Profilin 1 (PFN1) is a member of the profilin family of small actin-binding proteins. This 140-amino-acid protein acts as a major regulator of actin polymerisation through its binding of actin-ADP monomers, promoting the conversion of actin-ADP to actin-ATP. PFN1 also binds to phosphoinositides and a large network of proteins with poly-L-proline stretches. Through these binding interactions, PFN1 regulates a number of cellular functions including actin dynamics, membrane trafficking, neuronal synaptic structure and activity and small GTPase signaling.
Mutations in the PFN1 gene are associated with amyotrophic lateral sclerosis (ALS).
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage Temp:
Store at -20°C. Avoid freeze / thaw cycles.
Host Animal:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Expected Species:
Bovine, Cat, Rabbit
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000.
Antibody Number:
10091
Category:
Primary Antibodies
Other names:
Amyotrophic lateral sclerosis 18, ALS18, PFN1, Epididymis Tissue Protein Li 184a, Profilin-1
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
15kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Profilin 1 (PFN1) is a member of the profilin family of small actin-binding proteins. This 140-amino-acid protein acts as a major regulator of actin polymerisation through its binding of actin-ADP monomers, promoting the conversion of actin-ADP to actin-ATP. PFN1 also binds to phosphoinositides and a large network of proteins with poly-L-proline stretches. Through these binding interactions, PFN1 regulates a number of cellular functions including actin dynamics, membrane trafficking, neuronal synaptic structure and activity and small GTPase signaling.
Mutations in the PFN1 gene are associated with amyotrophic lateral sclerosis (ALS).
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage Temp:
Store at -20°C. Avoid freeze / thaw cycles.
Host Animal:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Expected Species:
Bovine, Cat, Rabbit
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000.
Antibody Number:
10091
Category:
Primary Antibodies
Other names:
Amyotrophic lateral sclerosis 18, ALS18, PFN1, Epididymis Tissue Protein Li 184a, Profilin-1
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
15kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR.
PFN1 Antibody detects endogenous levels of total PFN1
Immunogen:
A synthesized peptide derived from human PFN1
Cross Reactivity:
Human,Mouse,Rat
Conjugate:
Unconjugated
purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink(TM) Coupling Resin (Thermo Fisher Scientific).
Concentration:
1mg/ml
Buffer:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt
Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR.
PFN1 Antibody detects endogenous levels of total PFN1
Immunogen:
A synthesized peptide derived from human PFN1
Cross Reactivity:
Human,Mouse,Rat
Conjugate:
Unconjugated
purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink(TM) Coupling Resin (Thermo Fisher Scientific).
Concentration:
1mg/ml
Buffer:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt
Gene ID:
5216
Gene:
PFN1
Swiss-Prot:
P07737
Molecular Weight:
15kDa
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