T-cell intracellular antigen 1 (TIA1) is an RNA binding protein that binds to the 5'TOP sequence of 5'TOP mRNAs. Under stress conditions, TIA1 localises to cellular RNA-protein conglomerations (stress granules). The major granule-associated species is a 15-kDa protein that is likely derived from the carboxyl terminus of the 40-kDa product by proteolytic processing.
TIA1 has been shown to co-localise with hyperphosphorylated tau and progressively accumulate with aggregated tau in tau-mediated neurodegeneration. Additionally mutations in the TIA1 gene have been associated with amyotrophic lateral sclerosis, frontotemporal dementia and Welander distal myopathy.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage Temp:
Store at -20°C. Avoid freeze / thaw cycles.
Host Animal:
Rabbit
Species Reactivity:
Human, Mouse
Expected Species:
Rat, Guinea Pig, Goat, Bovine, Dog, Cat, Pig
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the C-terminal region of human TIA1
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
T-cell intracellular antigen 1 (TIA1) is an RNA binding protein that binds to the 5'TOP sequence of 5'TOP mRNAs. Under stress conditions, TIA1 localises to cellular RNA-protein conglomerations (stress granules). The major granule-associated species is a 15-kDa protein that is likely derived from the carboxyl terminus of the 40-kDa product by proteolytic processing.
TIA1 has been shown to co-localise with hyperphosphorylated tau and progressively accumulate with aggregated tau in tau-mediated neurodegeneration. Additionally mutations in the TIA1 gene have been associated with amyotrophic lateral sclerosis, frontotemporal dementia and Welander distal myopathy.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
Storage Temp:
Store at -20°C. Avoid freeze / thaw cycles.
Host Animal:
Rabbit
Species Reactivity:
Human, Mouse
Expected Species:
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
T-cell intracellular antigen 1 (TIA1) is an RNA binding protein that binds to the 5'TOP sequence of 5'TOP mRNAs. Under stress conditions, TIA1 localises to cellular RNA-protein conglomerations (stress granules). The major granule-associated species is a 15-kDa protein that is likely derived from the carboxyl terminus of the 40-kDa product by proteolytic processing.
TIA1 has been shown to co-localise with hyperphosphorylated tau and progressively accumulate with aggregated tau in tau-mediated neurodegeneration. Additionally mutations in the TIA1 gene have been associated with amyotrophic lateral sclerosis, frontotemporal dementia and Welander distal myopathy.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage Temp:
Store at -20°C. Avoid freeze / thaw cycles.
Host Animal:
Rabbit
Species Reactivity:
Human, Mouse
Expected Species:
Rat, Guinea Pig, Goat, Bovine, Dog, Cat, Pig
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
Immunogen:
A synthetic peptide from the C-terminal region of human TIA1
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
T-cell intracellular antigen 1 (TIA1) is an RNA binding protein that binds to the 5'TOP sequence of 5'TOP mRNAs. Under stress conditions, TIA1 localises to cellular RNA-protein conglomerations (stress granules). The major granule-associated species is a 15-kDa protein that is likely derived from the carboxyl terminus of the 40-kDa product by proteolytic processing.
TIA1 has been shown to co-localise with hyperphosphorylated tau and progressively accumulate with aggregated tau in tau-mediated neurodegeneration. Additionally mutations in the TIA1 gene have been associated with amyotrophic lateral sclerosis, frontotemporal dementia and Welander distal myopathy.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
Storage Temp:
Store at -20°C. Avoid freeze / thaw cycles.
Host Animal:
Rabbit
Species Reactivity:
Human, Mouse
Expected Species:
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
43kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Nucleus
Purification:
Affinity purification
Uniprot ID:
P31483
Gene ID:
7072
Gene symbol:
TIA1
Release Date:
May-19
Cookies:
X
We use cookies to help personalise and improve your web experience.
By using our website you consent to our use of cookies, some of which may have already been set on your device.
View our Cookie Policy to learn more.
