CD56, also known as neural cell adhesion molecule (NCAM), is a calcium-independent homophilic binding protein that belongs to a group of cell adhesion molecules including cadherins, selectins, and integrins. CD56 is involved in cellcell adhesion of neural cells during embryogenesis and is expressed on most neuroectodermally derived tissues. In normal tissue, anti-CD56 labels neurons, glia, schwann cells, NK (natural killer) cells, and a subset of T-cells.3 CD56 expression can be seen in most NK cell neoplasms, certain subtypes of T-cell lymphoma and in some plasma cell neoplasms. well
Antibody Isotype:
IgG1-k
Monosan Range:
MONOSAN
Clone:
123C3.D5
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Langdon, SP, et al. Cancer Research 1988;48(21):6161-6165
References 2:
Moolenaar, CE, et al. Cancer Research 1990;50(4):1102-1106
References 3:
Sumi M et al. Leuk Lymphoma. 2003 Jan; 44(1): 201-4
References 4:
Kibbelaar, RE, et al. Euro J of Cancer 1991;27(4):431-435
References 5:
Michalides, R, et al. International J of Cancer Sup 1994;8:34-37
CD56, also known as neural cell adhesion molecule (NCAM), is a calcium-independent homophilic binding protein that belongs to a group of cell adhesion molecules including cadherins, selectins, and integrins. CD56 is involved in cellcell adhesion of neural cells during embryogenesis and is expressed on most neuroectodermally derived tissues. In normal tissue, anti-CD56 labels neurons, glia, schwann cells, NK (natural killer) cells, and a subset of T-cells.3 CD56 expression can be seen in most NK cell neoplasms, certain subtypes of T-cell lymphoma and in some plasma cell neoplasms. well
Antibody Isotype:
IgG1-k
Monosan Range:
MONOSAN Ready To Use
Clone:
123C3.D5
Concentration:
n/a
Storage buffer:
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage:
2-8°C
References 1:
Langdon, SP, et al. Cancer Research 1988;48(21):6161-6165
References 2:
Moolenaar, CE, et al. Cancer Research 1990;50(4):1102-1106
References 3:
Sumi M et al. Leuk Lymphoma. 2003 Jan; 44(1): 201-4
References 4:
Kibbelaar, RE, et al. Euro J of Cancer 1991;27(4):431-435
References 5:
Michalides, R, et al. International J of Cancer Sup 1994;8:34-37
The antibody recognizes a transmembrane glycoprotein of 140 and 180 kD which has been identified as NCAM (Neural Cell Adhesion Module). At the international Workshop on SCLC antibodies 123C3 has been categorized as cluster 1 antibody. All cells in small cell carcinomas and carcinoids of the lung are strongly positive for 123C3. A minority of cases of other major types of lung carcinoma are sometimes positive as well: however this positivity is generally weak and focal. Adenoid cystic carcinomas of bronchial glands are strongly positive. Neuroblastoma's and Wilms tumors are usually also staining strongly positive. In non-small lung cell carcinomas, 123C3 staining has been associated with more advanced stage and a decreased survival after surgery. Furthermore, this antibody can be used to support diagnosis of lymphoma or to detect residual disease for cases of CD56 positive T/NK -cell lymphoma in which the neoplastic lymphoid cells are small and show minimal atypia, especially in small biopsies.
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