The vacuolar protein sorting 35 (VPS35) is a major component of the retromer recognition core complex which regulates intracellular protein sorting and trafficking.
Mutations in the VPS35 gene are linked to late-onset, autosomal dominant familial Parkinsons disease (PD) , which may involve a link with tau pathology with VPS35 shown to be significantly reduced in two distinct primary tauopathies (Progressive Supra-nuclear Palsy and Picks disease, two distinct primary tauopathies) [1]. There may also be a link between VPS35 and ?-synuclein accumulation, but more work is required to establish the details of the pathiogenic/neuroprotective role of VPS35.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
Storage Temp:
Store at -20?. Avoid freeze / thaw cycles.
Host Animal:
Rabbit
Species Reactivity:
Human, Mouse
Expected Species:
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000. IHC 1:25-100.
Antibody Number:
10109
Category:
Primary Antibodies
Other names:
MEM3, PARK17, Vacuolar protein sorting-associated protein 35, hVPS35, Maternal-embryonic 3, Vesicle protein sorting 35
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
92 kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Cytoplasm, Endosome
Purification:
Affinity purification
References:
[1] Vagnozzi, A.N., Li, J., Chiu, J. et al. VPS35 regulates tau phosphorylation and neuropathology in tauopathy. Mol Psychiatry (2019) doi:10.1038/s41380-019-0453-x
The vacuolar protein sorting 35 (VPS35) is a major component of the retromer recognition core complex which regulates intracellular protein sorting and trafficking.
Mutations in the VPS35 gene are linked to late-onset, autosomal dominant familial Parkinsons disease (PD) , which may involve a link with tau pathology with VPS35 shown to be significantly reduced in two distinct primary tauopathies (Progressive Supra-nuclear Palsy and Picks disease, two distinct primary tauopathies) [1]. There may also be a link between VPS35 and ?-synuclein accumulation, but more work is required to establish the details of the pathiogenic/neuroprotective role of VPS35.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
Storage Temp:
Store at -20?. Avoid freeze / thaw cycles.
Host Animal:
Rabbit
Species Reactivity:
Human, Mouse
Expected Species:
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000. IHC 1:25-100.
Antibody Number:
10109
Category:
Primary Antibodies
Other names:
MEM3, PARK17, Vacuolar protein sorting-associated protein 35, hVPS35, Maternal-embryonic 3, Vesicle protein sorting 35
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
92 kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Cytoplasm, Endosome
Purification:
Affinity purification
References:
[1] Vagnozzi, A.N., Li, J., Chiu, J. et al. VPS35 regulates tau phosphorylation and neuropathology in tauopathy. Mol Psychiatry (2019) doi:10.1038/s41380-019-0453-x
The vacuolar protein sorting 35 (VPS35) is a major component of the retromer recognition core complex which regulates intracellular protein sorting and trafficking.
Mutations in the VPS35 gene are linked to late-onset, autosomal dominant familial Parkinsons disease (PD) , which may involve a link with tau pathology with VPS35 shown to be significantly reduced in two distinct primary tauopathies (Progressive Supra-nuclear Palsy and Picks disease, two distinct primary tauopathies) [1]. There may also be a link between VPS35 and ?-synuclein accumulation, but more work is required to establish the details of the pathiogenic/neuroprotective role of VPS35.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage Temp:
Store at -20?. Avoid freeze / thaw cycles.
Host Animal:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Expected Species:
Bovine, Dog, Guinea Pig, Golden Hamster, Chicken
Immunogen:
Partial length recombinant human VPS35 from the N-terminal region
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000.
Antibody Number:
10110
Category:
Primary Antibodies
Other names:
MEM3, PARK17, Vacuolar protein sorting-associated protein 35, hVPS35, Maternal-embryonic 3, Vesicle protein sorting 35
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
92kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Cytoplasm, Endosome
Purification:
Affinity purification
References:
[1] Vagnozzi, A.N., Li, J., Chiu, J. et al. VPS35 regulates tau phosphorylation and neuropathology in tauopathy. Mol Psychiatry (2019) doi:10.1038/s41380-019-0453-x
The vacuolar protein sorting 35 (VPS35) is a major component of the retromer recognition core complex which regulates intracellular protein sorting and trafficking.
Mutations in the VPS35 gene are linked to late-onset, autosomal dominant familial Parkinsons disease (PD) , which may involve a link with tau pathology with VPS35 shown to be significantly reduced in two distinct primary tauopathies (Progressive Supra-nuclear Palsy and Picks disease, two distinct primary tauopathies) [1]. There may also be a link between VPS35 and ?-synuclein accumulation, but more work is required to establish the details of the pathiogenic/neuroprotective role of VPS35.
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage Temp:
Store at -20?. Avoid freeze / thaw cycles.
Host Animal:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Expected Species:
Bovine, Dog, Guinea Pig, Golden Hamster, Chicken
Immunogen:
Partial length recombinant human VPS35 from the N-terminal region
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000.
Antibody Number:
10110
Category:
Primary Antibodies
Other names:
MEM3, PARK17, Vacuolar protein sorting-associated protein 35, hVPS35, Maternal-embryonic 3, Vesicle protein sorting 35
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
92kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Cytoplasm, Endosome
Purification:
Affinity purification
References:
[1] Vagnozzi, A.N., Li, J., Chiu, J. et al. VPS35 regulates tau phosphorylation and neuropathology in tauopathy. Mol Psychiatry (2019) doi:10.1038/s41380-019-0453-x
Uniprot ID:
Q96QK1
Gene ID:
55737
Gene symbol:
VPS35
Release Date:
Sep-19
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