to allow the gentle filtration of the EVs whilst avoiding clogging issues. The EV protocol is simple and fast, providing a high recovery rate and it does not require any... read more and view the TFF-Easy Video.
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HansaBioMed’s TFF-MV concentrator allows one-step purification of microvesicles from large volume samples from just a few millilitres to several litres. With a filter cartridge made from polysulfone hollow fibers it can separate different extracellular vesicles (EVs) by size with no clogging. Water, small molecules and small EVs pass through the hollow fibre pores, leaving larger microvesicles (>150 nm) in the cartridge. The larger microvesicles can then be... read more about the TFF-easy and TF-MV concentrators.
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EXO-Prep is an efficient method for exosome isolation from biofluids (i.e plasma serum and urine) or cell culture supernatant.
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The exosomics range provides solutions for the isolation and selective enrichment of tumour-originating extracellular vesicles (EVs) and exosomes from complex biofluids, providing researchers invaluable solutions to detect early cancer hallmarks.
Current liquid biopsy methods generally isolate total nucleic acids from blood but with only low levels of tumour-derived RNA and DNA. Exosomics SeleCTEV-DNA and SoRTEV-RNA kits allow the isolation of tumour-derived genetic material without the need for special equipment.. Using unique proprietary affinity methods these kits selectively purify tumour-derived extracellular vesicles and exosomes from which RNA and DNA can then be extracted.
Read more about the purification of nucleic acids from tumour EVs and exosomes.
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