CD117 is a cell membrane protein encoded by the c-kit proto-oncogene. CD117 is expressed in mast cells, skin melanocytes and interstitial Cajal cells (ICC). These cells show a strong membrane and cytoplasmic staining. CD117 is also expressed in various epithelia (salivary glands, renal tubular cells etc.). Appendix serves as a good positive and negative control tissue. Neoplasms such as gastrointestinal stromal tumor (GIST), mast cell neoplasms and many other (seminoma, Mercel cell carcinoma etc.) express CD117. This antibody (together with DOG-1, CD34, SMA) is of great importance in the diagnosis of GIST, because of specific treatment of GIST patient with Gleveec.
CD117 is a cell membrane protein encoded by the c-kit proto-oncogene. CD117 is expressed in mast cells, skin melanocytes and interstitial Cajal cells (ICC). These cells show a strong membrane and cytoplasmic staining. CD117 is also expressed in various epithelia (salivary glands, renal tubular cells etc.). Appendix serves as a good positive and negative control tissue. Neoplasms such as gastrointestinal stromal tumor (GIST), mast cell neoplasms and many other (seminoma, Mercel cell carcinoma etc.) express CD117. This antibody (together with DOG-1, CD34, SMA) is of great importance in the diagnosis of GIST, because of specific treatment of GIST patient with Gleveec.
CD11b is a membranous protein with a role in adhesive interactions of many leukocytes, especially macrophages, and subsets of lymphocytes. The expression of CD11b increases during maturation and expression levels vary depending on the type of cell. CD11b can be used as common myeloid and NK cell marker. Useful marker for acute promyelocytic leukemia, hair cell leukemia and AML differentiations. Systemic lupus erythematosus is also shown to be associated with CD11b dysfunction.
CD11b is a membranous protein with a role in adhesive interactions of many leukocytes, especially macrophages, and subsets of lymphocytes. The expression of CD11b increases during maturation and expression levels vary depending on the type of cell. CD11b can be used as common myeloid and NK cell marker. Useful marker for acute promyelocytic leukemia, hair cell leukemia and AML differentiations. Systemic lupus erythematosus is also shown to be associated with CD11b dysfunction.
CD11c is cell surface transmembrane receptor which is mostly expressed on granulocytes, macrophages, monocytes, NK-cells, and some of T- and B-lymphocytes. CD11c is useful especially for diagnosis of hairy cell leukemia (HCL). CD11c can be offer great value for detection panel of HCL with DBA.44, CD103 and other HCL markers
CD11c is cell surface transmembrane receptor which is mostly expressed on granulocytes, macrophages, monocytes, NK-cells, and some of T- and B-lymphocytes. CD11c is useful especially for diagnosis of hairy cell leukemia (HCL). CD11c can be offer great value for detection panel of HCL with DBA.44, CD103 and other HCL markers
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