T-cell intracellular antigen 1 (TIA1) is an RNA binding protein that binds to the 5'TOP sequence of 5'TOP mRNAs. Under stress conditions, TIA1 localises to cellular RNA-protein conglomerations (stress granules). The major granule-associated species is a 15-kDa protein that is likely derived from the carboxyl terminus of the 40-kDa product by proteolytic processing.
TIA1 has been shown to co-localise with hyperphosphorylated tau and progressively accumulate with aggregated tau in tau-mediated neurodegeneration. Additionally mutations in the TIA1 gene have been associated with amyotrophic lateral sclerosis, frontotemporal dementia and Welander distal myopathy.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage Temp:
Store at -20°C. Avoid freeze / thaw cycles.
Host Animal:
Rabbit
Species Reactivity:
Human, Mouse
Expected Species:
Rat, Guinea Pig, Goat, Bovine, Dog, Cat, Pig
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the C-terminal region of human TIA1
If you would like further information regarding the immunogen used in the productiion of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
T-cell intracellular antigen 1 (TIA1) is an RNA binding protein that binds to the 5'TOP sequence of 5'TOP mRNAs. Under stress conditions, TIA1 localises to cellular RNA-protein conglomerations (stress granules). The major granule-associated species is a 15-kDa protein that is likely derived from the carboxyl terminus of the 40-kDa product by proteolytic processing.
TIA1 has been shown to co-localise with hyperphosphorylated tau and progressively accumulate with aggregated tau in tau-mediated neurodegeneration. Additionally mutations in the TIA1 gene have been associated with amyotrophic lateral sclerosis, frontotemporal dementia and Welander distal myopathy.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
Storage Temp:
Store at -20°C. Avoid freeze / thaw cycles.
Host Animal:
Rabbit
Species Reactivity:
Human, Mouse
Expected Species:
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the productiion of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
T-cell intracellular antigen 1 (TIA1) is an RNA binding protein that binds to the 5'TOP sequence of 5'TOP mRNAs. Under stress conditions, TIA1 localises to cellular RNA-protein conglomerations (stress granules). The major granule-associated species is a 15-kDa protein that is likely derived from the carboxyl terminus of the 40-kDa product by proteolytic processing.
TIA1 has been shown to co-localise with hyperphosphorylated tau and progressively accumulate with aggregated tau in tau-mediated neurodegeneration. Additionally mutations in the TIA1 gene have been associated with amyotrophic lateral sclerosis, frontotemporal dementia and Welander distal myopathy.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage Temp:
Store at -20°C. Avoid freeze / thaw cycles.
Host Animal:
Rabbit
Species Reactivity:
Human, Mouse
Expected Species:
Rat, Guinea Pig, Goat, Bovine, Dog, Cat, Pig
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the C-terminal region of human TIA1
If you would like further information regarding the immunogen used in the productiion of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
T-cell intracellular antigen 1 (TIA1) is an RNA binding protein that binds to the 5'TOP sequence of 5'TOP mRNAs. Under stress conditions, TIA1 localises to cellular RNA-protein conglomerations (stress granules). The major granule-associated species is a 15-kDa protein that is likely derived from the carboxyl terminus of the 40-kDa product by proteolytic processing.
TIA1 has been shown to co-localise with hyperphosphorylated tau and progressively accumulate with aggregated tau in tau-mediated neurodegeneration. Additionally mutations in the TIA1 gene have been associated with amyotrophic lateral sclerosis, frontotemporal dementia and Welander distal myopathy.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
Storage Temp:
Store at -20°C. Avoid freeze / thaw cycles.
Host Animal:
Rabbit
Species Reactivity:
Human, Mouse
Expected Species:
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the productiion of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
43kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Nucleus
Purification:
Affinity purification
Uniprot ID:
P31483
Gene ID:
7072
Gene symbol:
TIA1
Release Date:
May-19
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